Fatty acid metabolism

Pathway network for the Fatty acid metabolism SuperPath

Sources:

Reactome
WikiPathways
PubChem
PharmGKB

Pathways in the Fatty acid metabolism SuperPath

#	Name	Source	Genes
1	Fatty acid metabolism	Reactome	ABCC1 ABCD1 ACAA1 ACAA2 ACACA ACACB ACAD10 ACAD11 ACADL ACADM ACADS ACADVL ACBD4 ACBD5 ACBD6 ACBD7 ACLY ACOT1 ACOT11 ACOT12 ACOT13 ACOT2 ACOT4 ACOT7 ACOT8 ACOT9 ACOX1 ACOX2 ACOX3 ACOXL ACSBG1 ACSBG2 ACSF2 ACSF3 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ACSM3 ACSM6 AKR1C3 ALDH3A2 ALOX12 ALOX12B ALOX15 ALOX15B ALOX5 ALOX5AP ALOXE3 AMACR AWAT1 CBR1 CBR4 CPT1A CPT1B CPT2 CRAT CROT CYP1A1 CYP1A2 CYP1B1 CYP2C19 CYP2C8 CYP2C9 CYP2J2 CYP2U1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP8B1 DBI DECR1 DECR2 DPEP1 DPEP2 ECHS1 ECI1 ECI2 EHHADH ELOVL1 ELOVL2 ELOVL3 ELOVL4 ELOVL5 ELOVL6 ELOVL7 EPHX2 FAAH FAAH2 FADS1 FADS2 FASN GGT1 GGT5 GPX1 GPX2 GPX4 HACD1 HACD2 HACD3 HACD4 HACL1 HADH HADHA HADHB HAO2 HPGD HPGDS HSD17B12 HSD17B3 HSD17B4 HSD17B8 HTD2 LTA4H LTC4S MAPKAPK2 MCAT MCEE MECR MID1IP1 MLYCD MMAA MMUT MORC2 NDUFAB1 NUDT19 NUDT7 OLAH PCCA PCCB PCTP PECR PHYH PLA2G4A PON1 PON2 PON3 PPARD PPT1 PPT2 PRKAA2 PRKAB2 PRKAG2 PRXL2B PTGDS PTGES PTGES2 PTGES3 PTGIS PTGR1 PTGR2 PTGS1 PTGS2 RXRA SCD SCD5 SCP2 SLC22A5 SLC25A17 SLC25A20 SLC27A1 SLC27A2 SLC27A3 TBXAS1 TECR TECRL THEM4 THEM5 THRSP (see all 175) (see less)
2	Arachidonate metabolism	Reactome	ABCC1 AKR1C3 ALOX12 ALOX12B ALOX15 ALOX15B ALOX5 ALOX5AP ALOXE3 AWAT1 CBR1 CYP1A1 CYP1A2 CYP1B1 CYP2C19 CYP2C8 CYP2C9 CYP2J2 CYP2U1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP8B1 DPEP1 DPEP2 EPHX2 FAAH FAAH2 GGT1 GGT5 GPX1 GPX2 GPX4 HPGD HPGDS LTA4H LTC4S MAPKAPK2 PLA2G4A PON1 PON2 PON3 PRXL2B PTGDS PTGES PTGES2 PTGES3 PTGIS PTGR1 PTGR2 PTGS1 PTGS2 SLC27A1 TBXAS1 (see all 59) (see less)
3	Synthesis of Leukotrienes (LT) and Eoxins (EX)	Reactome	ABCC1 ALOX15 ALOX5 ALOX5AP CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F2 CYP4F22 CYP4F3 CYP4F8 DPEP1 DPEP2 GGT1 GGT5 LTA4H LTC4S MAPKAPK2 PTGR1 (see all 20) (see less)
4	Eicosanoid metabolism via lipooxygenases (LOX)	WikiPathways	ACAA1 ACOX1 ACOX2 ACOX3 ALOX12 ALOX15 ALOX5 CYP4A11 CYP4A22 CYP4F12 CYP4F2 DPEP1 EHHADH GGT5 HPGD LTA4H LTC4S PTGR1 PTGR2 (see all 19) (see less)
5	Mitochondrial long chain fatty acid beta-oxidation	WikiPathways	ACADL ACADM ACADS ACADVL ACSF2 ACSL1 ACSL3 ACSL4 CPT1A CPT2 ECI1 EHHADH HADH HADHA PECR SCP2 SLC25A20 (see all 17) (see less)
6	fatty acid β-oxidation I	PubChem	ACAA1 ACAA2 ACSBG1 ACSBG2 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ECHS1 EHHADH HADH HADHB HSD17B10 SCP2 SLC27A2 (see all 16) (see less)
7	fatty acid β-oxidation	PubChem	ACAA2 ACADL ACSBG1 ACSBG2 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ECHS1 ECI1 HADH HADHB HSD17B10 SCP2 SLC27A2 (see all 16) (see less)
