FGFR3 signaling in chondrocyte proliferation and terminal differentiation

No Pathway Network information available for FGFR3 signaling in chondrocyte proliferation and terminal differentiation

Pathways in the FGFR3 signaling in chondrocyte proliferation and terminal differentiation SuperPath

#	Name	Source	Genes
1	FGFR3 signaling in chondrocyte proliferation and terminal differentiation	WikiPathways	ATG5 BMP2 BMP4 CDKN1A CNP FGF18 FGF9 FGFR3 IHH MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 NPR2 PPP2CA PTH1R PTHLH RAF1 RBL1 SNAI1 SOX9 STAT1 THRA (see all 27) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ATG5	Autophagy Related 5	Protein Coding	1
2	FGF18	Fibroblast Growth Factor 18	Protein Coding	1
3	THRA	Thyroid Hormone Receptor Alpha	Protein Coding	1
4	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
5	SOX9	SRY-Box Transcription Factor 9	Protein Coding	1
6	SNAI1	Snail Family Transcriptional Repressor 1	Protein Coding	1
7	BMP4	Bone Morphogenetic Protein 4	Protein Coding	1
8	BMP2	Bone Morphogenetic Protein 2	Protein Coding	1
9	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
10	PTH1R	Parathyroid Hormone 1 Receptor	Protein Coding	1
11	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	1
12	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
13	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
14	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
15	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
16	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
17	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
18	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
19	NPR2	Natriuretic Peptide Receptor 2	Protein Coding	1
20	IHH	Indian Hedgehog Signaling Molecule	Protein Coding	1
21	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
22	FGF9	Fibroblast Growth Factor 9	Protein Coding	1
23	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
24	CNP	2'''',3''''-Cyclic Nucleotide 3'''' Phosphodiesterase	Protein Coding	1
25	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
26	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
27	RBL1	RB Transcriptional Corepressor Like 1	Protein Coding	1

