FGF signaling pathway

No Pathway Network information available for FGF signaling pathway

Pathways in the FGF signaling pathway SuperPath

#	Name	Source	Genes
1	FGF signaling pathway	PubChem	AKT1 BGLAP CAMK2A CBL CDH1 CDH2 CTNND1 CTTN DUSP6 FGF1 FGF19 FGF23 FGFR1 FGFR2 FGFR3 FGFR4 FOS FRS2 GAB1 GRB2 GZMB HGF IL17RD JUN KL KLB MAPK14 MAPK3 MET MMP9 NCAM1 PAK4 PDPK1 PIK3CA PIK3R1 PLAU PLAUR PLCG1 PSEN1 PTK2B PTPN11 RPS6KA1 RUNX2 SDC2 SDC4 SHC1 SOS1 SPP1 SPRY2 SRC SSH1 STAT1 STAT3 STAT5B (see all 54) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SSH1	Slingshot Protein Phosphatase 1	Protein Coding	1
2	KL	Klotho	Protein Coding	1
3	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	1
4	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	1
5	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	1
6	SDC4	Syndecan 4	Protein Coding	1
7	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
8	FGF1	Fibroblast Growth Factor 1	Protein Coding	1
9	CDH2	Cadherin 2	Protein Coding	1
10	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
11	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
12	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
13	CTTN	Cortactin	Protein Coding	1
14	IL17RD	Interleukin 17 Receptor D	Protein Coding	1
15	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
16	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
17	HGF	Hepatocyte Growth Factor	Protein Coding	1
18	FGF19	Fibroblast Growth Factor 19	Protein Coding	1
19	KLB	Klotho Beta	Protein Coding	1
20	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	1
21	FGF23	Fibroblast Growth Factor 23	Protein Coding	1
22	SPRY2	Sprouty RTK Signaling Antagonist 2	Protein Coding	1
23	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
24	GZMB	Granzyme B	Protein Coding	1
25	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
26	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	1
27	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
28	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
29	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
30	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
31	PSEN1	Presenilin 1	Protein Coding	1
32	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
33	CTNND1	Catenin Delta 1	Protein Coding	1
34	CDH1	Cadherin 1	Protein Coding	1
35	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
36	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
37	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	1
38	SDC2	Syndecan 2	Protein Coding	1
39	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
40	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
41	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
42	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	1
43	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
44	CBL	Cbl Proto-Oncogene	Protein Coding	1
45	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
46	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
47	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
48	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
49	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
50	SHC1	SHC Adaptor Protein 1	Protein Coding	1
51	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
52	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
53	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
54	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	1

