Fertilization

Sources:

#	Name	Source	Genes
1	Fertilization	Reactome	ACR ADAM2 ADAM20 ADAM21 ADAM30 B4GALT1 CATSPER1 CATSPER2 CATSPER3 CATSPER4 CATSPERB CATSPERD CATSPERG CD9 HVCN1 IZUMO1 IZUMO2 IZUMO3 IZUMO4 KCNU1 OVGP1 SPAM1 ZP1 ZP2 ZP3 ZP4 (see all 26) (see less)
2	Interaction With Cumulus Cells And The Zona Pellucida	Reactome	ADAM2 ADAM20 ADAM21 ADAM30 B4GALT1 OVGP1 SPAM1 ZP1 ZP2 ZP3 ZP4 (see all 11) (see less)
3	Sperm Motility And Taxes	Reactome	CATSPER1 CATSPER2 CATSPER3 CATSPER4 CATSPERB CATSPERD CATSPERG HVCN1 KCNU1 (see all 9) (see less)
4	Acrosome Reaction and Sperm:Oocyte Membrane Binding	Reactome	ACR CD9 IZUMO1 IZUMO2 IZUMO3 IZUMO4 (see all 6) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IZUMO3	IZUMO Family Member 3	Protein Coding	2
2	ADAM30	ADAM Metallopeptidase Domain 30	Protein Coding	2
3	IZUMO4	IZUMO Family Member 4	Protein Coding	2
4	CATSPER1	Cation Channel Sperm Associated 1	Protein Coding	2
5	CATSPER2	Cation Channel Sperm Associated 2	Protein Coding	2
6	IZUMO2	IZUMO Family Member 2	Protein Coding	2
7	KCNU1	Potassium Calcium-Activated Channel Subfamily U Member 1	Protein Coding	2
8	ZP1	Zona Pellucida Glycoprotein 1	Protein Coding	2
9	ADAM2	ADAM Metallopeptidase Domain 2	Protein Coding	2
10	CATSPERD	Catsper Channel Auxiliary Subunit Delta	Protein Coding	2
11	B4GALT1	Beta-1,4-Galactosyltransferase 1	Protein Coding	2
12	IZUMO1	Izumo Sperm-Oocyte Fusion 1	Protein Coding	2
13	CATSPER3	Cation Channel Sperm Associated 3	Protein Coding	2
14	CATSPER4	Cation Channel Sperm Associated 4	Protein Coding	2
15	ACR	Acrosin	Protein Coding	2
16	OVGP1	Oviductal Glycoprotein 1	Protein Coding	2
17	CATSPERG	Catsper Channel Auxiliary Subunit Gamma	Protein Coding	2
18	ZP4	Zona Pellucida Glycoprotein 4	Protein Coding	2
19	SPAM1	Sperm Adhesion Molecule 1	Protein Coding	2
20	ZP2	Zona Pellucida Glycoprotein 2	Protein Coding	2
21	ZP3	Zona Pellucida Glycoprotein 3	Protein Coding	2
22	CATSPERB	Catsper Channel Auxiliary Subunit Beta	Protein Coding	2
23	HVCN1	Hydrogen Voltage Gated Channel 1	Protein Coding	2
24	ADAM21	ADAM Metallopeptidase Domain 21	Protein Coding	2
25	ADAM20	ADAM Metallopeptidase Domain 20	Protein Coding	2
26	CD9	CD9 Molecule	Protein Coding	2

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Oocyte/zygote/embryo maturation arrest 1	Enrichment	ZP1, ZP2, ZP3	8.80
2	Oocyte/zygote/embryo maturation arrest 3	Enrichment	ZP1, ZP3	6.22
3	Spermatogenic failure 87	Enrichment	ACR	3.35
4	Spermatogenic failure 79	Enrichment	KCNU1	3.18
5	Congenital disorder of glycosylation, type iid	Enrichment	B4GALT1	3.09
6	Oocyte/zygote/embryo maturation arrest 6	Enrichment	ZP2	3.09
7	Combined low ldl and fibrinogen	Enrichment	B4GALT1	3.09
8	Spermatogenic failure 7	Enrichment	CATSPER1	2.88
9	Deafness-infertility syndrome	Enrichment	CATSPER2	2.58
10	Non-syndromic male infertility due to sperm motility disorder	Enrichment	CATSPER1	1.82
11	Male infertility	Enrichment	CATSPERB	1.65
12	Rare genetic deafness	Enrichment	CATSPER2	1.29

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Fertilization