Estrone metabolism

Pathway network for the Estrone metabolism SuperPath

Sources:

GeneGo (Thomson Reuters)

Pathways in the Estrone metabolism SuperPath

#	Name	Source	Genes
1	Estrone metabolism	GeneGo (Thomson Reuters)	COMT CYP1A2 CYP2C19 CYP2C9 CYP3A4 CYP3A5 HSD17B1 HSD17B2 HSD17B3 HSD17B7 HSD17B8 STS SULT1E1 SULT2B1 (see all 14) (see less)
2	Androstenedione and testosterone biosynthesis and metabolism p.1	GeneGo (Thomson Reuters)	CYP17A1 CYP1A1 CYP1A2 CYP2A13 CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A7 HSD17B1 HSD17B2 HSD17B3 HSD17B7 HSD17B8 HSD3B1 HSD3B2 STS SULT1E1 SULT2A1 (see all 19) (see less)
3	Estrogen biosynthesis	GeneGo (Thomson Reuters)	CYP11B1 CYP19A1 CYP2C19 CYP2C8 CYP2C9 CYP3A4 HSD17B1 HSD17B2 HSD17B3 HSD17B7 HSD17B8 (see all 11) (see less)

Gene overlap in member pathways for Estrone metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	3
2	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	3
3	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	3
4	HSD17B1	Hydroxysteroid 17-Beta Dehydrogenase 1	Protein Coding	3
5	HSD17B3	Hydroxysteroid 17-Beta Dehydrogenase 3	Protein Coding	3
6	HSD17B2	Hydroxysteroid 17-Beta Dehydrogenase 2	Protein Coding	3
7	HSD17B8	Hydroxysteroid 17-Beta Dehydrogenase 8	Protein Coding	3
8	HSD17B7	Hydroxysteroid 17-Beta Dehydrogenase 7	Protein Coding	3
9	STS	Steroid Sulfatase	Protein Coding	2
10	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	2
11	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	2
12	SULT1E1	Sulfotransferase Family 1E Member 1	Protein Coding	2
13	COMT	Catechol-O-Methyltransferase	Protein Coding	1
14	SULT2B1	Sulfotransferase Family 2B Member 1	Protein Coding	1
15	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	1
16	CYP3A7	Cytochrome P450 Family 3 Subfamily A Member 7	Protein Coding	1
17	CYP2A13	Cytochrome P450 Family 2 Subfamily A Member 13	Protein Coding	1
18	CYP17A1	Cytochrome P450 Family 17 Subfamily A Member 1	Protein Coding	1
19	HSD3B1	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 1	Protein Coding	1
20	HSD3B2	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 2	Protein Coding	1
21	SULT2A1	Sulfotransferase Family 2A Member 1	Protein Coding	1
22	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	1
23	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	1
24	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	1

Disorders associated with Estrone metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lipoid congenital adrenal hyperplasia	Enrichment	CYP17A1, HSD3B2	3.78
2	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	3.09
3	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	3.09
4	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.09
5	Ichthyosis, congenital, autosomal recessive 14	Enrichment	SULT2B1	2.99
6	Catechol-o-methyltransferase activity, variation in	Enrichment	COMT	2.99
7	Syndromic recessive x-linked ichthyosis	Enrichment	STS	2.99
8	17-beta hydroxysteroid dehydrogenase iii deficiency	Enrichment	HSD17B3	2.79
9	Ichthyosis, x-linked	Enrichment	STS	2.69
10	Adrenal hyperplasia, congenital, due to steroid 11-beta-hydroxylase deficiency	Enrichment	CYP11B1	2.61
11	Aromatase excess syndrome	Enrichment	CYP19A1	2.61
12	Coumarin resistance	Enrichment	CYP2C9	2.61
13	Aromatase deficiency	Enrichment	CYP19A1	2.61
14	Deficiency of steroid 11-beta-monooxygenase	Enrichment	CYP11B1	2.61
15	Adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency	Enrichment	HSD3B2	2.55
16	Hypospadias 1, x-linked	Enrichment	HSD3B2	2.55
17	3 beta-hydroxysteroid dehydrogenase deficiency	Enrichment	HSD3B2	2.55
18	Ichthyosis, congenital, autosomal recessive 1	Enrichment	SULT2B1	2.51
19	Pseudohermaphroditism	Enrichment	HSD17B3	2.39
20	Adrenal hyperplasia, congenital, due to 17-alpha-hydroxylase deficiency	Enrichment	CYP17A1	2.38
21	Hyperaldosteronism, familial, type i	Enrichment	CYP11B1	2.31
22	Ichthyosis, congenital, autosomal recessive 2	Enrichment	SULT2B1	2.29
23	Difference of sex development	Enrichment	HSD17B3	2.19
24	Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency	Enrichment	CYP17A1	2.08
25	21-hydroxylase-deficient congenital adrenal hyperplasia	Enrichment	CYP17A1	2.08
26	Epilepsy, myoclonic juvenile	Enrichment	HSD17B3	2.05
27	Congenital nonbullous ichthyosiform erythroderma	Enrichment	SULT2B1	1.99
28	Digeorge syndrome	Enrichment	COMT	1.91
29	Autosomal recessive congenital ichthyosis	Enrichment	SULT2B1	1.81
30	Hypertension, essential	Enrichment	CYP3A5	1.76
31	Bardet-biedl syndrome	Enrichment	COMT	1.37
32	Primary ovarian insufficiency	Enrichment	CYP19A1	1.33
33	Schizophrenia	Enrichment	COMT	1.23
34	Breast cancer	Enrichment	CYP17A1	1.00

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Estrone metabolism

Pathway Network for Estrone metabolism

Pathway network for the Estrone metabolism SuperPath

Member Pathways for Estrone metabolism

Pathways in the Estrone metabolism SuperPath

Gene overlap in member pathways for Estrone metabolism SuperPath

Associated Genes for Estrone metabolism

Associated Disorders for Estrone metabolism

Disorders associated with Estrone metabolism SuperPath

STRING Interaction Network for Estrone metabolism

Sources for Estrone metabolism