Disorders associated with FGF signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Colorectal cancer	Enrichment	AKT1, CDH1, FGFR2, FGFR3, MET, PIK3CA, PIK3R1, SRC	8.77
2	Breast cancer	Enrichment	AKT1, CDH1, JUN, PIK3CA, SHC1	4.94
3	Blepharocheilodontic syndrome 1	Enrichment	CDH1, CTNND1	4.81
4	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	4.81
5	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	4.81
6	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	4.81
7	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	4.81
8	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, PTPN11, SOS1	4.58
9	Crouzon syndrome	Enrichment	FGFR2, FGFR3	4.33
10	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	4.33
11	Tumoral calcinosis, hyperphosphatemic, familial, 1	Enrichment	FGF23, KL	4.33
12	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.33
13	Endometrial cancer	Enrichment	CDH1, FGFR2, PIK3CA	4.12
14	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	4.03
15	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	4.03
16	Noonan syndrome 1	Enrichment	CBL, PTPN11, SOS1	4.00
17	Kallmann syndrome	Enrichment	DUSP6, FGFR1, IL17RD	4.00
18	Rasopathy	Enrichment	CBL, PTPN11, SOS1	3.84
19	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	3.81
20	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.64
21	Lung squamous cell carcinoma	Enrichment	FGFR3, PIK3CA	3.64
22	Cleft lip with or without cleft palate	Enrichment	CDH1, CTNND1	3.64
23	Nevus, epidermal	Enrichment	FGFR3, PIK3CA	3.49
24	Noonan syndrome 3	Enrichment	PTPN11, SOS1	3.49
25	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.26
26	Gastric cancer	Enrichment	CDH1, FGFR2, PIK3CA	3.18
27	Ovarian cancer	Enrichment	AKT1, CDH1, MET, PIK3CA	3.16
28	Hereditary breast carcinoma	Enrichment	AKT1, CDH1, PIK3CA	3.15
29	Juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	3.00
30	Meningioma	Enrichment	AKT1, PIK3CA	3.00
31	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	2.93
32	Gliosarcoma	Enrichment	FGFR1, FGFR3	2.74
33	Alzheimer disease, familial, 1	Enrichment	PLAU, PSEN1	2.69
34	Giant cell glioblastoma	Enrichment	FGFR1, FGFR3	2.69
35	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6, FGFR1	2.64
36	Arteriovenous malformations of the brain	Enrichment	CDH2, IL17RD	2.59
37	Craniosynostosis	Enrichment	FGFR2, FGFR3	2.55
38	Hepatocellular carcinoma	Enrichment	MET, PIK3CA	2.47
39	Hypochondroplasia	Enrichment	FGFR3	2.40
40	Macrodactyly	Enrichment	PIK3CA	2.40
41	Proteus syndrome	Enrichment	AKT1	2.40
42	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.40
43	Osteoglophonic dysplasia	Enrichment	FGFR1	2.40
44	Metachondromatosis	Enrichment	PTPN11	2.40
45	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.40
46	Trigonocephaly 1	Enrichment	FGFR1	2.40
47	Muenke syndrome	Enrichment	FGFR3	2.40
48	Deafness, autosomal recessive 26	Enrichment	GAB1	2.40
49	Noonan syndrome 4	Enrichment	SOS1	2.40
50	Deafness, autosomal recessive 39	Enrichment	HGF	2.40
51	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.40
52	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.40
53	Apert syndrome	Enrichment	FGFR2	2.40
54	Leopard syndrome 1	Enrichment	PTPN11	2.40
55	Cowden syndrome 5	Enrichment	PIK3CA	2.40
56	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.40
57	Iga nephropathy 3	Enrichment	SPRY2	2.40
58	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.40
59	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.40
60	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.40
61	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.40
62	Tumoral calcinosis, hyperphosphatemic, familial, 3	Enrichment	KL	2.40
63	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.40
64	Short syndrome	Enrichment	PIK3R1	2.40
65	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.40
66	Osteofibrous dysplasia	Enrichment	MET	2.40
67	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	2.40
68	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.40
69	Deafness, autosomal recessive 97	Enrichment	MET	2.40
70	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.40
71	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.40
72	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.40
73	Autism 9	Enrichment	MET	2.40
74	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	2.40
75	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.40
76	Immunodeficiency 31a	Enrichment	STAT1	2.40
77	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.40
78	Cowden syndrome 6	Enrichment	AKT1	2.40
79	Hypogonadotropic hypogonadism 18 with or without anosmia	Enrichment	IL17RD	2.40
80	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	2.40
81	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.40
82	Immunodeficiency 31b	Enrichment	STAT1	2.40
83	Acne inversa, familial, 3	Enrichment	PSEN1	2.40
84	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.40
85	Tumoral calcinosis, hyperphosphatemic, familial, 2	Enrichment	FGF23	2.40
86	Hartsfield syndrome	Enrichment	FGFR1	2.40
87	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.40