8	Mitochondrial fatty acid oxidation disorders	WikiPathways	ACADL ACADM ACADS ACADVL ACSF2 ACSL1 ACSL3 ACSL4 ECI1 EHHADH HADH HADHA HADHB PECR SCP2 SLC25A20 (see all 16) (see less)
9	fatty acid β-oxidation (peroxisome)	PubChem	ACAA1 ACOX1 ACOX2 ACSBG1 ACSBG2 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 EHHADH HADH HSD17B4 SCP2 SLC27A2 (see all 15) (see less)
10	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Reactome	AKR1C3 CBR1 CYP8B1 HPGD HPGDS PRXL2B PTGDS PTGES PTGES2 PTGES3 PTGIS PTGR2 PTGS1 PTGS2 TBXAS1 (see all 15) (see less)
11	Carnitine shuttle	Reactome	ACACA ACACB CPT1A CPT1B CPT2 MID1IP1 PPARD PRKAA2 PRKAB2 PRKAG2 RXRA SLC22A5 SLC25A20 THRSP (see all 14) (see less)
12	fatty acid β-oxidation VI (peroxisome)	PubChem	ACAA1 ACOX1 ACOX2 ACSBG1 ACSBG2 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 EHHADH HSD17B4 SCP2 SLC27A2 (see all 14) (see less)
13	Omega-9 fatty acid synthesis	WikiPathways	ACOT2 ACSL1 ACSL3 ACSL4 ELOVL1 ELOVL2 ELOVL3 ELOVL5 ELOVL6 FADS1 FADS2 FASN SCD SCD5 (see all 14) (see less)
14	Leukotriene metabolic pathway	WikiPathways	ABCC1 ALOX5 ALOX5AP CYP4F3 DECR1 DECR2 DPEP1 DPEP2 GGT1 GGT5 LTA4H LTC4S PTGR1 (see all 13) (see less)
15	stearate biosynthesis	PubChem	ACOT1 ACOT2 ACOT4 ACOT7 ACSBG1 ACSBG2 ACSL1 ACSL3 ACSL4 ACSL5 ELOVL1 ELOVL6 SLC27A2 (see all 13) (see less)
16	Omega-3 / omega-6 fatty acid synthesis	WikiPathways	ACOT2 ACOX1 ACOX3 ACSL1 ACSL3 ACSL4 ELOVL2 ELOVL5 FADS1 FADS2 (see all 10) (see less)
17	C20 prostanoid biosynthesis	PubChem	HPGDS PTGDS PTGES PTGES2 PTGES3 PTGIS PTGS1 PTGS2 TBXAS1 (see all 9) (see less)
18	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	Reactome	CYP1A1 CYP1A2 CYP1B1 CYP2C19 CYP2C8 CYP2C9 CYP2U1 CYP4A11 CYP4F2 (see all 9) (see less)
19	Synthesis of 5-eicosatetraenoic acids	Reactome	ALOX5 ALOX5AP GPX1 GPX2 GPX4 LTC4S PON1 PON2 PON3 (see all 9) (see less)
20	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	Reactome	CYP1A1 CYP1A2 CYP1B1 CYP2C19 CYP2C8 CYP2C9 CYP2J2 EPHX2 (see all 8) (see less)
21	Synthesis of 12-eicosatetraenoic acid derivatives	Reactome	ALOX12 ALOX12B ALOX15 ALOXE3 GPX1 GPX2 GPX4 (see all 7) (see less)
22	Synthesis of 15-eicosatetraenoic acid derivatives	Reactome	ALOX15 ALOX15B GPX1 GPX2 GPX4 PTGS2 (see all 6) (see less)
23	stearate biosynthesis I (animals and fungi)	PubChem	ACOT1 ACOT2 ACOT4 ACSL1 ELOVL6 SLC27A2 (see all 6) (see less)
24	leukotriene biosynthesis	PubChem	ALOX5 DPEP1 DPEP2 GGT5 LTA4H LTC4S (see all 6) (see less)
25	Metabolism of alpha-linolenic acid	WikiPathways	ALOX12 ALOX15 ALOX5 FADS1 FADS2 PTGS2 (see all 6) (see less)
26	fatty acid β-oxidation (unsaturated, odd number)	PubChem	ECI1 ECI2 EHHADH
27	Amodiaquine Pathway, Pharmacokinetics	PharmGKB	CYP1A1 CYP1B1 CYP2C8
28	sphingosine and sphingosine-1-phosphate metabolism	PubChem	ACSL1 ALDH3A2
29	Defective CYP1B1 causes Glaucoma	Reactome	CYP1B1
30	fatty acid β-oxidation III (unsaturated, odd number)	PubChem	ECI2
31	Defective CYP2U1 causes SPG56	Reactome	CYP2U1

