Folate metabolism

No Pathway Network information available for Folate metabolism

Pathways in the Folate metabolism SuperPath

#	Name	Source	Genes
1	Folate metabolism	WikiPathways	CCL2 FOLR1 FOLR2 FOLR3 IZUMO1R NFKB1 NFKB2 RELA SLC19A1 SLC46A1 TP53 (see all 11) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IZUMO1R	IZUMO1 Receptor, JUNO	Protein Coding	1
2	TP53	Tumor Protein P53	Protein Coding	1
3	SLC19A1	Solute Carrier Family 19 Member 1	Protein Coding	1
4	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
5	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
6	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
7	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
8	FOLR2	Folate Receptor Beta	Protein Coding	1
9	FOLR1	Folate Receptor Alpha	Protein Coding	1
10	SLC46A1	Solute Carrier Family 46 Member 1	Protein Coding	1
11	FOLR3	Folate Receptor Gamma	Protein Coding	1

Disorders associated with Folate metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	4.90
2	Bone marrow failure syndrome 5	Enrichment	TP53	3.09
3	Megaloblastic anemia, folate-responsive	Enrichment	SLC19A1	3.09
4	Papilloma of choroid plexus	Enrichment	TP53	3.09
5	Basal cell carcinoma 7	Enrichment	TP53	3.09
6	Anaplastic thyroid carcinoma	Enrichment	TP53	3.09
7	Neurodegeneration due to cerebral folate transport deficiency	Enrichment	FOLR1	3.09
8	Ductal carcinoma in situ	Enrichment	TP53	3.09
9	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	3.09
10	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	3.09
11	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	3.09
12	Immunodeficiency 114, folate-responsive	Enrichment	SLC19A1	3.09
13	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	3.09
14	Neurodegenerative syndrome due to cerebral folate transport deficiency	Enrichment	FOLR1	3.09
15	Choroid plexus cancer	Enrichment	TP53	3.09
16	Pleomorphic xanthoastrocytoma	Enrichment	TP53	3.09
17	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.79
18	Cervical cancer	Enrichment	TP53	2.79
19	Lymphoma, hodgkin, classic	Enrichment	TP53	2.79
20	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.79
21	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.79
22	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.79
23	Rela fusion-positive ependymoma	Enrichment	RELA	2.79
24	Congenital fibrosarcoma	Enrichment	TP53	2.79
25	Li-fraumeni syndrome 1	Enrichment	TP53	2.79
26	Sarcoma	Enrichment	TP53	2.79
27	Glaucoma, primary closed-angle	Enrichment	SLC19A1	2.79
28	Cervix carcinoma	Enrichment	TP53	2.79
29	Hodgkin's lymphoma	Enrichment	TP53	2.79
30	Common variable immunodeficiency 12	Enrichment	NFKB1	2.79
31	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.79
32	Osteogenic sarcoma	Enrichment	TP53	2.61
33	Nasopharyngeal carcinoma	Enrichment	TP53	2.61
34	Folate malabsorption, hereditary	Enrichment	SLC46A1	2.61
35	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.61
36	Anaplastic astrocytoma	Enrichment	TP53	2.61
37	Squamous cell carcinoma	Enrichment	TP53	2.61
38	Adenocarcinoma	Enrichment	TP53	2.61
39	Bone osteosarcoma	Enrichment	TP53	2.61
40	Small cell cancer of the lung	Enrichment	TP53	2.49
41	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.49
42	Immunodeficiency, common variable, 1	Enrichment	NFKB2	2.49
43	Lung sarcomatoid carcinoma	Enrichment	TP53	2.49
44	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.49
45	Knobloch syndrome	Enrichment	SLC19A1	2.49
46	Rhabdomyosarcoma 2	Enrichment	TP53	2.39
47	Knobloch syndrome 1	Enrichment	SLC19A1	2.39
48	Lymphoma	Enrichment	TP53	2.39
49	Acute megakaryocytic leukemia	Enrichment	TP53	2.39
50	Li-fraumeni syndrome	Enrichment	TP53	2.31
51	Adrenocortical carcinoma	Enrichment	TP53	2.31
52	Breast adenocarcinoma	Enrichment	TP53	2.31
53	Esophageal cancer	Enrichment	TP53	2.25
54	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.25
55	Essential thrombocythemia	Enrichment	TP53	2.25
56	Gallbladder cancer	Enrichment	TP53	2.25
57	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	2.25
58	Glioma susceptibility 1	Enrichment	TP53	2.19
59	Lymphoma, non-hodgkin, familial	Enrichment	TP53	2.19
60	Adult hepatocellular carcinoma	Enrichment	TP53	2.14
61	Primary hyperaldosteronism	Enrichment	TP53	2.14
62	Leukemia, chronic lymphocytic	Enrichment	TP53	2.09
63	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	2.09
64	Familial colorectal cancer	Enrichment	TP53	2.09
65	Myelodysplastic syndrome	Enrichment	TP53	2.05
66	Lip and oral cavity carcinoma	Enrichment	TP53	2.01
67	Lung cancer susceptibility 3	Enrichment	TP53	1.95
68	Cataract	Enrichment	SLC19A1	1.95
69	Rhabdomyosarcoma	Enrichment	TP53	1.89
70	Gliosarcoma	Enrichment	TP53	1.89
71	Giant cell glioblastoma	Enrichment	TP53	1.86
72	Human immunodeficiency virus type 1	Enrichment	CCL2	1.84
73	Diffuse large b-cell lymphoma	Enrichment	TP53	1.82
74	Hepatoblastoma	Enrichment	TP53	1.77
75	Hepatocellular carcinoma	Enrichment	TP53	1.75
76	Diamond-blackfan anemia 1	Enrichment	TP53	1.73
77	Pancreatic cancer	Enrichment	TP53	1.70
78	Bladder cancer	Enrichment	TP53	1.63
79	Prostate cancer	Enrichment	TP53	1.63
80	Stargardt disease 1	Enrichment	SLC19A1	1.62
81	Lung cancer	Enrichment	SLC19A1	1.59
82	Diamond-blackfan anemia	Enrichment	TP53	1.54
83	Leukemia, acute myeloid	Enrichment	TP53	1.50
84	Gastric cancer	Enrichment	TP53	1.46
85	Hereditary breast carcinoma	Enrichment	TP53	1.45
86	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.36
87	Myeloma, multiple	Enrichment	TP53	1.35
88	Breast cancer	Enrichment	TP53	1.23
89	Colorectal cancer	Enrichment	TP53	1.17
90	Ovarian cancer	Enrichment	TP53	1.10
91	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.99
92	Retinitis pigmentosa	Enrichment	SLC19A1	0.80
93	Hereditary retinal dystrophy	Enrichment	SLC19A1	0.67
94	Fundus dystrophy	Enrichment	SLC19A1	0.67

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Folate metabolism

Member Pathways for Folate metabolism

Pathways in the Folate metabolism SuperPath

Associated Genes for Folate metabolism

Associated Disorders for Folate metabolism

Disorders associated with Folate metabolism SuperPath

STRING Interaction Network for Folate metabolism

Sources for Folate metabolism