Extrafollicular and follicular B cell activation by SARS-CoV-2

No Pathway Network information available for Extrafollicular and follicular B cell activation by SARS-CoV-2

Pathways in the Extrafollicular and follicular B cell activation by SARS-CoV-2 SuperPath

#	Name	Source	Genes
1	Extrafollicular and follicular B cell activation by SARS-CoV-2	WikiPathways	AICDA BACH2 BCL6 BCR BLNK BTLA C3 C4A C4B CCL19 CCL21 CCR7 CD19 CD1D CD22 CD40 CD40LG CD69 CD79A CD80 CD82 CR1 CR2 CRP CXCL12 CXCL13 CXCR4 CXCR5 EBI3 ETS1 FCRL5 FOXO1 GPR183 HSPA8 ICOS ICOSLG IFIT2 IFITM1 IFNAR2 IFNG IFNG-AS1 IGHV4-34 IL10 IL12A IL2 IL21 IL4 IL6 IRF4 IRF8 ISG15 ITGAX ITGB2 MFGE8 MS4A1 NEAT1 PAX5 PDCD1 PRDM1 PTCRA PTPRC SELL SH2D1A SLAMF7 STAT5A SYK TBX21 TLR4 TLR7 TMSB10 TNF TNFSF13 XBP1 ZEB2 (see all 74) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD1D	CD1d Molecule	Protein Coding	1
2	SH2D1A	SH2 Domain Containing 1A	Protein Coding	1
3	AICDA	Activation Induced Cytidine Deaminase	Protein Coding	1
4	IL21	Interleukin 21	Protein Coding	1
5	C4B	Complement C4B (Chido/Rodgers Blood Group)	Protein Coding	1
6	C4A	Complement C4A (Chido/Rodgers Blood Group)	Protein Coding	1
7	CD40LG	CD40 Ligand	Protein Coding	1
8	BTLA	B And T Lymphocyte Associated	Protein Coding	1
9	IFNG	Interferon Gamma	Protein Coding	1
10	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	1
11	C3	Complement C3	Protein Coding	1
12	TNF	Tumor Necrosis Factor	Protein Coding	1
13	IFNAR2	Interferon Alpha And Beta Receptor Subunit 2	Protein Coding	1
14	CD22	CD22 Molecule	Protein Coding	1
15	ZEB2	Zinc Finger E-Box Binding Homeobox 2	Protein Coding	1
16	CD79A	CD79a Molecule	Protein Coding	1
17	CD69	CD69 Molecule	Protein Coding	1
18	ISG15	ISG15 Ubiquitin Like Modifier	Protein Coding	1
19	CD40	CD40 Molecule	Protein Coding	1
20	CD80	CD80 Molecule	Protein Coding	1
21	MS4A1	Membrane Spanning 4-Domains A1	Protein Coding	1
22	CD19	CD19 Molecule	Protein Coding	1
23	TMSB10	Thymosin Beta 10	Protein Coding	1
24	TNFSF13	TNF Superfamily Member 13	Protein Coding	1
25	IFITM1	Interferon Induced Transmembrane Protein 1	Protein Coding	1
26	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
27	XBP1	X-Box Binding Protein 1	Protein Coding	1
28	TLR4	Toll Like Receptor 4	Protein Coding	1
29	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
30	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