88	Thrombocytopenia 6	Enrichment	SRC	2.40
89	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.40
90	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.40
91	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	2.40
92	Arthrogryposis, distal, type 11	Enrichment	MET	2.40
93	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.40
94	Hypospadias	Enrichment	PIK3CA	2.40
95	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.40
96	Breast lobular carcinoma	Enrichment	CDH1	2.40
97	Rare venous malformation	Enrichment	PIK3CA	2.40
98	Diaphragmatic eventration	Enrichment	PIK3CA	2.40
99	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.40
100	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.40
101	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.40
102	Rare combined vascular malformation	Enrichment	PIK3CA	2.40
103	Cavernous lymphangioma	Enrichment	PIK3CA	2.40
104	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.40
105	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.40
106	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.40
107	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.40
108	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.40
109	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.40
110	Macrodactyly of toe	Enrichment	PIK3CA	2.40
111	Malignant astrocytoma	Enrichment	PTPN11	2.40
112	Bladder cancer	Enrichment	FGFR3, PIK3CA	2.23
113	Prostate cancer	Enrichment	CDH1, PIK3CA	2.23
114	Lung cancer	Enrichment	MET, PIK3CA	2.15
115	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	2.10
116	Fibromatosis, gingival, 1	Enrichment	SOS1	2.10
117	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.10
118	Ovarian germ cell cancer	Enrichment	CBL	2.10
119	Alzheimer disease 3	Enrichment	PSEN1	2.10
120	Quebec platelet disorder	Enrichment	PLAU	2.10
121	Cervical cancer	Enrichment	FGFR3	2.10
122	Pulmonic stenosis	Enrichment	SOS1	2.10
123	Pick disease of brain	Enrichment	PSEN1	2.10
124	Aural atresia, congenital	Enrichment	FGFR2	2.10
125	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	2.10
126	Noonan syndrome 8	Enrichment	PIK3CA	2.10
127	Immunodeficiency 31c	Enrichment	STAT1	2.10
128	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.10
129	Blepharocheilodontic syndrome 2	Enrichment	CTNND1	2.10
130	Werner syndrome	Enrichment	PTPN11	2.10
131	Childhood hepatocellular carcinoma	Enrichment	MET	2.10
132	Split hand-foot malformation	Enrichment	FGFR2	2.10
133	Papillary renal cell carcinoma	Enrichment	MET	2.10
134	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.10
135	Cervix carcinoma	Enrichment	FGFR3	2.10
136	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.10
137	Metaphyseal anadysplasia	Enrichment	MMP9	2.10
138	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.10
139	Malignant germ cell tumor of ovary	Enrichment	CBL	2.10
140	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.10
141	Cleidocranial dysplasia 1	Enrichment	RUNX2	1.92
142	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.92
143	Achondroplasia	Enrichment	FGFR3	1.92
144	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.92
145	Larsen syndrome	Enrichment	FGFR3	1.92
146	Hypophosphatemic rickets, autosomal dominant	Enrichment	FGF23	1.92
147	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.92
148	Nuchal bleb, familial	Enrichment	SOS1	1.92
149	Alzheimer disease 4	Enrichment	PSEN1	1.92
150	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.92
151	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.92
152	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.92
153	Hyper ige syndrome	Enrichment	STAT3	1.92
154	Hamartoma	Enrichment	FGFR3	1.92
155	Testicular germ cell cancer	Enrichment	FGFR3	1.92
156	Immunodeficiency 14	Enrichment	PIK3R1	1.92
157	Cleidocranial dysplasia	Enrichment	RUNX2	1.92
158	Spermatocytoma	Enrichment	FGFR3	1.92
159	Tricuspid valve insufficiency	Enrichment	PTPN11	1.92
160	Renal cell carcinoma	Enrichment	MET	1.92
161	Testicular cancer	Enrichment	FGFR3	1.92
162	Keratoacanthoma	Enrichment	PIK3CA	1.92
163	Inherited cancer-predisposing syndrome	Enrichment	CDH1, MET, PTPN11	1.81
164	Thrombocytopenia	Enrichment	PTPN11, SRC	1.81
165	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1	1.80
166	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.80
167	Congenital generalized lipodystrophy	Enrichment	FOS	1.80
168	Cerebrovascular disease	Enrichment	PIK3CA	1.80
169	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.80
170	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.80
171	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.80
172	Pediatric systemic lupus erythematosus	Enrichment	SPP1	1.80
173	Glioma	Enrichment	FGFR2	1.80
174	Gingival fibromatosis	Enrichment	SOS1	1.80
175	Hypertelorism	Enrichment	FGFR2, PIK3CA	1.74
176	Capillary malformations, congenital	Enrichment	PIK3CA	1.70
177	Alzheimer disease 2	Enrichment	PLAU	1.70
178	Lymphoma	Enrichment	PTPN11	1.70
179	Myeloproliferative neoplasm	Enrichment	CBL	1.70
180	Holoprosencephaly	Enrichment	FGFR1	1.70
181	Histiocytoid hemangioma	Enrichment	FOS	1.70
