Expression of BMAL (ARNTL), CLOCK, and NPAS2

Pathway network for the Expression of BMAL (ARNTL), CLOCK, and NPAS2 SuperPath

Sources:

Reactome

Pathways in the Expression of BMAL (ARNTL), CLOCK, and NPAS2 SuperPath

#	Name	Source	Genes
1	Expression of BMAL (ARNTL), CLOCK, and NPAS2	Reactome	ATF2 BMAL1 CARM1 CHD9 CLOCK CREB1 CREBBP CRTC1 CRTC2 CRTC3 EP300 HDAC3 HELZ2 MED1 MEF2C MEF2D NCOA1 NCOA2 NCOA6 NCOR1 NPAS2 NR1D1 NRIP1 PPARA PPARGC1A RAI1 RORA RORB RORC RXRA SIRT1 SMARCD3 TBL1X TBL1XR1 TGS1 (see all 35) (see less)
2	Heme signaling	Reactome	APOA1 APOB ATF2 BACH1 BMAL1 CARM1 CHD9 CLEC1B CLOCK CREB1 CREBBP CRTC1 CRTC2 CRTC3 EP300 HBA1 HBA2 HBB HDAC3 HELZ2 HMOX1 LY96 MAFK MED1 MEF2C MEF2D NCOA1 NCOA2 NCOA6 NCOR1 NFE2L2 NPAS2 NR1D1 NRIP1 PGRMC2 PPARA PPARGC1A RAI1 RORA RXRA SIRT1 SLC46A1 SMARCD3 TBL1X TBL1XR1 TGS1 TLR4 XPO1 (see all 48) (see less)
3	BMAL1:CLOCK,NPAS2 activates circadian expression	Reactome	AVP BHLHE40 BHLHE41 BMAL1 BMAL2 CARM1 CHD9 CLOCK CREBBP F7 HELZ2 KLF15 MED1 NAMPT NCOA1 NCOA2 NCOA6 NOCT NPAS2 PPARA RXRA SERPINE1 SMARCD3 TBL1X TBL1XR1 TGS1 (see all 26) (see less)
4	RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Reactome	CARM1 CHD9 CPT1A CREBBP EP300 HDAC3 HELZ2 MED1 NCOA1 NCOA2 NCOA6 NCOR1 NR1D1 NRIP1 PPARA PPARGC1A RORA RORC RXRA SMARCD3 SREBF1 TBL1X TBL1XR1 TGS1 (see all 24) (see less)

