FOXA1 transcription factor network

No Pathway Network information available for FOXA1 transcription factor network

Pathways in the FOXA1 transcription factor network SuperPath

#	Name	Source	Genes
1	FOXA1 transcription factor network	PubChem	AP1B1 APOB AR ATP5PF BRCA1 C4BPB CCND1 CDKN1B CEBPB COL18A1 CYP2C18 DSCAM ESR1 FOS FOXA1 FOXA2 GCG INS JUN KLK3 NCOA3 NDUFV3 NKX3-1 NR2F2 NRIP1 PISD POU2F1 PRDM15 SCGB1A1 SERPINA1 SFTPD SHH SOD1 SP1 TFF1 VTN XBP1 (see all 37) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SCGB1A1	Secretoglobin Family 1A Member 1	Protein Coding	1
2	SERPINA1	Serpin Family A Member 1	Protein Coding	1
3	NKX3-1	NK3 Homeobox 1	Protein Coding	1
4	PRDM15	PR/SET Domain 15	Protein Coding	1
5	XBP1	X-Box Binding Protein 1	Protein Coding	1
6	KLK3	Kallikrein Related Peptidase 3	Protein Coding	1
7	CYP2C18	Cytochrome P450 Family 2 Subfamily C Member 18	Protein Coding	1
8	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
9	C4BPB	Complement Component 4 Binding Protein Beta	Protein Coding	1
10	SFTPD	Surfactant Protein D	Protein Coding	1
11	AR	Androgen Receptor	Protein Coding	1
12	TFF1	Trefoil Factor 1	Protein Coding	1
13	FOXA1	Forkhead Box A1	Protein Coding	1
14	NRIP1	Nuclear Receptor Interacting Protein 1	Protein Coding	1
15	POU2F1	POU Class 2 Homeobox 1	Protein Coding	1
16	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
17	CCND1	Cyclin D1	Protein Coding	1
18	NDUFV3	NADH:Ubiquinone Oxidoreductase Subunit V3	Protein Coding	1
19	GCG	Glucagon	Protein Coding	1
20	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
21	COL18A1	Collagen Type XVIII Alpha 1 Chain	Protein Coding	1
22	VTN	Vitronectin	Protein Coding	1
23	SP1	Sp1 Transcription Factor	Protein Coding	1
24	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
25	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
26	NCOA3	Nuclear Receptor Coactivator 3	Protein Coding	1
27	NR2F2	Nuclear Receptor Subfamily 2 Group F Member 2	Protein Coding	1
28	FOXA2	Forkhead Box A2	Protein Coding	1
29	DSCAM	DS Cell Adhesion Molecule	Protein Coding	1
30	ATP5PF	ATP Synthase Peripheral Stalk Subunit F6	Protein Coding	1
31	AP1B1	Adaptor Related Protein Complex 1 Subunit Beta 1	Protein Coding	1
32	APOB	Apolipoprotein B	Protein Coding	1
33	PISD	Phosphatidylserine Decarboxylase	Protein Coding	1
34	INS	Insulin	Protein Coding	1
35	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
36	SOD1	Superoxide Dismutase 1	Protein Coding	1
37	ESR1	Estrogen Receptor 1	Protein Coding	1

