FGF23 signaling in hypophosphatemic rickets and related disorders

No Pathway Network information available for FGF23 signaling in hypophosphatemic rickets and related disorders

Pathways in the FGF23 signaling in hypophosphatemic rickets and related disorders SuperPath

#	Name	Source	Genes
1	FGF23 signaling in hypophosphatemic rickets and related disorders	WikiPathways	ALPL CCND1 CDKN1A CYP11B2 CYP24A1 CYP27B1 DMP1 ENPP1 FAM20C FGF23 FGFR2 FGFR3 GALNT3 KL NFKB1 NFKB2 PHEX PTH ROS1 SLC34A1 SLC34A3 SPP1 (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	KL	Klotho	Protein Coding	1
2	FGF23	Fibroblast Growth Factor 23	Protein Coding	1
3	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
4	SLC34A1	Solute Carrier Family 34 Member 1	Protein Coding	1
5	ROS1	ROS Proto-Oncogene 1, Receptor Tyrosine Kinase	Protein Coding	1
6	CCND1	Cyclin D1	Protein Coding	1
7	PTH	Parathyroid Hormone	Protein Coding	1
8	FAM20C	FAM20C Golgi Associated Secretory Pathway Kinase	Protein Coding	1
9	PHEX	Phosphate Regulating Endopeptidase X-Linked	Protein Coding	1
10	ENPP1	Ectonucleotide Pyrophosphatase/Phosphodiesterase 1	Protein Coding	1
11	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
12	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
13	GALNT3	Polypeptide N-Acetylgalactosaminyltransferase 3	Protein Coding	1
14	ALPL	Alkaline Phosphatase, Biomineralization Associated	Protein Coding	1
15	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
16	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
17	DMP1	Dentin Matrix Acidic Phosphoprotein 1	Protein Coding	1
18	CYP27B1	Cytochrome P450 Family 27 Subfamily B Member 1	Protein Coding	1
19	CYP24A1	Cytochrome P450 Family 24 Subfamily A Member 1	Protein Coding	1
20	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	1
21	SLC34A3	Solute Carrier Family 34 Member 3	Protein Coding	1
22	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1