Gene overlap in member pathways for Expression of BMAL (ARNTL), CLOCK, and NPAS2 SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CARM1	Coactivator Associated Arginine Methyltransferase 1	Protein Coding	4
2	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	4
3	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	4
4	NCOA6	Nuclear Receptor Coactivator 6	Protein Coding	4
5	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	4
6	MED1	Mediator Complex Subunit 1	Protein Coding	4
7	RXRA	Retinoid X Receptor Alpha	Protein Coding	4
8	SMARCD3	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D3	Protein Coding	4
9	TBL1X	Transducin Beta Like 1 X-Linked	Protein Coding	4
10	TBL1XR1	TBL1X/Y Related 1	Protein Coding	4
11	CHD9	Chromodomain Helicase DNA Binding Protein 9	Protein Coding	4
12	HELZ2	Helicase With Zinc Finger 2	Protein Coding	4
13	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	4
14	TGS1	Trimethylguanosine Synthase 1	Protein Coding	4
15	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	3
16	EP300	EP300 Lysine Acetyltransferase	Protein Coding	3
17	BMAL1	Basic Helix-Loop-Helix ARNT Like 1	Protein Coding	3
18	NPAS2	Neuronal PAS Domain Protein 2	Protein Coding	3
19	RORA	RAR Related Orphan Receptor A	Protein Coding	3
20	NRIP1	Nuclear Receptor Interacting Protein 1	Protein Coding	3
21	HDAC3	Histone Deacetylase 3	Protein Coding	3
22	NR1D1	Nuclear Receptor Subfamily 1 Group D Member 1	Protein Coding	3
23	CLOCK	Clock Circadian Regulator	Protein Coding	3
24	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	3
25	RAI1	Retinoic Acid Induced 1	Protein Coding	2
26	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
27	ATF2	Activating Transcription Factor 2	Protein Coding	2
28	CRTC2	CREB Regulated Transcription Coactivator 2	Protein Coding	2
29	CRTC1	CREB Regulated Transcription Coactivator 1	Protein Coding	2
30	SIRT1	Sirtuin 1	Protein Coding	2
31	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	2
32	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	2
33	RORC	RAR Related Orphan Receptor C	Protein Coding	2
34	CRTC3	CREB Regulated Transcription Coactivator 3	Protein Coding	2
35	RORB	RAR Related Orphan Receptor B	Protein Coding	1
36	PGRMC2	Progesterone Receptor Membrane Component 2	Protein Coding	1
37	SLC46A1	Solute Carrier Family 46 Member 1	Protein Coding	1
38	LY96	Lymphocyte Antigen 96	Protein Coding	1
39	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	1
40	HBA2	Hemoglobin Subunit Alpha 2	Protein Coding	1
41	HBB	Hemoglobin Subunit Beta	Protein Coding	1
42	HMOX1	Heme Oxygenase 1	Protein Coding	1
43	APOA1	Apolipoprotein A1	Protein Coding	1
44	APOB	Apolipoprotein B	Protein Coding	1
45	NFE2L2	NFE2 Like BZIP Transcription Factor 2	Protein Coding	1
46	CLEC1B	C-Type Lectin Domain Family 1 Member B	Protein Coding	1
47	BACH1	BACH Transcriptional Regulator 1	Protein Coding	1
48	TLR4	Toll Like Receptor 4	Protein Coding	1
49	XPO1	Exportin 1	Protein Coding	1
50	MAFK	MAF BZIP Transcription Factor K	Protein Coding	1
51	NAMPT	Nicotinamide Phosphoribosyltransferase	Protein Coding	1
52	F7	Coagulation Factor VII	Protein Coding	1
53	NOCT	Nocturnin	Protein Coding	1
54	KLF15	KLF Transcription Factor 15	Protein Coding	1
55	SERPINE1	Serpin Family E Member 1	Protein Coding	1
56	AVP	Arginine Vasopressin	Protein Coding	1
57	BMAL2	Basic Helix-Loop-Helix ARNT Like 2	Protein Coding	1
58	BHLHE41	Basic Helix-Loop-Helix Family Member E41	Protein Coding	1
59	BHLHE40	Basic Helix-Loop-Helix Family Member E40	Protein Coding	1
60	CPT1A	Carnitine Palmitoyltransferase 1A	Protein Coding	1
61	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	1

