estradiol biosynthesis I
Pathways in the estradiol biosynthesis I SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | estradiol biosynthesis I | PubChem | |
| 2 | estradiol biosynthesis I (via estrone) | PubChem |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | HSD17B7 | Hydroxysteroid 17-Beta Dehydrogenase 7 | Protein Coding | 2 |
| 2 | CYP19A1 | Cytochrome P450 Family 19 Subfamily A Member 1 | Protein Coding | 2 |
| 3 | HSD17B11 | Hydroxysteroid 17-Beta Dehydrogenase 11 | Protein Coding | 1 |
| 4 | HSD17B1 | Hydroxysteroid 17-Beta Dehydrogenase 1 | Protein Coding | 1 |
| 5 | CYP2A6 | Cytochrome P450 Family 2 Subfamily A Member 6 | Protein Coding | 1 |
Disorders associated with estradiol biosynthesis I SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Letrozole toxicity | Enrichment | CYP2A6 | 3.43 |
| 2 | Aromatase excess syndrome | Enrichment | CYP19A1 | 3.35 |
| 3 | Aromatase deficiency | Enrichment | CYP19A1 | 3.35 |
| 4 | Coumarin resistance | Enrichment | CYP2A6 | 2.96 |
| 5 | Tobacco addiction | Enrichment | CYP2A6 | 2.83 |
| 6 | Primary ovarian insufficiency | Enrichment | CYP19A1 | 2.06 |
| 7 | Lung cancer | Enrichment | CYP2A6 | 1.93 |
