Extracellular vesicles in the crosstalk of cardiac cells

No Pathway Network information available for Extracellular vesicles in the crosstalk of cardiac cells

Pathways in the Extracellular vesicles in the crosstalk of cardiac cells SuperPath

#	Name	Source	Genes
1	Extracellular vesicles in the crosstalk of cardiac cells	WikiPathways	BIRC5 CD63 CD81 EGF EGFR ETS2 GATA4 HSPB1 IGF1 IL6 KDR MIR19A MIR320A MIR455 MMP9 PDLIM5 PTEN SOD1 SORBS2 SPP1 STAT3 TLR4 (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD81	CD81 Molecule	Protein Coding	1
2	CD63	CD63 Molecule	Protein Coding	1
3	SORBS2	Sorbin And SH3 Domain Containing 2	Protein Coding	1
4	TLR4	Toll Like Receptor 4	Protein Coding	1
5	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
6	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
7	SOD1	Superoxide Dismutase 1	Protein Coding	1
8	MIR455	MicroRNA 455	RNA Gene	1
9	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
10	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
11	MIR320A	MicroRNA 320a	RNA Gene	1
12	MIR19A	MicroRNA 19a	RNA Gene	1
13	KDR	Kinase Insert Domain Receptor	Protein Coding	1
14	IL6	Interleukin 6	Protein Coding	1
15	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
16	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
17	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
18	GATA4	GATA Binding Protein 4	Protein Coding	1
19	ETS2	ETS Proto-Oncogene 2, Transcription Factor	Protein Coding	1
20	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
21	EGF	Epidermal Growth Factor	Protein Coding	1
22	PDLIM5	PDZ And LIM Domain 5	Protein Coding	1

