fMLP Pathway

Pathway network for the fMLP Pathway SuperPath

Sources:

QIAGEN
GeneGo (Thomson Reuters)

Pathways in the fMLP Pathway SuperPath

#	Name	Source	Genes
1	fMLP Pathway	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 ACTR2 ACTR3 CALM1 CALM2 CALM3 CDC42 ELK1 FPR2 FPR3 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HRAS ITPR1 ITPR2 ITPR3 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MRAS NCF1 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA NFKBIB NFKBIE NRAS PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 RAC1 RAC2 RAC3 RAF1 RRAS RRAS2 WAS (see all 98) (see less)
2	Huntington's Disease Pathway	QIAGEN	AKT1 AKT2 AKT3 ARFIP2 CASP3 CASP8 CREBBP DCTN1 DLG4 GAPDH GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRINA GRM5 HAP1 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HIP1 HTT IFT57 IGF1 IGF1R ITPR1 ITPR2 ITPR3 NCOR1 NCOR2 PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 RCOR1 SIN3A SP1 TAF4 TP53 UBB UBC UBD (see all 135) (see less)
3	CXCR4 Pathway	QIAGEN	ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 CDC42 CRK CXCL12 CXCR4 ELK1 FOS GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG2 GNG3 GNG4 GRB2 HRAS ITPR1 ITPR2 ITPR3 JUN KRAS MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK10 MAPK12 MAPK3 MAPK6 MAPK7 MAPK8 MAPK9 MCF2L MRAS NET1 NFKB1 NRAS PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PTK2 PTK2B PXN RAC1 RAC2 RAC3 RAF1 RRAS RRAS2 SOS1 SOS2 STAT3 (see all 98) (see less)
4	Signal transduction Activation of PKC via G-Protein coupled receptor	GeneGo (Thomson Reuters)	ABL1 CALM1 CALM2 CALM3 CHUK ELK1 GNA11 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GSK3B HDAC7 IKBKB IKBKG ITPR1 ITPR2 ITPR3 MAP2K1 MAP2K2 MAPK1 MAPK3 MEF2A MEF2B MEF2C MEF2D MYL1 MYL3 MYL4 MYL6 MYL6B MYLK MYLK2 MYLK3 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NR4A1 PLCB1 PLCB2 PLCB3 PLCB4 PPP1CB PPP1R12A PPP1R14A PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 RAF1 REL RELA RELB RIPK1 SQSTM1 SRC (see all 87) (see less)
5	Internalin Pathway	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 ACTR2 ACTR3 AKT1 ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 C1QBP CBL CDC42 CDH1 CFL1 CFL2 CHUK CRKL CTNNA1 CTNNB1 GAB1 GRB2 HRAS IKBKB IKBKG JUP KRAS LIMK1 LIMK2 MCF2L MET MRAS NET1 NRAS PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 RAC1 RAC2 RAC3 RRAS RRAS2 SOS1 SOS2 WASF1 (see all 65) (see less)

