Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling

No Pathway Network information available for Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling

Pathways in the Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling SuperPath

#	Name	Source	Genes
1	Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling	WikiPathways	ACVR2B AKT1 AKT1S1 DEPTOR EIF2B2 EIF4E FBXO32 GSK3B IGF1 IGF1R IGFBP5 ILK IRS1 ITGB1 MAP1LC3A MAPKAP1 MLST8 MSTN MTOR NEB NFKB1 PDK1 PIK3CG PLD1 PPARGC1A PRKAB1 PTEN RICTOR RPS6KB1 RPTOR SMAD2 SMAD3 TNFRSF1A TNFSF9 TRIM63 WASL (see all 36) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACVR2B	Activin A Receptor Type 2B	Protein Coding	1
2	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	1
3	EIF2B2	Eukaryotic Translation Initiation Factor 2B Subunit Beta	Protein Coding	1
4	TNFSF9	TNF Superfamily Member 9	Protein Coding	1
5	TRIM63	Tripartite Motif Containing 63	Protein Coding	1
6	MAP1LC3A	Microtubule Associated Protein 1 Light Chain 3 Alpha	Protein Coding	1
7	AKT1S1	AKT1 Substrate 1	Protein Coding	1
8	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
9	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
10	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
11	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
12	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	1
13	PLD1	Phospholipase D1	Protein Coding	1
14	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
15	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
16	NEB	Nebulin	Protein Coding	1
17	SMAD3	SMAD Family Member 3	Protein Coding	1
18	SMAD2	SMAD Family Member 2	Protein Coding	1
19	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
20	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
21	ILK	Integrin Linked Kinase	Protein Coding	1
22	IGFBP5	Insulin Like Growth Factor Binding Protein 5	Protein Coding	1
23	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
24	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
25	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
26	MSTN	Myostatin	Protein Coding	1
27	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
28	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
29	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	1
30	FBXO32	F-Box Protein 32	Protein Coding	1
31	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
32	MAPKAP1	MAPK Associated Protein 1	Protein Coding	1
33	DEPTOR	DEP Domain Containing MTOR Interacting Protein	Protein Coding	1
34	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
35	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1
36	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	1