Disorders associated with FGFR3 signaling in chondrocyte proliferation and terminal differentiation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2, RAF1	5.50
2	Brachydactyly, type e1	Enrichment	PTH1R, PTHLH	4.94
3	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2, RAF1	4.92
4	Rasopathy	Enrichment	MAP2K1, MAP2K2, RAF1	4.75
5	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.64
6	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.64
7	Renal hypodysplasia/aplasia 3	Enrichment	BMP4, FGFR3	3.60
8	Craniosynostosis	Enrichment	FGFR3, NPR2	3.15
9	Bladder cancer	Enrichment	CDKN1A, FGFR3	2.82
10	Connective tissue disease	Enrichment	FGFR3, SOX9	2.74
11	Hypochondroplasia	Enrichment	FGFR3	2.70
12	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.70
13	Muenke syndrome	Enrichment	FGFR3	2.70
14	Noonan syndrome 5	Enrichment	RAF1	2.70
15	Melorheostosis, isolated	Enrichment	MAP2K1	2.70
16	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.70
17	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.70
18	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.70
19	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.70
20	Noonan syndrome 13	Enrichment	MAPK1	2.70
21	Spinocerebellar ataxia, autosomal recessive 25	Enrichment	ATG5	2.70
22	46,xy sex reversal 10	Enrichment	SOX9	2.70
23	46,xx sex reversal 2	Enrichment	SOX9	2.70
24	Leukodystrophy, hypomyelinating, 20	Enrichment	CNP	2.70
25	Microphthalmia, syndromic 6	Enrichment	BMP4	2.70
26	Orofacial cleft 11	Enrichment	BMP4	2.70
27	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.70
28	Acrocapitofemoral dysplasia	Enrichment	IHH	2.70
29	Melorheostosis	Enrichment	MAP2K1	2.70
30	Leopard syndrome 2	Enrichment	RAF1	2.70
31	Multiple synostoses syndrome 3	Enrichment	FGF9	2.70
32	Immunodeficiency 31a	Enrichment	STAT1	2.70
33	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.70
34	Brachydactyly, type e2	Enrichment	PTHLH	2.70
35	Immunodeficiency 31b	Enrichment	STAT1	2.70
36	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.70
37	20p12.3 microdeletion syndrome	Enrichment	BMP2	2.70
38	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Enrichment	BMP2	2.70
39	Trigonitis	Enrichment	RAF1	2.70
40	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.70
41	Resistance to thyroid hormone due to a mutation in thyroid hormone receptor alpha	Enrichment	THRA	2.70
42	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.70
43	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.70
44	Failure of tooth eruption, primary	Enrichment	PTH1R	2.40
45	Campomelic dysplasia	Enrichment	SOX9	2.40
46	Metaphyseal chondrodysplasia, jansen type	Enrichment	PTH1R	2.40
47	Chondrodysplasia, blomstrand type	Enrichment	PTH1R	2.40
48	Cervical cancer	Enrichment	FGFR3	2.40
49	Eiken syndrome	Enrichment	PTH1R	2.40
50	Keratosis, seborrheic	Enrichment	FGFR3	2.40
51	Epiphyseal chondrodysplasia, miura type	Enrichment	NPR2	2.40
52	Hypothyroidism, congenital, nongoitrous, 6	Enrichment	THRA	2.40
53	Immunodeficiency 31c	Enrichment	STAT1	2.40
54	Pseudohypoparathyroidism	Enrichment	PTH1R	2.40
55	Acromesomelic dysplasia 1	Enrichment	NPR2	2.40
56	Cervix carcinoma	Enrichment	FGFR3	2.40
57	Craniosynostosis 7	Enrichment	BMP2	2.40
58	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.40
59	Tafro syndrome	Enrichment	MAP2K2	2.40
60	Campomelic dysplasia and related disorders	Enrichment	SOX9	2.40
61	Brachydactyly, type a1	Enrichment	IHH	2.22
62	Crouzon syndrome	Enrichment	FGFR3	2.22
63	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR3	2.22
64	Achondroplasia	Enrichment	FGFR3	2.22
65	Larsen syndrome	Enrichment	FGFR3	2.22
66	Myopia 2, autosomal dominant	Enrichment	CNP	2.22
67	46,xx sex reversal 1	Enrichment	SOX9	2.22
68	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.22
69	Transposition of the great arteries, dextro-looped	Enrichment	BMP2	2.22
70	Epilepsy, familial focal, with variable foci 2	Enrichment	NPR2	2.22
71	Hamartoma	Enrichment	FGFR3	2.22
72	Testicular germ cell cancer	Enrichment	FGFR3	2.22
73	Spermatocytoma	Enrichment	FGFR3	2.22
74	Testicular cancer	Enrichment	FGFR3	2.22
75	Brachydactyly, type a2	Enrichment	BMP2	2.10
76	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	2.10
77	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.10
78	Saethre-chotzen syndrome	Enrichment	FGFR3	2.10
79	Short stature with nonspecific skeletal abnormalities 1	Enrichment	NPR2	2.10
80	Multiple synostoses syndrome	Enrichment	FGF9	2.10
81	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.10
82	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	2.10
83	Hemifacial hyperplasia	Enrichment	FGFR3	2.00
84	Enchondromatosis, multiple, ollier type	Enrichment	PTH1R	2.00
85	Ventricular septal defect 1	Enrichment	BMP2	2.00
86	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	SOX9	2.00
87	Atrial septal defect 1	Enrichment	BMP2	1.92
88	Pierre robin syndrome	Enrichment	SOX9	1.92
89	Testicular germ cell tumor	Enrichment	FGFR3	1.92
90	Anterior segment dysgenesis 5	Enrichment	BMP4	1.92
91	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.92
92	Lung squamous cell carcinoma	Enrichment	FGFR3	1.92
93	46,xy disorder of sex development	Enrichment	FGFR3	1.92
94	Colorectal cancer	Enrichment	FGFR3, SOX9	1.89
95	Nevus, epidermal	Enrichment	FGFR3	1.86
96	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.86
97	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.86
98	Noonan syndrome 3	Enrichment	RAF1	1.86
99	Pilomyxoid astrocytoma	Enrichment	RAF1	1.86
100	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.80
101	Hemochromatosis, type 1	Enrichment	BMP2	1.80
102	Arteriovenous malformation	Enrichment	MAP2K1	1.75
103	Peters-plus syndrome	Enrichment	BMP4	1.70
104	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.70
105	Stickler syndrome	Enrichment	BMP4	1.70
106	Primary bone dysplasia	Enrichment	FGFR3	1.70
107	46,xy complete gonadal dysgenesis	Enrichment	SOX9	1.66
108	Osteochondrodysplasia	Enrichment	FGFR3	1.66
109	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.66
110	Specific learning disability	Enrichment	MAPK1	1.66
111	Cleft lip/palate	Enrichment	BMP4	1.56
112	46,xy partial gonadal dysgenesis	Enrichment	SOX9	1.56
113	Gliosarcoma	Enrichment	FGFR3	1.50
114	Giant cell glioblastoma	Enrichment	FGFR3	1.48
115	Heart, malformation of	Enrichment	MAPK1	1.45
116	Hepatoblastoma	Enrichment	FGFR3	1.39
117	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.33
118	Hirschsprung disease 1	Enrichment	IHH	1.25
119	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.20
120	Left ventricular noncompaction	Enrichment	RAF1	1.17
121	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.00
122	Myeloma, multiple	Enrichment	FGFR3	0.98
123	Dilated cardiomyopathy	Enrichment	RAF1	0.83
124	Congenital nervous system abnormality	Enrichment	FGFR3	0.72
125	Nervous system disease	Enrichment	FGFR3	0.72
126	Autism spectrum disorder	Enrichment	MAP2K1	0.71
127	Microcephaly	Enrichment	MAPK1	0.66
128	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

FGFR3 signaling in chondrocyte proliferation and terminal differentiation

Pathway Network for FGFR3 signaling in chondrocyte proliferation and terminal differentiation

Member Pathways for FGFR3 signaling in chondrocyte proliferation and terminal differentiation

Pathways in the FGFR3 signaling in chondrocyte proliferation and terminal differentiation SuperPath

Associated Genes for FGFR3 signaling in chondrocyte proliferation and terminal differentiation

Associated Disorders for FGFR3 signaling in chondrocyte proliferation and terminal differentiation

Disorders associated with FGFR3 signaling in chondrocyte proliferation and terminal differentiation SuperPath

STRING Interaction Network for FGFR3 signaling in chondrocyte proliferation and terminal differentiation

Sources for FGFR3 signaling in chondrocyte proliferation and terminal differentiation