Fatty acid beta-oxidation

No Pathway Network information available for Fatty acid beta-oxidation

Pathways in the Fatty acid beta-oxidation SuperPath

#	Name	Source	Genes
1	Fatty acid beta-oxidation	WikiPathways	ACADL ACADM ACADS ACADVL ACAT1 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ACSS2 CHKB CPT1A CPT1B CPT2 CRAT DECR1 DLD ECHS1 ECI1 GCDH GK GK2 GPD2 HADH HADHA HADHB LIPC LIPE LIPF LPL PNPLA2 SLC25A20 TPI1 (see all 34) (see less)
2	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	Reactome	ACADL ACADM DECR1 ECI1 HADHA HADHB (see all 6) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ECI1	Enoyl-CoA Delta Isomerase 1	Protein Coding	2
2	ACADM	Acyl-CoA Dehydrogenase Medium Chain	Protein Coding	2
3	ACADL	Acyl-CoA Dehydrogenase Long Chain	Protein Coding	2
4	HADHB	Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Beta	Protein Coding	2
5	HADHA	Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Alpha	Protein Coding	2
6	DECR1	2,4-Dienoyl-CoA Reductase 1	Protein Coding	2
7	LIPF	Lipase F, Gastric Type	Protein Coding	1
8	ACSS2	Acyl-CoA Synthetase Short Chain Family Member 2	Protein Coding	1
9	GK2	Glycerol Kinase 2	Protein Coding	1
10	ACSL3	Acyl-CoA Synthetase Long Chain Family Member 3	Protein Coding	1
11	SLC25A20	Solute Carrier Family 25 Member 20	Protein Coding	1
12	TPI1	Triosephosphate Isomerase 1	Protein Coding	1
13	PNPLA2	Patatin Like Domain 2, Triacylglycerol Lipase	Protein Coding	1
14	ACSL5	Acyl-CoA Synthetase Long Chain Family Member 5	Protein Coding	1
15	LPL	Lipoprotein Lipase	Protein Coding	1
16	LIPE	Lipase E, Hormone Sensitive Type	Protein Coding	1
17	LIPC	Lipase C, Hepatic Type	Protein Coding	1
18	ACAT1	Acetyl-CoA Acetyltransferase 1	Protein Coding	1
19	ACADVL	Acyl-CoA Dehydrogenase Very Long Chain	Protein Coding	1
20	ACADS	Acyl-CoA Dehydrogenase Short Chain	Protein Coding	1
21	HADH	Hydroxyacyl-CoA Dehydrogenase	Protein Coding	1
22	GPD2	Glycerol-3-Phosphate Dehydrogenase 2	Protein Coding	1
23	GK	Glycerol Kinase	Protein Coding	1
24	GCDH	Glutaryl-CoA Dehydrogenase	Protein Coding	1
25	ACSL6	Acyl-CoA Synthetase Long Chain Family Member 6	Protein Coding	1
26	ACSL4	Acyl-CoA Synthetase Long Chain Family Member 4	Protein Coding	1
27	ACSL1	Acyl-CoA Synthetase Long Chain Family Member 1	Protein Coding	1
28	ECHS1	Enoyl-CoA Hydratase, Short Chain 1	Protein Coding	1
29	DLD	Dihydrolipoamide Dehydrogenase	Protein Coding	1
30	CPT2	Carnitine Palmitoyltransferase 2	Protein Coding	1
31	CPT1B	Carnitine Palmitoyltransferase 1B	Protein Coding	1
32	CPT1A	Carnitine Palmitoyltransferase 1A	Protein Coding	1
33	CHKB	Choline Kinase Beta	Protein Coding	1
34	CRAT	Carnitine O-Acetyltransferase	Protein Coding	1