Gene overlap in member pathways for fMLP Pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GNA11	G Protein Subunit Alpha 11	Protein Coding	4
2	GNB1	G Protein Subunit Beta 1	Protein Coding	4
3	GNB2	G Protein Subunit Beta 2	Protein Coding	4
4	GNB3	G Protein Subunit Beta 3	Protein Coding	4
5	GNB4	G Protein Subunit Beta 4	Protein Coding	4
6	GNB5	G Protein Subunit Beta 5	Protein Coding	4
7	GNG2	G Protein Subunit Gamma 2	Protein Coding	4
8	GNG3	G Protein Subunit Gamma 3	Protein Coding	4
9	GNG4	G Protein Subunit Gamma 4	Protein Coding	4
10	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	4
11	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	4
12	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	4
13	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	4
14	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	4
15	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	4
16	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	4
17	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	4
18	PLCB1	Phospholipase C Beta 1	Protein Coding	4
19	PLCB2	Phospholipase C Beta 2	Protein Coding	4
20	PLCB3	Phospholipase C Beta 3	Protein Coding	4
21	PLCB4	Phospholipase C Beta 4	Protein Coding	4
22	PRKCA	Protein Kinase C Alpha	Protein Coding	4
23	PRKCB	Protein Kinase C Beta	Protein Coding	4
24	PRKCD	Protein Kinase C Delta	Protein Coding	4
25	PRKCE	Protein Kinase C Epsilon	Protein Coding	4
26	PRKCG	Protein Kinase C Gamma	Protein Coding	4
27	PRKCH	Protein Kinase C Eta	Protein Coding	4
28	PRKCI	Protein Kinase C Iota	Protein Coding	4
29	PRKD1	Protein Kinase D1	Protein Coding	4
30	PRKCQ	Protein Kinase C Theta	Protein Coding	4
31	PRKCZ	Protein Kinase C Zeta	Protein Coding	4
32	CDC42	Cell Division Cycle 42	Protein Coding	3
33	ELK1	ETS Transcription Factor ELK1	Protein Coding	3
34	GNA12	G Protein Subunit Alpha 12	Protein Coding	3
35	GNA13	G Protein Subunit Alpha 13	Protein Coding	3
36	GNA14	G Protein Subunit Alpha 14	Protein Coding	3
37	GNA15	G Protein Subunit Alpha 15	Protein Coding	3
38	GNAI1	G Protein Subunit Alpha I1	Protein Coding	3
39	GNAI2	G Protein Subunit Alpha I2	Protein Coding	3
40	GNAI3	G Protein Subunit Alpha I3	Protein Coding	3
41	GNAS	GNAS Complex Locus	Protein Coding	3
42	GNG10	G Protein Subunit Gamma 10	Protein Coding	3
43	GNG11	G Protein Subunit Gamma 11	Protein Coding	3
44	GNG12	G Protein Subunit Gamma 12	Protein Coding	3
45	GNG13	G Protein Subunit Gamma 13	Protein Coding	3
46	GNG5	G Protein Subunit Gamma 5	Protein Coding	3
47	GNG7	G Protein Subunit Gamma 7	Protein Coding	3
48	GNG8	G Protein Subunit Gamma 8	Protein Coding	3
49	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	3
50	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	3
51	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
52	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	3
53	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
54	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
55	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	3
56	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	3
57	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	3
58	PRKD3	Protein Kinase D3	Protein Coding	3
59	RAC1	Rac Family Small GTPase 1	Protein Coding	3
60	RAC2	Rac Family Small GTPase 2	Protein Coding	3
61	RAC3	Rac Family Small GTPase 3	Protein Coding	3
62	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	3
63	RRAS	RAS Related	Protein Coding	3
64	RRAS2	RAS Related 2	Protein Coding	3
65	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	2
66	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	2
67	ACTB	Actin Beta	Protein Coding	2
68	ACTG1	Actin Gamma 1	Protein Coding	2
69	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	2
70	ACTR2	Actin Related Protein 2	Protein Coding	2
71	ACTR3	Actin Related Protein 3	Protein Coding	2
72	CALM1	Calmodulin 1	Protein Coding	2
73	CALM2	Calmodulin 2	Protein Coding	2
74	CALM3	Calmodulin 3	Protein Coding	2
75	GNAL	G Protein Subunit Alpha L	Protein Coding	2
76	GNAO1	G Protein Subunit Alpha O1	Protein Coding	2
77	GNAT1	G Protein Subunit Alpha Transducin 1	Protein Coding	2
78	GNAT2	G Protein Subunit Alpha Transducin 2	Protein Coding	2
79	GNAZ	G Protein Subunit Alpha Z	Protein Coding	2
80	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
81	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
82	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	2
83	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	2
84	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	2
85	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	2
86	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
87	NFKBIB	NFKB Inhibitor Beta	Protein Coding	2
88	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	2
89	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	2
90	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	2
91	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	2
92	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	2
93	PPP3R2	Protein Phosphatase 3 Regulatory Subunit B, Beta	Protein Coding	2
94	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
95	HDAC7	Histone Deacetylase 7	Protein Coding	2
96	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
97	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	2
98	ARHGEF10	Rho Guanine Nucleotide Exchange Factor 10	Protein Coding	2
99	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	2
100	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	2
101	ARHGEF15	Rho Guanine Nucleotide Exchange Factor 15	Protein Coding	2
102	ARHGEF16	Rho Guanine Nucleotide Exchange Factor 16	Protein Coding	2
103	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	2
104	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	2
105	ARHGEF4	Rho Guanine Nucleotide Exchange Factor 4	Protein Coding	2
106	ARHGEF5	Rho Guanine Nucleotide Exchange Factor 5	Protein Coding	2
107	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	2
108	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	2
109	ARHGEF9	Cdc42 Guanine Nucleotide Exchange Factor 9	Protein Coding	2
110	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
111	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	2
112	NET1	Neuroepithelial Cell Transforming 1	Protein Coding	2
113	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
114	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
115	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	2
116	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	2
117	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	2
118	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	2
119	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
120	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	2
121	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
122	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
123	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
124	FPR2	Formyl Peptide Receptor 2	Protein Coding	1
125	FPR3	Formyl Peptide Receptor 3	Protein Coding	1
126	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	1
127	NFAT5	Nuclear Factor Of Activated T Cells 5	Protein Coding	1
128	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
129	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
130	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
131	ARFIP2	ARF Interacting Protein 2	Protein Coding	1
132	CASP3	Caspase 3	Protein Coding	1
133	CASP8	Caspase 8	Protein Coding	1
