Estrogen signaling pathway

No Pathway Network information available for Estrogen signaling pathway

Pathways in the Estrogen signaling pathway SuperPath

#	Name	Source	Genes
1	Estrogen signaling pathway	WikiPathways	AKT1 BCL2 BRAF CHUK CREB1 ELK1 ESR1 FOS GNAS GNB1 GNGT1 GPER1 IKBKB IKBKG JUN MAP2K1 MAPK1 MAPK14 MAPK9 NFKB1 PIK3CA PRKACA SP1 (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
2	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
3	SP1	Sp1 Transcription Factor	Protein Coding	1
4	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
5	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
6	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
7	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
8	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
9	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
10	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
11	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
12	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
13	GPER1	G Protein-Coupled Estrogen Receptor 1	Protein Coding	1
14	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	1
15	GNB1	G Protein Subunit Beta 1	Protein Coding	1
16	GNAS	GNAS Complex Locus	Protein Coding	1
17	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
18	ESR1	Estrogen Receptor 1	Protein Coding	1
19	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
20	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
21	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
22	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
23	ELK1	ETS Transcription Factor ELK1	Protein Coding	1

Disorders associated with Estrogen signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung non-small cell carcinoma	Enrichment	BRAF, MAP2K1, PIK3CA	6.16
2	Breast cancer	Enrichment	AKT1, ESR1, JUN, PIK3CA	5.15
3	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	5.08
4	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, MAP2K1	4.78
5	Cardiofaciocutaneous syndrome	Enrichment	BRAF, MAP2K1	4.78
6	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.39
7	Hereditary breast carcinoma	Enrichment	AKT1, ESR1, PIK3CA	4.27
8	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	4.24
9	Gallbladder cancer	Enrichment	BRAF, PIK3CA	4.24
10	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA	4.01
11	Primary hyperaldosteronism	Enrichment	BRAF, GNAS	4.01
12	Cowden syndrome	Enrichment	AKT1, PIK3CA	4.01
13	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA	3.91
14	Meningioma	Enrichment	AKT1, PIK3CA	3.75
15	Lip and oral cavity carcinoma	Enrichment	BRAF, PIK3CA	3.75
16	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, MAP2K1	3.55
17	Colorectal cancer	Enrichment	AKT1, BRAF, PIK3CA	3.39
18	Noonan syndrome 1	Enrichment	BRAF, MAP2K1	3.17
19	Rasopathy	Enrichment	BRAF, MAP2K1	3.06
20	Lung cancer	Enrichment	BRAF, PIK3CA	2.88
21	Macrodactyly	Enrichment	PIK3CA	2.77
22	Proteus syndrome	Enrichment	AKT1	2.77
23	Incontinentia pigmenti	Enrichment	IKBKG	2.77
24	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.77
25	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.77
26	Melorheostosis, isolated	Enrichment	MAP2K1	2.77
27	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.77
28	Osseous heteroplasia, progressive	Enrichment	GNAS	2.77
29	Noonan syndrome 7	Enrichment	BRAF	2.77
30	Leopard syndrome 3	Enrichment	BRAF	2.77
31	Cowden syndrome 5	Enrichment	PIK3CA	2.77
32	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.77
33	Fetal encasement syndrome	Enrichment	CHUK	2.77
34	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.77
35	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.77
36	Immunodeficiency 15b	Enrichment	IKBKB	2.77
37	Noonan syndrome 13	Enrichment	MAPK1	2.77
38	Immunodeficiency 15a	Enrichment	IKBKB	2.77
39	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.77
40	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.77
41	Lymphangioma	Enrichment	BRAF	2.77
42	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.77
43	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.77
44	Phace association	Enrichment	BRAF	2.77
45	Melorheostosis	Enrichment	MAP2K1	2.77
46	Cowden syndrome 6	Enrichment	AKT1	2.77
47	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.77
48	Disorders of gnas inactivation	Enrichment	GNAS	2.77
49	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.77
50	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.77
51	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.77
52	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.77
53	Hypospadias	Enrichment	PIK3CA	2.77
54	Rare venous malformation	Enrichment	PIK3CA	2.77
55	Diaphragmatic eventration	Enrichment	PIK3CA	2.77
56	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.77
57	Syringocystadenoma papilliferum	Enrichment	BRAF	2.77
58	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.77
59	Rare combined vascular malformation	Enrichment	PIK3CA	2.77
60	Ganglioglioma	Enrichment	BRAF	2.77
61	Cavernous lymphangioma	Enrichment	PIK3CA	2.77
62	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.77
63	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.77
64	Monostotic fibrous dysplasia	Enrichment	GNAS	2.77
65	Phace syndrome	Enrichment	BRAF	2.77
66	Classic hairy cell leukemia	Enrichment	BRAF	2.77
67	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.77
68	Mazabraud syndrome	Enrichment	GNAS	2.77
69	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.77
70	Macrodactyly of toe	Enrichment	PIK3CA	2.77
71	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.47
72	Immunodeficiency 33	Enrichment	IKBKG	2.47
73	Pulmonic stenosis	Enrichment	BRAF	2.47