31	CXCR5	C-X-C Motif Chemokine Receptor 5	Protein Coding	1
32	SELL	Selectin L	Protein Coding	1
33	PRDM1	PR/SET Domain 1	Protein Coding	1
34	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	1
35	CCL21	C-C Motif Chemokine Ligand 21	Protein Coding	1
36	CCL19	C-C Motif Chemokine Ligand 19	Protein Coding	1
37	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	1
38	BACH2	BACH Transcriptional Regulator 2	Protein Coding	1
39	BCL6	BCL6 Transcription Repressor	Protein Coding	1
40	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
41	PDCD1	Programmed Cell Death 1	Protein Coding	1
42	TLR7	Toll Like Receptor 7	Protein Coding	1
43	PAX5	Paired Box 5	Protein Coding	1
44	MFGE8	Milk Fat Globule EGF And Factor V/VIII Domain Containing	Protein Coding	1
45	CD82	CD82 Molecule	Protein Coding	1
46	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
47	ITGAX	Integrin Subunit Alpha X	Protein Coding	1
48	IRF4	Interferon Regulatory Factor 4	Protein Coding	1
49	IL12A	Interleukin 12A	Protein Coding	1
50	IL10	Interleukin 10	Protein Coding	1
51	IL6	Interleukin 6	Protein Coding	1
52	IL4	Interleukin 4	Protein Coding	1
53	IL2	Interleukin 2	Protein Coding	1
54	IFIT2	Interferon Induced Protein With Tetratricopeptide Repeats 2	Protein Coding	1
55	IRF8	Interferon Regulatory Factor 8	Protein Coding	1
56	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	1
57	TBX21	T-Box Transcription Factor 21	Protein Coding	1
58	ICOS	Inducible T Cell Costimulator	Protein Coding	1
59	BLNK	B Cell Linker	Protein Coding	1
60	NEAT1	Nuclear Paraspeckle Assembly Transcript 1	RNA Gene	1
61	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	1
62	FOXO1	Forkhead Box O1	Protein Coding	1
63	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
64	GPR183	G Protein-Coupled Receptor 183	Protein Coding	1
65	PTCRA	Pre T Cell Antigen Receptor Alpha	Protein Coding	1
66	CRP	C-Reactive Protein	Protein Coding	1
67	CR2	Complement C3d Receptor 2	Protein Coding	1
68	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	1
69	CCR7	C-C Motif Chemokine Receptor 7	Protein Coding	1
70	EBI3	Epstein-Barr Virus Induced 3	Protein Coding	1
71	IFNG-AS1	IFNG Regulatory Antisense RNA 1	RNA Gene	1
72	FCRL5	Fc Receptor Like 5	Protein Coding	1
73	SLAMF7	SLAM Family Member 7	Protein Coding	1
74	IGHV4-34	Immunoglobulin Heavy Variable 4-34	Protein Coding	1