Disorders associated with FGF23 signaling in hypophosphatemic rickets and related disorders SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hypophosphatemic rickets	Enrichment	DMP1, ENPP1, FGF23, PHEX	9.66
2	Tumoral calcinosis, hyperphosphatemic, familial, 1	Enrichment	FGF23, GALNT3, KL	8.43
3	Hypophosphatemic rickets with hypercalciuria, hereditary	Enrichment	SLC34A1, SLC34A3	5.60
4	Autosomal recessive hypophosphatemic rickets	Enrichment	DMP1, ENPP1	5.60
5	Nephrolithiasis/osteoporosis, hypophosphatemic, 1	Enrichment	SLC34A1, SLC34A3	5.60
6	Autosomal recessive infantile hypercalcemia	Enrichment	CYP24A1, SLC34A1	5.60
7	Crouzon syndrome	Enrichment	FGFR2, FGFR3	5.12
8	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	5.12
9	Hypophosphatemic rickets, autosomal dominant	Enrichment	FGF23, PHEX	5.12
10	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	4.82
11	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	4.60
12	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	4.28
13	Giant cell glioblastoma	Enrichment	FGFR3, ROS1	3.47
14	Colorectal cancer	Enrichment	CCND1, FGFR2, FGFR3	3.44
15	Craniosynostosis	Enrichment	FGFR2, FGFR3	3.33
16	Bladder cancer	Enrichment	CDKN1A, FGFR3	3.00
17	Hypochondroplasia	Enrichment	FGFR3	2.79
18	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.79
19	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.79
20	Hypophosphatemic rickets, autosomal recessive, 1	Enrichment	DMP1	2.79
21	Muenke syndrome	Enrichment	FGFR3	2.79
22	Raine syndrome	Enrichment	FAM20C	2.79
23	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.79
24	Hypophosphatasia, adult	Enrichment	ALPL	2.79
25	Apert syndrome	Enrichment	FGFR2	2.79
26	Hypophosphatasia, childhood	Enrichment	ALPL	2.79
27	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.79
28	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.79
29	Fanconi renotubular syndrome 2	Enrichment	SLC34A1	2.79
30	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.79
31	Arterial calcification, generalized, of infancy, 1	Enrichment	ENPP1	2.79
32	Tumoral calcinosis, hyperphosphatemic, familial, 3	Enrichment	KL	2.79
33	Hypercalcemia, infantile, 2	Enrichment	SLC34A1	2.79
34	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.79
35	Ossification of the posterior longitudinal ligament of spine	Enrichment	ENPP1	2.79
36	Hypophosphatemic rickets, autosomal recessive, 2	Enrichment	ENPP1	2.79
37	Cole disease	Enrichment	ENPP1	2.79
38	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.79
39	Tumoral calcinosis, hyperphosphatemic, familial, 2	Enrichment	FGF23	2.79
40	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.79
41	Prenatal benign hypophosphatasia	Enrichment	ALPL	2.79
42	Autosomal recessive hypophosphatemic bone disease	Enrichment	SLC34A3	2.79
43	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.79
44	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.79
45	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.79
46	Hypopigmentation-punctate palmoplantar keratoderma syndrome	Enrichment	ENPP1	2.79
47	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.79
48	Hypoparathyroidism, familial isolated, 1	Enrichment	PTH	2.49
49	Corticosterone methyloxidase type i deficiency	Enrichment	CYP11B2	2.49
50	Cervical cancer	Enrichment	FGFR3	2.49
51	Corticosterone methyloxidase type ii deficiency	Enrichment	CYP11B2	2.49
52	Hypercalcemia, infantile, 1	Enrichment	CYP24A1	2.49
53	Aural atresia, congenital	Enrichment	FGFR2	2.49
54	Keratosis, seborrheic	Enrichment	FGFR3	2.49
55	Pfeiffer syndrome	Enrichment	FGFR2	2.49
56	Jackson-weiss syndrome	Enrichment	FGFR2	2.49
57	Factor xii deficiency	Enrichment	SLC34A1	2.49
58	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.49
59	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.49
60	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.49
61	Alpha-thalassemia/impaired intellectual development syndrome, x-linked	Enrichment	ALPL	2.49
62	Hypophosphatemia	Enrichment	PHEX	2.49
63	Split hand-foot malformation	Enrichment	FGFR2	2.49
64	Hypophosphatasia	Enrichment	ALPL	2.49
65	Cervix carcinoma	Enrichment	FGFR3	2.49
