Extracellular vesicle-mediated signaling in recipient cells

No Pathway Network information available for Extracellular vesicle-mediated signaling in recipient cells

Pathways in the Extracellular vesicle-mediated signaling in recipient cells SuperPath

#	Name	Source	Genes
1	Extracellular vesicle-mediated signaling in recipient cells	WikiPathways	AKT1 APC AXIN1 CTNNB1 DKK4 EGFR ERBB2 HGF HRAS KRAS MET MFGE8 MTOR PIK3R5 PROM1 RAF1 SMAD2 SMAD3 SMAD4 TGFA TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR3 TSPAN8 WNT3A WNT5A (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	WNT3A	Wnt Family Member 3A	Protein Coding	1
2	PROM1	Prominin 1	Protein Coding	1
3	AXIN1	Axin 1	Protein Coding	1
4	WNT5A	Wnt Family Member 5A	Protein Coding	1
5	TSPAN8	Tetraspanin 8	Protein Coding	1
6	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
7	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
8	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
9	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
10	TGFA	Transforming Growth Factor Alpha	Protein Coding	1
11	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
12	MFGE8	Milk Fat Globule EGF And Factor V/VIII Domain Containing	Protein Coding	1
13	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
14	SMAD4	SMAD Family Member 4	Protein Coding	1
15	SMAD3	SMAD Family Member 3	Protein Coding	1
16	SMAD2	SMAD Family Member 2	Protein Coding	1
17	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
18	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
19	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
20	HGF	Hepatocyte Growth Factor	Protein Coding	1
21	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
22	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
23	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
24	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	1
25	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
26	CTNNB1	Catenin Beta 1	Protein Coding	1
27	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1
28	DKK4	Dickkopf Wnt Signaling Pathway Inhibitor 4	Protein Coding	1

