Ferroptosis

No Pathway Network information available for Ferroptosis

Pathways in the Ferroptosis SuperPath

#	Name	Source	Genes
1	Ferroptosis	WikiPathways	ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 AIFM2 AKR1C1 AKR1C2 AKR1C3 ALOX15 ATG5 ATG7 CBS CHMP5 CHMP6 CISD1 COQ2 CP CTH CYBB DPP4 FDFT1 FTH1 FTL FTMT GCH1 GCLC GCLM GPX4 GRIK1-AS2 GSS HMGCR HMOX1 HSPB1 IREB2 LPCAT3 MAP1LC3A MAP1LC3B MAP1LC3C NCOA4 NOX1 NOX4 PCBP1 PCBP2 PHKG2 POR PRNP SAT1 SAT2 SLC11A2 SLC1A5 SLC38A1 SLC39A14 SLC39A8 SLC3A2 SLC40A1 SLC7A11 STEAP3 TF TFRC TP53 TXNRD1 VDAC2 VDAC3 (see all 64) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ALOX15	Arachidonate 15-Lipoxygenase	Protein Coding	1
2	ACSL3	Acyl-CoA Synthetase Long Chain Family Member 3	Protein Coding	1
3	LPCAT3	Lysophosphatidylcholine Acyltransferase 3	Protein Coding	1
4	ATG5	Autophagy Related 5	Protein Coding	1
5	CBS	Cystathionine Beta-Synthase	Protein Coding	1
6	AKR1C3	Aldo-Keto Reductase Family 1 Member C3	Protein Coding	1
7	MAP1LC3A	Microtubule Associated Protein 1 Light Chain 3 Alpha	Protein Coding	1
8	MAP1LC3B	Microtubule Associated Protein 1 Light Chain 3 Beta	Protein Coding	1
9	NCOA4	Nuclear Receptor Coactivator 4	Protein Coding	1
10	VDAC2	Voltage Dependent Anion Channel 2	Protein Coding	1
11	TXNRD1	Thioredoxin Reductase 1	Protein Coding	1
12	TP53	Tumor Protein P53	Protein Coding	1
13	TFRC	Transferrin Receptor	Protein Coding	1
14	TF	Transferrin	Protein Coding	1
15	SLC3A2	Solute Carrier Family 3 Member 2	Protein Coding	1
16	SLC1A5	Solute Carrier Family 1 Member 5	Protein Coding	1
17	SLC39A8	Solute Carrier Family 39 Member 8	Protein Coding	1
18	SAT1	Spermidine/Spermine N1-Acetyltransferase 1	Protein Coding	1
19	PRNP	Prion Protein (Kanno Blood Group)	Protein Coding	1
20	STEAP3	STEAP3 Metalloreductase	Protein Coding	1
21	POR	Cytochrome P450 Oxidoreductase	Protein Coding	1
22	PHKG2	Phosphorylase Kinase Catalytic Subunit Gamma 2	Protein Coding	1
23	ACSL5	Acyl-CoA Synthetase Long Chain Family Member 5	Protein Coding	1
24	CHMP5	Charged Multivesicular Body Protein 5	Protein Coding	1
25	PCBP1	Poly(RC) Binding Protein 1	Protein Coding	1
26	NOX4	NADPH Oxidase 4	Protein Coding	1
27	SLC11A2	Solute Carrier Family 11 Member 2	Protein Coding	1
28	IREB2	Iron Responsive Element Binding Protein 2	Protein Coding	1
29	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
30	HMOX1	Heme Oxygenase 1	Protein Coding	1
31	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	1
32	SLC40A1	Solute Carrier Family 40 Member 1	Protein Coding	1
33	GSS	Glutathione Synthetase	Protein Coding	1
34	GPX4	Glutathione Peroxidase 4	Protein Coding	1
35	GCLM	Glutamate-Cysteine Ligase Modifier Subunit	Protein Coding	1
36	GCLC	Glutamate-Cysteine Ligase Catalytic Subunit	Protein Coding	1
37	COQ2	Coenzyme Q2, Polyprenyltransferase	Protein Coding	1
38	NOX1	NADPH Oxidase 1	Protein Coding	1
39	GCH1	GTP Cyclohydrolase 1	Protein Coding	1
40	FTL	Ferritin Light Chain	Protein Coding	1
41	FTH1	Ferritin Heavy Chain 1	Protein Coding	1
42	SLC7A11	Solute Carrier Family 7 Member 11	Protein Coding	1
43	SLC39A14	Solute Carrier Family 39 Member 14	Protein Coding	1
44	ACSL6	Acyl-CoA Synthetase Long Chain Family Member 6	Protein Coding	1
45	FDFT1	Farnesyl-Diphosphate Farnesyltransferase 1	Protein Coding	1
46	ACSL4	Acyl-CoA Synthetase Long Chain Family Member 4	Protein Coding	1
47	ACSL1	Acyl-CoA Synthetase Long Chain Family Member 1	Protein Coding	1
48	DPP4	Dipeptidyl Peptidase 4	Protein Coding	1
49	AKR1C2	Aldo-Keto Reductase Family 1 Member C2	Protein Coding	1
50	AKR1C1	Aldo-Keto Reductase Family 1 Member C1	Protein Coding	1
51	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	1
52	CTH	Cystathionine Gamma-Lyase	Protein Coding	1
53	CP	Ceruloplasmin	Protein Coding	1
54	ATG7	Autophagy Related 7	Protein Coding	1
55	AIFM2	AIF Family Member 2	Protein Coding	1
56	SAT2	Spermidine/Spermine N1-Acetyltransferase Family Member 2	Protein Coding	1
57	SLC38A1	Solute Carrier Family 38 Member 1	Protein Coding	1
58	CHMP6	Charged Multivesicular Body Protein 6	Protein Coding	1
59	VDAC3	Voltage Dependent Anion Channel 3	Protein Coding	1
60	CISD1	CDGSH Iron Sulfur Domain 1	Protein Coding	1
61	PCBP2	Poly(RC) Binding Protein 2	Protein Coding	1
62	MAP1LC3C	Microtubule Associated Protein 1 Light Chain 3 Gamma	Protein Coding	1
63	FTMT	Ferritin Mitochondrial	Protein Coding	1
64	GRIK1-AS2	GRIK1 Antisense RNA 2	RNA Gene	1

