Fluoropyrimidine activity

Pathway network for the Fluoropyrimidine activity SuperPath

Sources:

WikiPathways
PharmGKB
PubChem

Pathways in the Fluoropyrimidine activity SuperPath

#	Name	Source	Genes
1	Fluoropyrimidine activity	WikiPathways	ABCC3 ABCC4 ABCC5 ABCG2 CDA CES1 CES2 CYP2A6 DHFR DPYD DPYS ERCC2 FPGS GGH MIR29C MTHFR PPAT RRM1 RRM2 SLC22A7 SLC29A1 SMUG1 TDG TK1 TP53 TYMP TYMS UCK1 UCK2 UMPS UPB1 UPP1 UPP2 XRCC3 (see all 34) (see less)
2	Fluoropyrimidine Pathway, Pharmacokinetics	PharmGKB	ABCC3 ABCC4 ABCC5 ABCG2 CDA CES1 CES2 CYP2A6 DPYD DPYS PPAT RRM1 RRM2 SLC22A7 SLC29A1 TK1 TYMP TYMS UCK1 UCK2 UMPS UPB1 UPP1 UPP2 (see all 24) (see less)
3	Fluoropyrimidine Pathway, Pharmacodynamics	PharmGKB	DHFR ERCC2 FPGS GGH MTHFR SMUG1 TDG TP53 TYMS XRCC3 (see all 10) (see less)
4	superpathway of pyrimidine ribonucleosides degradation	PubChem	CDA DPYD DPYS UPB1 UPP1

Gene overlap in member pathways for Fluoropyrimidine activity SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDA	Cytidine Deaminase	Protein Coding	3
2	UPP1	Uridine Phosphorylase 1	Protein Coding	3
3	TYMS	Thymidylate Synthetase	Protein Coding	3
4	UPB1	Beta-Ureidopropionase 1	Protein Coding	3
5	DPYS	Dihydropyrimidinase	Protein Coding	3
6	DPYD	Dihydropyrimidine Dehydrogenase	Protein Coding	3
7	TDG	Thymine DNA Glycosylase	Protein Coding	2
8	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	2
9	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	2
10	GGH	Gamma-Glutamyl Hydrolase	Protein Coding	2
11	CES2	Carboxylesterase 2	Protein Coding	2
12	ABCC3	ATP Binding Cassette Subfamily C Member 3	Protein Coding	2
13	XRCC3	X-Ray Repair Cross Complementing 3	Protein Coding	2
14	UMPS	Uridine Monophosphate Synthetase	Protein Coding	2
15	UCK2	Uridine-Cytidine Kinase 2	Protein Coding	2
16	TP53	Tumor Protein P53	Protein Coding	2
17	TK1	Thymidine Kinase 1	Protein Coding	2
18	RRM2	Ribonucleotide Reductase Regulatory Subunit M2	Protein Coding	2
19	RRM1	Ribonucleotide Reductase Catalytic Subunit M1	Protein Coding	2
20	PPAT	Phosphoribosyl Pyrophosphate Amidotransferase	Protein Coding	2
21	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	2
22	FPGS	Folylpolyglutamate Synthase	Protein Coding	2
23	ERCC2	ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit	Protein Coding	2
24	SLC29A1	Solute Carrier Family 29 Member 1 (Augustine Blood Group)	Protein Coding	2
25	TYMP	Thymidine Phosphorylase	Protein Coding	2
26	DHFR	Dihydrofolate Reductase	Protein Coding	2
27	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	2
28	UPP2	Uridine Phosphorylase 2	Protein Coding	2
29	CES1	Carboxylesterase 1	Protein Coding	2
30	ABCC4	ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group)	Protein Coding	2
31	ABCC5	ATP Binding Cassette Subfamily C Member 5	Protein Coding	2
32	SLC22A7	Solute Carrier Family 22 Member 7	Protein Coding	2
33	UCK1	Uridine-Cytidine Kinase 1	Protein Coding	2
34	MIR29C	MicroRNA 29c	RNA Gene	1