134	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
135	DCTN1	Dynactin Subunit 1	Protein Coding	1
136	DLG4	Discs Large MAGUK Scaffold Protein 4	Protein Coding	1
137	IFT57	Intraflagellar Transport 57	Protein Coding	1
138	GAPDH	Glyceraldehyde-3-Phosphate Dehydrogenase	Protein Coding	1
139	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	1
140	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	1
141	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	1
142	GRIN2C	Glutamate Ionotropic Receptor NMDA Type Subunit 2C	Protein Coding	1
143	GRIN2D	Glutamate Ionotropic Receptor NMDA Type Subunit 2D	Protein Coding	1
144	GRINA	Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1	Protein Coding	1
145	GRM5	Glutamate Metabotropic Receptor 5	Protein Coding	1
146	HAP1	Huntingtin Associated Protein 1	Protein Coding	1
147	HTT	Huntingtin	Protein Coding	1
148	HDAC1	Histone Deacetylase 1	Protein Coding	1
149	HDAC10	Histone Deacetylase 10	Protein Coding	1
150	HDAC11	Histone Deacetylase 11	Protein Coding	1
151	HDAC2	Histone Deacetylase 2	Protein Coding	1
152	HDAC3	Histone Deacetylase 3	Protein Coding	1
153	HDAC5	Histone Deacetylase 5	Protein Coding	1
154	HDAC6	Histone Deacetylase 6	Protein Coding	1
155	HDAC8	Histone Deacetylase 8	Protein Coding	1
156	HDAC9	Histone Deacetylase 9	Protein Coding	1
157	HIP1	Huntingtin Interacting Protein 1	Protein Coding	1
158	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
159	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
160	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	1
161	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	1
162	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	1
163	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
164	PLCD1	Phospholipase C Delta 1	Protein Coding	1
165	PLCD3	Phospholipase C Delta 3	Protein Coding	1
166	PLCD4	Phospholipase C Delta 4	Protein Coding	1
167	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1
168	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
169	PLCZ1	Phospholipase C Zeta 1	Protein Coding	1
170	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	1
171	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	1
172	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	1
173	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	1
174	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	1
175	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	1
176	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	1
177	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	1
178	PSMB10	Proteasome 20S Subunit Beta 10	Protein Coding	1
179	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	1
180	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	1
181	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	1
182	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	1
183	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	1
184	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	1
185	PSMB8	Proteasome 20S Subunit Beta 8	Protein Coding	1
186	PSMB9	Proteasome 20S Subunit Beta 9	Protein Coding	1
187	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	1
188	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	1
189	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	1
190	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	1
191	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	1
192	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	1
193	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	1
194	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	1
195	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	1
196	PSMD4	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 4	Protein Coding	1
197	PSMD5	Proteasome 26S Subunit, Non-ATPase 5	Protein Coding	1
198	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	1
199	RCOR1	REST Corepressor 1	Protein Coding	1
200	SIN3A	SIN3 Transcription Regulator Family Member A	Protein Coding	1
201	SP1	Sp1 Transcription Factor	Protein Coding	1
202	TAF4	TATA-Box Binding Protein Associated Factor 4	Protein Coding	1
203	TP53	Tumor Protein P53	Protein Coding	1
204	UBB	Ubiquitin B	Protein Coding	1
205	UBC	Ubiquitin C	Protein Coding	1
206	UBD	Ubiquitin Like Modifier D	Protein Coding	1
207	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
208	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	1
209	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
210	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
211	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
212	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
213	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
214	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
215	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
216	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
217	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
218	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
219	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
220	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
221	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
222	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
223	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
224	PXN	Paxillin	Protein Coding	1
225	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
226	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
227	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
228	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
229	NR4A1	Nuclear Receptor Subfamily 4 Group A Member 1	Protein Coding	1
230	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	1
231	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
232	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	1
233	MYL1	Myosin Light Chain 1	Protein Coding	1
234	MYL3	Myosin Light Chain 3	Protein Coding	1
235	MYL4	Myosin Light Chain 4	Protein Coding	1
236	MYL6	Myosin Light Chain 6	Protein Coding	1
237	MYLK	Myosin Light Chain Kinase	Protein Coding	1
238	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	1
239	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
240	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	1
241	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
242	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
243	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
244	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
245	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
246	SQSTM1	Sequestosome 1	Protein Coding	1
247	MYLK2	Myosin Light Chain Kinase 2	Protein Coding	1
248	MYLK3	Myosin Light Chain Kinase 3	Protein Coding	1
249	PPP1R14A	Protein Phosphatase 1 Regulatory Inhibitor Subunit 14A	Protein Coding	1
250	MYL6B	Myosin Light Chain 6B	Protein Coding	1
251	MEF2B	Myocyte Enhancer Factor 2B	Protein Coding	1
252	C1QBP	Complement C1q Binding Protein	Protein Coding	1
253	CBL	Cbl Proto-Oncogene	Protein Coding	1
254	CDH1	Cadherin 1	Protein Coding	1
255	CFL1	Cofilin 1	Protein Coding	1
256	CFL2	Cofilin 2	Protein Coding	1
257	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
258	CTNNA1	Catenin Alpha 1	Protein Coding	1
259	CTNNB1	Catenin Beta 1	Protein Coding	1
260	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
261	JUP	Junction Plakoglobin	Protein Coding	1
262	LIMK1	LIM Domain Kinase 1	Protein Coding	1
263	LIMK2	LIM Domain Kinase 2	Protein Coding	1
264	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
265	WASF1	WASP Family Member 1	Protein Coding	1