Disorders associated with Extracellular vesicle-mediated signaling in recipient cells SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1	10.66
2	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1	9.56
3	Ovarian cancer	Enrichment	AKT1, APC, CTNNB1, EGFR, ERBB2, KRAS, MET	8.97
4	Bladder cancer	Enrichment	CTNNB1, EGFR, ERBB2, HRAS, KRAS	8.53
5	Lung non-small cell carcinoma	Enrichment	EGFR, ERBB2, HRAS, KRAS	8.32
6	Colorectal cancer	Enrichment	AKT1, APC, CTNNB1, ERBB2, MET, SMAD4	7.71
7	Hepatocellular carcinoma	Enrichment	APC, AXIN1, CTNNB1, MET	6.98
8	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1	6.56
9	Gallbladder cancer	Enrichment	CTNNB1, KRAS, SMAD4	6.56
10	Lung cancer	Enrichment	EGFR, ERBB2, KRAS, MET	6.30
11	Gastric cancer	Enrichment	APC, ERBB2, KRAS, SMAD4	5.77
12	Lung cancer susceptibility 3	Enrichment	EGFR, ERBB2, KRAS	5.55
13	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, RAF1	5.45
14	Childhood hepatocellular carcinoma	Enrichment	CTNNB1, MET	5.39
15	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	5.39
16	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	4.91
17	Desmoid tumor	Enrichment	APC, CTNNB1	4.91
18	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1	4.91
19	Noonan syndrome 1	Enrichment	HRAS, KRAS, RAF1	4.87
20	Rasopathy	Enrichment	HRAS, KRAS, RAF1	4.70
21	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS	4.61
22	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	4.61
23	Craniopharyngioma	Enrichment	APC, CTNNB1	4.61
24	Breast adenocarcinoma	Enrichment	AKT1, KRAS	4.21
25	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS	4.21
26	Nevus, epidermal	Enrichment	HRAS, KRAS	4.07
27	Renal cell carcinoma, papillary, 1	Enrichment	MET, MTOR	4.07
28	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	4.07
29	Hereditary breast carcinoma	Enrichment	AKT1, APC, KRAS	4.01
30	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.94
31	Inherited cancer-predisposing syndrome	Enrichment	APC, EGFR, MET, SMAD4	3.83
32	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	3.83
33	Marfan syndrome	Enrichment	TGFB2, TGFBR1	3.74
34	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS	3.57
35	Medulloblastoma	Enrichment	APC, CTNNB1	3.43
36	Renal cell carcinoma, nonpapillary	Enrichment	MET, MTOR	3.37
37	Breast cancer	Enrichment	AKT1, APC, KRAS	3.32
38	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	3.16
39	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2	3.16
40	Hepatoblastoma	Enrichment	APC, CTNNB1	3.07
41	Pancreatic cancer	Enrichment	KRAS, SMAD4	2.92
42	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS	2.79
43	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.73
44	Proteus syndrome	Enrichment	AKT1	2.69
45	Paget disease, extramammary	Enrichment	ERBB2	2.69
46	Oculoectodermal syndrome	Enrichment	KRAS	2.69
47	Noonan syndrome 5	Enrichment	RAF1	2.69
48	Deafness, autosomal recessive 39	Enrichment	HGF	2.69
49	Stargardt disease 4	Enrichment	PROM1	2.69
50	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.69
51	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.69
52	Caudal duplication anomaly	Enrichment	AXIN1	2.69
53	Macular dystrophy, retinal, 2	Enrichment	PROM1	2.69
54	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.69
55	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.69
56	Osteofibrous dysplasia	Enrichment	MET	2.69
57	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.69
58	Deafness, autosomal recessive 97	Enrichment	MET	2.69
59	Camurati-engelmann disease 2	Enrichment	TGFB2	2.69
60	Autism 9	Enrichment	MET	2.69
61	Leopard syndrome 2	Enrichment	RAF1	2.69
62	Cowden syndrome 6	Enrichment	AKT1	2.69
63	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.69
64	Retinitis pigmentosa 41	Enrichment	PROM1	2.69
65	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.69
66	Trigonitis	Enrichment	RAF1	2.69
67	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.69
68	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.69
69	Adenoid ameloblastoma	Enrichment	CTNNB1	2.69
70	Arthrogryposis, distal, type 11	Enrichment	MET	2.69
71	Heritable thoracic aortic disease	Enrichment	SMAD4	2.69
72	Congenital pulmonary airway malformation	Enrichment	KRAS	2.69
73	Familial adenomatous polyposis	Enrichment	APC	2.69
74	Gardner syndrome	Enrichment	APC	2.69
75	5q22 microdeletion syndrome	Enrichment	APC	2.69
76	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.69
77	Attenuated familial adenomatous polyposis	Enrichment	APC	2.69
78	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.69
79	Microcystic stromal tumor	Enrichment	CTNNB1	2.69
80	Myhre syndrome	Enrichment	SMAD4	2.38
81	Camurati-engelmann disease 1	Enrichment	TGFB1	2.38
82	Costello syndrome	Enrichment	HRAS	2.38
83	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.38
84	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.38
85	Loeys-dietz syndrome 2	Enrichment	TGFBR1	2.38
86	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.38
87	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.38
88	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS	2.38
89	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.38
90	Cebalid syndrome	Enrichment	MTOR	2.38
91	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.38
92	Papillary renal cell carcinoma	Enrichment	MET	2.38
93	Camurati-engelmann disease	Enrichment	TGFB1	2.38
94	Periampullary adenoma	Enrichment	APC	2.38
95	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	2.38
96	Smith-kingsmore syndrome	Enrichment	MTOR	2.38
97	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.38
98	Teratoma	Enrichment	CTNNB1	2.38
99	Wooly hair nevus	Enrichment	HRAS	2.38
100	Juvenile polyposis syndrome	Enrichment	SMAD4	2.21
101	Osteoporosis, juvenile	Enrichment	WNT3A	2.21
102	Cone-rod dystrophy 12	Enrichment	PROM1	2.21
103	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.21
104	Cenani-lenz syndactyly syndrome	Enrichment	APC	2.21
105	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.21