Disorders associated with Extrafollicular and follicular B cell activation by SARS-CoV-2 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Systemic lupus erythematosus	Enrichment	C4A, C4B, CR2, ETS1, IL10, PDCD1, TLR7, TNF	10.54
2	Behcet syndrome	Enrichment	C4A, IL10, IL12A, TLR4	5.53
3	Human immunodeficiency virus type 1	Enrichment	CXCL12, IFNG, IL10	3.92
4	Immunodeficiency due to a classical component pathway complement deficiency	Enrichment	C4A, C4B	3.09
5	Autosomal non-syndromic agammaglobulinemia	Enrichment	BLNK, CD79A	2.89
6	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	2.26
7	Hemolytic uremic syndrome, atypical 5	Enrichment	C3	2.26
8	Immunodeficiency 38 with basal ganglia calcification	Enrichment	ISG15	2.26
9	Whim syndrome 1	Enrichment	CXCR4	2.26
10	Agammaglobulinemia 3, autosomal recessive	Enrichment	CD79A	2.26
11	Immunodeficiency 32a	Enrichment	IRF8	2.26
12	Immunodeficiency 69	Enrichment	IFNG	2.26
13	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.26
14	Immunodeficiency with hyper-igm, type 1	Enrichment	CD40LG	2.26
15	Lymphoproliferative syndrome, x-linked, 1	Enrichment	SH2D1A	2.26
16	Immunodeficiency 131	Enrichment	IRF4	2.26
17	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.26
18	Autoimmune disease, multisystem, infantile-onset, 4	Enrichment	PDCD1	2.26
19	Complement component 4a deficiency	Enrichment	C4A	2.26
20	Immunodeficiency 60	Enrichment	BACH2	2.26
21	Graft-versus-host disease	Enrichment	IL10	2.26
22	X-linked immunodeficiency 74	Enrichment	TLR7	2.26
23	Immunodeficiency 119	Enrichment	ICOSLG	2.26
24	Systemic lupus erythematosus 17	Enrichment	TLR7	2.26
25	Major affective disorder 7	Enrichment	XBP1	2.26
26	Systemic lupus erythematosus 2	Enrichment	PDCD1	2.26
27	Immunodeficiency with hyper-igm, type 3	Enrichment	CD40	2.26
28	Blood group, chido/rodgers system	Enrichment	C4A	2.26
29	Complement component 4b deficiency	Enrichment	C4B	2.26
30	Immunodeficiency, common variable, 3	Enrichment	CD19	2.26
31	Macular degeneration, age-related, 9	Enrichment	C3	2.26
32	Macular degeneration, age-related, 10	Enrichment	TLR4	2.26
33	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.26
34	Complement component 3 deficiency, autosomal recessive	Enrichment	C3	2.26
35	Immunodeficiency, common variable, 5	Enrichment	MS4A1	2.26
36	Immunodeficiency 60 and autoimmunity	Enrichment	BACH2	2.26
37	Cd45 deficiency	Enrichment	PTPRC	2.26
38	Immunodeficiency 88	Enrichment	TBX21	2.26
39	Complement component 3 deficiency	Enrichment	C3	2.26
40	Immunodeficiency 126	Enrichment	PTCRA	2.26
41	Colitis	Enrichment	SYK	2.26
42	Hairy cell leukemia	Enrichment	IGHV4-34	2.26
43	Membranoproliferative glomerulonephritis	Enrichment	C3	2.26
44	Primary membranoproliferative glomerulonephritis	Enrichment	C3	2.26
45	Cd40 ligand deficiency	Enrichment	CD40LG	2.26
46	Agammaglobulinemia 3	Enrichment	CD79A	2.26
47	Whipple disease	Enrichment	IRF4	2.26
48	Late-onset combined immunodeficiency due to icosl deficiency	Enrichment	ICOSLG	2.26
49	Malaria	Enrichment	CR1, TNF	2.16
50	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.96
51	Immunodeficiency 32b	Enrichment	IRF8	1.96
52	Immunodeficiency, common variable, 2	Enrichment	CR2	1.96
53	Mowat-wilson syndrome	Enrichment	ZEB2	1.96
54	Agammaglobulinemia 4, autosomal recessive	Enrichment	BLNK	1.96
55	Immunodeficiency with hyper-igm, type 2	Enrichment	AICDA	1.96
56	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.96
57	Immunodeficiency 45	Enrichment	IFNAR2	1.96
58	Intravascular large b-cell lymphoma	Enrichment	BCL6	1.96
59	Immunodeficiency, common variable, 7	Enrichment	CR2	1.96
60	Immunodeficiency 127	Enrichment	TNF	1.96
61	Lymphoproliferative syndrome	Enrichment	SH2D1A	1.96
62	Agammaglobulinemia 4	Enrichment	BLNK	1.96
63	Immunodeficiency 104, severe combined	Enrichment	PTPRC	1.96
64	Common variable immunodeficiency phenotype due to cd19/cd81 deficiency	Enrichment	CD19	1.96
65	Arthritis	Enrichment	SYK	1.96
66	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6	1.96