74	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.47
75	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.47
76	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.47
77	Keratosis, seborrheic	Enrichment	PIK3CA	2.47
78	Noonan syndrome 8	Enrichment	PIK3CA	2.47
79	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.47
80	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.47
81	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.47
82	Pseudohypoparathyroidism	Enrichment	GNAS	2.47
83	Fibrolamellar carcinoma	Enrichment	PRKACA	2.47
84	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.47
85	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.47
86	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.47
87	Common variable immunodeficiency 12	Enrichment	NFKB1	2.47
88	Cerebral visual impairment	Enrichment	GNB1	2.47
89	Mccune-albright syndrome	Enrichment	GNAS	2.29
90	Ataxia-telangiectasia	Enrichment	BRAF	2.29
91	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.29
92	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.29
93	Estrogen resistance	Enrichment	ESR1	2.29
94	Tethered spinal cord syndrome	Enrichment	BRAF	2.29
95	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.29
96	Migraine without aura	Enrichment	ESR1	2.29
97	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	2.29
98	Melanoma of soft tissue	Enrichment	CREB1	2.29
99	Keratoacanthoma	Enrichment	PIK3CA	2.29
100	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	2.17
101	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	2.17
102	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.17
103	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.17
104	Congenital generalized lipodystrophy	Enrichment	FOS	2.17
105	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	2.17
106	Cerebrovascular disease	Enrichment	PIK3CA	2.17
107	Craniopharyngioma	Enrichment	BRAF	2.17
108	Noonan syndrome with multiple lentigines	Enrichment	BRAF	2.17
109	Newborn respiratory distress syndrome	Enrichment	BRAF	2.17
110	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.17
111	Capillary malformations, congenital	Enrichment	PIK3CA	2.07
112	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.07
113	Follicular lymphoma	Enrichment	BCL2	2.07
114	Histiocytoid hemangioma	Enrichment	FOS	2.07
115	Hemimegalencephaly	Enrichment	PIK3CA	2.07
116	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.99
117	Cowden syndrome 1	Enrichment	PIK3CA	1.99
118	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.99
119	Wilms tumor 5	Enrichment	BRAF	1.99
120	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.99
121	Nevus, epidermal	Enrichment	PIK3CA	1.93
122	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	1.93
123	Brachydactyly	Enrichment	GNAS	1.93
124	Pilomyxoid astrocytoma	Enrichment	BRAF	1.93
125	Common variable immunodeficiency	Enrichment	NFKB1	1.93
126	Follicular thyroid carcinoma	Enrichment	BRAF	1.93
127	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.90
128	Melanocytic nevus syndrome, congenital	Enrichment	BRAF	1.87
129	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.87
130	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.87
131	Hypothyroidism	Enrichment	GNB1	1.87
132	Autism spectrum disorder	Enrichment	GNB1, MAP2K1	1.84
133	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.82
134	Ellis-van creveld syndrome	Enrichment	PRKACA	1.82
135	Coronary heart disease 5	Enrichment	IKBKG	1.82
136	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.82
137	Ventricular septal defect	Enrichment	BRAF	1.82
138	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.77
139	Melanoma	Enrichment	BRAF	1.77
140	Microcephaly	Enrichment	GNB1, MAPK1	1.74
141	Migraine with or without aura 1	Enrichment	ESR1	1.73
142	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.73
143	Myelodysplastic syndrome	Enrichment	GNB1	1.73
144	Specific learning disability	Enrichment	MAPK1	1.73
145	Lung cancer susceptibility 3	Enrichment	BRAF	1.63
146	Wilms tumor 1	Enrichment	BRAF	1.60
147	Lynch syndrome	Enrichment	PIK3CA	1.60
148	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.55
149	Cleft palate, isolated	Enrichment	GNB1	1.55
150	Dandy-walker syndrome	Enrichment	BRAF	1.55
151	Heart, malformation of	Enrichment	MAPK1	1.52
152	Arteriovenous malformations of the brain	Enrichment	BRAF	1.50
153	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.50
154	Endometrial cancer	Enrichment	PIK3CA	1.46
155	Hepatocellular carcinoma	Enrichment	PIK3CA	1.44
156	Myocardial infarction	Enrichment	ESR1	1.44
157	Malaria	Enrichment	IKBKG	1.42
158	Strabismus	Enrichment	GNB1	1.35
159	Bladder cancer	Enrichment	PIK3CA	1.32
160	Prostate cancer	Enrichment	PIK3CA	1.32
161	Differentiated thyroid carcinoma	Enrichment	BRAF	1.32
162	Severe combined immunodeficiency	Enrichment	IKBKB	1.26
163	Dystonia	Enrichment	GNB1	1.24
164	Cerebral palsy	Enrichment	GNB1	1.19
165	Gastric cancer	Enrichment	PIK3CA	1.15
166	Body mass index quantitative trait locus 11	Enrichment	GNAS	1.09
167	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	1.09
168	Hypertelorism	Enrichment	PIK3CA	1.07
169	Myeloma, multiple	Enrichment	BRAF	1.04
170	Dilated cardiomyopathy	Enrichment	BRAF	0.90

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Estrogen signaling pathway

Pathway Network for Estrogen signaling pathway

Member Pathways for Estrogen signaling pathway

Pathways in the Estrogen signaling pathway SuperPath

Associated Genes for Estrogen signaling pathway

Associated Disorders for Estrogen signaling pathway

Disorders associated with Estrogen signaling pathway SuperPath

STRING Interaction Network for Estrogen signaling pathway

Sources for Estrogen signaling pathway