Formation of WDR5-containing histone-modifying complexes

No Pathway Network information available for Formation of WDR5-containing histone-modifying complexes

Pathways in the Formation of WDR5-containing histone-modifying complexes SuperPath

#	Name	Source	Genes
1	Formation of WDR5-containing histone-modifying complexes	Reactome	AKAP8L ASH2L BOD1 BOD1L1 CXXC1 DPY30 DR1 HCFC1 HCFC2 KANSL1 KANSL2 KANSL3 KAT14 KAT2A KAT2B KAT8 KDM6A KMT2A KMT2B KMT2C KMT2D MBIP MCRS1 MEN1 NCOA6 PAGR1 PAXIP1 PHF20 PHF20L1 PSIP1 RBBP5 SETD1A SETD1B SGF29 TADA2A TADA3 TASP1 WDR5 WDR82 YEATS2 ZZZ3 (see all 41) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MCRS1	Microspherule Protein 1	Protein Coding	1
2	TADA3	Transcriptional Adaptor 3	Protein Coding	1
3	WDR5	WD Repeat Domain 5	Protein Coding	1
4	PSIP1	PC4 And SRSF1 Interacting Protein 1	Protein Coding	1
5	SGF29	SAGA Complex Associated Factor 29	Protein Coding	1
6	DR1	Down-Regulator Of Transcription 1	Protein Coding	1
7	PAXIP1	PAX Interacting Protein 1	Protein Coding	1
8	NCOA6	Nuclear Receptor Coactivator 6	Protein Coding	1
9	SETD1B	SET Domain Containing 1B, Histone Lysine Methyltransferase	Protein Coding	1
10	BOD1L1	Biorientation Of Chromosomes In Cell Division 1 Like 1	Protein Coding	1
11	ZZZ3	Zinc Finger ZZ-Type Containing 3	Protein Coding	1
12	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	1
13	AKAP8L	A-Kinase Anchoring Protein 8 Like	Protein Coding	1
14	KANSL1	KAT8 Regulatory NSL Complex Subunit 1	Protein Coding	1
15	HCFC2	Host Cell Factor C2	Protein Coding	1
16	HCFC1	Host Cell Factor C1	Protein Coding	1
17	CXXC1	CXXC Finger Protein 1	Protein Coding	1
18	MEN1	Menin 1	Protein Coding	1
19	KMT2A	Lysine Methyltransferase 2A	Protein Coding	1
20	PHF20L1	PHD Finger Protein 20 Like 1	Protein Coding	1
21	PHF20	PHD Finger Protein 20	Protein Coding	1
22	MBIP	MAP3K12 Binding Inhibitory Protein 1	Protein Coding	1
23	KANSL2	KAT8 Regulatory NSL Complex Subunit 2	Protein Coding	1
24	TASP1	Taspase 1	Protein Coding	1
25	KANSL3	KAT8 Regulatory NSL Complex Subunit 3	Protein Coding	1
26	YEATS2	YEATS Domain Containing 2	Protein Coding	1
27	KAT14	Lysine Acetyltransferase 14	Protein Coding	1
28	KMT2C	Lysine Methyltransferase 2C	Protein Coding	1
29	RBBP5	RB Binding Protein 5, Histone Lysine Methyltransferase Complex Subunit	Protein Coding	1
30	TADA2A	Transcriptional Adaptor 2A	Protein Coding	1
31	KDM6A	Lysine Demethylase 6A	Protein Coding	1
32	PAGR1	PAXIP1 Associated Glutamate Rich Protein 1	Protein Coding	1
33	WDR82	WD Repeat Domain 82	Protein Coding	1
34	KMT2D	Lysine Methyltransferase 2D	Protein Coding	1
35	KAT8	Lysine Acetyltransferase 8	Protein Coding	1
36	DPY30	Dpy-30 Histone Methyltransferase Complex Regulatory Subunit	Protein Coding	1
37	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
38	ASH2L	ASH2 Like, Histone Lysine Methyltransferase Complex Subunit	Protein Coding	1
39	BOD1	Biorientation Of Chromosomes In Cell Division 1	Protein Coding	1
40	SETD1A	SET Domain Containing 1A, Histone Lysine Methyltransferase	Protein Coding	1
41	KMT2B	Lysine Methyltransferase 2B	Protein Coding	1