Disorders associated with FOXA1 transcription factor network SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast cancer	Enrichment	BRCA1, ESR1, JUN	2.96
2	Ovarian cancer	Enrichment	AR, BRCA1, CDKN1B	2.59
3	Holoprosencephaly 3	Enrichment	SHH	2.56
4	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.56
5	Keratitis-ichthyosis-deafness syndrome, autosomal recessive	Enrichment	AP1B1	2.56
6	Prostate cancer, hereditary, x-linked 3	Enrichment	AR	2.56
7	Androgen insensitivity, partial	Enrichment	AR	2.56
8	Microphthalmia/coloboma 5	Enrichment	SHH	2.56
9	46,xx sex reversal 5	Enrichment	NR2F2	2.56
10	Infant-type hemispheric glioma	Enrichment	BRCA1	2.56
11	Major affective disorder 7	Enrichment	XBP1	2.56
12	Neuroendocrine tumor	Enrichment	CDKN1B	2.56
13	Alpha-1-antitrypsin deficiency	Enrichment	SERPINA1	2.56
14	Congenital anomalies of kidney and urinary tract 3	Enrichment	NRIP1	2.56
15	Non-acquired combined pituitary hormone deficiency	Enrichment	FOXA2	2.56
16	Hemorrhagic disease due to alpha-1-antitrypsin pittsburgh mutation	Enrichment	SERPINA1	2.56
17	Complete androgen insensitivity syndrome	Enrichment	AR	2.56
18	Primary peritoneal carcinoma	Enrichment	BRCA1	2.56
19	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	2.56
20	Prostate cancer	Enrichment	AR, BRCA1	2.55
21	Spinal and bulbar muscular atrophy, x-linked 1	Enrichment	AR	2.26
22	Solitary median maxillary central incisor	Enrichment	SHH	2.26
23	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.26
24	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.26
25	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	2.26
26	Hyperproinsulinemia	Enrichment	INS	2.26
27	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.26
28	46,xy sex reversal 1	Enrichment	AR	2.26
29	Androgen insensitivity syndrome	Enrichment	AR	2.26
30	Pancreatic cancer 4	Enrichment	BRCA1	2.26
31	Hypospadias 1, x-linked	Enrichment	AR	2.26
32	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.26
33	Glaucoma, primary closed-angle	Enrichment	COL18A1	2.26
34	Liberfarb syndrome	Enrichment	PISD	2.26
35	Spastic tetraplegia and axial hypotonia, progressive	Enrichment	SOD1	2.26
36	Hypobetalipoproteinemia	Enrichment	APOB	2.26
37	Inflammatory breast carcinoma	Enrichment	BRCA1	2.26
38	Peritoneum cancer	Enrichment	BRCA1	2.26
39	Bilateral breast cancer	Enrichment	BRCA1	2.26
40	Posterior hypospadias	Enrichment	AR	2.26
41	Isolated radial hemimelia	Enrichment	SHH	2.26
42	Hereditary breast carcinoma	Enrichment	BRCA1, ESR1	2.20
43	Type 1 diabetes mellitus 2	Enrichment	INS	2.09
44	Hypercholesterolemia, familial, 2	Enrichment	APOB	2.09
45	Syndactyly, type iv	Enrichment	SHH	2.09
46	Intellectual developmental disorder, x-linked 109	Enrichment	SERPINA1	2.09
47	Mednik syndrome	Enrichment	AP1B1	2.09
48	Estrogen resistance	Enrichment	ESR1	2.09
49	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	2.09
50	Migraine without aura	Enrichment	ESR1	2.09
51	Polydactyly, preaxial ii	Enrichment	SHH	1.96
52	Schizencephaly	Enrichment	SHH	1.96
53	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.96
54	Cholangiocarcinoma	Enrichment	BRCA1	1.96
55	Congenital generalized lipodystrophy	Enrichment	FOS	1.96
56	Mantle cell lymphoma	Enrichment	CCND1	1.96
57	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.96
58	Neonatal diabetes mellitus	Enrichment	INS	1.96
59	Knobloch syndrome	Enrichment	COL18A1	1.96
60	Primary hyperparathyroidism	Enrichment	CDKN1B	1.96
61	Hyperlipidemia, familial combined, 3	Enrichment	APOB	1.87
62	Von hippel-lindau syndrome	Enrichment	CCND1	1.87
63	Knobloch syndrome 1	Enrichment	COL18A1	1.87
64	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	SOD1	1.87
