ethanol degradation II

Sources:

#	Name	Source	Genes
1	ethanol degradation II	PubChem	ACSS2 ADH1B ALDH2 ALDH3A2
2	Fluoroacetic acid toxicity	WikiPathways	ACO2 ACSS2 ALDH2 ALDH3A2 ALDH9A1 CS (see all 6) (see less)
3	noradrenaline and adrenaline degradation	PubChem	ADH1B ADH4 ALDH2 ALDH3A2 COMT PNMT (see all 6) (see less)
4	oxidative ethanol degradation III	PubChem	ACSS1 ACSS2 ACSS3 ALDH2 ALDH3A2 CYP2E1 (see all 6) (see less)
5	L-phenylalanine degradation IV (mammalian, via side chain)	PubChem	ALDH2 ALDH3A2 HPD MAOB
6	ethanol degradation III	PubChem	ACSS2 ALDH2 ALDH3A2 CYP2E1
7	ethanol degradation IV	PubChem	ACSS2 ALDH2 ALDH3A2 CAT
8	putrescine degradation III	PubChem	ALDH2 ALDH3A2 MAOB
9	acetate conversion to acetyl-CoA	PubChem	ACSS2

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ALDH3A2	Aldehyde Dehydrogenase 3 Family Member A2	Protein Coding	8
2	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	8
3	ACSS2	Acyl-CoA Synthetase Short Chain Family Member 2	Protein Coding	6
4	ADH1B	Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide	Protein Coding	2
5	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	2
6	MAOB	Monoamine Oxidase B	Protein Coding	2
7	ACO2	Aconitase 2	Protein Coding	1
8	ALDH9A1	Aldehyde Dehydrogenase 9 Family Member A1	Protein Coding	1
9	CS	Citrate Synthase	Protein Coding	1
10	ADH4	Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide	Protein Coding	1
11	PNMT	Phenylethanolamine N-Methyltransferase	Protein Coding	1
12	COMT	Catechol-O-Methyltransferase	Protein Coding	1
13	ACSS1	Acyl-CoA Synthetase Short Chain Family Member 1	Protein Coding	1
14	ACSS3	Acyl-CoA Synthetase Short Chain Family Member 3	Protein Coding	1
15	HPD	4-Hydroxyphenylpyruvate Dioxygenase	Protein Coding	1
16	CAT	Catalase	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Alcohol dependence	Enrichment	ADH1B, ALDH2	6.01
2	Alcohol sensitivity, acute	Enrichment	ALDH2	3.66
3	Acatalasemia	Enrichment	CAT	3.53
4	Amed syndrome, digenic	Enrichment	ALDH2	3.35
5	Sjogren-larsson syndrome	Enrichment	ALDH3A2	3.35
6	Catechol-o-methyltransferase activity, variation in	Enrichment	COMT	3.35
7	Tyrosinemia, type iii	Enrichment	HPD	3.23
8	Hawkinsinuria	Enrichment	HPD	3.23
9	Orofacial cleft 1	Enrichment	ACSS2	3.18
10	Tyrosinemia	Enrichment	HPD	3.05
11	Porphyria, acute intermittent	Enrichment	ACO2	3.05
12	Acute porphyria	Enrichment	ACO2	3.05
13	Infantile cerebellar-retinal degeneration	Enrichment	ACO2	2.88
14	Optic atrophy 9	Enrichment	ACO2	2.88
15	Autosomal recessive isolated optic atrophy	Enrichment	ACO2	2.75
16	Digeorge syndrome	Enrichment	COMT	2.28
17	Isolated macular dystrophy	Enrichment	ACO2	2.21
18	Cerebral palsy	Enrichment	ALDH3A2	2.07
19	Bardet-biedl syndrome	Enrichment	COMT	1.73
20	Optic atrophy plus syndrome	Enrichment	ACO2	1.71
21	Schizophrenia	Enrichment	COMT	1.59
22	Hereditary retinal dystrophy	Enrichment	ACO2	0.91
23	Fundus dystrophy	Enrichment	ACO2	0.91

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for ethanol degradation II