Disorders associated with fMLP Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	CBL, HRAS, KRAS, MRAS, NRAS, RRAS2, SOS1, SOS2	11.95
2	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2	10.82
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	9.23
4	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	7.05
5	Colorectal cancer	Enrichment	AKT1, CDH1, CTNNA1, CTNNB1, MET, NRAS, PIK3R1	6.74
6	Juvenile myelomonocytic leukemia	Enrichment	CBL, KRAS, NRAS, RRAS	6.64
7	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.38
8	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, CTNNA1, KRAS	6.38
9	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, MAP2K1, NRAS	6.09
10	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	5.84
11	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	5.84
12	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	5.44
13	Melanoma, uveal	Enrichment	GNA11, GNAQ, PLCB4	5.30
14	Ovarian cancer	Enrichment	AKT1, CDH1, CTNNB1, KRAS, MET, RRAS2	5.07
15	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	4.86
16	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	4.70
17	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.65
18	Childhood hepatocellular carcinoma	Enrichment	CTNNB1, MET	4.65
19	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.65
20	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	4.42
21	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.39
22	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	4.39
23	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.17
24	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4, PSMB9	4.01
25	Anastomosing haemangioma	Enrichment	GNA11, GNAQ	3.92
26	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.87
27	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, CDC42	3.87
28	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	3.81
29	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11, PIK3R1	3.81
30	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4, PSMB8	3.53
31	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4, PSMB8	3.53
32	Auriculocondylar syndrome 1	Enrichment	GNAI3, PLCB4	3.51
33	Achromatopsia 4	Enrichment	GNAI3, GNAT2	3.51
34	Breast adenocarcinoma	Enrichment	AKT1, KRAS	3.48
35	Typical nemaline myopathy	Enrichment	ACTA1, CFL2	3.48
36	Bladder cancer	Enrichment	CTNNB1, HRAS, KRAS	3.45
37	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	3.45
38	Capillary malformations, congenital	Enrichment	GNA11, GNAQ	3.40
39	Non-immune hydrops fetalis	Enrichment	ACTA1, HRAS, KRAS	3.37
40	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.33
41	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.33
42	Gallbladder cancer	Enrichment	CTNNB1, KRAS	3.33
43	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.33
44	Lung cancer	Enrichment	ACTA2, KRAS, MET	3.33
45	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3R2	3.23
46	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.23
47	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.08
48	West syndrome	Enrichment	GNAO1, GRIN1, GRIN2B, PLCB1	3.03
49	Insulin-like growth factor i	Enrichment	IGF1, IGF1R	3.02
50	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	2.97
51	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	2.97
52	Hereditary breast carcinoma	Enrichment	AKT1, CDH1, KRAS	2.92
53	Microcephaly	Enrichment	GNAO1, GNB1, GRIN2B, HDAC8, IGF1R, PSMC3	2.85
54	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	2.74
55	Lung cancer susceptibility 3	Enrichment	ACTA2, KRAS	2.70
56	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	2.65
57	Myeloma, multiple	Enrichment	CREBBP, NCOR2, PIK3R2, TP53	2.64
58	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.59
59	Adult hepatocellular carcinoma	Enrichment	CASP8, TP53	2.47
60	Primary hyperaldosteronism	Enrichment	GNAS, TP53	2.47
61	Polymicrogyria	Enrichment	AKT3, PSMC3	2.38
62	Centronuclear myopathy	Enrichment	ACTA1, CFL2	2.35
63	Proteus syndrome	Enrichment	AKT1	2.32
64	Baraitser-winter syndrome 1	Enrichment	ACTB	2.32
65	Oculoectodermal syndrome	Enrichment	KRAS	2.32
66	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.32
67	Incontinentia pigmenti	Enrichment	IKBKG	2.32
68	Developmental and epileptic encephalopathy 8	Enrichment	ARHGEF9	2.32
69	Deafness, autosomal recessive 26	Enrichment	GAB1	2.32
70	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.32
71	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.32
72	Noonan syndrome 4	Enrichment	SOS1	2.32
73	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.32
74	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.32
75	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.32
76	Melanosis, neurocutaneous	Enrichment	NRAS	2.32
77	Noonan syndrome 9	Enrichment	SOS2	2.32
78	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.32
79	Noonan syndrome 6	Enrichment	NRAS	2.32
80	Fetal encasement syndrome	Enrichment	CHUK	2.32
81	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.32
82	Immunodeficiency 62	Enrichment	ARHGEF1	2.32
83	Noonan syndrome 11	Enrichment	MRAS	2.32
84	Naxos disease	Enrichment	JUP	2.32
85	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.32
86	Neurodevelopmental disorder with absent language and variable seizures	Enrichment	WASF1	2.32
87	Immunodeficiency 15b	Enrichment	IKBKB	2.32
88	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.32
89	Immunodeficiency 15a	Enrichment	IKBKB	2.32
90	Combined oxidative phosphorylation deficiency 33	Enrichment	C1QBP	2.32
91	Knobloch syndrome 2	Enrichment	PAK2	2.32
92	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.32
93	Short syndrome	Enrichment	PIK3R1	2.32
94	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.32
95	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.32
96	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.32
97	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.32
98	Osteofibrous dysplasia	Enrichment	MET	2.32
99	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	2.32
100	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.32
101	Nemaline myopathy 7	Enrichment	CFL2	2.32
102	Slowed nerve conduction velocity, autosomal dominant	Enrichment	ARHGEF10	2.32
103	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.32
104	Deafness, autosomal recessive 97	Enrichment	MET	2.32
105	Becker nevus syndrome	Enrichment	ACTB	2.32
106	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.32
107	Autism 9	Enrichment	MET	2.32
108	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.32
109	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.32
110	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.32
111	Cowden syndrome 6	Enrichment	AKT1	2.32
112	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.32
113	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.32
114	Brain small vessel disease 5 with osteoporosis	Enrichment	ARHGEF15	2.32
115	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.32
116	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.32
117	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.32
118	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.32
119	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.32
120	Adenoid ameloblastoma	Enrichment	CTNNB1	2.32
121	Arthrogryposis, distal, type 11	Enrichment	MET	2.32
122	Baraitser-winter syndrome	Enrichment	ACTB	2.32
123	Breast lobular carcinoma	Enrichment	CDH1	2.32
