FCERI mediated Ca+2 mobilization

Pathway network for the FCERI mediated Ca+2 mobilization SuperPath

Sources:

Reactome

Pathways in the FCERI mediated Ca+2 mobilization SuperPath

#	Name	Source	Genes
1	FCERI mediated Ca+2 mobilization	Reactome	AHCYL1 BTK CALM1 CALM2 CALM3 FCER1A FCER1G GRAP2 GRB2 ITK ITPR1 ITPR2 ITPR3 LAT LCP2 LYN MS4A2 NFATC1 NFATC2 NFATC3 PLCG1 PLCG2 PPP3CA PPP3CB PPP3R1 SHC1 SOS1 SYK VAV1 VAV2 VAV3 (see all 31) (see less)
2	FCERI mediated MAPK activation	Reactome	FCER1A FCER1G FOS GRAP2 GRB2 HRAS JUN KRAS LAT LCP2 LYN MAP2K4 MAP2K7 MAP3K1 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MS4A2 NRAS PAK1 PAK2 PLCG1 PLCG2 RAC1 SHC1 SOS1 SYK VAV1 VAV2 VAV3 (see all 32) (see less)
3	CLEC7A (Dectin-1) induces NFAT activation	Reactome	AHCYL1 CALM1 CALM2 CALM3 ITPR1 ITPR2 ITPR3 NFATC1 NFATC2 NFATC3 PPP3CA PPP3CB PPP3R1 (see all 13) (see less)

Gene overlap in member pathways for FCERI mediated Ca+2 mobilization SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	2
2	AHCYL1	Adenosylhomocysteinase Like 1	Protein Coding	2
3	FCER1A	Fc Epsilon Receptor Ia	Protein Coding	2
4	MS4A2	Membrane Spanning 4-Domains A2	Protein Coding	2
5	FCER1G	Fc Epsilon Receptor Ig	Protein Coding	2
6	LAT	Linker For Activation Of T Cells	Protein Coding	2
7	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
8	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	2
9	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	2
10	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	2
11	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	2
12	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
13	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	2
14	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	2
15	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	2
16	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
17	PLCG2	Phospholipase C Gamma 2	Protein Coding	2
18	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	2
19	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	2
20	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	2
21	SHC1	SHC Adaptor Protein 1	Protein Coding	2
22	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
23	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	2
24	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	2
25	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	2
26	CALM1	Calmodulin 1	Protein Coding	2
27	CALM2	Calmodulin 2	Protein Coding	2
28	CALM3	Calmodulin 3	Protein Coding	2
29	GRAP2	GRB2 Related Adaptor Protein 2	Protein Coding	2
30	ITK	IL2 Inducible T Cell Kinase	Protein Coding	1
31	BTK	Bruton Tyrosine Kinase	Protein Coding	1
32	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
33	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
34	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
35	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
36	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
37	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
38	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
39	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
40	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
41	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
42	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
43	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
44	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
45	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
46	RAC1	Rac Family Small GTPase 1	Protein Coding	1
47	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1

