FLT3 signaling in disease

Pathway network for the FLT3 signaling in disease SuperPath

Sources:

Reactome

Pathways in the FLT3 signaling in disease SuperPath

#	Name	Source	Genes
1	FLT3 signaling in disease	Reactome	BCL2L1 CBL CDKN1A ETV6 FLT3 FLT3LG GAB2 GOLGB1 GRB2 HRAS KRAS MYO18A NOX4 NRAS PIK3CA PIK3R1 PIM1 PTPN11 RPS27A SOS1 SPTBN1 STAT5A STAT5B TRIP11 UBA52 UBB UBC ZMYM2 (see all 28) (see less)
2	FLT3 Signaling	Reactome	ABL2 AKT1 AKT2 AKT3 BCL2L11 CBL CDKN1B CSK FLT3 FLT3LG FOXO3 FYN GAB2 GRAP2 GRB10 GRB2 HCK HRAS KRAS LCK NRAS PIK3CA PIK3R1 PTPN11 PTPRJ RPS27A SH2B3 SLA SLA2 SOCS2 SOCS6 SOS1 STAT5A STAT5B SYK UBA52 UBB UBC (see all 38) (see less)
3	Signaling by FLT3 fusion proteins	Reactome	CDKN1A ETV6 GAB2 GOLGB1 GRB2 HRAS KRAS MYO18A NOX4 NRAS PIK3CA PIK3R1 PIM1 SOS1 SPTBN1 STAT5A STAT5B TRIP11 ZMYM2 (see all 19) (see less)
4	Signaling by FLT3 ITD and TKD mutants	Reactome	BCL2L1 CDKN1A FLT3 GAB2 GRB2 HRAS KRAS NOX4 NRAS PIK3CA PIK3R1 PIM1 PTPN11 SOS1 STAT5A STAT5B (see all 16) (see less)
5	Negative regulation of FLT3	Reactome	ABL2 CBL CSK FLT3 FLT3LG PTPRJ RPS27A SH2B3 SLA SLA2 SOCS2 SOCS6 UBA52 UBB UBC (see all 15) (see less)
6	STAT5 activation downstream of FLT3 ITD mutants	Reactome	BCL2L1 CDKN1A FLT3 GAB2 GRB2 NOX4 PIM1 PTPN11 STAT5A STAT5B (see all 10) (see less)
7	FLT3 signaling by CBL mutants	Reactome	CBL FLT3 FLT3LG RPS27A UBA52 UBB UBC (see all 7) (see less)
8	STAT5 Activation	Reactome	FLT3 FLT3LG GAB2 GRB2 PTPN11 STAT5A STAT5B (see all 7) (see less)
9	FLT3 signaling through SRC family kinases	Reactome	FLT3 FLT3LG FYN HCK LCK SYK (see all 6) (see less)

Gene overlap in member pathways for FLT3 signaling in disease SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	8
2	FLT3LG	Fms Related Receptor Tyrosine Kinase 3 Ligand	Protein Coding	6
3	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	6
4	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	6
5	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	6
6	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	6
7	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	5
8	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	4
9	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	4
10	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	4
11	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	4
12	NOX4	NADPH Oxidase 4	Protein Coding	4
13	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	4
14	PIM1	Pim-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	4
15	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	4
16	RPS27A	Ribosomal Protein S27a	Protein Coding	4
17	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	4
18	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	4
19	UBB	Ubiquitin B	Protein Coding	4
20	UBC	Ubiquitin C	Protein Coding	4
21	CBL	Cbl Proto-Oncogene	Protein Coding	4
22	BCL2L1	BCL2 Like 1	Protein Coding	3
23	ETV6	ETS Variant Transcription Factor 6	Protein Coding	2
24	GOLGB1	Golgin B1	Protein Coding	2
25	MYO18A	Myosin XVIIIA	Protein Coding	2
26	SPTBN1	Spectrin Beta, Non-Erythrocytic 1	Protein Coding	2
27	ZMYM2	Zinc Finger MYM-Type Containing 2	Protein Coding	2
28	TRIP11	Thyroid Hormone Receptor Interactor 11	Protein Coding	2
29	SH2B3	SH2B Adaptor Protein 3	Protein Coding	2
30	CSK	C-Terminal Src Kinase	Protein Coding	2
31	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
32	ABL2	ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase	Protein Coding	2
33	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
34	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
35	PTPRJ	Protein Tyrosine Phosphatase Receptor Type J	Protein Coding	2
36	SLA	Src Like Adaptor	Protein Coding	2
37	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	2
38	SLA2	Src Like Adaptor 2	Protein Coding	2
39	SOCS2	Suppressor Of Cytokine Signaling 2	Protein Coding	2
40	SOCS6	Suppressor Of Cytokine Signaling 6	Protein Coding	2
41	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
42	BCL2L11	BCL2 Like 11	Protein Coding	1
43	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
44	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
45	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
46	FOXO3	Forkhead Box O3	Protein Coding	1
47	GRB10	Growth Factor Receptor Bound Protein 10	Protein Coding	1
48	GRAP2	GRB2 Related Adaptor Protein 2	Protein Coding	1

