Fibrin complement receptor 3 signaling pathway

No Pathway Network information available for Fibrin complement receptor 3 signaling pathway

Pathways in the Fibrin complement receptor 3 signaling pathway SuperPath

#	Name	Source	Genes
1	Fibrin complement receptor 3 signaling pathway	WikiPathways	AKT1 CBLB CCL2 CD14 CHUK CXCL10 CXCL3 FGA FGB FGG IFNB1 IKBKB IKBKG IL12B IL6 IRAK1 IRAK2 IRAK4 IRF3 ITGAM ITGB2 LBP LY96 MYD88 NFKB1 NOS2 PIK3CA PLAT PLG RASSF5 REL RELA RHOA SRC SYK TICAM1 TICAM2 TIRAP TLR3 TLR4 TNF TRAF6 TYROBP (see all 43) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD14	CD14 Molecule	Protein Coding	1
2	CBLB	Cbl Proto-Oncogene B	Protein Coding	1
3	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
4	RASSF5	Ras Association Domain Family Member 5	Protein Coding	1
5	TYROBP	Transmembrane Immune Signaling Adaptor TYROBP	Protein Coding	1
6	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
7	TNF	Tumor Necrosis Factor	Protein Coding	1
8	TLR4	Toll Like Receptor 4	Protein Coding	1
9	TLR3	Toll Like Receptor 3	Protein Coding	1
10	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
11	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
12	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
13	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
14	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
15	PLG	Plasminogen	Protein Coding	1
16	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	1
17	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
18	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	1
19	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
20	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
21	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	1
22	LBP	Lipopolysaccharide Binding Protein	Protein Coding	1
23	RHOA	Ras Homolog Family Member A	Protein Coding	1
24	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
25	ITGAM	Integrin Subunit Alpha M	Protein Coding	1
26	IRF3	Interferon Regulatory Factor 3	Protein Coding	1
27	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	1
28	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	1
29	IL12B	Interleukin 12B	Protein Coding	1
30	IL6	Interleukin 6	Protein Coding	1
31	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
32	TICAM2	TIR Domain Containing Adaptor Molecule 2	Protein Coding	1
33	IFNB1	Interferon Beta 1	Protein Coding	1
34	CXCL3	C-X-C Motif Chemokine Ligand 3	Protein Coding	1
35	LY96	Lymphocyte Antigen 96	Protein Coding	1
36	FGG	Fibrinogen Gamma Chain	Protein Coding	1
37	FGB	Fibrinogen Beta Chain	Protein Coding	1
38	FGA	Fibrinogen Alpha Chain	Protein Coding	1
39	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
40	TICAM1	TIR Domain Containing Adaptor Molecule 1	Protein Coding	1
41	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
42	TIRAP	TIR Domain Containing Adaptor Protein	Protein Coding	1
43	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	1