65	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.87
66	Congenital heart defects, multiple types, 4	Enrichment	NR2F2	1.87
67	Pervasive developmental disorder	Enrichment	PRDM15	1.87
68	Histiocytoid hemangioma	Enrichment	FOS	1.87
69	Rare pervasive developmental disorder	Enrichment	PRDM15	1.87
70	Type 1 diabetes mellitus	Enrichment	INS	1.79
71	46,xy disorder of sex development	Enrichment	NR2F2	1.79
72	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.72
73	Motor neuron disease	Enrichment	SOD1	1.72
74	Homozygous familial hypercholesterolemia	Enrichment	APOB	1.67
75	Permanent neonatal diabetes mellitus	Enrichment	INS	1.67
76	Difference of sex development	Enrichment	AR	1.67
77	Combined pituitary hormone deficiency	Enrichment	FOXA2	1.67
78	Colorectal cancer	Enrichment	BRCA1, CCND1	1.63
79	Coronary heart disease 5	Enrichment	APOB	1.61
80	Amyotrophic lateral sclerosis 1	Enrichment	SOD1	1.57
81	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.57
82	Migraine with or without aura 1	Enrichment	ESR1	1.53
83	46,xy complete gonadal dysgenesis	Enrichment	AR	1.53
84	Diabetes mellitus	Enrichment	INS	1.53
85	Uterine corpus cancer	Enrichment	BRCA1	1.53
86	Septooptic dysplasia	Enrichment	SHH	1.49
87	Hypercholesterolemia, familial, 1	Enrichment	APOB	1.46
88	Breast-ovarian cancer, familial 1	Enrichment	BRCA1	1.46
89	Pulmonary disease, chronic obstructive	Enrichment	SERPINA1	1.46
90	Periventricular nodular heterotopia	Enrichment	BRCA1	1.43
91	Heart disease	Enrichment	NR2F2	1.43
92	Cataract	Enrichment	COL18A1	1.43
93	Familial hypercholesterolemia	Enrichment	APOB	1.40
94	Septopreoptic holoprosencephaly	Enrichment	SHH	1.40
95	Midline interhemispheric variant of holoprosencephaly	Enrichment	SHH	1.40
96	Rhabdomyosarcoma	Enrichment	BRCA1	1.37
97	Microform holoprosencephaly	Enrichment	SHH	1.37
98	Lobar holoprosencephaly	Enrichment	SHH	1.37
99	Alobar holoprosencephaly	Enrichment	SHH	1.34
100	Semilobar holoprosencephaly	Enrichment	SHH	1.32
101	Inherited cancer-predisposing syndrome	Enrichment	BRCA1, CDKN1B	1.30
102	Macs syndrome	Enrichment	SHH	1.27
103	Maturity-onset diabetes of the young	Enrichment	INS	1.27
104	Endometrial cancer	Enrichment	BRCA1	1.25
105	Myocardial infarction	Enrichment	ESR1	1.23
106	Pancreatic cancer	Enrichment	BRCA1	1.18
107	Bladder cancer	Enrichment	BRCA1	1.12
108	Hirschsprung disease 1	Enrichment	DSCAM	1.12
109	Stargardt disease 1	Enrichment	COL18A1	1.10
110	Lung cancer	Enrichment	BRCA1	1.08
111	Cystic fibrosis	Enrichment	SERPINA1	1.08
112	Male infertility	Enrichment	AR	1.05
113	Cakut	Enrichment	NRIP1	1.05
114	Fanconi anemia, complementation group a	Enrichment	BRCA1	1.04
115	Gastric cancer	Enrichment	BRCA1	0.95
116	Hereditary breast ovarian cancer syndrome	Enrichment	BRCA1	0.85
117	Myeloma, multiple	Enrichment	CCND1	0.85
118	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	AR	0.85
119	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SOD1	0.83
120	Autism	Enrichment	SHH	0.75
121	Retinitis pigmentosa	Enrichment	COL18A1	0.35
122	Hereditary retinal dystrophy	Enrichment	COL18A1	0.26
123	Fundus dystrophy	Enrichment	COL18A1	0.26

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

FOXA1 transcription factor network

Pathway Network for FOXA1 transcription factor network

Member Pathways for FOXA1 transcription factor network

Pathways in the FOXA1 transcription factor network SuperPath

Associated Genes for FOXA1 transcription factor network

Associated Disorders for FOXA1 transcription factor network

Disorders associated with FOXA1 transcription factor network SuperPath

STRING Interaction Network for FOXA1 transcription factor network

Sources for FOXA1 transcription factor network