Disorders associated with Formation of WDR5-containing histone-modifying complexes SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Kabuki syndrome 1	Enrichment	KDM6A, KMT2A, KMT2D	6.29
2	Charge syndrome	Enrichment	KDM6A, KMT2D	3.50
3	Autism spectrum disorder	Enrichment	KDM6A, KMT2A, KMT2C, SETD1A	3.50
4	Kabuki syndrome 2	Enrichment	KDM6A	2.52
5	Branchial cleft anomalies	Enrichment	KMT2D	2.52
6	Li-ghorbani-weisz-hubshman syndrome	Enrichment	KAT8	2.52
7	Neurodevelopmental disorder with speech impairment and dysmorphic facies	Enrichment	SETD1A	2.52
8	Adrenal cortical adenoma	Enrichment	MEN1	2.52
9	Epilepsy, early-onset, 2, with or without developmental delay	Enrichment	SETD1A	2.52
10	Epilepsy, familial adult myoclonic, 4	Enrichment	YEATS2	2.52
11	Intellectual developmental disorder with seizures and language delay	Enrichment	SETD1B	2.52
12	Branchial arch abnormalities, choanal atresia, athelia, hearing loss, and hypothyroidism syndrome	Enrichment	KMT2D	2.52
13	Kleefstra syndrome 2	Enrichment	KMT2C	2.52
14	Intellectual developmental disorder, autosomal dominant 68	Enrichment	KMT2B	2.52
15	Suleiman-el-hattab syndrome	Enrichment	TASP1	2.52
16	Generalized isolated dystonia	Enrichment	KMT2B	2.52
17	Kmt2b-related disorders	Enrichment	KMT2B	2.52
18	Acute myeloid leukemia with mll rearrangement	Enrichment	KMT2A	2.52
19	Adrenal adenoma	Enrichment	MEN1	2.52
20	Hyperparathyroidism 1	Enrichment	MEN1	2.22
21	Complement component c1s deficiency	Enrichment	KMT2D	2.22
22	Choanal atresia, posterior	Enrichment	KMT2D	2.22
23	Mitochondrial complex iv deficiency, nuclear type 19	Enrichment	KAT14	2.22
24	Kleefstra syndrome	Enrichment	KMT2C	2.22
25	Medullary thyroid carcinoma	Enrichment	MEN1	2.22
26	Insulinoma	Enrichment	MEN1	2.22
27	Dystonia 28, childhood-onset	Enrichment	KMT2B	2.22
28	Kleefstra syndrome due to a point mutation	Enrichment	KMT2C	2.22
29	Acute myeloid leukemia with t(9;11)(p22;q23)	Enrichment	KMT2A	2.22
30	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	KMT2A	2.22
31	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KMT2A	2.22
32	Null pituitary adenoma	Enrichment	MEN1	2.22
33	Silent pituitary adenoma	Enrichment	MEN1	2.22
34	Gigantism	Enrichment	MEN1	2.22
35	Complex neurodevelopmental disorder	Enrichment	KAT8, KMT2B, SETD1A	2.21
36	Dystonia 12	Enrichment	KMT2B	2.04
37	Methylmalonic aciduria and homocystinuria, cblx type	Enrichment	HCFC1	2.04
38	Pituitary adenoma 1, multiple types	Enrichment	MEN1	2.04
39	Koolen-de vries syndrome	Enrichment	KANSL1	2.04
40	Cellular ependymoma	Enrichment	MEN1	2.04
41	Tanycytic ependymoma	Enrichment	MEN1	2.04
42	Papillary ependymoma	Enrichment	MEN1	2.04
43	Parathyroid adenoma	Enrichment	MEN1	2.04
44	Growth hormone secreting pituitary adenoma	Enrichment	MEN1	2.04
45	Aip familial isolated pituitary adenomas	Enrichment	MEN1	2.04
46	Familial isolated hyperparathyroidism	Enrichment	MEN1	2.04