Disorders associated with Ferroptosis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hyperostosis cranialis interna	Enrichment	SLC39A14	2.33
2	Cystathioninuria	Enrichment	CTH	2.33
3	Glutathione synthetase deficiency	Enrichment	GSS	2.33
4	Fatal familial insomnia	Enrichment	PRNP	2.33
5	Immunodeficiency 34	Enrichment	CYBB	2.33
6	Intellectual developmental disorder, x-linked 63	Enrichment	ACSL4	2.33
7	Aceruloplasminemia	Enrichment	CP	2.33
8	Neurodegeneration with brain iron accumulation 3	Enrichment	FTL	2.33
9	Glycogen storage disease ixc	Enrichment	PHKG2	2.33
10	Gerstmann-straussler disease	Enrichment	PRNP	2.33
11	Anemia, congenital, nonspherocytic hemolytic, 6	Enrichment	GSS	2.33
12	Spondylometaphyseal dysplasia, sedaghatian type	Enrichment	GPX4	2.33
13	Anemia, congenital, nonspherocytic hemolytic, 7	Enrichment	GCLC	2.33
14	Kuru	Enrichment	PRNP	2.33
15	Anemia, hypochromic microcytic, with iron overload 1	Enrichment	SLC11A2	2.33
16	Atransferrinemia	Enrichment	TF	2.33
17	Spinocerebellar ataxia, autosomal recessive 25	Enrichment	ATG5	2.33
18	Diarrhea 13	Enrichment	ACSL5	2.33
19	Brachycephaly, deafness, cataract, microstomia, and impaired intellectual development	Enrichment	POR	2.33
20	Bone marrow failure syndrome 5	Enrichment	TP53	2.33
21	Spongiform encephalopathy with neuropsychiatric features	Enrichment	PRNP	2.33
22	Hyperhomocysteinemia	Enrichment	CBS	2.33
23	Papilloma of choroid plexus	Enrichment	TP53	2.33
24	Basal cell carcinoma 7	Enrichment	TP53	2.33
25	Anaplastic thyroid carcinoma	Enrichment	TP53	2.33
26	Huntington disease-like 1	Enrichment	PRNP	2.33
27	Hemochromatosis, type 4	Enrichment	SLC40A1	2.33
28	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.33
29	Familial alzheimer-like prion disease	Enrichment	PRNP	2.33
30	Immunodeficiency 46	Enrichment	TFRC	2.33
31	L-ferritin deficiency	Enrichment	FTL	2.33
32	Ductal carcinoma in situ	Enrichment	TP53	2.33
33	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.33
34	Hypermanganesemia with dystonia 2	Enrichment	SLC39A14	2.33
35	Prion disease	Enrichment	PRNP	2.33
36	Neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia	Enrichment	IREB2	2.33
37	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.33
38	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.33
39	Low density lipoprotein cholesterol level quantitative trait locus 3	Enrichment	HMGCR	2.33
40	Muscular dystrophy, limb-girdle, autosomal recessive 28	Enrichment	HMGCR	2.33
41	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.33
42	Genetic hyperferritinemia without iron overload	Enrichment	FTL	2.33
43	Choroid plexus cancer	Enrichment	TP53	2.33
44	Prp systemic amyloidosis	Enrichment	PRNP	2.33
45	Inherited human prion disease	Enrichment	PRNP	2.33
46	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.33
47	Multiple system atrophy, parkinsonian type	Enrichment	COQ2	2.33
48	Inherited creutzfeldt-jakob disease	Enrichment	PRNP	2.33
49	Myocardial infarction	Enrichment	GCLC, GCLM	2.32
50	Multiple system atrophy 1	Enrichment	COQ2	2.03
51	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.03
52	Vitreoretinochoroidopathy	Enrichment	FTH1	2.03
53	Antley-bixler syndrome with genital anomalies and disordered steroidogenesis	Enrichment	POR	2.03
54	Cervical cancer	Enrichment	TP53	2.03
55	Retinitis pigmentosa 50	Enrichment	FTH1	2.03
56	Creutzfeldt-jakob disease	Enrichment	PRNP	2.03
