Etoposide Pathway, Pharmacokinetics/Pharmacodynamics

No Pathway Network information available for Etoposide Pathway, Pharmacokinetics/Pharmacodynamics

#	Name	Source	Genes
1	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 ABCC1 ABCC3 CYP3A4 CYP3A5 GSTP1 GSTT1 MPO NR1I2 PTGS1 PTGS2 TOP2A TOP2B UGT1A1 VDR (see all 15) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PTGS1	Prostaglandin-Endoperoxide Synthase 1	Protein Coding	1
2	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
3	VDR	Vitamin D Receptor	Protein Coding	1
4	TOP2A	DNA Topoisomerase II Alpha	Protein Coding	1
5	TOP2B	DNA Topoisomerase II Beta	Protein Coding	1
6	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	1
7	ABCC3	ATP Binding Cassette Subfamily C Member 3	Protein Coding	1
8	NR1I2	Nuclear Receptor Subfamily 1 Group I Member 2	Protein Coding	1
9	MPO	Myeloperoxidase	Protein Coding	1
10	ABCC1	ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)	Protein Coding	1
11	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	1
12	GSTT1	Glutathione S-Transferase Theta 1	Protein Coding	1
13	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	1
14	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	1
15	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	B-cell immunodeficiency, distal limb anomalies, and urogenital malformations	Enrichment	TOP2B	2.96
2	Colchicine resistance	Enrichment	ABCB1	2.96
3	Encephalopathy, acute transient	Enrichment	ABCB1	2.96
4	Deafness, autosomal dominant 77	Enrichment	ABCC1	2.96
5	Inflammatory bowel disease 13	Enrichment	ABCB1	2.96
6	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	2.96
7	Rickets	Enrichment	VDR	2.96
8	Kala-azar 2	Enrichment	GSTP1	2.66
9	Myeloperoxidase deficiency	Enrichment	MPO	2.35
10	Vitamin d-dependent rickets, type 2a	Enrichment	VDR	2.26
11	Alzheimer's disease 1	Enrichment	MPO	2.11
12	Crigler-najjar syndrome, type i	Enrichment	UGT1A1	1.96
13	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1	1.96
14	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1	1.96
15	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1	1.96
16	Gilbert syndrome	Enrichment	UGT1A1	1.92
17	Epilepsy, idiopathic generalized	Enrichment	ABCB1	1.92
18	Bilirubin metabolic disorder	Enrichment	UGT1A1	1.92
19	Pulmonary disease, chronic obstructive	Enrichment	VDR	1.85
20	Alzheimer's disease	Enrichment	MPO	1.85
21	Alzheimer disease, familial, 1	Enrichment	MPO	1.73
22	Hypertension, essential	Enrichment	CYP3A5	1.73
23	Hepatocellular carcinoma	Enrichment	VDR	1.62
24	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ABCC1	1.25
25	Autism spectrum disorder	Enrichment	TOP2B	0.94

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Etoposide Pathway, Pharmacokinetics/Pharmacodynamics