Disorders associated with Extracellular vesicles in the crosstalk of cardiac cells SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cowden syndrome 1	Enrichment	EGFR, PTEN	4.43
2	Squamous cell carcinoma, head and neck	Enrichment	EGFR, PTEN	4.28
3	Arteriovenous malformations of the brain	Enrichment	EGFR, IL6	3.37
4	Diffuse large b-cell lymphoma	Enrichment	PTEN, STAT3	3.37
5	Tetralogy of fallot	Enrichment	GATA4, KDR	3.10
6	Bladder cancer	Enrichment	EGFR, PTEN	3.00
7	Vacterl association with hydrocephalus	Enrichment	PTEN	2.79
8	Hypomagnesemia 4, renal	Enrichment	EGF	2.79
9	Immunodeficiency, common variable, 6	Enrichment	CD81	2.79
10	Atrioventricular septal defect 4	Enrichment	GATA4	2.79
11	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.79
12	Papillary tumor of the pineal region	Enrichment	PTEN	2.79
13	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.79
14	Atrial septal defect 2	Enrichment	GATA4	2.79
15	Testicular anomalies with or without congenital heart disease	Enrichment	GATA4	2.79
16	Macular degeneration, age-related, 10	Enrichment	TLR4	2.79
17	Glioma susceptibility 2	Enrichment	PTEN	2.79
18	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.79
19	8p23.1 microdeletion syndrome	Enrichment	GATA4	2.79
20	Tufted angioma of skin	Enrichment	KDR	2.79
21	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.79
22	Partial atrioventricular septal defect with ventricular hypoplasia	Enrichment	GATA4	2.79
23	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.79
24	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.79
25	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.79
26	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	2.49
27	Angioma, tufted	Enrichment	KDR	2.49
28	46,xy sex reversal 3	Enrichment	GATA4	2.49
29	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.49
30	Spastic tetraplegia and axial hypotonia, progressive	Enrichment	SOD1	2.49
31	Metaphyseal anadysplasia	Enrichment	MMP9	2.49
32	Common variable immunodeficiency phenotype due to cd19/cd81 deficiency	Enrichment	CD81	2.49
33	Vacterl with hydrocephalus	Enrichment	PTEN	2.49
34	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	2.49
35	Juvenile polyposis of infancy	Enrichment	PTEN	2.49
36	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.31
37	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.31
38	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.31
39	Hyper ige syndrome	Enrichment	STAT3	2.31
40	Laryngeal squamous cell carcinoma	Enrichment	PTEN	2.31
41	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.31
42	Kaposi sarcoma	Enrichment	IL6	2.19
43	Pediatric systemic lupus erythematosus	Enrichment	SPP1	2.19
44	Transposition of the great arteries	Enrichment	GATA4	2.19
45	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.19
46	Glioma	Enrichment	PTEN	2.19
47	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	2.09
48	Macrocephaly/autism syndrome	Enrichment	PTEN	2.09
49	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	2.09
50	Insulin-like growth factor i	Enrichment	IGF1	2.09
51	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	SOD1	2.09
52	Ventricular septal defect 1	Enrichment	GATA4	2.09
53	Congenital heart defects, multiple types, 4	Enrichment	GATA4	2.09
54	Hemangioma	Enrichment	PTEN	2.09
55	Acute megakaryocytic leukemia	Enrichment	PTEN	2.09
56	Hemimegalencephaly	Enrichment	PTEN	2.09
57	Type 1 diabetes mellitus	Enrichment	IL6	2.01
58	Hemangioma, capillary infantile	Enrichment	KDR	2.01
59	Lung squamous cell carcinoma	Enrichment	EGFR	2.01
60	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.95
61	Fundus albipunctatus	Enrichment	CD63	1.95
62	Motor neuron disease	Enrichment	SOD1	1.95
63	Follicular thyroid carcinoma	Enrichment	PTEN	1.95
64	Ovarian cancer	Enrichment	EGFR, PTEN	1.94
65	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.89
66	Inflammatory bowel disease 1	Enrichment	IL6	1.84
67	Adult hepatocellular carcinoma	Enrichment	EGF	1.84
68	Cowden syndrome	Enrichment	PTEN	1.84
69	Amyotrophic lateral sclerosis 1	Enrichment	SOD1	1.79
70	Melanoma	Enrichment	PTEN	1.79
71	Meningioma, familial	Enrichment	PTEN	1.75
72	Lung non-small cell carcinoma	Enrichment	EGFR	1.75
73	Uterine corpus cancer	Enrichment	PTEN	1.75
74	Inherited cancer-predisposing syndrome	Enrichment	EGFR, PTEN	1.72
75	Meningioma	Enrichment	PTEN	1.71
76	Lip and oral cavity carcinoma	Enrichment	EGFR	1.71
77	Acute promyelocytic leukemia	Enrichment	STAT3	1.68
78	Aortic aneurysm, familial thoracic 1	Enrichment	GATA4	1.65
79	Lung cancer susceptibility 3	Enrichment	EGFR	1.65
80	Heart disease	Enrichment	GATA4	1.65
81	46,xy partial gonadal dysgenesis	Enrichment	GATA4	1.65
82	Rhabdomyosarcoma	Enrichment	PTEN	1.59
83	Gliosarcoma	Enrichment	EGFR	1.59
84	Giant cell glioblastoma	Enrichment	EGFR	1.56
85	Heart, malformation of	Enrichment	GATA4	1.54
86	Patent foramen ovale	Enrichment	GATA4	1.54
87	Behcet syndrome	Enrichment	TLR4	1.52
88	Endometrial cancer	Enrichment	PTEN	1.47
89	Congenital stationary night blindness	Enrichment	CD63	1.44
90	Familial atrial fibrillation	Enrichment	GATA4	1.42
91	Prostate cancer	Enrichment	PTEN	1.34
92	Lung cancer	Enrichment	EGFR	1.30
93	Systemic lupus erythematosus	Enrichment	SPP1	1.21
94	Charcot-marie-tooth disease	Enrichment	HSPB1	1.19
95	Type 2 diabetes mellitus	Enrichment	IL6	1.18
96	Gastric cancer	Enrichment	PTEN	1.17
97	Hereditary breast carcinoma	Enrichment	PTEN	1.16
98	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	1.07
99	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GATA4	1.06
100	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SOD1	1.05
101	Primary ovarian insufficiency	Enrichment	KDR	1.04
102	Breast cancer	Enrichment	PTEN	0.94
103	Congenital nervous system abnormality	Enrichment	PTEN	0.80
104	Nervous system disease	Enrichment	PTEN	0.80
105	Autism spectrum disorder	Enrichment	PTEN	0.79
106	Hereditary retinal dystrophy	Enrichment	CD63	0.42
107	Fundus dystrophy	Enrichment	CD63	0.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Extracellular vesicles in the crosstalk of cardiac cells

Pathway Network for Extracellular vesicles in the crosstalk of cardiac cells

Member Pathways for Extracellular vesicles in the crosstalk of cardiac cells

Pathways in the Extracellular vesicles in the crosstalk of cardiac cells SuperPath

Associated Genes for Extracellular vesicles in the crosstalk of cardiac cells

Associated Disorders for Extracellular vesicles in the crosstalk of cardiac cells

Disorders associated with Extracellular vesicles in the crosstalk of cardiac cells SuperPath

STRING Interaction Network for Extracellular vesicles in the crosstalk of cardiac cells

Sources for Extracellular vesicles in the crosstalk of cardiac cells