47	Mixed phenotype acute leukemia with t	Enrichment	KMT2A	2.04
48	Clear cell ependymoma	Enrichment	MEN1	2.04
49	Microtia-anotia	Enrichment	KMT2D	1.92
50	Intellectual developmental disorder, autosomal dominant 26	Enrichment	KMT2D	1.92
51	Prolactinoma	Enrichment	MEN1	1.92
52	Primary hyperparathyroidism	Enrichment	MEN1	1.92
53	Benign ependymoma	Enrichment	MEN1	1.92
54	Myeloma, multiple	Enrichment	KMT2C, KMT2D	1.91
55	Amblyopia	Enrichment	KMT2D	1.82
56	Lymphoma	Enrichment	KMT2D	1.82
57	Acute megakaryocytic leukemia	Enrichment	KMT2A	1.82
58	Wiedemann-steiner syndrome	Enrichment	KMT2A	1.74
59	Kleefstra syndrome 1	Enrichment	KMT2C	1.74
60	Familial adult myoclonic epilepsy	Enrichment	YEATS2	1.74
61	Autism	Enrichment	KMT2B, KMT2D	1.70
62	Multiple endocrine neoplasia, type i	Enrichment	MEN1	1.68
63	Gastrointestinal stromal tumor	Enrichment	MEN1	1.68
64	Methylmalonic aciduria and homocystinuria, cblc type	Enrichment	HCFC1	1.62
65	Cornelia de lange syndrome 1	Enrichment	KMT2A	1.57
66	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	SETD1A	1.57
67	Cornelia de lange syndrome	Enrichment	KMT2A	1.57
68	Diabetes mellitus	Enrichment	MEN1	1.48
69	Specific learning disability	Enrichment	KMT2B	1.48
70	Rare genetic intellectual disability	Enrichment	KMT2A	1.35
71	Male infertility with spermatogenesis disorder	Enrichment	KMT2D	1.35
72	Hypertension	Enrichment	MEN1	1.33
73	Dandy-walker syndrome	Enrichment	KMT2D	1.30
74	Microcephaly	Enrichment	KMT2A, KMT2D	1.27
75	Strabismus	Enrichment	KMT2D	1.10
76	Bladder cancer	Enrichment	KDM6A	1.08
77	Lung cancer	Enrichment	KMT2D	1.03
78	Dystonia	Enrichment	KMT2B	1.00
79	Non-syndromic x-linked intellectual disability	Enrichment	HCFC1	0.99
80	Leukemia, acute myeloid	Enrichment	KMT2A	0.94
81	Epilepsy	Enrichment	SETD1B	0.94
82	Autosomal dominant non-syndromic intellectual disability	Enrichment	SETD1B	0.85
83	Hereditary breast ovarian cancer syndrome	Enrichment	MEN1	0.81
84	Schizophrenia	Enrichment	SETD1A	0.79
85	Congenital nervous system abnormality	Enrichment	KMT2D	0.56
86	Nervous system disease	Enrichment	KMT2D	0.56
87	Inherited cancer-predisposing syndrome	Enrichment	MEN1	0.48

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Formation of WDR5-containing histone-modifying complexes

Pathway Network for Formation of WDR5-containing histone-modifying complexes

Member Pathways for Formation of WDR5-containing histone-modifying complexes

Pathways in the Formation of WDR5-containing histone-modifying complexes SuperPath

Associated Genes for Formation of WDR5-containing histone-modifying complexes

Associated Disorders for Formation of WDR5-containing histone-modifying complexes

Disorders associated with Formation of WDR5-containing histone-modifying complexes SuperPath

STRING Interaction Network for Formation of WDR5-containing histone-modifying complexes

Sources for Formation of WDR5-containing histone-modifying complexes