67	B-lymphoblastic leukemia/lymphoma with t(7;9)(q11.2;p13.2)	Enrichment	PAX5	1.96
68	Jacobsen syndrome	Enrichment	ETS1	1.79
69	Asthma, nasal polyps, and aspirin intolerance	Enrichment	TBX21	1.79
70	Tuberous sclerosis 1	Enrichment	IFNG	1.79
71	Systemic lupus erythematosus 9	Enrichment	CR2	1.79
72	Psoriatic arthritis	Enrichment	TNF	1.79
73	Hepatitis c virus	Enrichment	IFNG	1.79
74	Tuberous sclerosis 2	Enrichment	IFNG	1.79
75	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR	1.79
76	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL6	1.79
77	Migraine without aura	Enrichment	TNF	1.79
78	Immunodeficiency 44	Enrichment	IFNAR2	1.79
79	Immunodeficiency, common variable, 11	Enrichment	IL21	1.79
80	Genetic atypical hemolytic-uremic syndrome	Enrichment	C3	1.79
81	Kaposi sarcoma	Enrichment	IL6	1.66
82	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR	1.66
83	Immunodeficiency, common variable, 1	Enrichment	ICOS	1.66
84	Hepatitis b	Enrichment	IFNAR2	1.66
85	Cerebral malaria	Enrichment	TNF	1.66
86	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.66
87	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.57
88	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.57
89	Systemic lupus erythematosus 16	Enrichment	C4A	1.57
90	Follicular lymphoma	Enrichment	BCL6	1.57
91	Vascular dementia	Enrichment	TNF	1.57
92	Idiopathic aplastic anemia	Enrichment	IFNG	1.57
93	Type 1 diabetes mellitus	Enrichment	IL6	1.49
94	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10	1.49
95	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	C3	1.49
96	Leukemia, chronic myeloid	Enrichment	BCR	1.43
97	Megacolon	Enrichment	ZEB2	1.43
98	Common variable immunodeficiency	Enrichment	CD40LG	1.43
99	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	BCR	1.43
100	Melanocytic nevus syndrome, congenital	Enrichment	ZEB2	1.37
101	Rheumatoid arthritis	Enrichment	IL10	1.32
102	Inflammatory bowel disease 1	Enrichment	IL6	1.32
103	Leukemia, acute lymphoblastic 3	Enrichment	PAX5	1.32
104	Primary biliary cholangitis	Enrichment	IL12A	1.32
105	Ciliary dyskinesia, primary, 3	Enrichment	BACH2	1.27
106	Aplastic anemia	Enrichment	IFNG	1.27
107	Immune deficiency disease	Enrichment	SYK	1.23
108	Asthma	Enrichment	TNF	1.23
109	Leukemia, acute lymphoblastic	Enrichment	PAX5	1.23
110	Combined immunodeficiency	Enrichment	ICOSLG	1.23
111	Combined t cell and b cell immunodeficiency	Enrichment	ICOSLG	1.23
112	Combined t and b cell immunodeficiency	Enrichment	ICOSLG	1.23
113	Alzheimer's disease	Enrichment	TNF	1.16
114	Atypical hemolytic-uremic syndrome	Enrichment	C3	1.10
115	Arteriovenous malformations of the brain	Enrichment	IL6	1.01
116	Diffuse large b-cell lymphoma	Enrichment	FOXO1	1.01
117	Esophageal atresia/tracheoesophageal fistula	Enrichment	IRF8	1.01
118	Multisystem inflammatory syndrome in children	Enrichment	IFNAR2	0.95
119	Precursor t-cell acute lymphoblastic leukemia	Enrichment	BCR	0.93
120	Autoinflammatory disease	Enrichment	SH2D1A	0.91
121	Severe combined immunodeficiency	Enrichment	PTPRC	0.78
122	Type 2 diabetes mellitus	Enrichment	IL6	0.69
123	Breast cancer	Enrichment	IL2	0.47
124	Congenital nervous system abnormality	Enrichment	ZEB2	0.36
125	Nervous system disease	Enrichment	ZEB2	0.36

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Extrafollicular and follicular B cell activation by SARS-CoV-2

Pathway Network for Extrafollicular and follicular B cell activation by SARS-CoV-2

Member Pathways for Extrafollicular and follicular B cell activation by SARS-CoV-2

Pathways in the Extrafollicular and follicular B cell activation by SARS-CoV-2 SuperPath

Associated Genes for Extrafollicular and follicular B cell activation by SARS-CoV-2

Associated Disorders for Extrafollicular and follicular B cell activation by SARS-CoV-2

Disorders associated with Extrafollicular and follicular B cell activation by SARS-CoV-2 SuperPath

STRING Interaction Network for Extrafollicular and follicular B cell activation by SARS-CoV-2

Sources for Extrafollicular and follicular B cell activation by SARS-CoV-2