124	Congenital pulmonary airway malformation	Enrichment	KRAS	2.32
125	Zebra body myopathy	Enrichment	ACTA1	2.32
126	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.32
127	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.32
128	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.32
129	Nocarh syndrome	Enrichment	CDC42	2.32
130	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.32
131	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.32
132	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.32
133	Actin-accumulation myopathy	Enrichment	ACTA1	2.32
134	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.32
135	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.32
136	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.32
137	Neurocutaneous melanocytosis	Enrichment	NRAS	2.32
138	Microcystic stromal tumor	Enrichment	CTNNB1	2.32
139	Actg2 visceral myopathy	Enrichment	ACTG2	2.32
140	Hepatocellular carcinoma	Enrichment	CTNNB1, MET	2.31
141	Myelodysplastic syndrome	Enrichment	GNB1, TP53	2.29
142	Breast cancer	Enrichment	AKT1, CDH1, KRAS	2.26
143	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.19
144	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.19
145	Paget disease of bone 3	Enrichment	SQSTM1	2.19
146	Noonan syndrome 5	Enrichment	RAF1	2.19
147	Cardiomyopathy, familial hypertrophic, 8	Enrichment	MYL3	2.19
148	Melorheostosis, isolated	Enrichment	MAP2K1	2.19
149	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.19
150	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.19
151	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.19
152	Sturge-weber syndrome	Enrichment	GNAQ	2.19
153	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.19
154	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	2.19
155	Noonan syndrome 13	Enrichment	MAPK1	2.19
156	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.19
157	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	2.19
158	Immunodeficiency 92	Enrichment	REL	2.19
159	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.19
160	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.19
161	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.19
162	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.19
163	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.19
164	Atrial fibrillation, familial, 18	Enrichment	MYL4	2.19
165	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.19
166	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.19
167	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.19
168	Melorheostosis	Enrichment	MAP2K1	2.19
169	Leopard syndrome 2	Enrichment	RAF1	2.19
170	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.19
171	Long qt syndrome 16	Enrichment	CALM3	2.19
172	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.19
173	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.19
174	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.19
175	Thrombocytopenia 6	Enrichment	SRC	2.19
176	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.19
177	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.19
178	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.19
179	Immunodeficiency 53	Enrichment	RELB	2.19
180	Sick sinus syndrome 4	Enrichment	GNB2	2.19
181	Congenital myopathy 14	Enrichment	MYL1	2.19
182	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.19
183	Trigonitis	Enrichment	RAF1	2.19
184	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.19
185	Long qt syndrome 15	Enrichment	CALM2	2.19
186	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.19
187	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.19
188	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.19
189	Mef2c-related disorder	Enrichment	MEF2C	2.19
190	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.19
191	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.19
192	Hydrops fetalis, nonimmune	Enrichment	ACTA1, HRAS	2.17
193	Thrombocytopenia 1	Enrichment	WAS	2.14
194	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.14
195	Osseous heteroplasia, progressive	Enrichment	GNAS	2.14
196	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	2.14
197	Ventricular tachycardia, familial	Enrichment	GNAI2	2.14
198	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.14
199	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.14
200	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.14
201	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	2.14
202	Night blindness, congenital stationary, autosomal dominant 3	Enrichment	GNAT1	2.14
203	Dystonia 25	Enrichment	GNAL	2.14
204	Night blindness, congenital stationary, type 1g	Enrichment	GNAT1	2.14
205	Disorders of gnas inactivation	Enrichment	GNAS	2.14
206	Was-related disorders	Enrichment	WAS	2.14
207	Monostotic fibrous dysplasia	Enrichment	GNAS	2.14
208	Gnao1-related disorder	Enrichment	GNAO1	2.14
209	Kaposiform hemangioendothelioma	Enrichment	GNA14	2.14
210	Mazabraud syndrome	Enrichment	GNAS	2.14
211	Inflammatory bowel disease-recurrent sinopulmonary infections syndrome	Enrichment	NFAT5	2.14
212	Whim syndrome 1	Enrichment	CXCR4	2.14
213	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.14
214	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.14
215	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.14
216	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.14
217	Verrucous hemangioma	Enrichment	MAP3K3	2.14
218	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.14
219	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1, GRIN2A, PLCB1	2.11
220	Complex neurodevelopmental disorder	Enrichment	DLG4, GNB2, GRIN2B, HTT, TAF4	2.10
221	Centralopathic epilepsy	Enrichment	GRIN1, GRIN2A, PLCB1	2.05
222	Rare genetic intellectual disability	Enrichment	CREBBP, GNAO1	2.02
223	Blepharocheilodontic syndrome 1	Enrichment	CDH1	2.02
224	Fibromatosis, gingival, 1	Enrichment	SOS1	2.02
225	Costello syndrome	Enrichment	HRAS	2.02
226	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.02
227	Ovarian germ cell cancer	Enrichment	CBL	2.02
228	Immunodeficiency 33	Enrichment	IKBKG	2.02
229	Pulmonic stenosis	Enrichment	SOS1	2.02
230	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.02
231	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.02
232	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.02
233	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.02
234	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.02
235	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.02
236	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.02
237	Moyamoya disease 5	Enrichment	ACTA2	2.02
238	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.02
239	Noonan syndrome 12	Enrichment	RRAS2	2.02
240	Papillary renal cell carcinoma	Enrichment	MET	2.02
241	Immune system disease	Enrichment	CDC42	2.02
242	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.02
243	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.02
244	Malignant germ cell tumor of ovary	Enrichment	CBL	2.02
245	Teratoma	Enrichment	CTNNB1	2.02
246	Intestinal obstruction	Enrichment	ACTG2	2.02
247	Wooly hair nevus	Enrichment	HRAS	2.02
248	Perry syndrome	Enrichment	DCTN1	2.00
249	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.00
250	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	2.00
251	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	2.00
252	Caspase 8 deficiency	Enrichment	CASP8	2.00