Disorders associated with Fibrin complement receptor 3 signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Dysfibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	7.53
2	Familial dysfibrinogenemia	Enrichment	FGA, FGB, FGG	7.53
3	Familial hypofibrinogenemia	Enrichment	FGA, FGB, FGG	7.53
4	Afibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	6.93
5	Malaria	Enrichment	IKBKG, NOS2, TIRAP, TNF	6.13
6	Immunodeficiency 33	Enrichment	IKBKG, IRAK4	5.01
7	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	5.01
8	Multisystem inflammatory syndrome in children	Enrichment	IFNB1, IRF3, TLR3	4.36
9	Herpes simplex virus encephalitis	Enrichment	TICAM1, TLR3	4.01
10	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.84
11	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.84
12	Systemic lupus erythematosus	Enrichment	IRAK1, ITGAM, TNF	3.60
13	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.46
14	Meningioma	Enrichment	AKT1, PIK3CA	3.20
15	Human immunodeficiency virus type 1	Enrichment	CCL2, TLR3	2.84
16	Colorectal cancer	Enrichment	AKT1, PIK3CA, SRC	2.58
17	Macrodactyly	Enrichment	PIK3CA	2.50
18	Proteus syndrome	Enrichment	AKT1	2.50
19	Incontinentia pigmenti	Enrichment	IKBKG	2.50
20	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.50
21	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.50
22	Immunodeficiency 68	Enrichment	MYD88	2.50
23	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.50
24	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.50
25	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.50
26	Cowden syndrome 5	Enrichment	PIK3CA	2.50
27	Bacteremia 1	Enrichment	TIRAP	2.50
28	Fetal encasement syndrome	Enrichment	CHUK	2.50
29	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	2.50
30	Encephalopathy, acute, infection-induced 6	Enrichment	TICAM1	2.50
31	Angioedema, hereditary, 4	Enrichment	PLG	2.50
32	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.50
33	Immunodeficiency 15b	Enrichment	IKBKB	2.50
34	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.50
35	Immunodeficiency 15a	Enrichment	IKBKB	2.50
36	Immunodeficiency 92	Enrichment	REL	2.50
37	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.50
38	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.50
39	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.50
40	Immunodeficiency 67	Enrichment	IRAK4	2.50
41	Immunodeficiency 29	Enrichment	IL12B	2.50
42	Cowden syndrome 6	Enrichment	AKT1	2.50
43	Macular degeneration, age-related, 10	Enrichment	TLR4	2.50
44	Thrombocytopenia 6	Enrichment	SRC	2.50
45	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.50
46	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.50
47	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.50
48	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.50
49	Congenital fibrinogen deficiency	Enrichment	FGG	2.50
50	Hypospadias	Enrichment	PIK3CA	2.50
51	Colitis	Enrichment	SYK	2.50
52	Rare venous malformation	Enrichment	PIK3CA	2.50
53	Diaphragmatic eventration	Enrichment	PIK3CA	2.50
54	Waldenstram macroglobulinemia	Enrichment	MYD88	2.50
55	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.50
56	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.50
57	Rare combined vascular malformation	Enrichment	PIK3CA	2.50
58	Cavernous lymphangioma	Enrichment	PIK3CA	2.50
59	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.50
60	Lethal hydranencephaly-diaphragmatic hernia syndrome	Enrichment	PLAT	2.50
61	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.50
62	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.50
63	Macrodactyly of toe	Enrichment	PIK3CA	2.50
64	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	2.20
65	Plasminogen deficiency, type i	Enrichment	PLG	2.20
66	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1	Enrichment	TYROBP	2.20
67	Keratosis, seborrheic	Enrichment	PIK3CA	2.20
68	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	2.20
69	Noonan syndrome 8	Enrichment	PIK3CA	2.20
70	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.20
71	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.20
72	Autoimmune disease, multisystem, infantile-onset, 3	Enrichment	CBLB	2.20
73	Immunodeficiency 127	Enrichment	TNF	2.20
74	Rela fusion-positive ependymoma	Enrichment	RELA	2.20
75	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.20
76	Congenital dyserythropoietic anemia	Enrichment	IRAK4	2.20
77	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.20
78	Hereditary angioedema	Enrichment	PLG	2.20
79	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.20
80	Arthritis	Enrichment	SYK	2.20
81	Common variable immunodeficiency 12	Enrichment	NFKB1	2.20
82	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.07
83	Angioedema, hereditary, 1	Enrichment	PLG	2.02
84	Takayasu arteritis	Enrichment	IL12B	2.02
85	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.02
86	Psoriatic arthritis	Enrichment	TNF	2.02
87	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.02
88	Migraine without aura	Enrichment	TNF	2.02
89	Keratoacanthoma	Enrichment	PIK3CA	2.02
90	Thrombocytopenia	Enrichment	FGG, SRC	2.00
91	Kaposi sarcoma	Enrichment	IL6	1.90
92	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.90
93	Cerebrovascular disease	Enrichment	PIK3CA	1.90
94	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.90
95	Cerebral malaria	Enrichment	TNF	1.90
96	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	1.90
97	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.90
98	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.80
99	Capillary malformations, congenital	Enrichment	PIK3CA	1.80
100	Amyloidosis, hereditary systemic 2	Enrichment	FGA	1.80
101	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.80
102	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.80
103	Vascular dementia	Enrichment	TNF	1.80
104	Hemimegalencephaly	Enrichment	PIK3CA	1.80
105	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.72
106	Cowden syndrome 1	Enrichment	PIK3CA	1.72
107	Type 1 diabetes mellitus	Enrichment	IL6	1.72
108	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.72
109	Nevus, epidermal	Enrichment	PIK3CA	1.66
110	Thrombophilia due to thrombin defect	Enrichment	FGA	1.66
111	Myelofibrosis	Enrichment	SRC	1.66
112	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.66
113	Gallbladder cancer	Enrichment	PIK3CA	1.66
114	Common variable immunodeficiency	Enrichment	NFKB1	1.66
115	Breast cancer	Enrichment	AKT1, PIK3CA	1.63
116	Spastic paraplegia 4, autosomal dominant	Enrichment	FGG	1.60
117	Inflammatory bowel disease 1	Enrichment	IL6	1.55
118	Coronary heart disease 5	Enrichment	IKBKG	1.55
119	Arteriovenous malformation	Enrichment	PIK3CA	1.55
120	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.55
121	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.50
122	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.50
123	Immune deficiency disease	Enrichment	SYK	1.46
124	Asthma	Enrichment	TNF	1.46
125	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.46
126	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.43
127	Alzheimer's disease	Enrichment	TNF	1.39
128	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.39
129	Osteoporosis	Enrichment	SRC	1.36
130	Lynch syndrome	Enrichment	PIK3CA	1.33
131	Arteriovenous malformations of the brain	Enrichment	IL6	1.23
132	Behcet syndrome	Enrichment	TLR4	1.23
133	Diffuse large b-cell lymphoma	Enrichment	MYD88	1.23
134	Endometrial cancer	Enrichment	PIK3CA	1.19
135	Hepatocellular carcinoma	Enrichment	PIK3CA	1.17
136	Bladder cancer	Enrichment	PIK3CA	1.06
137	Prostate cancer	Enrichment	PIK3CA	1.06
138	Lung cancer	Enrichment	PIK3CA	1.01
139	Cystic fibrosis	Enrichment	PLG	1.01
140	Severe combined immunodeficiency	Enrichment	IKBKB	1.00
141	Type 2 diabetes mellitus	Enrichment	IL6	0.90
142	Gastric cancer	Enrichment	PIK3CA	0.89
143	Hypertelorism	Enrichment	PIK3CA	0.82

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Fibrin complement receptor 3 signaling pathway

Pathway Network for Fibrin complement receptor 3 signaling pathway

Member Pathways for Fibrin complement receptor 3 signaling pathway

Pathways in the Fibrin complement receptor 3 signaling pathway SuperPath

Associated Genes for Fibrin complement receptor 3 signaling pathway

Associated Disorders for Fibrin complement receptor 3 signaling pathway

Disorders associated with Fibrin complement receptor 3 signaling pathway SuperPath

STRING Interaction Network for Fibrin complement receptor 3 signaling pathway

Sources for Fibrin complement receptor 3 signaling pathway