Ethanol effects on histone modifications

No Pathway Network information available for Ethanol effects on histone modifications

Pathways in the Ethanol effects on histone modifications SuperPath

#	Name	Source	Genes
1	Ethanol effects on histone modifications	WikiPathways	ACSS2 ADH1A ADH1B ADH1C AHCY ALDH1A1 ALDH1A2 ALDH1A3 ALDH2 ATF2 CYP2E1 DHFR EHMT2 ELP3 HAT1 HDAC1 HDAC10 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 KAT2B MAT1A MTHFR MTR SLC19A1 TYMS (see all 31) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HDAC10	Histone Deacetylase 10	Protein Coding	1
2	ACSS2	Acyl-CoA Synthetase Short Chain Family Member 2	Protein Coding	1
3	HDAC7	Histone Deacetylase 7	Protein Coding	1
4	HDAC8	Histone Deacetylase 8	Protein Coding	1
5	HDAC4	Histone Deacetylase 4	Protein Coding	1
6	HDAC9	Histone Deacetylase 9	Protein Coding	1
7	ALDH1A2	Aldehyde Dehydrogenase 1 Family Member A2	Protein Coding	1
8	HDAC3	Histone Deacetylase 3	Protein Coding	1
9	TYMS	Thymidylate Synthetase	Protein Coding	1
10	SLC19A1	Solute Carrier Family 19 Member 1	Protein Coding	1
11	ELP3	Elongator Acetyltransferase Complex Subunit 3	Protein Coding	1
12	MTR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase	Protein Coding	1
13	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	1
14	MAT1A	Methionine Adenosyltransferase 1A	Protein Coding	1
15	HDAC2	Histone Deacetylase 2	Protein Coding	1
16	HDAC1	Histone Deacetylase 1	Protein Coding	1
17	ALDH1A3	Aldehyde Dehydrogenase 1 Family Member A3	Protein Coding	1
18	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	1
19	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	1
20	AHCY	Adenosylhomocysteinase	Protein Coding	1
21	DHFR	Dihydrofolate Reductase	Protein Coding	1
22	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	1
23	ATF2	Activating Transcription Factor 2	Protein Coding	1
24	ADH1C	Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide	Protein Coding	1
25	ADH1B	Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide	Protein Coding	1
26	ADH1A	Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide	Protein Coding	1
27	EHMT2	Euchromatic Histone Lysine Methyltransferase 2	Protein Coding	1
28	HDAC5	Histone Deacetylase 5	Protein Coding	1
29	HDAC6	Histone Deacetylase 6	Protein Coding	1
30	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
31	HAT1	Histone Acetyltransferase 1	Protein Coding	1

Disorders associated with Ethanol effects on histone modifications SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Alcohol dependence	Enrichment	ADH1B, ADH1C, ALDH2	6.67
2	Neural tube defects, folate-sensitive	Enrichment	MTHFR, MTR	4.52
3	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	2.64
4	Homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity	Enrichment	MTHFR	2.64
5	Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency	Enrichment	AHCY	2.64
6	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	2.64
7	Auriculocondylar syndrome 4	Enrichment	HDAC9	2.64
8	Cornelia de lange syndrome 5	Enrichment	HDAC8	2.64
9	Megaloblastic anemia, folate-responsive	Enrichment	SLC19A1	2.64
10	Alcohol sensitivity, acute	Enrichment	ALDH2	2.64
11	Diaphragmatic hernia 4, with cardiovascular defects	Enrichment	ALDH1A2	2.64
12	Megaloblastic anemia due to dihydrofolate reductase deficiency	Enrichment	DHFR	2.64
13	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	2.64
14	Immunodeficiency 114, folate-responsive	Enrichment	SLC19A1	2.64
15	Methionine adenosyltransferase i/iii deficiency	Enrichment	MAT1A	2.34
16	Syndactyly, type iii	Enrichment	HDAC8	2.34
17	Amed syndrome, digenic	Enrichment	ALDH2	2.34
18	Wilson-turner syndrome	Enrichment	HDAC8	2.34
19	Microphthalmia, isolated 8	Enrichment	ALDH1A3	2.34
20	Glaucoma, primary closed-angle	Enrichment	SLC19A1	2.34
21	Disorders of intracellular cobalamin metabolism	Enrichment	MTR	2.34
22	Dyskeratosis congenita, digenic	Enrichment	TYMS	2.34
23	Isolated anencephaly	Enrichment	MTHFR	2.34
24	Isolated exencephaly	Enrichment	MTHFR	2.34
25	Methionine adenosyltransferase deficiency	Enrichment	MAT1A	2.34
26	Homocystinuria-megaloblastic anemia, cblg type	Enrichment	MTR	2.16
27	Familial adenomatous polyposis 4	Enrichment	DHFR	2.16
28	Isolated anophthalmia-microphthalmia syndrome	Enrichment	ALDH1A3	2.16
29	Homocystinuria	Enrichment	MTR	2.16
30	Parkinson disease, mitochondrial	Enrichment	ADH1C	2.04
31	Knobloch syndrome	Enrichment	SLC19A1	2.04
32	Knobloch syndrome 1	Enrichment	SLC19A1	1.94
33	Thrombophilia due to thrombin defect	Enrichment	MTHFR	1.80
34	Fanconi anemia, complementation group c	Enrichment	HDAC8	1.74
35	Orofacial cleft 1	Enrichment	ACSS2	1.69
36	Cornelia de lange syndrome 1	Enrichment	HDAC8	1.69
37	Cornelia de lange syndrome	Enrichment	HDAC8	1.69
38	Nanophthalmos	Enrichment	ALDH1A3	1.60
39	Atrial heart septal defect	Enrichment	HDAC8	1.60
40	Interatrial communication	Enrichment	HDAC8	1.60
41	Neural tube defects	Enrichment	MTHFR	1.53
42	Cataract	Enrichment	SLC19A1	1.50
43	Polycystic kidney disease	Enrichment	HDAC8	1.39
44	Dyskeratosis congenita	Enrichment	TYMS	1.37
45	Macs syndrome	Enrichment	ALDH1A3	1.35
46	Endometrial cancer	Enrichment	DHFR	1.33
47	Microphthalmia	Enrichment	ALDH1A3	1.31
48	Parkinson disease, late-onset	Enrichment	ADH1C	1.27
49	Stargardt disease 1	Enrichment	SLC19A1	1.18
50	Lung cancer	Enrichment	SLC19A1	1.15
51	Epilepsy	Enrichment	MTR	1.06
52	West syndrome	Enrichment	MTHFR	1.02
53	Myeloma, multiple	Enrichment	HDAC4	0.92
54	Schizophrenia	Enrichment	MTHFR	0.90
55	Autism	Enrichment	ALDH1A3	0.82
56	Microcephaly	Enrichment	HDAC8	0.61
57	Inherited cancer-predisposing syndrome	Enrichment	DHFR	0.58
58	Retinitis pigmentosa	Enrichment	SLC19A1	0.41
59	Hereditary retinal dystrophy	Enrichment	SLC19A1	0.31
60	Fundus dystrophy	Enrichment	SLC19A1	0.31

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Ethanol effects on histone modifications

Pathway Network for Ethanol effects on histone modifications

Member Pathways for Ethanol effects on histone modifications

Pathways in the Ethanol effects on histone modifications SuperPath

Associated Genes for Ethanol effects on histone modifications

Associated Disorders for Ethanol effects on histone modifications

Disorders associated with Ethanol effects on histone modifications SuperPath

STRING Interaction Network for Ethanol effects on histone modifications

Sources for Ethanol effects on histone modifications