FGFR3 mutant receptor activation

Pathway network for the FGFR3 mutant receptor activation SuperPath

Sources:

Reactome

Pathways in the FGFR3 mutant receptor activation SuperPath

#	Name	Source	Genes
1	FGFR3 mutant receptor activation	Reactome	FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 (see all 12) (see less)
2	FGFR3 ligand binding and activation	Reactome	FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 GALNT3 (see all 13) (see less)
3	FGFR3c ligand binding and activation	Reactome	FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 GALNT3 (see all 13) (see less)
4	Signaling by activated point mutants of FGFR3	Reactome	FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 (see all 12) (see less)
5	FGFR3b ligand binding and activation	Reactome	FGF1 FGF17 FGF18 FGF20 FGF8 FGF9 FGFR3 (see all 7) (see less)

Gene overlap in member pathways for FGFR3 mutant receptor activation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FGF1	Fibroblast Growth Factor 1	Protein Coding	5
2	FGF8	Fibroblast Growth Factor 8	Protein Coding	5
3	FGF9	Fibroblast Growth Factor 9	Protein Coding	5
4	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	5
5	FGF20	Fibroblast Growth Factor 20	Protein Coding	5
6	FGF18	Fibroblast Growth Factor 18	Protein Coding	5
7	FGF17	Fibroblast Growth Factor 17	Protein Coding	5
8	FGF2	Fibroblast Growth Factor 2	Protein Coding	4
9	FGF4	Fibroblast Growth Factor 4	Protein Coding	4
10	FGF5	Fibroblast Growth Factor 5	Protein Coding	4
11	FGF23	Fibroblast Growth Factor 23	Protein Coding	4
12	FGF16	Fibroblast Growth Factor 16	Protein Coding	4
13	GALNT3	Polypeptide N-Acetylgalactosaminyltransferase 3	Protein Coding	2

Disorders associated with FGFR3 mutant receptor activation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bone development disease	Direct
2	Tumoral calcinosis, hyperphosphatemic, familial, 1	Enrichment	FGF23, GALNT3	5.59
3	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF17, FGF8	4.46
4	Kallmann syndrome	Enrichment	FGF17, FGF8	4.24
5	Hypochondroplasia	Enrichment	FGFR3	3.29
6	Thanatophoric dysplasia, type i	Enrichment	FGFR3	3.29
7	Muenke syndrome	Enrichment	FGFR3	3.29
8	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	3.29
9	Hypogonadotropic hypogonadism 20 with or without anosmia	Enrichment	FGF17	3.29
10	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	3.29
11	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	3.29
12	Multiple synostoses syndrome 3	Enrichment	FGF9	3.29
13	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	3.29
14	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	3.29
15	Renal hypodysplasia/aplasia 2	Enrichment	FGF20	3.29
16	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	3.29
17	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	3.29
18	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	3.29
19	Metacarpal 4-5 fusion	Enrichment	FGF16	3.02
20	Familial isolated trichomegaly	Enrichment	FGF5	3.02
21	Tumoral calcinosis, hyperphosphatemic, familial, 2	Enrichment	FGF23	3.02
22	Short-rib thoracic dysplasia 22 without polydactyly	Enrichment	FGF4	3.02
23	Cervical cancer	Enrichment	FGFR3	2.99
24	Keratosis, seborrheic	Enrichment	FGFR3	2.99
25	Cervix carcinoma	Enrichment	FGFR3	2.99
26	Crouzon syndrome	Enrichment	FGFR3	2.81
27	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR3	2.81
28	Achondroplasia	Enrichment	FGFR3	2.81
29	Larsen syndrome	Enrichment	FGFR3	2.81
30	Hamartoma	Enrichment	FGFR3	2.81
31	Testicular germ cell cancer	Enrichment	FGFR3	2.81
32	Spermatocytoma	Enrichment	FGFR3	2.81
33	Testicular cancer	Enrichment	FGFR3	2.81
34	Trichomegaly	Enrichment	FGF5	2.72
35	Saethre-chotzen syndrome	Enrichment	FGFR3	2.69
36	Multiple synostoses syndrome	Enrichment	FGF9	2.69
37	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	2.69
38	Hemifacial hyperplasia	Enrichment	FGFR3	2.59
39	Holoprosencephaly	Enrichment	FGF8	2.59
40	Hypophosphatemic rickets, autosomal dominant	Enrichment	FGF23	2.54
41	Holoprosencephaly 1	Enrichment	FGF8	2.51
42	Testicular germ cell tumor	Enrichment	FGFR3	2.51
43	Lung squamous cell carcinoma	Enrichment	FGFR3	2.51
44	46,xy disorder of sex development	Enrichment	FGFR3	2.51
45	Nevus, epidermal	Enrichment	FGFR3	2.44
46	Renal agenesis, bilateral	Enrichment	FGF20	2.33
47	Primary bone dysplasia	Enrichment	FGFR3	2.29
48	Osteochondrodysplasia	Enrichment	FGFR3	2.25
49	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	2.21
50	Hypophosphatemic rickets	Enrichment	FGF23	2.17
51	Septopreoptic holoprosencephaly	Enrichment	FGF8	2.11
52	Midline interhemispheric variant of holoprosencephaly	Enrichment	FGF8	2.11
53	Gliosarcoma	Enrichment	FGFR3	2.08
54	Microform holoprosencephaly	Enrichment	FGF8	2.08
55	Lobar holoprosencephaly	Enrichment	FGF8	2.08
56	Giant cell glioblastoma	Enrichment	FGFR3	2.06
57	Alobar holoprosencephaly	Enrichment	FGF8	2.06
58	Semilobar holoprosencephaly	Enrichment	FGF8	2.03
59	Craniosynostosis	Enrichment	FGFR3	1.99
60	Hepatoblastoma	Enrichment	FGFR3	1.97
61	Bladder cancer	Enrichment	FGFR3	1.83
62	Connective tissue disease	Enrichment	FGFR3	1.79
63	Myeloma, multiple	Enrichment	FGFR3	1.54
64	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8	1.54
65	Colorectal cancer	Enrichment	FGFR3	1.36
66	Congenital nervous system abnormality	Enrichment	FGFR3	1.27
67	Nervous system disease	Enrichment	FGFR3	1.27

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

FGFR3 mutant receptor activation

Pathway Network for FGFR3 mutant receptor activation

Pathway network for the FGFR3 mutant receptor activation SuperPath

Member Pathways for FGFR3 mutant receptor activation

Pathways in the FGFR3 mutant receptor activation SuperPath

Gene overlap in member pathways for FGFR3 mutant receptor activation SuperPath

Associated Genes for FGFR3 mutant receptor activation

Associated Disorders for FGFR3 mutant receptor activation

Disorders associated with FGFR3 mutant receptor activation SuperPath

STRING Interaction Network for FGFR3 mutant receptor activation

Sources for FGFR3 mutant receptor activation