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACSL1	Acyl-CoA Synthetase Long Chain Family Member 1	Protein Coding	12
2	ACSL3	Acyl-CoA Synthetase Long Chain Family Member 3	Protein Coding	10
3	ACSL4	Acyl-CoA Synthetase Long Chain Family Member 4	Protein Coding	10
4	EHHADH	Enoyl-CoA Hydratase And 3-Hydroxyacyl CoA Dehydrogenase	Protein Coding	8
5	ALOX5	Arachidonate 5-Lipoxygenase	Protein Coding	8
6	SLC27A2	Solute Carrier Family 27 Member 2	Protein Coding	7
7	ALOX15	Arachidonate 15-Lipoxygenase	Protein Coding	7
8	LTC4S	Leukotriene C4 Synthase	Protein Coding	7
9	SCP2	Sterol Carrier Protein 2	Protein Coding	7
10	CYP1B1	Cytochrome P450 Family 1 Subfamily B Member 1	Protein Coding	6
11	DPEP1	Dipeptidase 1	Protein Coding	6
12	ACSBG1	Acyl-CoA Synthetase Bubblegum Family Member 1	Protein Coding	6
13	GGT5	Gamma-Glutamyltransferase 5	Protein Coding	6
14	HADH	Hydroxyacyl-CoA Dehydrogenase	Protein Coding	6
15	LTA4H	Leukotriene A4 Hydrolase	Protein Coding	6
16	ACSL5	Acyl-CoA Synthetase Long Chain Family Member 5	Protein Coding	6
17	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	6
18	ACSBG2	Acyl-CoA Synthetase Bubblegum Family Member 2	Protein Coding	6
19	ACOT2	Acyl-CoA Thioesterase 2	Protein Coding	5
20	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	5
21	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	5
22	CYP4A11	Cytochrome P450 Family 4 Subfamily A Member 11	Protein Coding	5
23	ECI1	Enoyl-CoA Delta Isomerase 1	Protein Coding	5
24	PTGR1	Prostaglandin Reductase 1	Protein Coding	5
25	ACSL6	Acyl-CoA Synthetase Long Chain Family Member 6	Protein Coding	5
26	ALOX12	Arachidonate 12-Lipoxygenase, 12S Type	Protein Coding	5
27	ALOX5AP	Arachidonate 5-Lipoxygenase Activating Protein	Protein Coding	5
28	GPX1	Glutathione Peroxidase 1	Protein Coding	5
29	GPX2	Glutathione Peroxidase 2	Protein Coding	5
30	GPX4	Glutathione Peroxidase 4	Protein Coding	5
31	ACAA1	Acetyl-CoA Acyltransferase 1	Protein Coding	5
32	ACOX1	Acyl-CoA Oxidase 1	Protein Coding	5
33	DPEP2	Dipeptidase 2	Protein Coding	5
34	CYP4F2	Cytochrome P450 Family 4 Subfamily F Member 2	Protein Coding	5
35	PTGES3	Prostaglandin E Synthase 3	Protein Coding	4
36	CYP2U1	Cytochrome P450 Family 2 Subfamily U Member 1	Protein Coding	4
37	PTGR2	Prostaglandin Reductase 2	Protein Coding	4
38	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	4
39	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	4
40	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	4
41	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	4
42	HPGDS	Hematopoietic Prostaglandin D Synthase	Protein Coding	4
43	CYP4A22	Cytochrome P450 Family 4 Subfamily A Member 22	Protein Coding	4
44	HADHB	Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Beta	Protein Coding	4
45	HPGD	15-Hydroxyprostaglandin Dehydrogenase	Protein Coding	4
46	ACADL	Acyl-CoA Dehydrogenase Long Chain	Protein Coding	4
47	FADS1	Fatty Acid Desaturase 1	Protein Coding	4
48	CYP4F3	Cytochrome P450 Family 4 Subfamily F Member 3	Protein Coding	4
49	ABCC1	ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)	Protein Coding	4
50	PTGDS	Prostaglandin D2 Synthase	Protein Coding	4
51	PTGIS	Prostaglandin I2 Synthase	Protein Coding	4
52	PTGS1	Prostaglandin-Endoperoxide Synthase 1	Protein Coding	4
53	TBXAS1	Thromboxane A Synthase 1	Protein Coding	4
54	SLC25A20	Solute Carrier Family 25 Member 20	Protein Coding	4
55	ELOVL6	ELOVL Fatty Acid Elongase 6	Protein Coding	4
56	PTGES2	Prostaglandin E Synthase 2	Protein Coding	4
57	ACOX2	Acyl-CoA Oxidase 2	Protein Coding	4
58	FADS2	Fatty Acid Desaturase 2	Protein Coding	4