Disorders associated with Expression of BMAL (ARNTL), CLOCK, and NPAS2 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Methemoglobinemia, beta type	Enrichment	HBA1, HBA2, HBB	6.08
2	Autosomal dominant secondary polycythemia	Enrichment	HBA1, HBA2, HBB	6.08
3	Heinz body anemias	Enrichment	HBA1, HBA2, HBB	5.64
4	Heinz body anemia	Enrichment	HBA1, HBA2, HBB	5.64
5	Alpha-thalassemia	Enrichment	HBA1, HBA2, HBB	5.46
6	Protein-deficiency anemia	Enrichment	HBA1, HBA2, HBB	4.94
7	Alpha thalassemia-intellectual disability syndrome type 1	Enrichment	HBA1, HBA2	4.44
8	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	4.35
9	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	4.35
10	Erythrocytosis, familial, 7	Enrichment	HBA1, HBA2	4.14
11	Hemoglobin h disease	Enrichment	HBA1, HBA2	4.14
12	Thalassemia	Enrichment	HBA2, HBB	3.91
13	Beta-thalassemia	Enrichment	HBA2, HBB	3.59
14	Beta-thalassemia major	Enrichment	HBA2, HBB	3.59
15	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	3.51
16	Diffuse large b-cell lymphoma	Enrichment	CREBBP, TBL1XR1	3.30
17	Hypothyroidism, congenital, nongoitrous, 8	Enrichment	TBL1X	2.75
18	Mucoepithelial dysplasia, hereditary	Enrichment	SREBF1	2.75
19	Ifap syndrome 2	Enrichment	SREBF1	2.75
20	Immunodeficiency 42	Enrichment	RORC	2.75
21	Congenital anomalies of kidney and urinary tract 3	Enrichment	NRIP1	2.75
22	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.75
23	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.75
24	Menke-hennekam syndrome	Enrichment	CREBBP	2.75
25	Diabetes insipidus, neurohypophyseal	Enrichment	AVP	2.72
26	Factor vii deficiency	Enrichment	F7	2.72
27	Short sleep, familial natural, 1	Enrichment	BHLHE41	2.72
28	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.72
29	Central diabetes insipidus	Enrichment	AVP	2.72
30	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.72
31	Congenital factor vii deficiency	Enrichment	F7	2.72
32	Hereditary arginine vasopressin deficiency	Enrichment	AVP	2.72
33	Epilepsy, idiopathic generalized 15	Enrichment	RORB	2.59
34	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.59
35	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.59
36	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.59
37	Mef2c-related disorder	Enrichment	MEF2C	2.59
38	Thumb deformity	Enrichment	CREBBP	2.45
39	Carnitine palmitoyltransferase i deficiency	Enrichment	CPT1A	2.45
40	Hypothyroidism, congenital, nongoitrous, 6	Enrichment	NR1D1	2.45
41	Menke-hennekam syndrome 2	Enrichment	EP300	2.45
42	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.45
43	Intellectual developmental disorder with or without epilepsy or cerebellar ataxia	Enrichment	RORA	2.45
44	Immunodeficiency, developmental delay, and hypohomocysteinemia	Enrichment	NFE2L2	2.45
45	Macular degeneration, age-related, 10	Enrichment	TLR4	2.45
46	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.45
47	Sickle cell-beta-thalassemia disease syndrome	Enrichment	HBB	2.45
48	Hemoglobin c-beta-thalassemia syndrome	Enrichment	HBB	2.45
49	Sickle cell s-o arab disease	Enrichment	HBB	2.45
50	Sickle cell-beta zero-thalassemia	Enrichment	HBB	2.45
51	Sickle cell s-d punjab disease	Enrichment	HBB	2.45
52	Sickle cell s-c disease	Enrichment	HBB	2.45
53	Sickle cell s-e disease	Enrichment	HBB	2.45
54	Homozygous hemoglobin o arab disease	Enrichment	HBB	2.45
55	Sickle cell s-other specified hemoglobin variant	Enrichment	HBB	2.45
56	Hydrops fetalis, nonimmune	Enrichment	HBA1, HBA2	2.42
57	Myeloma, multiple	Enrichment	CREBBP, RXRA	2.36
58	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.29
59	Yuan-harel-lupski syndrome	Enrichment	RAI1	2.29
60	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	SREBF1	2.28
61	Pierpont syndrome	Enrichment	TBL1XR1	2.28
62	Tethered spinal cord syndrome	Enrichment	CREBBP	2.28
63	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.28
64	Intellectual developmental disorder, autosomal dominant 41	Enrichment	TBL1XR1	2.28
65	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	2.15
66	Methemoglobinemia, alpha type	Enrichment	HBA1	2.15
67	Hemoglobin lepore-beta-thalassemia syndrome	Enrichment	HBB	2.15
68	Hypobetalipoproteinemia	Enrichment	APOB	2.15
69	Hypoalphalipoproteinemia, primary, 2, intermediate	Enrichment	APOA1	2.15
70	Amyloidosis, hereditary systemic 3	Enrichment	APOA1	2.15
71	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	2.15