Disorders associated with Fluoropyrimidine activity SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hepatoblastoma	Enrichment	ERCC2, TP53	3.99
2	Bladder cancer	Enrichment	ERCC2, TP53	3.71
3	Dihydropyrimidinase deficiency	Enrichment	DPYS	3.43
4	Beta-ureidopropionase deficiency	Enrichment	UPB1	3.43
5	1p21.3 microdeletion syndrome	Enrichment	DPYD	3.43
6	Homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity	Enrichment	MTHFR	3.13
7	Bone marrow failure syndrome 5	Enrichment	TP53	3.13
8	Papilloma of choroid plexus	Enrichment	TP53	3.13
9	Basal cell carcinoma 7	Enrichment	TP53	3.13
10	Xeroderma pigmentosum, complementation group d	Enrichment	ERCC2	3.13
11	Anaplastic thyroid carcinoma	Enrichment	TP53	3.13
12	Cerebrooculofacioskeletal syndrome 2	Enrichment	ERCC2	3.13
13	Megaloblastic anemia due to dihydrofolate reductase deficiency	Enrichment	DHFR	3.13
14	Ductal carcinoma in situ	Enrichment	TP53	3.13
15	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	3.13
16	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	3.13
17	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	3.13
18	Choroid plexus cancer	Enrichment	TP53	3.13
19	Xeroderma pigmentosum group d	Enrichment	ERCC2	3.13
20	Pleomorphic xanthoastrocytoma	Enrichment	TP53	3.13
21	Dihydropyrimidine dehydrogenase deficiency	Enrichment	DPYD	2.96
22	Breast cancer	Enrichment	TP53, XRCC3	2.88
23	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.83
24	Cervical cancer	Enrichment	TP53	2.83
25	Melanoma, cutaneous malignant 6	Enrichment	XRCC3	2.83
26	Lymphoma, hodgkin, classic	Enrichment	TP53	2.83
27	Congenital fibrosarcoma	Enrichment	TP53	2.83
28	Li-fraumeni syndrome 1	Enrichment	TP53	2.83
29	Sarcoma	Enrichment	TP53	2.83
30	Cervix carcinoma	Enrichment	TP53	2.83
31	Hodgkin's lymphoma	Enrichment	TP53	2.83
32	Dyskeratosis congenita, digenic	Enrichment	TYMS	2.83
33	Isolated anencephaly	Enrichment	MTHFR	2.83
34	Isolated exencephaly	Enrichment	MTHFR	2.83
35	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.83
36	Orotic aciduria	Enrichment	UMPS	2.75
37	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.75
38	Drug metabolism, altered, ces1-related	Enrichment	CES1	2.75
39	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6	Enrichment	RRM1	2.75
40	Hemolytic disease of the fetus	Enrichment	SLC29A1	2.75
41	Blood group, junior system	Enrichment	ABCG2	2.75
42	Letrozole toxicity	Enrichment	CYP2A6	2.75
43	Trichothiodystrophy 1, photosensitive	Enrichment	ERCC2	2.66
44	Osteogenic sarcoma	Enrichment	TP53	2.66
45	Nasopharyngeal carcinoma	Enrichment	TP53	2.66
46	Familial adenomatous polyposis 4	Enrichment	DHFR	2.66
47	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.66
48	Anaplastic astrocytoma	Enrichment	TP53	2.66
49	Squamous cell carcinoma	Enrichment	TP53	2.66
50	Adenocarcinoma	Enrichment	TP53	2.66
51	Bone osteosarcoma	Enrichment	TP53	2.66
52	Ovarian cancer	Enrichment	ERCC2, TP53	2.62
53	Small cell cancer of the lung	Enrichment	TP53	2.53
54	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.53
55	Neural tube defects, folate-sensitive	Enrichment	MTHFR	2.53
56	Lung sarcomatoid carcinoma	Enrichment	TP53	2.53
57	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.53
58	Craniopharyngioma	Enrichment	ERCC2	2.53
59	Rhabdomyosarcoma 2	Enrichment	TP53	2.43
60	Lymphoma	Enrichment	TP53	2.43
61	Acute megakaryocytic leukemia	Enrichment	TP53	2.43
62	Xeroderma pigmentosum-cockayne syndrome complex	Enrichment	ERCC2	2.43