59	PTGES	Prostaglandin E Synthase	Protein Coding	4
60	ACAA2	Acetyl-CoA Acyltransferase 2	Protein Coding	3
61	ECI2	Enoyl-CoA Delta Isomerase 2	Protein Coding	3
62	CYP4F8	Cytochrome P450 Family 4 Subfamily F Member 8	Protein Coding	3
63	ACOT4	Acyl-CoA Thioesterase 4	Protein Coding	3
64	CYP4F22	Cytochrome P450 Family 4 Subfamily F Member 22	Protein Coding	3
65	PRXL2B	Peroxiredoxin Like 2B	Protein Coding	3
66	CPT1A	Carnitine Palmitoyltransferase 1A	Protein Coding	3
67	CPT2	Carnitine Palmitoyltransferase 2	Protein Coding	3
68	CYP2J2	Cytochrome P450 Family 2 Subfamily J Member 2	Protein Coding	3
69	CYP4B1	Cytochrome P450 Family 4 Subfamily B Member 1	Protein Coding	3
70	CYP8B1	Cytochrome P450 Family 8 Subfamily B Member 1	Protein Coding	3
71	ECHS1	Enoyl-CoA Hydratase, Short Chain 1	Protein Coding	3
72	EPHX2	Epoxide Hydrolase 2	Protein Coding	3
73	ALOX12B	Arachidonate 12-Lipoxygenase, 12R Type	Protein Coding	3
74	ALOX15B	Arachidonate 15-Lipoxygenase Type B	Protein Coding	3
75	HADHA	Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Alpha	Protein Coding	3
76	HSD17B4	Hydroxysteroid 17-Beta Dehydrogenase 4	Protein Coding	3
77	ACADM	Acyl-CoA Dehydrogenase Medium Chain	Protein Coding	3
78	ACADS	Acyl-CoA Dehydrogenase Short Chain	Protein Coding	3
79	ACADVL	Acyl-CoA Dehydrogenase Very Long Chain	Protein Coding	3
80	PON1	Paraoxonase 1	Protein Coding	3
81	PON2	Paraoxonase 2	Protein Coding	3
82	PON3	Paraoxonase 3	Protein Coding	3
83	ELOVL2	ELOVL Fatty Acid Elongase 2	Protein Coding	3
84	PECR	Peroxisomal Trans-2-Enoyl-CoA Reductase	Protein Coding	3
85	CYP4F11	Cytochrome P450 Family 4 Subfamily F Member 11	Protein Coding	3
86	ALOXE3	Arachidonate Epidermal Lipoxygenase 3	Protein Coding	3
87	ELOVL5	ELOVL Fatty Acid Elongase 5	Protein Coding	3
88	ACOT1	Acyl-CoA Thioesterase 1	Protein Coding	3
89	ELOVL1	ELOVL Fatty Acid Elongase 1	Protein Coding	3
90	ACSF2	Acyl-CoA Synthetase Family Member 2	Protein Coding	3
91	ACOX3	Acyl-CoA Oxidase 3, Pristanoyl	Protein Coding	3
92	AKR1C3	Aldo-Keto Reductase Family 1 Member C3	Protein Coding	3
93	CBR1	Carbonyl Reductase 1	Protein Coding	3
94	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	3
95	ACOT7	Acyl-CoA Thioesterase 7	Protein Coding	2
96	CPT1B	Carnitine Palmitoyltransferase 1B	Protein Coding	2
97	FAAH2	Fatty Acid Amide Hydrolase 2	Protein Coding	2
98	AWAT1	Acyl-CoA Wax Alcohol Acyltransferase 1	Protein Coding	2
99	DECR1	2,4-Dienoyl-CoA Reductase 1	Protein Coding	2
100	FAAH	Fatty Acid Amide Hydrolase	Protein Coding	2
101	FASN	Fatty Acid Synthase	Protein Coding	2
102	ALDH3A2	Aldehyde Dehydrogenase 3 Family Member A2	Protein Coding	2
103	DECR2	2,4-Dienoyl-CoA Reductase 2	Protein Coding	2
104	ACACA	Acetyl-CoA Carboxylase Alpha	Protein Coding	2
105	ACACB	Acetyl-CoA Carboxylase Beta	Protein Coding	2
106	SLC27A1	Solute Carrier Family 27 Member 1	Protein Coding	2
107	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	2
108	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	2
109	PPARD	Peroxisome Proliferator Activated Receptor Delta	Protein Coding	2
110	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	2
111	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	2
112	MID1IP1	MID1 Interacting Protein 1	Protein Coding	2
113	RXRA	Retinoid X Receptor Alpha	Protein Coding	2
114	SCD	Stearoyl-CoA Desaturase	Protein Coding	2
115	SLC22A5	Solute Carrier Family 22 Member 5	Protein Coding	2
116	THRSP	Thyroid Hormone Responsive	Protein Coding	2
117	SCD5	Stearoyl-CoA Desaturase 5	Protein Coding	2
118	ELOVL3	ELOVL Fatty Acid Elongase 3	Protein Coding	2