Disorders associated with FCERI mediated Ca+2 mobilization SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	7.86
2	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, SOS1	7.47
3	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	7.42
4	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.32
5	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1	6.66
6	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1	6.43
7	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	6.38
8	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	6.38
9	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS	5.71
10	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.27
11	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.79
12	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.49
13	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	4.38
14	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.95
15	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.95
16	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.95
17	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	3.82
18	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	3.46
19	Long qt syndrome	Enrichment	CALM1, CALM2	3.41
20	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	3.32
21	Breast cancer	Enrichment	JUN, KRAS, SHC1	3.14
22	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	3.02
23	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	3.02
24	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	3.02
25	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	3.02
26	Long qt syndrome 16	Enrichment	CALM3	3.02
27	Long qt syndrome 15	Enrichment	CALM2	3.02
28	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	3.02
29	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.72
30	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.72
31	Long qt syndrome 14	Enrichment	CALM1	2.72
32	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.72
33	Bladder cancer	Enrichment	HRAS, KRAS	2.68
34	Noonan syndrome 4	Enrichment	SOS1	2.64
35	Immunodeficiency 81	Enrichment	LCP2	2.64
36	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.64
37	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.64
38	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.64
39	Lymphoproliferative syndrome 1	Enrichment	ITK	2.64
40	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.64
41	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.64
42	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.64
43	Colitis	Enrichment	SYK	2.64
44	Oculoectodermal syndrome	Enrichment	KRAS	2.63
45	Melanosis, neurocutaneous	Enrichment	NRAS	2.63
46	Noonan syndrome 6	Enrichment	NRAS	2.63
47	46,xy sex reversal 6	Enrichment	MAP3K1	2.63
48	Noonan syndrome 13	Enrichment	MAPK1	2.63
49	Knobloch syndrome 2	Enrichment	PAK2	2.63
50	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.63
51	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.63
52	Congenital pulmonary airway malformation	Enrichment	KRAS	2.63
53	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.63
54	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.63
55	Neurocutaneous melanocytosis	Enrichment	NRAS	2.63
56	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.62
57	Gillespie syndrome	Enrichment	ITPR1	2.54
58	Spinocerebellar ataxia 15	Enrichment	ITPR1	2.42
59	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.40
60	Fibromatosis, gingival, 1	Enrichment	SOS1	2.34
61	Pulmonic stenosis	Enrichment	SOS1	2.34
62	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	2.34
63	Agammaglobulinemia, x-linked	Enrichment	BTK	2.34
64	Lymphoproliferative syndrome	Enrichment	ITK	2.34
65	Immunodeficiency 52	Enrichment	LAT	2.34
66	Arthritis	Enrichment	SYK	2.34
67	Costello syndrome	Enrichment	HRAS	2.33
68	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.33
69	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.33
70	Wooly hair nevus	Enrichment	HRAS	2.33
71	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	2.24
72	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	2.24
73	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	2.16
74	Nuchal bleb, familial	Enrichment	SOS1	2.16
75	Agammaglobulinemia 1	Enrichment	BTK	2.16
76	Langerhans cell histiocytosis	Enrichment	NRAS	2.15
77	Spermatocytoma	Enrichment	HRAS	2.15
78	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	2.12
79	Gingival fibromatosis	Enrichment	SOS1	2.04
80	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.03
81	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.03
82	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.03
83	Congenital generalized lipodystrophy	Enrichment	FOS	2.03
84	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.03
85	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.03
86	Pilocytic astrocytoma	Enrichment	KRAS	2.03
87	Epidermolytic nevus	Enrichment	HRAS	2.03
88	Knobloch syndrome	Enrichment	PAK2	2.03
89	Congenital long qt syndrome	Enrichment	ITPR3	1.94
90	Knobloch syndrome 1	Enrichment	PAK2	1.93
91	Histiocytoid hemangioma	Enrichment	FOS	1.93
92	Multiple sclerosis	Enrichment	ITPR1	1.87
93	Breast adenocarcinoma	Enrichment	KRAS	1.85
94	Lung squamous cell carcinoma	Enrichment	KRAS	1.85
95	Anterior segment dysgenesis	Enrichment	ITPR1	1.85
96	Sudden infant death syndrome	Enrichment	CALM2	1.79
97	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	1.79
98	Gallbladder cancer	Enrichment	KRAS	1.79
99	Pilomyxoid astrocytoma	Enrichment	KRAS	1.79
100	Lennox-gastaut syndrome	Enrichment	MAPK10	1.73
101	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.70
102	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.68
103	Arteriovenous malformation	Enrichment	HRAS	1.68
104	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.63
105	Ovarian cancer	Enrichment	KRAS, MAP3K1	1.63
106	Immune deficiency disease	Enrichment	SYK	1.60
107	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.59
108	Specific learning disability	Enrichment	MAPK1	1.59
109	Lip and oral cavity carcinoma	Enrichment	HRAS	1.55
110	Aortic valve disease 1	Enrichment	SOS1	1.53
111	Protein-deficiency anemia	Enrichment	NRAS	1.52
112	Lung cancer susceptibility 3	Enrichment	KRAS	1.49
113	Lynch syndrome	Enrichment	KRAS	1.46
114	Rhabdomyosarcoma	Enrichment	HRAS	1.43
115	Heart, malformation of	Enrichment	MAPK1	1.38
116	Diffuse large b-cell lymphoma	Enrichment	BTK	1.37
117	Arteriovenous malformations of the brain	Enrichment	KRAS	1.36
118	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	1.33
119	Spastic ataxia	Enrichment	ITPR1	1.30
120	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	1.28
121	Pancreatic cancer	Enrichment	KRAS	1.24
122	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.22
123	Lung cancer	Enrichment	KRAS	1.14
124	Gastric cancer	Enrichment	KRAS	1.01
125	Hereditary breast carcinoma	Enrichment	KRAS	1.01
126	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.91
127	Myeloma, multiple	Enrichment	KRAS	0.91
128	Colorectal cancer	Enrichment	NRAS	0.73
129	Microcephaly	Enrichment	MAPK1	0.60

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

FCERI mediated Ca+2 mobilization

Pathway Network for FCERI mediated Ca+2 mobilization

Pathway network for the FCERI mediated Ca+2 mobilization SuperPath

Member Pathways for FCERI mediated Ca+2 mobilization

Pathways in the FCERI mediated Ca+2 mobilization SuperPath

Gene overlap in member pathways for FCERI mediated Ca+2 mobilization SuperPath

Associated Genes for FCERI mediated Ca+2 mobilization

Associated Disorders for FCERI mediated Ca+2 mobilization

Disorders associated with FCERI mediated Ca+2 mobilization SuperPath

STRING Interaction Network for FCERI mediated Ca+2 mobilization

Sources for FCERI mediated Ca+2 mobilization