Folate-alcohol and cancer pathway hypotheses

No Pathway Network information available for Folate-alcohol and cancer pathway hypotheses

#	Name	Source	Genes
1	Folate-alcohol and cancer pathway hypotheses	WikiPathways	ADH5 ALDH1A1 ALDH1L1 CBS CEBPB CREB1 CYP2E1 MTHFR MTR (see all 9) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CBS	Cystathionine Beta-Synthase	Protein Coding	1
2	MTR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase	Protein Coding	1
3	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	1
4	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	1
5	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	1
6	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
7	ADH5	Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide	Protein Coding	1
8	ALDH1L1	Aldehyde Dehydrogenase 1 Family Member L1	Protein Coding	1
9	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Homocystinuria	Enrichment	CBS, MTR	5.93
2	Neural tube defects, folate-sensitive	Enrichment	MTHFR, MTR	5.63
3	Homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity	Enrichment	MTHFR	3.18
4	Hyperhomocysteinemia	Enrichment	CBS	3.18
5	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.88
6	Amed syndrome, digenic	Enrichment	ADH5	2.88
7	Disorders of intracellular cobalamin metabolism	Enrichment	MTR	2.88
8	Isolated anencephaly	Enrichment	MTHFR	2.88
9	Isolated exencephaly	Enrichment	MTHFR	2.88
10	Homocystinuria-megaloblastic anemia, cblg type	Enrichment	MTR	2.70
11	Homocystinuria due to cystathionine beta-synthase deficiency	Enrichment	CBS	2.70
12	Melanoma of soft tissue	Enrichment	CREB1	2.70
13	Thrombophilia due to thrombin defect	Enrichment	MTHFR	2.33
14	Neural tube defects	Enrichment	MTHFR	2.07
15	Connective tissue disease	Enrichment	CBS	1.68
16	Epilepsy	Enrichment	MTR	1.58
17	West syndrome	Enrichment	MTHFR	1.54
18	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	CBS	1.54
19	Schizophrenia	Enrichment	MTHFR	1.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Folate-alcohol and cancer pathway hypotheses