57	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	2.03
58	Anemia, hypochromic microcytic, with iron overload 2	Enrichment	STEAP3	2.03
59	Fatty liver disease 1	Enrichment	ATG7	2.03
60	Lymphoma, hodgkin, classic	Enrichment	TP53	2.03
61	Albinism, oculocutaneous, type ia	Enrichment	NOX4	2.03
62	Hermansky-pudlak syndrome 3	Enrichment	CP	2.03
63	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	POR	2.03
64	Hyperferritinemia with or without cataract	Enrichment	FTL	2.03
65	Squalene synthase deficiency	Enrichment	FDFT1	2.03
66	Hemochromatosis, type 5	Enrichment	FTH1	2.03
67	Spinocerebellar ataxia, autosomal recessive 31	Enrichment	ATG7	2.03
68	Congenital fibrosarcoma	Enrichment	TP53	2.03
69	Li-fraumeni syndrome 1	Enrichment	TP53	2.03
70	Sarcoma	Enrichment	TP53	2.03
71	Cic-rearranged sarcoma	Enrichment	AKR1C2	2.03
72	Disordered steroidogenesis due to cytochrome p450 oxidoreductase deficiency	Enrichment	POR	2.03
73	Cervix carcinoma	Enrichment	TP53	2.03
74	Hodgkin's lymphoma	Enrichment	TP53	2.03
75	Cytochrome p450 oxidoreductase deficiency	Enrichment	POR	2.03
76	Glycogen storage disease due to liver phosphorylase kinase deficiency	Enrichment	PHKG2	2.03
77	Neurodegeneration with brain iron accumulation 9	Enrichment	FTH1	2.03
78	Multiple system atrophy	Enrichment	COQ2	2.03
79	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.03
80	Multiple system atrophy, cerebellar type	Enrichment	COQ2	2.03
81	Cystic fibrosis	Enrichment	GCLC, HMOX1	2.00
82	Dystonia, dopa-responsive	Enrichment	GCH1	1.85
83	Homocystinuria due to cystathionine beta-synthase deficiency	Enrichment	CBS	1.85
84	Hyperphenylalaninemia, bh4-deficient, b	Enrichment	GCH1	1.85
85	Osteogenic sarcoma	Enrichment	TP53	1.85
86	Nasopharyngeal carcinoma	Enrichment	TP53	1.85
87	Coenzyme q10 deficiency, primary, 1	Enrichment	COQ2	1.85
88	46,xy sex reversal 8	Enrichment	AKR1C2	1.85
89	Congenital disorder of glycosylation, type iin	Enrichment	SLC39A8	1.85
90	Keratosis follicularis spinulosa decalvans	Enrichment	SAT1	1.85
91	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.85
92	Anaplastic astrocytoma	Enrichment	TP53	1.85
93	Squamous cell carcinoma	Enrichment	TP53	1.85
94	Adenocarcinoma	Enrichment	TP53	1.85
95	Bone osteosarcoma	Enrichment	TP53	1.85
96	Gtp cyclohydrolase 1-deficient dopa-responsive dystonia	Enrichment	GCH1	1.85
97	Homocystinuria	Enrichment	CBS	1.85
98	Small cell cancer of the lung	Enrichment	TP53	1.73
99	Granulomatous disease, chronic, x-linked	Enrichment	CYBB	1.73
100	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.73
101	Frontotemporal dementia 2	Enrichment	PRNP	1.73
102	Amme complex	Enrichment	ACSL4	1.73
103	Bestrophinopathy, autosomal recessive	Enrichment	FTH1	1.73
104	Lung sarcomatoid carcinoma	Enrichment	TP53	1.73
105	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.73
106	Pediatric systemic lupus erythematosus	Enrichment	SAT1	1.73
107	Macular dystrophy, vitelliform, 2	Enrichment	FTH1	1.63
108	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.63
109	Rhabdomyosarcoma 2	Enrichment	TP53	1.63
110	Lymphoma	Enrichment	TP53	1.63
111	Phosphorylase kinase deficiency	Enrichment	PHKG2	1.63
112	Acute megakaryocytic leukemia	Enrichment	TP53	1.63
113	Sleep disorder	Enrichment	GCH1	1.63
114	Developmental dysplasia of the hip 1	Enrichment	AKR1C1	1.55
115	Li-fraumeni syndrome	Enrichment	TP53	1.55
116	Hyperphenylalaninemia, bh4-deficient, a	Enrichment	GCH1	1.55