253	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	2.00
254	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.00
255	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.00
256	Orofaciodigital syndrome xviii	Enrichment	IFT57	2.00
257	Auriculocondylar syndrome 4	Enrichment	HDAC9	2.00
258	Cornelia de lange syndrome 5	Enrichment	HDAC8	2.00
259	Bone marrow failure syndrome 5	Enrichment	TP53	2.00
260	Papilloma of choroid plexus	Enrichment	TP53	2.00
261	Basal cell carcinoma 7	Enrichment	TP53	2.00
262	Anaplastic thyroid carcinoma	Enrichment	TP53	2.00
263	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	2.00
264	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.00
265	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.00
266	Neuronopathy, distal hereditary motor, autosomal dominant 14	Enrichment	DCTN1	2.00
267	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.00
268	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.00
269	Proteasome-associated autoinflammatory syndrome 6	Enrichment	PSMB9	2.00
270	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.00
271	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.00
272	Ductal carcinoma in situ	Enrichment	TP53	2.00
273	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.00
274	Lopes-maciel-rodan syndrome	Enrichment	HTT	2.00
275	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.00
276	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.00
277	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.00
278	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.00
279	Capillary hemangioma	Enrichment	AKT3	2.00
280	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.00
281	Chromosome 15q24 deletion syndrome	Enrichment	SIN3A	2.00
282	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.00
283	Landau-kleffner syndrome	Enrichment	GRIN2A	2.00
284	Choroid plexus cancer	Enrichment	TP53	2.00
285	Menke-hennekam syndrome	Enrichment	CREBBP	2.00
286	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.00
287	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.00
288	Juvenile huntington disease	Enrichment	HTT	2.00
289	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	2.00
290	Grin2a-related disorders	Enrichment	GRIN2A	2.00
291	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.00
292	Cardiomyopathy, familial hypertrophic, 1	Enrichment	MYLK2, RAF1	1.99
293	Congenital stationary night blindness	Enrichment	GNAT1, GNB3	1.93
294	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.89
295	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.89
296	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.89
297	Welander distal myopathy	Enrichment	SQSTM1	1.89
298	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.89
299	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.89
300	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.89
301	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.89
302	Long qt syndrome 14	Enrichment	CALM1	1.89
303	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	1.89
304	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	1.89
305	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	1.89
306	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.89
307	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	1.89
308	Rela fusion-positive ependymoma	Enrichment	RELA	1.89
309	Autosomal dominant hypocalcemia	Enrichment	GNA11	1.89
310	Ocular melanoma	Enrichment	PLCB4	1.89
311	Paget's disease of bone	Enrichment	SQSTM1	1.89
312	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.89
313	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	1.89
314	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	1.89
315	Common variable immunodeficiency 12	Enrichment	NFKB1	1.89
316	Tafro syndrome	Enrichment	MAP2K2	1.89
317	Cerebral visual impairment	Enrichment	GNB1	1.89
318	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	1.89
319	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1, GRIN1, GRIN2B	1.87
320	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1, GRIN1	1.87
321	Desmoid disease, hereditary	Enrichment	CTNNB1	1.84
322	Nuchal bleb, familial	Enrichment	SOS1	1.84
323	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	1.84
324	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.84
325	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.84
326	Anus, imperforate	Enrichment	CTNNB1	1.84
327	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.84
328	Desmoid tumor	Enrichment	CTNNB1	1.84
329	Immunodeficiency 14	Enrichment	PIK3R1	1.84
330	Spermatocytoma	Enrichment	HRAS	1.84
331	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	1.84
332	Renal cell carcinoma	Enrichment	MET	1.84
333	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	1.84
334	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	1.84
335	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.84
336	Neutropenia, severe congenital, x-linked	Enrichment	WAS	1.84
337	Wiskott-aldrich syndrome	Enrichment	WAS	1.84
338	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	1.84
339	Pseudopseudohypoparathyroidism	Enrichment	GNAS	1.84
340	Angioma, tufted	Enrichment	GNA14	1.84
341	Pseudohypoparathyroidism	Enrichment	GNAS	1.84
342	Hypopituitarism	Enrichment	GNAI2	1.84
343	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	1.84
344	Scoliosis, isolated 1	Enrichment	MAPK7	1.84
345	Diffuse large b-cell lymphoma	Enrichment	CREBBP, TP53	1.82
346	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.80
347	Long qt syndrome	Enrichment	CALM1, CALM2	1.78
348	Gastric cancer	Enrichment	CDH1, KRAS	1.74
349	Familial hypertrophic cardiomyopathy	Enrichment	MYL3, RAF1	1.72
350	Nemaline myopathy 2	Enrichment	ACTA1	1.72
351	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.72
352	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	1.72
353	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.72
354	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL	1.72
355	Pilomatrixoma	Enrichment	CTNNB1	1.72
356	Aminoacylase 1 deficiency	Enrichment	ACTB	1.72
357	Alazami syndrome	Enrichment	CTNNB1	1.72
358	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.72
359	Craniopharyngioma	Enrichment	CTNNB1	1.72
360	Pilocytic astrocytoma	Enrichment	KRAS	1.72
361	Epidermolytic nevus	Enrichment	HRAS	1.72
362	Knobloch syndrome	Enrichment	PAK2	1.72
363	Intermediate nemaline myopathy	Enrichment	ACTA1	1.72
364	Gingival fibromatosis	Enrichment	SOS1	1.72
365	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.72
366	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.72
367	Gillespie syndrome	Enrichment	ITPR1	1.72
368	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.72
369	Aortic aneurysm, familial thoracic 7	Enrichment	MYLK	1.72
370	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.72
371	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.70
372	Thumb deformity	Enrichment	CREBBP	1.70
373	Cervical cancer	Enrichment	TP53	1.70
374	Spermatogenic failure 17	Enrichment	PLCZ1	1.70
375	Lymphoma, hodgkin, classic	Enrichment	TP53	1.70
376	Syndactyly, type iii	Enrichment	HDAC8	1.70
377	Proteasome-associated autoinflammatory syndrome 5	Enrichment	PSMB10	1.70
378	Intellectual developmental disorder, autosomal dominant 73	Enrichment	TAF4	1.70
379	Immunodeficiency 121 with autoinflammation	Enrichment	PSMB10	1.70
380	Birk-aharoni syndrome	Enrichment	PSMC1	1.70
381	Microcephaly 21, primary, autosomal recessive	Enrichment	GAPDH	1.70