Disorders associated with FLT3 signaling in disease SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	CBL, HRAS, KRAS, NRAS, PTPN11, SOS1	11.23
2	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, HRAS, KRAS, NRAS, PTPN11, SOS1	10.97
3	Noonan syndrome 1	Enrichment	CBL, HRAS, KRAS, NRAS, PTPN11, SOS1	10.45
4	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	10.18
5	Noonan syndrome 3	Enrichment	HRAS, KRAS, PTPN11, SOS1	10.18
6	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS, PIK3CA	9.36
7	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	8.27
8	Juvenile myelomonocytic leukemia	Enrichment	CBL, KRAS, NRAS, PTPN11	8.15
9	Bladder cancer	Enrichment	CDKN1A, HRAS, KRAS, PIK3CA	7.52
10	Differentiated thyroid carcinoma	Enrichment	ETV6, HRAS, KRAS, NRAS	7.19
11	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	6.39
12	Leukemia, acute myeloid	Enrichment	ETV6, FLT3, KRAS, NRAS	5.90
13	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.88
14	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.41
15	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.41
16	Colorectal cancer	Enrichment	AKT1, NRAS, PIK3CA, PIK3R1, PTPRJ	5.39
17	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS, PTPN11	5.23
18	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.11
19	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	4.71
20	Chronic myelomonocytic leukemia	Enrichment	ETV6, FLT3	4.61
21	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	4.61
22	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.56
23	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	4.56
24	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.56
25	Gallbladder cancer	Enrichment	KRAS, PIK3CA	4.56
26	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.56
27	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	4.44
28	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA	4.34
29	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	4.33
30	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	4.23
31	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	4.12
32	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	4.07
33	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.87
34	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3, MYO18A	3.83
35	Ovarian cancer	Enrichment	AKT1, CDKN1B, KRAS, PIK3CA	3.75
36	Leukemia, acute lymphoblastic	Enrichment	ETV6, FLT3	3.65
37	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA	3.61
38	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.57
39	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	3.38
40	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	3.35
41	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	3.35
42	Immunodeficiency 22	Enrichment	LCK	3.35
43	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	3.35
44	Immunodeficiency 125	Enrichment	FLT3LG	3.35
45	Colitis	Enrichment	SYK	3.35
46	Rhabdomyosarcoma	Enrichment	CBL, HRAS	3.31
47	Meningioma	Enrichment	AKT1, PIK3CA	3.30
48	Myeloma, multiple	Enrichment	FLT3, KRAS, SH2B3	3.29
49	Metachondromatosis	Enrichment	PTPN11	3.29
50	Leopard syndrome 1	Enrichment	PTPN11	3.29
51	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	3.29
52	Malignant astrocytoma	Enrichment	PTPN11	3.29
53	Lung cancer	Enrichment	KRAS, PIK3CA	3.20
54	Acute myeloid leukemia without maturation	Enrichment	FLT3	3.05
55	Arthritis	Enrichment	SYK	3.05
56	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	3.05
57	Ovarian germ cell cancer	Enrichment	CBL	2.99
58	Malignant germ cell tumor of ovary	Enrichment	CBL	2.99
59	Submucosal cleft palate	Enrichment	UBB	2.99
60	Cleft hard palate	Enrichment	UBB	2.99
61	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.99
62	Werner syndrome	Enrichment	PTPN11	2.99
63	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.99
64	Thrombocytopenia 10	Enrichment	PTPRJ	2.96
65	Growth retardation-mild developmental delay-chronic hepatitis syndrome	Enrichment	SH2B3	2.96
66	Gastric cancer	Enrichment	KRAS, PIK3CA	2.94
67	Macrodactyly	Enrichment	PIK3CA	2.93
68	Oculoectodermal syndrome	Enrichment	KRAS	2.93
69	Noonan syndrome 4	Enrichment	SOS1	2.93