119	HSD17B10	Hydroxysteroid 17-Beta Dehydrogenase 10	Protein Coding	2
120	ACOT8	Acyl-CoA Thioesterase 8	Protein Coding	1
121	SLC25A17	Solute Carrier Family 25 Member 17	Protein Coding	1
122	HTD2	Hydroxyacyl-Thioester Dehydratase Type 2	Protein Coding	1
123	SLC27A3	Solute Carrier Family 27 Member 3	Protein Coding	1
124	THEM4	Thioesterase Superfamily Member 4	Protein Coding	1
125	ACOT12	Acyl-CoA Thioesterase 12	Protein Coding	1
126	CRAT	Carnitine O-Acetyltransferase	Protein Coding	1
127	ACSM6	Acyl-CoA Synthetase Medium Chain Family Member 6	Protein Coding	1
128	DBI	Diazepam Binding Inhibitor, Acyl-CoA Binding Protein	Protein Coding	1
129	MMAA	Metabolism Of Cobalamin Associated A	Protein Coding	1
130	ACSF3	Acyl-CoA Synthetase Family Member 3	Protein Coding	1
131	HACD2	3-Hydroxyacyl-CoA Dehydratase 2	Protein Coding	1
132	ABCD1	ATP Binding Cassette Subfamily D Member 1	Protein Coding	1
133	MORC2	MORC Family CW-Type Zinc Finger 2	Protein Coding	1
134	MLYCD	Malonyl-CoA Decarboxylase	Protein Coding	1
135	ACOT9	Acyl-CoA Thioesterase 9	Protein Coding	1
136	AMACR	Alpha-Methylacyl-CoA Racemase	Protein Coding	1
137	TECRL	Trans-2,3-Enoyl-CoA Reductase Like	Protein Coding	1
138	ACOT11	Acyl-CoA Thioesterase 11	Protein Coding	1
139	HACL1	2-Hydroxyacyl-CoA Lyase 1	Protein Coding	1
140	MCAT	Malonyl-CoA-Acyl Carrier Protein Transacylase	Protein Coding	1
141	NUDT7	Nudix Hydrolase 7	Protein Coding	1
142	THEM5	Thioesterase Superfamily Member 5	Protein Coding	1
143	HSD17B3	Hydroxysteroid 17-Beta Dehydrogenase 3	Protein Coding	1
144	NUDT19	Nudix Hydrolase 19	Protein Coding	1
145	HACD4	3-Hydroxyacyl-CoA Dehydratase 4	Protein Coding	1
146	ACBD7	Acyl-CoA Binding Domain Containing 7	Protein Coding	1
147	MMUT	Methylmalonyl-CoA Mutase	Protein Coding	1
148	ACLY	ATP Citrate Lyase	Protein Coding	1
149	NDUFAB1	NADH:Ubiquinone Oxidoreductase Subunit AB1	Protein Coding	1
150	PCCA	Propionyl-CoA Carboxylase Subunit Alpha	Protein Coding	1
151	PCCB	Propionyl-CoA Carboxylase Subunit Beta	Protein Coding	1
152	MECR	Mitochondrial Trans-2-Enoyl-CoA Reductase	Protein Coding	1
153	HSD17B12	Hydroxysteroid 17-Beta Dehydrogenase 12	Protein Coding	1
154	HAO2	Hydroxyacid Oxidase 2	Protein Coding	1
155	HACD3	3-Hydroxyacyl-CoA Dehydratase 3	Protein Coding	1
156	PHYH	Phytanoyl-CoA 2-Hydroxylase	Protein Coding	1
157	CROT	Carnitine O-Octanoyltransferase	Protein Coding	1
158	ACOXL	Acyl-CoA Oxidase Like	Protein Coding	1
159	OLAH	Oleoyl-ACP Hydrolase	Protein Coding	1
160	PPT1	Palmitoyl-Protein Thioesterase 1	Protein Coding	1
161	ACOT13	Acyl-CoA Thioesterase 13	Protein Coding	1
162	PCTP	Phosphatidylcholine Transfer Protein	Protein Coding	1
163	ACSM3	Acyl-CoA Synthetase Medium Chain Family Member 3	Protein Coding	1
164	ELOVL4	ELOVL Fatty Acid Elongase 4	Protein Coding	1
165	HSD17B8	Hydroxysteroid 17-Beta Dehydrogenase 8	Protein Coding	1
166	ACBD4	Acyl-CoA Binding Domain Containing 4	Protein Coding	1
167	ELOVL7	ELOVL Fatty Acid Elongase 7	Protein Coding	1
168	ACAD10	Acyl-CoA Dehydrogenase Family Member 10	Protein Coding	1
169	ACAD11	Acyl-CoA Dehydrogenase Family Member 11	Protein Coding	1
170	ACBD6	Acyl-CoA Binding Domain Containing 6	Protein Coding	1
171	MCEE	Methylmalonyl-CoA Epimerase	Protein Coding	1
172	CBR4	Carbonyl Reductase 4	Protein Coding	1
173	ACBD5	Acyl-CoA Binding Domain Containing 5	Protein Coding	1
174	HACD1	3-Hydroxyacyl-CoA Dehydratase 1	Protein Coding	1
175	PPT2	Palmitoyl-Protein Thioesterase 2	Protein Coding	1
176	TECR	Trans-2,3-Enoyl-CoA Reductase	Protein Coding	1
177	CYP4F12	Cytochrome P450 Family 4 Subfamily F Member 12	Protein Coding	1

