Farnesoid X receptor pathway

No Pathway Network information available for Farnesoid X receptor pathway

#	Name	Source	Genes
1	Farnesoid X receptor pathway	WikiPathways	ABCB11 ABCB4 BAAT CYP3A4 CYP7A1 CYP8B1 FGF19 FKBP5 IP6K3 IRS2 NR0B2 NR1H4 PPARGC1A RXRA SLC10A1 SLC27A5 SLCO2B1 SULT2A1 UGT2B4 (see all 19) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BAAT	Bile Acid-CoA:Amino Acid N-Acyltransferase	Protein Coding	1
2	SLC27A5	Solute Carrier Family 27 Member 5	Protein Coding	1
3	NR1H4	Nuclear Receptor Subfamily 1 Group H Member 4	Protein Coding	1
4	FGF19	Fibroblast Growth Factor 19	Protein Coding	1
5	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
6	ABCB11	ATP Binding Cassette Subfamily B Member 11	Protein Coding	1
7	NR0B2	Nuclear Receptor Subfamily 0 Group B Member 2	Protein Coding	1
8	UGT2B4	UDP Glucuronosyltransferase Family 2 Member B4	Protein Coding	1
9	SULT2A1	Sulfotransferase Family 2A Member 1	Protein Coding	1
10	SLC10A1	Solute Carrier Family 10 Member 1	Protein Coding	1
11	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
12	ABCB4	ATP Binding Cassette Subfamily B Member 4	Protein Coding	1
13	FKBP5	FKBP Prolyl Isomerase 5	Protein Coding	1
14	CYP8B1	Cytochrome P450 Family 8 Subfamily B Member 1	Protein Coding	1
15	CYP7A1	Cytochrome P450 Family 7 Subfamily A Member 1	Protein Coding	1
16	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	1
17	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
18	IP6K3	Inositol Hexakisphosphate Kinase 3	Protein Coding	1
19	SLCO2B1	Solute Carrier Organic Anion Transporter Family Member 2B1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Intrahepatic cholestasis of pregnancy	Enrichment	ABCB11, ABCB4, NR1H4	8.03
2	Cholestasis, progressive familial intrahepatic, 3	Enrichment	ABCB11, ABCB4	5.73
3	Cholestasis, intrahepatic, of pregnancy 3	Enrichment	ABCB11, ABCB4	5.73
4	Intrahepatic cholestasis	Enrichment	ABCB11, ABCB4	5.73
5	Cholestasis, progressive familial intrahepatic, 1	Enrichment	ABCB4, NR1H4	4.56
6	Familial hypercholanemia	Enrichment	BAAT, SLC10A1	4.56
7	Progressive familial intrahepatic cholestasis	Enrichment	ABCB11, ABCB4	4.41
8	Gallbladder disease 1	Enrichment	ABCB4	2.85
9	Hypercholanemia, familial, 2	Enrichment	SLC10A1	2.85
10	Cholestasis, progressive familial intrahepatic, 5	Enrichment	NR1H4	2.85
11	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	2.85
12	Hypercholanemia, familial 3	Enrichment	BAAT	2.85
13	Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency	Enrichment	CYP7A1	2.85
14	Cholestasis, benign recurrent intrahepatic, 2	Enrichment	ABCB11	2.55
15	Cholestasis, progressive familial intrahepatic, 4	Enrichment	ABCB11	2.55
16	Cholestasis, progressive familial intrahepatic, 2	Enrichment	ABCB11	2.55
17	Major depressive disorder	Enrichment	FKBP5	2.16
18	Asthma	Enrichment	FKBP5	1.82
19	Type 2 diabetes mellitus	Enrichment	IRS2	1.24
20	Body mass index quantitative trait locus 11	Enrichment	NR0B2	1.17
21	Myeloma, multiple	Enrichment	RXRA	1.12
22	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	1.11

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Farnesoid X receptor pathway