117	Adrenocortical carcinoma	Enrichment	TP53	1.55
118	Breast adenocarcinoma	Enrichment	TP53	1.55
119	Esophageal cancer	Enrichment	TP53	1.49
120	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.49
121	Essential thrombocythemia	Enrichment	TP53	1.49
122	Gallbladder cancer	Enrichment	TP53	1.49
123	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.49
124	Glioma susceptibility 1	Enrichment	TP53	1.43
125	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.43
126	Adult hepatocellular carcinoma	Enrichment	TP53	1.38
127	Chronic granulomatous disease	Enrichment	CYBB	1.38
128	Primary hyperaldosteronism	Enrichment	TP53	1.38
129	Limb-girdle muscular dystrophy	Enrichment	HMGCR	1.38
130	Leukemia, chronic lymphocytic	Enrichment	TP53	1.34
131	Stroke, ischemic	Enrichment	ACSL4	1.34
132	Neurodegeneration with brain iron accumulation	Enrichment	CP	1.34
133	Familial colorectal cancer	Enrichment	TP53	1.34
134	Myelodysplastic syndrome	Enrichment	TP53	1.29
135	Combined immunodeficiency	Enrichment	TFRC	1.29
136	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	1.29
137	Combined t and b cell immunodeficiency	Enrichment	TFRC	1.29
138	Lip and oral cavity carcinoma	Enrichment	TP53	1.26
139	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.22
140	Lipoid congenital adrenal hyperplasia	Enrichment	POR	1.19
141	Lung cancer susceptibility 3	Enrichment	TP53	1.19
142	Hermansky-pudlak syndrome	Enrichment	CP	1.16
143	Hermansky-pudlak syndrome 1	Enrichment	CP	1.14
144	Rhabdomyosarcoma	Enrichment	TP53	1.14
145	Gliosarcoma	Enrichment	TP53	1.14
146	Giant cell glioblastoma	Enrichment	TP53	1.11
147	Diffuse large b-cell lymphoma	Enrichment	TP53	1.07
148	Focal segmental glomerulosclerosis	Enrichment	COQ2	1.04
149	Hepatoblastoma	Enrichment	TP53	1.02
150	Hepatocellular carcinoma	Enrichment	TP53	1.00
151	Diamond-blackfan anemia 1	Enrichment	TP53	0.99
152	Pancreatic cancer	Enrichment	TP53	0.95
153	Bladder cancer	Enrichment	TP53	0.89
154	Prostate cancer	Enrichment	TP53	0.89
155	Differentiated thyroid carcinoma	Enrichment	NCOA4	0.89
156	Connective tissue disease	Enrichment	CBS	0.85
157	Dystonia	Enrichment	GCH1	0.82
158	Non-syndromic x-linked intellectual disability	Enrichment	ACSL4	0.80
159	Diamond-blackfan anemia	Enrichment	TP53	0.80
160	Leukemia, acute myeloid	Enrichment	TP53	0.76
161	Charcot-marie-tooth disease	Enrichment	HSPB1	0.75
162	Gastric cancer	Enrichment	TP53	0.73
163	Nephrotic syndrome	Enrichment	COQ2	0.73
164	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	CBS	0.73
165	Hereditary breast carcinoma	Enrichment	TP53	0.73
166	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.64
167	Myeloma, multiple	Enrichment	TP53	0.63
168	Primary ovarian insufficiency	Enrichment	POR	0.61
169	Breast cancer	Enrichment	TP53	0.52
170	Colorectal cancer	Enrichment	TP53	0.47
171	Ovarian cancer	Enrichment	TP53	0.42
172	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.33
173	Hereditary retinal dystrophy	Enrichment	FTH1	0.12
174	Fundus dystrophy	Enrichment	FTH1	0.12

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Ferroptosis

Pathway Network for Ferroptosis

Member Pathways for Ferroptosis

Pathways in the Ferroptosis SuperPath

Associated Genes for Ferroptosis

Associated Disorders for Ferroptosis

Disorders associated with Ferroptosis SuperPath

STRING Interaction Network for Ferroptosis

Sources for Ferroptosis