Disorders associated with Fatty acid metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Open-angle glaucoma	Direct
2	Glaucoma, primary open angle	Direct
3	Intraocular pressure quantitative trait locus	Direct
4	Hereditary spastic paraplegia	Direct
5	Self-improving collodion baby	Enrichment	ALOX12B, ALOXE3	6.16
6	Isolated methylmalonic acidemia	Enrichment	ACSF3, MCEE, MMAA, MMUT	6.04
7	Methylmalonic acidemia	Enrichment	ACSF3, MCEE, MMAA, MMUT	5.74
8	Ichthyosis, congenital, autosomal recessive 2	Enrichment	ALOX12B, ALOXE3	5.64
9	D-bifunctional protein deficiency	Enrichment	EHHADH, HSD17B4	5.53
10	Mitochondrial trifunctional protein deficiency 1	Enrichment	HADHA, HADHB	5.41
11	Mitochondrial trifunctional protein deficiency	Enrichment	HADHA, HADHB	5.41
12	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PON1, PON2, PON3	5.21
13	Congenital nonbullous ichthyosiform erythroderma	Enrichment	ALOX12B, ALOXE3	4.99
14	Ichthyosis	Enrichment	ALOX12B, ALOXE3	4.90
15	Autosomal recessive congenital ichthyosis	Enrichment	ALOX12B, ALOXE3	4.62
16	Fanconi renotubular syndrome 3	Enrichment	EHHADH	3.66
17	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	3.66
18	Sjogren-larsson syndrome	Enrichment	ALDH3A2	3.53
19	Glaucoma 1, open angle, a	Enrichment	CYP1B1	3.35
20	Anterior segment dysgenesis 6	Enrichment	CYP1B1	3.35
21	Primary congenital glaucoma	Enrichment	CYP1B1	3.35
22	Spondylometaphyseal dysplasia, sedaghatian type	Enrichment	GPX4	3.35
23	Glutathione peroxidase deficiency	Enrichment	GPX1	3.35
24	Leukotriene c4 synthase deficiency	Enrichment	LTC4S	3.35
25	Atherosclerosis	Enrichment	ALOX5	3.35
26	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	3.23
27	Ghosal hematodiaphyseal dysplasia	Enrichment	TBXAS1	3.18
28	Intellectual developmental disorder, x-linked 63	Enrichment	ACSL4	3.13
29	Peroxisomal acyl-coa oxidase deficiency	Enrichment	ACOX1	3.13
30	Mitchell syndrome	Enrichment	ACOX1	3.13
31	Spinocerebellar ataxia 38	Enrichment	ELOVL5	3.13
32	Primary fanconi renotubular syndrome	Enrichment	EHHADH	3.05
33	Glaucoma 3, primary infantile, b	Enrichment	CYP1B1	3.05
34	Glutathionuria	Enrichment	GGT1	3.02
35	Deafness, autosomal dominant 77	Enrichment	ABCC1	3.02
36	Diarrhea 13	Enrichment	ACSL5	3.02
37	Propionic acidemia	Enrichment	PCCA, PCCB	3.01
38	Carnitine-acylcarnitine translocase deficiency	Enrichment	SLC25A20	2.99
39	Acetyl-coa carboxylase-alpha deficiency	Enrichment	ACACA	2.99
40	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	2.99
41	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	2.99
42	Bile acid synthesis defect, congenital, 6	Enrichment	ACOX2	2.99
43	Leukoencephalopathy with dystonia and motor neuropathy	Enrichment	SCP2	2.99
44	Deafness, autosomal dominant 79	Enrichment	SCD5	2.99
45	Juvenile glaucoma	Enrichment	CYP1B1	2.96
46	3-hydroxyacyl-coa dehydrogenase deficiency	Enrichment	HADH	2.96
47	Digital clubbing, isolated congenital	Enrichment	HPGD	2.96
48	Hsd10 mitochondrial disease	Enrichment	HSD17B10	2.93
49	Syndromic x-linked intellectual disability type 10	Enrichment	HSD17B10	2.93
50	Mitochondrial trifunctional protein deficiency 2	Enrichment	HADHB	2.93
51	Acyl-coa dehydrogenase, medium-chain, deficiency of	Enrichment	ACADM	2.93
52	Acute fatty liver of pregnancy	Enrichment	HADHA	2.93
53	Medium-chain acyl-coenzyme a dehydrogenase deficiency	Enrichment	ACADM	2.93
54	Anterior segment dysgenesis 5	Enrichment	CYP1B1	2.88
55	Bleeding disorder, platelet-type, 14	Enrichment	TBXAS1	2.88
56	Microvascular complications of diabetes 5	Enrichment	PON1	2.88
57	Ichthyosis, congenital, autosomal recessive 5	Enrichment	CYP4F22	2.83
58	Ichthyosis, congenital, autosomal recessive 3	Enrichment	ALOXE3	2.81
59	Glaucoma 3, primary congenital, a	Enrichment	CYP1B1	2.81
60	Coumarin resistance	Enrichment	CYP2C9	2.75
61	Ichthyotic keratoderma, spasticity, hypomyelination, and dysmorphic facial features	Enrichment	ELOVL1	2.72
62	Hereditary spastic paraplegia 56	Enrichment	CYP2U1	2.70