70	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.93
71	Cowden syndrome 5	Enrichment	PIK3CA	2.93
72	Melanosis, neurocutaneous	Enrichment	NRAS	2.93
73	Noonan syndrome 6	Enrichment	NRAS	2.93
74	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.93
75	Short syndrome	Enrichment	PIK3R1	2.93
76	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.93
77	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.93
78	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.93
79	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.93
80	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.93
81	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.93
82	Hypospadias	Enrichment	PIK3CA	2.93
83	Congenital pulmonary airway malformation	Enrichment	KRAS	2.93
84	Rare venous malformation	Enrichment	PIK3CA	2.93
85	Diaphragmatic eventration	Enrichment	PIK3CA	2.93
86	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.93
87	Rare combined vascular malformation	Enrichment	PIK3CA	2.93
88	Cavernous lymphangioma	Enrichment	PIK3CA	2.93
89	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.93
90	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.93
91	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.93
92	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.93
93	Macrodactyly of toe	Enrichment	PIK3CA	2.93
94	Neurocutaneous melanocytosis	Enrichment	NRAS	2.93
95	Breast cancer	Enrichment	AKT1, KRAS, PIK3CA	2.92
96	Mixed phenotype acute leukemia with t	Enrichment	FLT3	2.88
97	Achondrogenesis, type ia	Enrichment	TRIP11	2.85
98	Odontochondrodysplasia 1	Enrichment	TRIP11	2.85
99	Developmental delay, impaired speech, and behavioral abnormalities	Enrichment	SPTBN1	2.85
100	Neurodevelopmental-craniofacial syndrome with variable renal and cardiac abnormalities	Enrichment	ZMYM2	2.85
101	B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1)	Enrichment	ETV6	2.85
102	Albinism, oculocutaneous, type ia	Enrichment	NOX4	2.83
103	Uvula, bifid	Enrichment	UBB	2.81
104	Cleft soft palate	Enrichment	UBB	2.81
105	Tricuspid valve insufficiency	Enrichment	PTPN11	2.81
106	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3	2.75
107	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.69
108	Acute myeloid leukemia with maturation	Enrichment	FLT3	2.66
109	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3	2.66
110	Fibromatosis, gingival, 1	Enrichment	SOS1	2.63
111	Costello syndrome	Enrichment	HRAS	2.63
112	Pulmonic stenosis	Enrichment	SOS1	2.63
113	Keratosis, seborrheic	Enrichment	PIK3CA	2.63
114	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.63
115	Noonan syndrome 8	Enrichment	PIK3CA	2.63
116	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.63
117	Wooly hair nevus	Enrichment	HRAS	2.63
118	Myeloproliferative neoplasm	Enrichment	CBL	2.59
119	Aggressive systemic mastocytosis	Enrichment	CBL	2.59
120	Lymphoma	Enrichment	PTPN11	2.59
121	Hematologic cancer	Enrichment	ETV6	2.55
122	Congenital mesoblastic nephroma	Enrichment	ETV6	2.55
123	Fibrosarcoma	Enrichment	ETV6	2.55
124	Proteus syndrome	Enrichment	AKT1	2.55
125	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.55
126	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.55
127	Neuroendocrine tumor	Enrichment	CDKN1B	2.55
128	Cowden syndrome 6	Enrichment	AKT1	2.55
129	Capillary hemangioma	Enrichment	AKT3	2.55
130	Silver-russell syndrome due to maternal uniparental disomy of chromosome 7	Enrichment	GRB10	2.55
131	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.55
132	Patent ductus arteriosus	Enrichment	PTPN11	2.51
133	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	2.51
134	Thrombocythemia 1	Enrichment	SH2B3	2.48
135	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.45
136	Nuchal bleb, familial	Enrichment	SOS1	2.45
137	Langerhans cell histiocytosis	Enrichment	NRAS	2.45
138	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.45
139	Immunodeficiency 14	Enrichment	PIK3R1	2.45
140	Spermatocytoma	Enrichment	HRAS	2.45
141	Keratoacanthoma	Enrichment	PIK3CA	2.45
142	Thrombocytopenia 5	Enrichment	ETV6	2.38
143	Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy	Enrichment	SPTBN1	2.38
144	Thrombocytopenia	Enrichment	ETV6, PTPN11	2.36