382	Wilson-turner syndrome	Enrichment	HDAC8	1.70
383	Bilateral generalized polymicrogyria	Enrichment	GRIN1	1.70
384	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	1.70
385	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.70
386	Senior-loken syndrome 7	Enrichment	AKT3	1.70
387	Developmental and epileptic encephalopathy 46	Enrichment	GRIN2D	1.70
388	Vulto-van silfhout-de vries syndrome	Enrichment	DLG4	1.70
389	Congenital fibrosarcoma	Enrichment	TP53	1.70
390	Li-fraumeni syndrome 1	Enrichment	TP53	1.70
391	Sarcoma	Enrichment	TP53	1.70
392	Witteveen-kolk syndrome	Enrichment	SIN3A	1.70
393	Cervix carcinoma	Enrichment	TP53	1.70
394	Hodgkin's lymphoma	Enrichment	TP53	1.70
395	Bardet-biedl syndrome 16	Enrichment	AKT3	1.70
396	Distal hereditary motor neuropathy type 7	Enrichment	DCTN1	1.70
397	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	1.70
398	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	1.70
399	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.70
400	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	1.70
401	Submucosal cleft palate	Enrichment	UBB	1.70
402	Cleft hard palate	Enrichment	UBB	1.70
403	Mccune-albright syndrome	Enrichment	GNAS	1.67
404	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1	1.67
405	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.67
406	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.67
407	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.67
408	Hyper ige syndrome	Enrichment	STAT3	1.67
409	Scoliosis	Enrichment	CREBBP, GRIN2B	1.63
410	Visceral myopathy 1	Enrichment	ACTG2	1.62
411	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.62
412	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.62
413	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.62
414	Knobloch syndrome 1	Enrichment	PAK2	1.62
415	Mosaic variegated aneuploidy syndrome 1	Enrichment	PAK6	1.62
416	Myeloproliferative neoplasm	Enrichment	CBL	1.62
417	Coloboma of choroid and retina	Enrichment	ACTG1	1.62
418	Aggressive systemic mastocytosis	Enrichment	CBL	1.62
419	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.62
420	Inherited cancer-predisposing syndrome	Enrichment	CDH1, CTNNA1, MET	1.60
421	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1, GRIN1	1.60
422	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.59
423	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	1.59
424	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.59
425	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.59
426	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.59
427	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.59
428	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.59
429	Hereditary ataxia	Enrichment	PRKCG	1.59
430	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.59
431	Paget's disease of bone 2	Enrichment	SQSTM1	1.59
432	Familial sick sinus syndrome	Enrichment	GNB2	1.59
433	Dystonia	Enrichment	GNAL, GNB1	1.58
434	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.55
435	Moyamoya disease 1	Enrichment	ACTA2	1.55
436	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.55
437	Adrenocortical carcinoma	Enrichment	CTNNB1	1.55
438	Lung squamous cell carcinoma	Enrichment	KRAS	1.55
439	Cleft lip with or without cleft palate	Enrichment	CDH1	1.55
440	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1, KRAS	1.54
441	Granulomatous disease, chronic, x-linked	Enrichment	NCF1	1.54
442	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.54
443	Congenital generalized lipodystrophy	Enrichment	FOS	1.54
444	Uvula, bifid	Enrichment	UBB	1.53
445	Heart defects, congenital, and other congenital anomalies	Enrichment	DLG4	1.53
446	Osteogenic sarcoma	Enrichment	TP53	1.53
447	Cleft soft palate	Enrichment	UBB	1.53
448	Nephrotic syndrome, type 3	Enrichment	PLCE1	1.53
449	Auditory neuropathy and optic atrophy	Enrichment	GRIN2C	1.53
450	Tethered spinal cord syndrome	Enrichment	CREBBP	1.53
451	Intellectual developmental disorder, autosomal dominant 62	Enrichment	DLG4	1.53
452	Neurodevelopmental disorder with hypotonia and impaired expressive language and with or without seizures	Enrichment	DLG4	1.53
453	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.53
454	Anaplastic astrocytoma	Enrichment	TP53	1.53
455	Squamous cell carcinoma	Enrichment	TP53	1.53
456	Adenocarcinoma	Enrichment	TP53	1.53
457	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.53
458	Bone osteosarcoma	Enrichment	TP53	1.53
459	Dlg4-related synaptopathy	Enrichment	DLG4	1.53
460	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.53
461	Thyroid hemiagenesis	Enrichment	PSMD3	1.53
462	Autism spectrum disorder	Enrichment	GNB1, MAP2K1, MEF2C	1.48
463	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.48
464	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.48
465	Overgrowth syndrome	Enrichment	PIK3R1	1.48
466	Night blindness, congenital stationary, type 1c	Enrichment	GNAT1	1.45
467	Histiocytoid hemangioma	Enrichment	FOS	1.45
468	Arthrogryposis, distal, type 1a	Enrichment	MET	1.42
469	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.42
470	Mosaic variegated aneuploidy syndrome	Enrichment	PAK6	1.42
471	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	1.42
472	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.42
473	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.42
474	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.42
475	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.42
476	Huntington disease	Enrichment	HTT	1.41
477	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DLG4	1.41
478	Small cell cancer of the lung	Enrichment	TP53	1.41
479	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.41
480	Astigmatism	Enrichment	GRIN2B	1.41
481	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.41
482	Coronary heart disease 5	Enrichment	IKBKG	1.37
483	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.37
484	Cowden syndrome	Enrichment	AKT1	1.37
485	Myelofibrosis	Enrichment	SRC	1.36
486	Moyamoya angiopathy	Enrichment	ABL1	1.36
487	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.36
488	Cat eye syndrome	Enrichment	ACTG1	1.33
489	Nemaline myopathy	Enrichment	ACTA1	1.33
490	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.33
491	Rhabdomyosarcoma 2	Enrichment	TP53	1.31
492	Lymphoma	Enrichment	TP53	1.31
493	Acute megakaryocytic leukemia	Enrichment	TP53	1.31
494	Hemimegalencephaly	Enrichment	AKT3	1.31
495	Genetic motor neuron disease	Enrichment	DCTN1	1.31
496	Sleep disorder	Enrichment	GRIN2B	1.31
497	Brachydactyly	Enrichment	GNAS	1.31
498	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.30
499	Hypothyroidism	Enrichment	GNB1	1.30
500	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C, SQSTM1	1.27
501	Meningioma	Enrichment	AKT1	1.25
502	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	JUP	1.25
503	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	JUP	1.25
504	Lip and oral cavity carcinoma	Enrichment	HRAS	1.25
505	Dilated cardiomyopathy	Enrichment	ACTA1, JUP	1.25
506	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.25
507	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.25
508	Familial thoracic aortic aneurysm and dissection	Enrichment	MYLK	1.25
509	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	1.25
510	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.25
511	Choreatic disease	Enrichment	GNAO1	1.25