182	Hemimegalencephaly	Enrichment	PIK3CA	1.70
183	Dementia	Enrichment	PSEN1	1.70
184	Aggressive systemic mastocytosis	Enrichment	CBL	1.70
185	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.70
186	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	KLB, PTPN11	1.68
187	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.63
188	Cowden syndrome 1	Enrichment	PIK3CA	1.63
189	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	1.63
190	Split-hand/foot malformation 1	Enrichment	FGFR2	1.63
191	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.63
192	Holoprosencephaly 1	Enrichment	FGFR1	1.63
193	Testicular germ cell tumor	Enrichment	FGFR3	1.63
194	Patent ductus arteriosus	Enrichment	PTPN11	1.63
195	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.63
196	46,xy disorder of sex development	Enrichment	FGFR3	1.63
197	Myelofibrosis	Enrichment	SRC	1.56
198	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.56
199	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.56
200	Semantic dementia	Enrichment	PSEN1	1.56
201	Gallbladder cancer	Enrichment	PIK3CA	1.56
202	Pilomyxoid astrocytoma	Enrichment	FGFR1	1.56
203	Overgrowth syndrome	Enrichment	PIK3R1	1.56
204	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1	1.56
205	Hypophosphatemic rickets	Enrichment	FGF23	1.56
206	Arthrogryposis, distal, type 1a	Enrichment	MET	1.50
207	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.50
208	Arteriovenous malformation	Enrichment	PIK3CA	1.45
209	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.45
210	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.45
211	Progressive non-fluent aphasia	Enrichment	PSEN1	1.45
212	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	1.45
213	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.41
214	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.41
215	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.41
216	Primary bone dysplasia	Enrichment	FGFR3	1.41
217	Pectus excavatum	Enrichment	PTPN11	1.37
218	Frontotemporal dementia 1	Enrichment	PSEN1	1.37
219	Osteochondrodysplasia	Enrichment	FGFR3	1.37
220	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.37
221	Specific learning disability	Enrichment	PTPN11	1.37
222	Epicanthus	Enrichment	PTPN11	1.33
223	Septooptic dysplasia	Enrichment	FGFR1	1.33
224	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.33
225	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.33
226	Congenital long qt syndrome	Enrichment	PTPN11	1.33
227	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF, MET	1.31
228	Aortic valve disease 1	Enrichment	SOS1	1.30
229	Alzheimer's disease	Enrichment	PSEN1	1.30
230	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.26
231	Osteoporosis	Enrichment	SRC	1.26
232	Cleft lip/palate	Enrichment	CDH1	1.26
233	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2	1.26
234	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.26
235	Renal cell carcinoma, nonpapillary	Enrichment	MET	1.24
236	Corpus callosum, agenesis of	Enrichment	CDH2	1.24
237	Hydrocephalus	Enrichment	FGFR2	1.24
238	Lynch syndrome	Enrichment	PIK3CA	1.24
239	Isolated corpus callosum agenesis	Enrichment	CDH2	1.24
240	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDH2	1.24
241	Rhabdomyosarcoma	Enrichment	CBL	1.21
242	Microform holoprosencephaly	Enrichment	FGFR1	1.21
243	Lobar holoprosencephaly	Enrichment	FGFR1	1.21
244	Congenital nervous system abnormality	Enrichment	FGFR3, PSEN1	1.18
245	Nervous system disease	Enrichment	FGFR3, PSEN1	1.18
246	Patent foramen ovale	Enrichment	PTPN11	1.16
247	Semilobar holoprosencephaly	Enrichment	FGFR1	1.16
248	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.14
249	Hepatoblastoma	Enrichment	FGFR3	1.09
250	Tooth agenesis	Enrichment	FGFR1	1.08
251	Scoliosis	Enrichment	PTPN11	1.04
252	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.01
253	Auditory neuropathy	Enrichment	CDH2	1.01
254	Strabismus	Enrichment	PTPN11	0.99
255	Long qt syndrome 1	Enrichment	PTPN11	0.95
256	Non-immune hydrops fetalis	Enrichment	PTPN11	0.93
257	Connective tissue disease	Enrichment	FGFR3	0.92
258	Systemic lupus erythematosus	Enrichment	SPP1	0.84
259	Nephrotic syndrome	Enrichment	RUNX2	0.80
260	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.80
261	Sensorineural hearing loss	Enrichment	HGF	0.76
262	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A	0.74
263	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1	0.72
264	Myeloma, multiple	Enrichment	FGFR3	0.70
265	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	0.68
266	Autism spectrum disorder	Enrichment	PTPN11	0.45
267	Microcephaly	Enrichment	PTPN11	0.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

FGF signaling pathway

Pathway Network for FGF signaling pathway

Member Pathways for FGF signaling pathway

Pathways in the FGF signaling pathway SuperPath

Associated Genes for FGF signaling pathway

Associated Disorders for FGF signaling pathway

Disorders associated with FGF signaling pathway SuperPath

STRING Interaction Network for FGF signaling pathway

Sources for FGF signaling pathway