106	Anus, imperforate	Enrichment	CTNNB1	2.21
107	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.21
108	Large congenital melanocytic nevus	Enrichment	HRAS	2.21
109	Spermatocytoma	Enrichment	HRAS	2.21
110	Colon adenocarcinoma	Enrichment	APC	2.21
111	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.21
112	Renal cell carcinoma	Enrichment	MET	2.21
113	Apc-associated polyposis conditions	Enrichment	APC	2.21
114	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.08
115	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.08
116	Robinow syndrome, autosomal dominant 1	Enrichment	WNT5A	2.08
117	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.08
118	Pilomatrixoma	Enrichment	CTNNB1	2.08
119	Barrett esophagus	Enrichment	ERBB2	2.08
120	Alazami syndrome	Enrichment	CTNNB1	2.08
121	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.08
122	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.08
123	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS	2.08
124	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.08
125	Pilocytic astrocytoma	Enrichment	KRAS	2.08
126	Epidermolytic nevus	Enrichment	HRAS	2.08
127	Autosomal dominant robinow syndrome	Enrichment	WNT5A	2.08
128	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.08
129	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.99
130	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.99
131	Robinow syndrome, autosomal recessive 1	Enrichment	WNT5A	1.99
132	Familial adenomatous polyposis 1	Enrichment	APC	1.99
133	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.99
134	Hemimegalencephaly	Enrichment	MTOR	1.99
135	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.99
136	Familial cerebral saccular aneurysm	Enrichment	TGFBR3	1.99
137	Atrial septal defect 1	Enrichment	TGFB2	1.91
138	Cowden syndrome 1	Enrichment	EGFR	1.91
139	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.91
140	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.91
141	Autosomal recessive robinow syndrome	Enrichment	WNT5A	1.91
142	Adrenocortical carcinoma	Enrichment	CTNNB1	1.91
143	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.91
144	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.91
145	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.84
146	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.84
147	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	1.84
148	Leukemia, chronic myeloid	Enrichment	KRAS	1.84
149	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.84
150	Follicular thyroid carcinoma	Enrichment	HRAS	1.84
151	Overgrowth syndrome	Enrichment	MTOR	1.84
152	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF, MET	1.84
153	Arthrogryposis, distal, type 1a	Enrichment	MET	1.79
154	Glioma susceptibility 1	Enrichment	ERBB2	1.79
155	Leber congenital amaurosis 1	Enrichment	PROM1	1.79
156	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.79
157	Arteriovenous malformation	Enrichment	HRAS	1.73
158	Colonic benign neoplasm	Enrichment	APC	1.73
159	Cowden syndrome	Enrichment	AKT1	1.73
160	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.73
161	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.69
162	Pectus excavatum	Enrichment	TGFBR1	1.65
163	Juvenile myelomonocytic leukemia	Enrichment	KRAS	1.61
164	Meningioma	Enrichment	AKT1	1.61
165	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	1.61
166	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	1.61
167	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.54
168	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	1.54
169	Isolated macular dystrophy	Enrichment	PROM1	1.54
170	Lynch syndrome	Enrichment	KRAS	1.52
171	Rare genetic intellectual disability	Enrichment	MTOR	1.52
172	Rhabdomyosarcoma	Enrichment	HRAS	1.49
173	Gliosarcoma	Enrichment	EGFR	1.49
174	Polycystic liver disease	Enrichment	CTNNB1	1.46
175	Giant cell glioblastoma	Enrichment	EGFR	1.46
176	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.46
177	Tooth agenesis	Enrichment	TGFA	1.35
178	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.31
179	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.28
180	Hirschsprung disease 1	Enrichment	ERBB2	1.23
181	Stargardt disease 1	Enrichment	PROM1	1.22
182	Cystic fibrosis	Enrichment	TGFB1	1.19
183	Connective tissue disease	Enrichment	SMAD3	1.19
184	Usher syndrome	Enrichment	PROM1	1.18
185	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.18
186	Left ventricular noncompaction	Enrichment	RAF1	1.16
187	Leukemia, acute myeloid	Enrichment	KRAS	1.10
188	Sensorineural hearing loss	Enrichment	HGF	1.02
189	Thrombocytopenia	Enrichment	SMAD4	1.02
190	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.98
191	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.97
192	Myeloma, multiple	Enrichment	KRAS	0.96
193	Cone-rod dystrophy 2	Enrichment	PROM1	0.88
194	Dilated cardiomyopathy	Enrichment	RAF1	0.82
195	Leber plus disease	Enrichment	PROM1	0.75
196	Congenital nervous system abnormality	Enrichment	CTNNB1	0.70
197	Nervous system disease	Enrichment	CTNNB1	0.70
198	Microcephaly	Enrichment	CTNNB1	0.65
199	Retinitis pigmentosa	Enrichment	PROM1	0.45
200	Hereditary retinal dystrophy	Enrichment	PROM1	0.34
201	Fundus dystrophy	Enrichment	PROM1	0.34

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Extracellular vesicle-mediated signaling in recipient cells

Pathway Network for Extracellular vesicle-mediated signaling in recipient cells

Member Pathways for Extracellular vesicle-mediated signaling in recipient cells

Pathways in the Extracellular vesicle-mediated signaling in recipient cells SuperPath

Associated Genes for Extracellular vesicle-mediated signaling in recipient cells

Associated Disorders for Extracellular vesicle-mediated signaling in recipient cells

Disorders associated with Extracellular vesicle-mediated signaling in recipient cells SuperPath

STRING Interaction Network for Extracellular vesicle-mediated signaling in recipient cells

Sources for Extracellular vesicle-mediated signaling in recipient cells