512	Lennox-gastaut syndrome	Enrichment	MAPK10	1.25
513	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.25
514	Cerebral palsy	Enrichment	GNB1, GRIN2B	1.24
515	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.23
516	Li-fraumeni syndrome	Enrichment	TP53	1.23
517	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	1.23
518	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	1.23
519	Patent ductus arteriosus	Enrichment	PSMC3	1.23
520	Hypertrichosis	Enrichment	CREBBP	1.23
521	Epilepsy	Enrichment	GRIN2A, GRIN2B	1.22
522	Aortic valve disease 1	Enrichment	SOS1	1.22
523	Protein-deficiency anemia	Enrichment	NRAS	1.22
524	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1	1.21
525	Stroke, ischemic	Enrichment	PRKCH	1.21
526	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.21
527	Cardiomyopathy, familial hypertrophic, 4	Enrichment	NCF1	1.20
528	Chronic granulomatous disease	Enrichment	NCF1	1.20
529	Medulloblastoma	Enrichment	CTNNB1	1.19
530	Cleft lip/palate	Enrichment	CDH1	1.19
531	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	JUP	1.19
532	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.19
533	Esophageal cancer	Enrichment	TP53	1.17
534	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.17
535	Essential thrombocythemia	Enrichment	TP53	1.17
536	Megacolon	Enrichment	AKT3	1.17
537	Immune deficiency disease	Enrichment	RIPK1	1.17
538	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.17
539	Specific learning disability	Enrichment	MAPK1	1.17
540	Renal cell carcinoma, nonpapillary	Enrichment	MET	1.16
541	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	1.16
542	Lynch syndrome	Enrichment	KRAS	1.16
543	Achromatopsia	Enrichment	GNAT2	1.16
544	Wolff-parkinson-white syndrome	Enrichment	JUP	1.13
545	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	JUP	1.13
546	Congenital long qt syndrome	Enrichment	ITPR3	1.13
547	Movement disease	Enrichment	GNAO1	1.12
548	Glioma susceptibility 1	Enrichment	TP53	1.11
549	Fanconi anemia, complementation group c	Enrichment	HDAC8	1.11
550	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.11
551	Polycystic liver disease	Enrichment	CTNNB1	1.11
552	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.11
553	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.10
554	Neuromuscular disease	Enrichment	ACTA1	1.08
555	Cornelia de lange syndrome 1	Enrichment	HDAC8	1.06
556	Nephrotic syndrome, type 1	Enrichment	PLCE1	1.06
557	Cornelia de lange syndrome	Enrichment	HDAC8	1.06
558	Multiple sclerosis	Enrichment	ITPR1	1.06
559	Osteoporosis	Enrichment	SRC	1.06
560	Aortic aneurysm, familial thoracic 1	Enrichment	MYLK	1.06
561	Heart disease	Enrichment	ABL1	1.06
562	Arteriovenous malformations of the brain	Enrichment	KRAS	1.06
563	Congenital myopathy	Enrichment	ACTA1	1.06
564	Congenital nervous system abnormality	Enrichment	CREBBP, GNAO1, GNB5	1.05
565	Nervous system disease	Enrichment	CREBBP, GNAO1, GNB5	1.05
566	Acute promyelocytic leukemia	Enrichment	STAT3	1.05
567	Williams-beuren syndrome	Enrichment	LIMK1	1.04
568	Craniosynostosis	Enrichment	CTNNA1	1.04
569	Anterior segment dysgenesis	Enrichment	ITPR1	1.04
570	Amyotrophic lateral sclerosis 1	Enrichment	DCTN1	1.02
571	Leukemia, chronic lymphocytic	Enrichment	TP53	1.02
572	Omenn syndrome	Enrichment	PSMB10	1.02
573	Familial colorectal cancer	Enrichment	TP53	1.02
574	Endometrial cancer	Enrichment	CDH1	1.02
575	Lissencephaly	Enrichment	ACTG1	1.02
576	Hepatoblastoma	Enrichment	CTNNB1	1.02
577	Cone-rod dystrophy 6	Enrichment	GNAT2	1.02
578	Gliosarcoma	Enrichment	NFKBIA	1.01
579	Hypertension, essential	Enrichment	GNB3	0.98
580	Cleft palate, isolated	Enrichment	GNB1	0.98
581	Dandy-walker syndrome	Enrichment	PPP1CB	0.98
582	Sudden infant death syndrome	Enrichment	CALM2	0.98
583	Giant cell glioblastoma	Enrichment	NFKBIA	0.98
584	Frontotemporal dementia 1	Enrichment	DCTN1	0.98
585	Atrial heart septal defect	Enrichment	HDAC8	0.98
586	Interatrial communication	Enrichment	HDAC8	0.98
587	Malaria	Enrichment	IKBKG	0.98
588	Heart, malformation of	Enrichment	MAPK1	0.96
589	Pancreatic cancer	Enrichment	KRAS	0.95
590	Nk-cell enteropathy	Enrichment	IGF1R	0.91
591	Human immunodeficiency virus type 1	Enrichment	CXCL12	0.91
592	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	0.90
593	Prostate cancer	Enrichment	CDH1	0.89
594	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.88
595	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	0.86
596	Corpus callosum, agenesis of	Enrichment	CREBBP	0.86
597	Isolated corpus callosum agenesis	Enrichment	CREBBP	0.86
598	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	0.86
599	Connective tissue disease	Enrichment	ACTA2	0.85
600	Familial atrial fibrillation	Enrichment	MYL4	0.84
601	Severe combined immunodeficiency	Enrichment	IKBKB	0.83
602	Cakut	Enrichment	ACTG1	0.82
603	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	0.80
604	Developmental and epileptic encephalopathy	Enrichment	ARHGEF15	0.80
605	Non-syndromic genetic deafness	Enrichment	ACTG1	0.80
606	Strabismus	Enrichment	GNB1	0.80
607	Cone dystrophy	Enrichment	GNAT2	0.80
608	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	0.79
609	Patent foramen ovale	Enrichment	PSMC3	0.78
610	Polycystic kidney disease	Enrichment	HDAC8	0.78
611	Myopathy	Enrichment	ACTA1	0.76
612	Charcot-marie-tooth disease	Enrichment	ARHGEF10	0.75
613	Focal segmental glomerulosclerosis	Enrichment	PLCE1	0.74
614	Distal arthrogryposis	Enrichment	ACTA1	0.74
615	Nonsyndromic hearing loss	Enrichment	ACTG1	0.74
616	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2	0.72
617	Myocardial infarction	Enrichment	PSMA6	0.70
618	Left ventricular noncompaction	Enrichment	RAF1	0.69
619	Diamond-blackfan anemia 1	Enrichment	TP53	0.69
620	Autoinflammatory disease	Enrichment	PSMB8	0.67
621	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.65
622	Eye disease	Enrichment	GNAT2	0.65
623	Undetermined early-onset epileptic encephalopathy	Enrichment	LIMK1	0.63
624	Hypertrophic cardiomyopathy	Enrichment	MYL3	0.62
625	Thrombocytopenia	Enrichment	SRC	0.57
626	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	0.54
627	Spastic ataxia	Enrichment	ITPR1	0.54
628	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.54
629	Diamond-blackfan anemia	Enrichment	TP53	0.52
630	Body mass index quantitative trait locus 11	Enrichment	GNAS	0.52
631	Rare genetic deafness	Enrichment	ACTG1	0.50
632	Mitochondrial disease	Enrichment	C1QBP	0.47
633	Type 2 diabetes mellitus	Enrichment	AKT2	0.46
634	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MET	0.46
635	Nephrotic syndrome	Enrichment	PLCE1	0.46
636	Joubert syndrome 1	Enrichment	RCOR1	0.40
637	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIN1	0.36
638	Autism	Enrichment	CREBBP	0.29
639	Hereditary retinal dystrophy	Enrichment	GNAT1, GNAT2	0.21
640	Fundus dystrophy	Enrichment	GNAT1, GNAT2	0.21
641	Retinitis pigmentosa	Enrichment	GNAT1	0.10

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

fMLP Pathway

Pathway Network for fMLP Pathway

Pathway network for the fMLP Pathway SuperPath

Member Pathways for fMLP Pathway

Pathways in the fMLP Pathway SuperPath

Gene overlap in member pathways for fMLP Pathway SuperPath

Associated Genes for fMLP Pathway

Associated Disorders for fMLP Pathway

Disorders associated with fMLP Pathway SuperPath

STRING Interaction Network for fMLP Pathway

Sources for fMLP Pathway