145	Erythrocytosis, familial, 1	Enrichment	SH2B3	2.35
146	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.33
147	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.33
148	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.33
149	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.33
150	Cerebrovascular disease	Enrichment	PIK3CA	2.33
151	Pilocytic astrocytoma	Enrichment	KRAS	2.33
152	Epidermolytic nevus	Enrichment	HRAS	2.33
153	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.33
154	Gingival fibromatosis	Enrichment	SOS1	2.33
155	Immune deficiency disease	Enrichment	SYK	2.31
156	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	2.29
157	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.25
158	Senior-loken syndrome 7	Enrichment	AKT3	2.25
159	Bardet-biedl syndrome 16	Enrichment	AKT3	2.25
160	Pectus excavatum	Enrichment	PTPN11	2.25
161	Specific learning disability	Enrichment	PTPN11	2.25
162	Capillary malformations, congenital	Enrichment	PIK3CA	2.23
163	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, PTPN11, SH2B3	2.23
164	Epicanthus	Enrichment	PTPN11	2.21
165	Congenital long qt syndrome	Enrichment	PTPN11	2.21
166	Acute promyelocytic leukemia	Enrichment	STAT5B	2.17
167	Pervasive developmental disorder	Enrichment	SPTBN1	2.16
168	Autosomal thrombocytopenia with normal platelets	Enrichment	ETV6	2.16
169	Primary hypereosinophilic syndrome	Enrichment	ETV6	2.16
170	Rare pervasive developmental disorder	Enrichment	SPTBN1	2.16
171	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.15
172	Cowden syndrome 1	Enrichment	PIK3CA	2.15
173	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.15
174	Myelofibrosis	Enrichment	SH2B3	2.11
175	Essential thrombocythemia	Enrichment	SH2B3	2.11
176	Pilomyxoid astrocytoma	Enrichment	KRAS	2.08
177	Overgrowth syndrome	Enrichment	PIK3R1	2.08
178	Patent foramen ovale	Enrichment	PTPN11	2.03
179	Precursor t-cell acute lymphoblastic leukemia	Enrichment	FLT3	1.99
180	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.98
181	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.95
182	Primary hyperparathyroidism	Enrichment	CDKN1B	1.95
183	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.93
184	Scoliosis	Enrichment	PTPN11	1.91
185	Complex neurodevelopmental disorder	Enrichment	SPTBN1, ZMYM2	1.89
186	Strabismus	Enrichment	PTPN11	1.86
187	Severe combined immunodeficiency	Enrichment	LCK	1.84
188	Aortic valve disease 1	Enrichment	SOS1	1.82
189	Protein-deficiency anemia	Enrichment	NRAS	1.82
190	Long qt syndrome 1	Enrichment	PTPN11	1.81
191	Lung cancer susceptibility 3	Enrichment	KRAS	1.79
192	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.79
193	Megacolon	Enrichment	AKT3	1.71
194	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.66
195	Hermansky-pudlak syndrome 1	Enrichment	ETV6	1.65
196	Arteriovenous malformations of the brain	Enrichment	KRAS	1.65
197	Endometrial cancer	Enrichment	PIK3CA	1.61
198	Hepatocellular carcinoma	Enrichment	PIK3CA	1.59
199	Diffuse large b-cell lymphoma	Enrichment	ETV6	1.58
200	Polymicrogyria	Enrichment	AKT3	1.56
201	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.54
202	Pancreatic cancer	Enrichment	KRAS	1.54
203	Prostate cancer	Enrichment	PIK3CA	1.47
204	Connective tissue disease	Enrichment	TRIP11	1.36
205	Cakut	Enrichment	ZMYM2	1.33
206	Autism spectrum disorder	Enrichment	PTPN11	1.26
207	Hypertelorism	Enrichment	PIK3CA	1.22
208	Microcephaly	Enrichment	PTPN11	1.21
209	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.20
210	Type 2 diabetes mellitus	Enrichment	AKT2	0.95

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

FLT3 signaling in disease

Pathway Network for FLT3 signaling in disease

Pathway network for the FLT3 signaling in disease SuperPath

Member Pathways for FLT3 signaling in disease

Pathways in the FLT3 signaling in disease SuperPath

Gene overlap in member pathways for FLT3 signaling in disease SuperPath

Associated Genes for FLT3 signaling in disease

Associated Disorders for FLT3 signaling in disease

Disorders associated with FLT3 signaling in disease SuperPath

STRING Interaction Network for FLT3 signaling in disease

Sources for FLT3 signaling in disease