63	Spastic paraplegia 56, autosomal recessive, with or without pseudoxanthoma elasticum	Enrichment	CYP2U1	2.70
64	Carnitine palmitoyltransferase ii deficiency, infantile	Enrichment	CPT2	2.69
65	Carnitine palmitoyltransferase ii deficiency, lethal neonatal	Enrichment	CPT2	2.69
66	Carnitine palmitoyltransferase i deficiency	Enrichment	CPT1A	2.69
67	Carnitine palmitoyltransferase ii deficiency, myopathic, stress-induced	Enrichment	CPT2	2.69
68	Encephalopathy, acute, infection-induced 4	Enrichment	CPT2	2.69
69	Myasthenic syndrome, congenital, 20, presynaptic	Enrichment	SLC22A5	2.69
70	Acute necrotizing encephalopathy of childhood	Enrichment	CPT2	2.69
71	Peters-plus syndrome	Enrichment	CYP1B1	2.66
72	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	HADH	2.66
73	Primary hypertrophic osteoarthropathy	Enrichment	HPGD	2.66
74	Mitochondrial short-chain enoyl-coa hydratase 1 deficiency	Enrichment	ECHS1	2.63
75	Acyl-coa dehydrogenase, short-chain, deficiency of	Enrichment	ACADS	2.63
76	Congenital nervous system abnormality	Enrichment	ABCD1, CPT2, CYP2U1, HSD17B4, PPT1, SLC22A5	2.60
77	Nervous system disease	Enrichment	ABCD1, CPT2, CYP2U1, HSD17B4, PPT1, SLC22A5	2.60
78	Amme complex	Enrichment	ACSL4	2.53
79	Carnitine deficiency, systemic primary	Enrichment	SLC22A5	2.51
80	Hyperinsulinemic hypoglycemia	Enrichment	HADH	2.48
81	Hypertrophic osteoarthropathy, primary, autosomal recessive, 1	Enrichment	HPGD	2.48
82	Anterior segment dysgenesis	Enrichment	CYP1B1	2.48
83	Heart defects, congenital, and other congenital anomalies	Enrichment	ACADVL	2.45
84	Long-chain 3-hydroxyacyl-coa dehydrogenase deficiency	Enrichment	HADHA	2.45
85	Intellectual developmental disorder, autosomal dominant 62	Enrichment	ACADVL	2.45
86	Dlg4-related synaptopathy	Enrichment	ACADVL	2.45
87	Leukoencephalopathy, brain calcifications, and cysts	Enrichment	ALOX12B	2.44
88	Polysubstance abuse	Enrichment	FAAH	2.36
89	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.36
90	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.36
91	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.36
92	Currarino syndrome	Enrichment	HPGD	2.35
93	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	ACADVL	2.33
94	Hydrocephalus, congenital, 2, with or without brain or eye anomalies	Enrichment	ACADM	2.33
95	Asthma	Enrichment	ALOX5	2.31
96	Cerebral palsy	Enrichment	ALDH3A2	2.24
97	Stroke, ischemic	Enrichment	ALOX5AP	2.18
98	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	HADH	2.18
99	Nonsyndromic genetic hyperinsulinism	Enrichment	HADH	2.18
100	Hypercholesterolemia, familial, 1	Enrichment	EPHX2	2.12
101	Perrault syndrome	Enrichment	HSD17B4	2.08
102	Familial hypercholesterolemia	Enrichment	EPHX2	2.05
103	Perrault syndrome 2	Enrichment	HSD17B4	2.03
104	Hypertension, essential	Enrichment	PTGIS	1.95
105	Methylmalonyl-coa epimerase deficiency	Enrichment	MCEE	1.89
106	Carnitine acetyltransferase deficiency	Enrichment	CRAT	1.89
107	Spinocerebellar ataxia 34	Enrichment	ELOVL4	1.89
108	Hypoadrenocorticism, familial	Enrichment	ABCD1	1.89
109	Methylmalonic aciduria, cbla type	Enrichment	MMAA	1.89
110	Ventricular tachycardia, catecholaminergic polymorphic, 3	Enrichment	TECRL	1.89
111	Intellectual developmental disorder, autosomal recessive 14	Enrichment	TECR	1.89
112	Retinal dystrophy with leukodystrophy	Enrichment	ACBD5	1.89
113	Congenital myopathy 11	Enrichment	HACD1	1.89
114	Optic atrophy 15	Enrichment	MCAT	1.89
115	Optic atrophy 16	Enrichment	MECR	1.89
116	Ichthyosis, spastic quadriplegia, and impaired intellectual development	Enrichment	ELOVL4	1.89
117	Developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy	Enrichment	MORC2	1.89
118	Encephalitis	Enrichment	ABCD1	1.89
119	Dystonia, childhood-onset, with optic atrophy and basal ganglia abnormalities	Enrichment	MECR	1.89
120	Charcot-marie-tooth disease, axonal, type 2z	Enrichment	MORC2	1.89