Disorders associated with Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Insulin-like growth factor i	Enrichment	IGF1, IGF1R	4.17
2	Hemimegalencephaly	Enrichment	MTOR, PTEN	4.17
3	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3	3.61
4	Cowden syndrome	Enrichment	AKT1, PTEN	3.61
5	Meningioma	Enrichment	AKT1, PTEN	3.35
6	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.58
7	Proteus syndrome	Enrichment	AKT1	2.58
8	Vacterl association with hydrocephalus	Enrichment	PTEN	2.58
9	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.58
10	Autism 19	Enrichment	EIF4E	2.58
11	Cardiomyopathy, familial hypertrophic, 31	Enrichment	TRIM63	2.58
12	Papillary tumor of the pineal region	Enrichment	PTEN	2.58
13	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.58
14	Cowden syndrome 6	Enrichment	AKT1	2.58
15	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.58
16	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.58
17	Glioma susceptibility 2	Enrichment	PTEN	2.58
18	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.58
19	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.58
20	Leukoencephalopathy with vanishing white matter 2	Enrichment	EIF2B2	2.58
21	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.58
22	Distal nebulin myopathy	Enrichment	NEB	2.58
23	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.28
24	Heterotaxy, visceral, 4, autosomal	Enrichment	ACVR2B	2.28
25	Muscle hypertrophy	Enrichment	MSTN	2.28
26	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.28
27	Cebalid syndrome	Enrichment	MTOR	2.28
28	Myostatin-related muscle hypertrophy	Enrichment	MSTN	2.28
29	Smith-kingsmore syndrome	Enrichment	MTOR	2.28
30	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.28
31	Vacterl with hydrocephalus	Enrichment	PTEN	2.28
32	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	2.28
33	Common variable immunodeficiency 12	Enrichment	NFKB1	2.28
34	Juvenile polyposis of infancy	Enrichment	PTEN	2.28
35	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3	2.22
36	Hereditary breast carcinoma	Enrichment	AKT1, PTEN	2.22
37	Arthrogryposis multiplex congenita 6	Enrichment	NEB	2.10
38	Loeys-dietz syndrome 1	Enrichment	SMAD2	2.10
39	Laryngeal squamous cell carcinoma	Enrichment	PTEN	2.10
40	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	2.10
41	Nemaline myopathy 2	Enrichment	NEB	1.98
42	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.98
43	Aortic aneurysm	Enrichment	SMAD3	1.98
44	Intermediate nemaline myopathy	Enrichment	NEB	1.98
45	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.98
46	Glioma	Enrichment	PTEN	1.98
47	Primary ovarian insufficiency	Enrichment	EIF2B2, RICTOR	1.97
48	Macrocephaly/autism syndrome	Enrichment	PTEN	1.88
49	Hemangioma	Enrichment	PTEN	1.88
50	Acute megakaryocytic leukemia	Enrichment	PTEN	1.88
51	Severe congenital nemaline myopathy	Enrichment	NEB	1.88
52	Cowden syndrome 1	Enrichment	PTEN	1.80
53	Breast adenocarcinoma	Enrichment	AKT1	1.80
54	Typical nemaline myopathy	Enrichment	NEB	1.80
55	Breast cancer	Enrichment	AKT1, PTEN	1.77
56	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.73
57	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.73
58	Leukoencephalopathy with vanishing white matter 1	Enrichment	EIF2B2	1.73
59	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.73
60	Common variable immunodeficiency	Enrichment	NFKB1	1.73
61	Follicular thyroid carcinoma	Enrichment	PTEN	1.73
62	Childhood-onset nemaline myopathy	Enrichment	NEB	1.73
63	Overgrowth syndrome	Enrichment	MTOR	1.73
64	Multiple pterygium syndrome, lethal type	Enrichment	NEB	1.68
65	Leukoencephalopathy with vanishing white matter 5	Enrichment	EIF2B2	1.68
66	Charge syndrome	Enrichment	TNFRSF1A	1.63
67	Leukoencephalopathy with vanishing white matter	Enrichment	EIF2B2	1.63
68	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.63
69	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.58
70	Nemaline myopathy	Enrichment	NEB	1.58
71	Melanoma	Enrichment	PTEN	1.58
72	Meningioma, familial	Enrichment	PTEN	1.54
73	Uterine corpus cancer	Enrichment	PTEN	1.54
74	Ovarian cancer	Enrichment	AKT1, PTEN	1.53
75	Congenital nervous system abnormality	Enrichment	EIF2B2, PTEN	1.49
76	Nervous system disease	Enrichment	EIF2B2, PTEN	1.49
77	Neural tube defects	Enrichment	ITGB1	1.47
78	Premature menopause	Enrichment	EIF2B2	1.47
79	Nk-cell enteropathy	Enrichment	IGF1R	1.47
80	Multiple sclerosis	Enrichment	TNFRSF1A	1.44
81	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.44
82	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.41
83	Rare genetic intellectual disability	Enrichment	MTOR	1.41
84	Rhabdomyosarcoma	Enrichment	PTEN	1.38
85	Behcet syndrome	Enrichment	TNFRSF1A	1.31
86	Diffuse large b-cell lymphoma	Enrichment	PTEN	1.31
87	Ehlers-danlos syndrome	Enrichment	SMAD3	1.31
88	Endometrial cancer	Enrichment	PTEN	1.27
89	Visceral heterotaxy	Enrichment	ACVR2B	1.25
90	Brittle bone disorder	Enrichment	EIF2B2	1.23
91	Autoinflammatory disease	Enrichment	TNFRSF1A	1.21
92	Muscular dystrophy	Enrichment	NEB	1.21
93	Bladder cancer	Enrichment	PTEN	1.13
94	Prostate cancer	Enrichment	PTEN	1.13
95	Connective tissue disease	Enrichment	SMAD3	1.09
96	Type 2 diabetes mellitus	Enrichment	IRS1	0.98
97	Gastric cancer	Enrichment	PTEN	0.97
98	Hypertrophic cardiomyopathy	Enrichment	TRIM63	0.97
99	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.87
100	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	0.84
101	Colorectal cancer	Enrichment	AKT1	0.68
102	Autism spectrum disorder	Enrichment	PTEN	0.60
103	Microcephaly	Enrichment	IGF1R	0.55
104	Inherited cancer-predisposing syndrome	Enrichment	PTEN	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling

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Pathways in the Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling SuperPath

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Associated Disorders for Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling

Disorders associated with Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling SuperPath

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