72	Sickle cell s-lepore disease	Enrichment	HBB	2.15
73	Diabetes insipidus	Enrichment	AVP	2.12
74	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	2.12
75	Potocki-lupski syndrome	Enrichment	RAI1	2.11
76	Melanoma of soft tissue	Enrichment	CREB1	2.11
77	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.05
78	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C, PPARGC1A	2.01
79	Hypertrichosis	Enrichment	CREBBP	1.98
80	Hypercholesterolemia, familial, 2	Enrichment	APOB	1.98
81	Folate malabsorption, hereditary	Enrichment	SLC46A1	1.98
82	Hypoalphalipoproteinemia, primary, 2	Enrichment	APOA1	1.98
83	Hemoglobin e disease	Enrichment	HBB	1.98
84	Spastic paraplegia 50, autosomal recessive	Enrichment	APOA1	1.98
85	Sickle cell-hemoglobin c disease	Enrichment	HBB	1.98
86	Hemoglobin d disease	Enrichment	HBB	1.98
87	Delta beta-thalassemia	Enrichment	HBB	1.98
88	Unstable hemoglobin disease	Enrichment	HBB	1.98
89	Hemoglobin e/beta thalassemia disease	Enrichment	HBB	1.98
90	Smith-magenis syndrome	Enrichment	RAI1	1.89
91	Hypoalphalipoproteinemia, primary, 1	Enrichment	APOA1	1.85
92	Sickle cell disease	Enrichment	HBB	1.85
93	Beta-thalassemia, dominant inclusion body type	Enrichment	HBB	1.85
94	Erythrocytosis, familial, 6	Enrichment	HBB	1.85
95	Beta-thalassemia intermedia	Enrichment	HBB	1.85
96	Hemoglobinopathy	Enrichment	HBB	1.85
97	Hemoglobin c disease	Enrichment	HBB	1.85
98	Hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome	Enrichment	HBB	1.85
99	Methemoglobinemia, beta-globin type	Enrichment	HBB	1.85
100	Epilepsy, childhood absence 1	Enrichment	RORB	1.81
101	Charge syndrome	Enrichment	EP300	1.80
102	Hyperlipidemia, familial combined, 3	Enrichment	APOB	1.76
103	Amyloidosis, hereditary systemic 2	Enrichment	APOA1	1.76
104	Hereditary persistence of fetal hemoglobin-sickle cell disease syndrome	Enrichment	HBB	1.76
105	Acute promyelocytic leukemia	Enrichment	TBL1XR1	1.64
106	Heart disease	Enrichment	CREBBP	1.61
107	Hemolytic anemia	Enrichment	HBB	1.61
108	Pulmonary disease, chronic obstructive	Enrichment	BMAL2	1.61
109	Polydactyly, postaxial, type a1	Enrichment	EP300	1.58
110	Corpus callosum, agenesis of	Enrichment	CREBBP	1.58
111	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.58
112	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.58
113	Fetal hemoglobin quantitative trait locus 1	Enrichment	HBB	1.55
114	Homozygous familial hypercholesterolemia	Enrichment	APOB	1.55
115	Epilepsy, idiopathic generalized	Enrichment	RORB	1.55
116	Coronary heart disease 5	Enrichment	APOB	1.50
117	Colorectal cancer	Enrichment	EP300, NFE2L2	1.42
118	Myocardial infarction	Enrichment	F7	1.38
119	Scoliosis	Enrichment	CREBBP	1.38
120	Syndromic intellectual disability	Enrichment	RAI1	1.37
121	Hypercholesterolemia, familial, 1	Enrichment	APOB	1.35
122	Hirschsprung disease 1	Enrichment	SREBF1	1.30
123	Atypical hemolytic-uremic syndrome	Enrichment	HBB	1.29
124	Familial hypercholesterolemia	Enrichment	APOB	1.29
125	Cakut	Enrichment	NRIP1	1.23
126	Behcet syndrome	Enrichment	TLR4	1.19
127	Malaria	Enrichment	HBB	1.11
128	Epilepsy	Enrichment	RORB	1.01
129	Non-immune hydrops fetalis	Enrichment	HBA2	0.98
130	Lung cancer	Enrichment	NFE2L2	0.97
131	Cystic fibrosis	Enrichment	HMOX1	0.97
132	Autism	Enrichment	CREBBP	0.92
133	Congenital nervous system abnormality	Enrichment	CREBBP	0.77
134	Nervous system disease	Enrichment	CREBBP	0.77
135	Microcephaly	Enrichment	EP300	0.71
136	Complex neurodevelopmental disorder	Enrichment	RORA	0.70
137	Autism spectrum disorder	Enrichment	MEF2C	0.61

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Expression of BMAL (ARNTL), CLOCK, and NPAS2

Pathway Network for Expression of BMAL (ARNTL), CLOCK, and NPAS2

Pathway network for the Expression of BMAL (ARNTL), CLOCK, and NPAS2 SuperPath

Member Pathways for Expression of BMAL (ARNTL), CLOCK, and NPAS2

Pathways in the Expression of BMAL (ARNTL), CLOCK, and NPAS2 SuperPath

Gene overlap in member pathways for Expression of BMAL (ARNTL), CLOCK, and NPAS2 SuperPath

Associated Genes for Expression of BMAL (ARNTL), CLOCK, and NPAS2

Associated Disorders for Expression of BMAL (ARNTL), CLOCK, and NPAS2

Disorders associated with Expression of BMAL (ARNTL), CLOCK, and NPAS2 SuperPath

STRING Interaction Network for Expression of BMAL (ARNTL), CLOCK, and NPAS2

Sources for Expression of BMAL (ARNTL), CLOCK, and NPAS2