121	Neurodegeneration with brain iron accumulation 8	Enrichment	CRAT	1.89
122	X-linked cerebral adrenoleukodystrophy	Enrichment	ABCD1	1.89
123	Neurodevelopmental disorder with progressive movement abnormalities	Enrichment	ACBD6	1.89
124	Vitamin b12-responsive methylmalonic acidemia	Enrichment	MMAA	1.89
125	Adrenomyeloneuropathy	Enrichment	ABCD1	1.89
126	Chronic primary adrenal insufficiency	Enrichment	ABCD1	1.89
127	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	1.79
128	Perrault syndrome 1	Enrichment	HSD17B4	1.79
129	Cardiomyopathy, dilated, 1a	Enrichment	SLC22A5	1.67
130	Spondyloepimetaphyseal dysplasia, x-linked	Enrichment	ABCD1	1.59
131	Ceroid lipofuscinosis, neuronal, 1	Enrichment	PPT1	1.59
132	Adrenoleukodystrophy	Enrichment	ABCD1	1.59
133	Stargardt disease 3	Enrichment	ELOVL4	1.59
134	Combined malonic and methylmalonic aciduria	Enrichment	ACSF3	1.59
135	Bile acid synthesis defect, congenital, 4	Enrichment	AMACR	1.59
136	Alpha-methylacyl-coa racemase deficiency	Enrichment	AMACR	1.59
137	17-beta hydroxysteroid dehydrogenase iii deficiency	Enrichment	HSD17B3	1.59
138	Neurodevelopmental disorder with speech delay and variable ocular anomalies	Enrichment	ACSM3	1.59
139	Cadds	Enrichment	ABCD1	1.59
140	Non-syndromic x-linked intellectual disability	Enrichment	ACSL4	1.58
141	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.47
142	Methylmalonic aciduria due to methylmalonyl-coa mutase deficiency	Enrichment	MMUT	1.42
143	Pituitary hormone deficiency, combined, 4	Enrichment	ACBD6	1.42
144	Ehlers-danlos syndrome, kyphoscoliotic type, 1	Enrichment	ABCD1	1.42
145	Refsum disease, classic	Enrichment	PHYH	1.42
146	Plod1-related kyphoscoliotic ehlers-danlos syndrome	Enrichment	ABCD1	1.42
147	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.36
148	Myopathy	Enrichment	ACADVL	1.34
149	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ABCC1	1.31
150	Malonyl-coa decarboxylase deficiency	Enrichment	MLYCD	1.30
151	Autosomal recessive isolated optic atrophy	Enrichment	MCAT	1.30
152	Myeloma, multiple	Enrichment	RXRA	1.25
153	Liver failure, infantile, transient	Enrichment	MMUT	1.20
154	Pontocerebellar hypoplasia, type 2d	Enrichment	PCCA	1.20
155	Pseudohermaphroditism	Enrichment	HSD17B3	1.20
156	Leigh syndrome, nuclear	Enrichment	ECHS1	1.11
157	Rare genetic deafness	Enrichment	HSD17B4	1.10
158	Leigh disease	Enrichment	ECHS1	1.07
159	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	TECRL	1.01
160	Myocarditis	Enrichment	ABCD1	1.01
161	Difference of sex development	Enrichment	HSD17B3	1.01
162	Orofacial cleft 1	Enrichment	PHYH	0.96
163	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	PPT1	0.96
164	Neurodegeneration with brain iron accumulation	Enrichment	CRAT	0.91
165	Epilepsy, myoclonic juvenile	Enrichment	HSD17B3	0.88
166	Spastic ataxia	Enrichment	ELOVL4, PPT1	0.83
167	Congenital myopathy 4a, autosomal dominant	Enrichment	HACD1	0.75
168	Neuronal ceroid lipofuscinosis	Enrichment	PPT1	0.75
169	Hirschsprung disease 1	Enrichment	ABCD1	0.50
170	Stargardt disease 1	Enrichment	ELOVL4	0.49
171	Long qt syndrome	Enrichment	TECRL	0.48
172	Optic atrophy plus syndrome	Enrichment	MECR	0.36
173	Autosomal recessive non-syndromic intellectual disability	Enrichment	TECR	0.28
174	Mitochondrial disease	Enrichment	MECR	0.17
175	Retinitis pigmentosa	Enrichment	PHYH, PPT1	0.12
176	Hereditary retinal dystrophy	Enrichment	ELOVL4, PHYH	0.05
177	Fundus dystrophy	Enrichment	ELOVL4, PHYH	0.05

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Fatty acid metabolism

Pathway Network for Fatty acid metabolism

Pathway network for the Fatty acid metabolism SuperPath

Member Pathways for Fatty acid metabolism

Pathways in the Fatty acid metabolism SuperPath

Associated Genes for Fatty acid metabolism

Associated Disorders for Fatty acid metabolism

Disorders associated with Fatty acid metabolism SuperPath

STRING Interaction Network for Fatty acid metabolism

Sources for Fatty acid metabolism