63	Inherited cancer-predisposing syndrome	Enrichment	DHFR, TP53	2.40
64	Li-fraumeni syndrome	Enrichment	TP53	2.35
65	Cerebrooculofacioskeletal syndrome 1	Enrichment	ERCC2	2.35
66	Adrenocortical carcinoma	Enrichment	TP53	2.35
67	Breast adenocarcinoma	Enrichment	TP53	2.35
68	Esophageal cancer	Enrichment	TP53	2.29
69	Thrombophilia due to thrombin defect	Enrichment	MTHFR	2.29
70	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.29
71	Essential thrombocythemia	Enrichment	TP53	2.29
72	Gallbladder cancer	Enrichment	TP53	2.29
73	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	2.29
74	Coumarin resistance	Enrichment	CYP2A6	2.28
75	Glioma susceptibility 1	Enrichment	TP53	2.23
76	Lymphoma, non-hodgkin, familial	Enrichment	TP53	2.23
77	Inflammatory bowel disease 1	Enrichment	ERCC2	2.18
78	Adult hepatocellular carcinoma	Enrichment	TP53	2.18
79	Primary hyperaldosteronism	Enrichment	TP53	2.18
80	Hypotrichosis simplex	Enrichment	ERCC2	2.18
81	Trichothiodystrophy	Enrichment	ERCC2	2.18
82	Tobacco addiction	Enrichment	CYP2A6	2.15
83	Leukemia, chronic lymphocytic	Enrichment	TP53	2.13
84	Familial colorectal cancer	Enrichment	TP53	2.13
85	Xeroderma pigmentosum, variant type	Enrichment	ERCC2	2.09
86	Myelodysplastic syndrome	Enrichment	TP53	2.09
87	Lip and oral cavity carcinoma	Enrichment	TP53	2.05
88	Neural tube defects	Enrichment	MTHFR	2.02
89	Lung cancer susceptibility 3	Enrichment	TP53	1.99
90	Mitochondrial dna depletion syndrome 1	Enrichment	TYMP	1.98
91	Corpus callosum, agenesis of	Enrichment	ERCC2	1.96
92	Isolated corpus callosum agenesis	Enrichment	ERCC2	1.96
93	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	ERCC2	1.96
94	Rhabdomyosarcoma	Enrichment	TP53	1.93
95	Gliosarcoma	Enrichment	TP53	1.93
96	Giant cell glioblastoma	Enrichment	TP53	1.90
97	Diffuse large b-cell lymphoma	Enrichment	TP53	1.86
98	Dyskeratosis congenita	Enrichment	TYMS	1.86
99	Mitochondrial dna depletion syndrome 4b	Enrichment	TYMP	1.85
100	Leukodystrophy	Enrichment	ERCC2	1.83
101	Endometrial cancer	Enrichment	DHFR	1.81
102	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	TYMP	1.80
103	Hepatocellular carcinoma	Enrichment	TP53	1.79
104	Diamond-blackfan anemia 1	Enrichment	TP53	1.77
105	Pancreatic cancer	Enrichment	TP53	1.74
106	Prostate cancer	Enrichment	TP53	1.67
107	Diamond-blackfan anemia	Enrichment	TP53	1.58
108	Leukemia, acute myeloid	Enrichment	TP53	1.54
109	Gastric cancer	Enrichment	TP53	1.50
110	West syndrome	Enrichment	MTHFR	1.50
111	Hereditary breast carcinoma	Enrichment	TP53	1.50
112	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.40
113	Myeloma, multiple	Enrichment	TP53	1.39
114	Schizophrenia	Enrichment	MTHFR	1.37
115	Lung cancer	Enrichment	CYP2A6	1.26
116	Colorectal cancer	Enrichment	TP53	1.21

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Fluoropyrimidine activity

Pathway Network for Fluoropyrimidine activity

Pathway network for the Fluoropyrimidine activity SuperPath

Member Pathways for Fluoropyrimidine activity

Pathways in the Fluoropyrimidine activity SuperPath

Gene overlap in member pathways for Fluoropyrimidine activity SuperPath

Associated Genes for Fluoropyrimidine activity

Associated Disorders for Fluoropyrimidine activity

Disorders associated with Fluoropyrimidine activity SuperPath

STRING Interaction Network for Fluoropyrimidine activity

Sources for Fluoropyrimidine activity