66	Alpha thalassemia-x-linked intellectual disability syndrome	Enrichment	ALPL	2.49
67	Dystonia 28, childhood-onset	Enrichment	ENPP1	2.49
68	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.49
69	Arterial calcification of infancy	Enrichment	ENPP1	2.49
70	Familial hypoaldosteronism	Enrichment	CYP11B2	2.49
71	Dominant hypophosphatemia with nephrolithiasis or osteoporosis	Enrichment	SLC34A1	2.49
72	Common variable immunodeficiency 12	Enrichment	NFKB1	2.49
73	Early-onset familial hypoaldosteronism	Enrichment	CYP11B2	2.49
74	Myeloma, multiple	Enrichment	CCND1, FGFR3	2.44
75	Achondroplasia	Enrichment	FGFR3	2.31
76	Larsen syndrome	Enrichment	FGFR3	2.31
77	Hypophosphatasia, infantile	Enrichment	ALPL	2.31
78	Vitamin d hydroxylation-deficient rickets, type 1a	Enrichment	CYP27B1	2.31
79	Familial isolated hypoparathyroidism	Enrichment	PTH	2.31
80	Hamartoma	Enrichment	FGFR3	2.31
81	Testicular germ cell cancer	Enrichment	FGFR3	2.31
82	Spermatocytoma	Enrichment	FGFR3	2.31
83	Testicular cancer	Enrichment	FGFR3	2.31
84	Hypophosphatemic rickets, x-linked dominant	Enrichment	PHEX	2.19
85	Immunodeficiency, common variable, 1	Enrichment	NFKB2	2.19
86	Cholangiocarcinoma	Enrichment	ROS1	2.19
87	Mantle cell lymphoma	Enrichment	CCND1	2.19
88	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	2.19
89	Pediatric systemic lupus erythematosus	Enrichment	SPP1	2.19
90	Primary hyperparathyroidism	Enrichment	PTH	2.19
91	Glioma	Enrichment	FGFR2	2.19
92	Primary fanconi renotubular syndrome	Enrichment	SLC34A1	2.19
93	Von hippel-lindau syndrome	Enrichment	CCND1	2.09
94	Vitamin d-dependent rickets, type 2a	Enrichment	PHEX	2.09
95	Hyperaldosteronism, familial, type i	Enrichment	CYP11B2	2.01
96	Split-hand/foot malformation 1	Enrichment	FGFR2	2.01
97	Testicular germ cell tumor	Enrichment	FGFR3	2.01
98	Pseudoxanthoma elasticum	Enrichment	ENPP1	2.01
99	Lung squamous cell carcinoma	Enrichment	FGFR3	2.01
100	46,xy disorder of sex development	Enrichment	FGFR3	2.01
101	Nevus, epidermal	Enrichment	FGFR3	1.95
102	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.95
103	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.79
104	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.79
105	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.79
106	Nephrocalcinosis	Enrichment	SLC34A1	1.79
107	Nephrolithiasis	Enrichment	SLC34A1	1.79
108	Primary bone dysplasia	Enrichment	FGFR3	1.79
109	Osteochondrodysplasia	Enrichment	FGFR3	1.75
110	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.71
111	Multiple sclerosis	Enrichment	CYP27B1	1.65
112	Lung cancer susceptibility 3	Enrichment	ROS1	1.65
113	Osteogenesis imperfecta, type iii	Enrichment	SLC34A1	1.62
114	Hydrocephalus	Enrichment	FGFR2	1.62
115	Gliosarcoma	Enrichment	FGFR3	1.59
116	Endometrial cancer	Enrichment	FGFR2	1.47
117	Hepatoblastoma	Enrichment	FGFR3	1.47
118	Brittle bone disorder	Enrichment	ALPL	1.44
119	Connective tissue disease	Enrichment	FGFR3	1.30
120	Systemic lupus erythematosus	Enrichment	SPP1	1.21
121	Type 2 diabetes mellitus	Enrichment	ENPP1	1.18
122	Gastric cancer	Enrichment	FGFR2	1.17
123	Body mass index quantitative trait locus 11	Enrichment	ENPP1	1.11
124	Hypertelorism	Enrichment	FGFR2	1.09
125	Congenital nervous system abnormality	Enrichment	FGFR3	0.80
126	Nervous system disease	Enrichment	FGFR3	0.80

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

FGF23 signaling in hypophosphatemic rickets and related disorders

Pathway Network for FGF23 signaling in hypophosphatemic rickets and related disorders

Member Pathways for FGF23 signaling in hypophosphatemic rickets and related disorders

Pathways in the FGF23 signaling in hypophosphatemic rickets and related disorders SuperPath

Associated Genes for FGF23 signaling in hypophosphatemic rickets and related disorders

Associated Disorders for FGF23 signaling in hypophosphatemic rickets and related disorders

Disorders associated with FGF23 signaling in hypophosphatemic rickets and related disorders SuperPath

STRING Interaction Network for FGF23 signaling in hypophosphatemic rickets and related disorders

Sources for FGF23 signaling in hypophosphatemic rickets and related disorders