Disorders associated with Fatty acid beta-oxidation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mitochondrial trifunctional protein deficiency 1	Enrichment	HADHA, HADHB	6.31
2	Mitochondrial trifunctional protein deficiency	Enrichment	HADHA, HADHB	6.31
3	Acyl-coa dehydrogenase, medium-chain, deficiency of	Enrichment	ACADM	3.35
4	Mitochondrial trifunctional protein deficiency 2	Enrichment	HADHB	3.35
5	Acute fatty liver of pregnancy	Enrichment	HADHA	3.35
6	Medium-chain acyl-coenzyme a dehydrogenase deficiency	Enrichment	ACADM	3.35
7	Long-chain 3-hydroxyacyl-coa dehydrogenase deficiency	Enrichment	HADHA	2.88
8	Hydrocephalus, congenital, 2, with or without brain or eye anomalies	Enrichment	ACADM	2.75
9	3-hydroxyacyl-coa dehydrogenase deficiency	Enrichment	HADH	2.60
10	Carnitine-acylcarnitine translocase deficiency	Enrichment	SLC25A20	2.60
11	Intellectual developmental disorder, x-linked 63	Enrichment	ACSL4	2.60
12	Carnitine acetyltransferase deficiency	Enrichment	CRAT	2.60
13	Hepatic lipase deficiency	Enrichment	LIPC	2.60
14	Triosephosphate isomerase deficiency	Enrichment	TPI1	2.60
15	High density lipoprotein cholesterol level quantitative trait locus 12	Enrichment	LIPC	2.60
16	Diarrhea 13	Enrichment	ACSL5	2.60
17	Proximal myopathy with focal depletion of mitochondria	Enrichment	CHKB	2.60
18	Neurodegeneration with brain iron accumulation 8	Enrichment	CRAT	2.60
19	Hyperlipidemia due to hepatic triglyceride lipase deficiency	Enrichment	LIPC	2.60
20	Primary triglyceride deposit cardiomyovasculopathy	Enrichment	PNPLA2	2.60
21	Type 2 diabetes mellitus	Enrichment	GPD2, LIPC	2.31
22	Hyperlipoproteinemia, type i	Enrichment	LPL	2.30
23	Acyl-coa dehydrogenase, short-chain, deficiency of	Enrichment	ACADS	2.30
24	Alpha-methylacetoacetic aciduria	Enrichment	ACAT1	2.30
25	Dihydrolipoamide dehydrogenase deficiency	Enrichment	DLD	2.30
26	Glycerol kinase deficiency	Enrichment	GK	2.30
27	Carnitine palmitoyltransferase ii deficiency, infantile	Enrichment	CPT2	2.30
28	Neutral lipid storage disease with myopathy	Enrichment	PNPLA2	2.30
29	Carnitine palmitoyltransferase ii deficiency, lethal neonatal	Enrichment	CPT2	2.30
30	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	HADH	2.30
31	Methemoglobinemia due to deficiency of methemoglobin reductase	Enrichment	DLD	2.30
32	Lipase deficiency, combined	Enrichment	LPL	2.30
33	Carnitine palmitoyltransferase i deficiency	Enrichment	CPT1A	2.30
34	Carnitine palmitoyltransferase ii deficiency, myopathic, stress-induced	Enrichment	CPT2	2.30
35	Mitochondrial short-chain enoyl-coa hydratase 1 deficiency	Enrichment	ECHS1	2.30
36	Encephalopathy, acute, infection-induced 4	Enrichment	CPT2	2.30
37	Familial lipoprotein lipase deficiency	Enrichment	LPL	2.30
38	Acute necrotizing encephalopathy of childhood	Enrichment	CPT2	2.30
39	Heart defects, congenital, and other congenital anomalies	Enrichment	ACADVL	2.12
40	Leukodystrophy, hypomyelinating, 2	Enrichment	GCDH	2.12
41	Lipodystrophy, familial partial, type 6	Enrichment	LIPE	2.12
42	Intellectual developmental disorder, autosomal dominant 62	Enrichment	ACADVL	2.12
43	Hyperinsulinemic hypoglycemia	Enrichment	HADH	2.12
44	Dlg4-related synaptopathy	Enrichment	ACADVL	2.12
45	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	ACADVL	2.00
46	Amme complex	Enrichment	ACSL4	2.00
47	Muscular dystrophy, congenital, megaconial type	Enrichment	CHKB	2.00
48	Anemia, congenital dyserythropoietic, type iva	Enrichment	GCDH	2.00
49	Fetal hemoglobin quantitative trait locus 6	Enrichment	GCDH	2.00
50	Ciliary dyskinesia, primary, 29	Enrichment	GCDH	2.00
51	Coronary artery anomaly	Enrichment	LPL	2.00
52	Hyperlipidemia, familial combined, 3	Enrichment	LPL	1.90
53	Glutaric acidemia i	Enrichment	GCDH	1.90
54	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	HADH	1.83
55	Lipid metabolism disorder	Enrichment	LIPC	1.83
56	Nonsyndromic genetic hyperinsulinism	Enrichment	HADH	1.83
57	Orofacial cleft 1	Enrichment	ACSS2	1.65
58	Stroke, ischemic	Enrichment	ACSL4	1.61
59	Neurodegeneration with brain iron accumulation	Enrichment	CRAT	1.61
60	Lactic acidosis	Enrichment	DLD	1.53
61	Cardiomyopathy, dilated, 1a	Enrichment	LPL	1.29
62	Muscular dystrophy	Enrichment	CHKB	1.23
63	Non-syndromic x-linked intellectual disability	Enrichment	ACSL4	1.06
64	Myopathy	Enrichment	ACADVL	1.02
65	Leigh syndrome, nuclear	Enrichment	ECHS1	0.80
66	Leigh disease	Enrichment	ECHS1	0.76
67	Congenital nervous system abnormality	Enrichment	CPT2	0.63
68	Nervous system disease	Enrichment	CPT2	0.63

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Fatty acid beta-oxidation

Pathway Network for Fatty acid beta-oxidation

Member Pathways for Fatty acid beta-oxidation

Pathways in the Fatty acid beta-oxidation SuperPath

Associated Genes for Fatty acid beta-oxidation

Associated Disorders for Fatty acid beta-oxidation

Disorders associated with Fatty acid beta-oxidation SuperPath

STRING Interaction Network for Fatty acid beta-oxidation

Sources for Fatty acid beta-oxidation