FOXA2 and FOXA3 transcription factor networks

No Pathway Network information available for FOXA2 and FOXA3 transcription factor networks

Pathways in the FOXA2 and FOXA3 transcription factor networks SuperPath

#	Name	Source	Genes
1	FOXA2 and FOXA3 transcription factor networks	PubChem	ABCC8 ACADM ACADVL AFP AKT1 ALAS1 ALB ALDOB APOA1 BDH1 CEBPB CREB1 DLK1 F2 FOXA1 FOXA2 FOXA3 FOXF1 G6PC1 GCK HADH HMGCS1 HNF1A HNF4A IGFBP1 INS KCNJ11 LPL NF1 NKX2-1 NR3C1 PCK1 PDX1 PKLR SLC2A2 SP1 TAT TFRC TTR UCP2 (see all 40) (see less)
2	FOXA transcription factor networks	PubChem	FOXA1 FOXA2 FOXA3

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FOXA1	Forkhead Box A1	Protein Coding	2
2	FOXA2	Forkhead Box A2	Protein Coding	2
3	FOXA3	Forkhead Box A3	Protein Coding	2
4	NKX2-1	NK2 Homeobox 1	Protein Coding	1
5	UCP2	Uncoupling Protein 2	Protein Coding	1
6	AFP	Alpha Fetoprotein	Protein Coding	1
7	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
8	TAT	Tyrosine Aminotransferase	Protein Coding	1
9	IGFBP1	Insulin Like Growth Factor Binding Protein 1	Protein Coding	1
10	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	1
11	NF1	Neurofibromin 1	Protein Coding	1
12	DLK1	Delta Like Non-Canonical Notch Ligand 1	Protein Coding	1
13	TTR	Transthyretin	Protein Coding	1
14	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
15	BDH1	3-Hydroxybutyrate Dehydrogenase 1	Protein Coding	1
16	HADH	Hydroxyacyl-CoA Dehydrogenase	Protein Coding	1
17	ACADVL	Acyl-CoA Dehydrogenase Very Long Chain	Protein Coding	1
18	HMGCS1	3-Hydroxy-3-Methylglutaryl-CoA Synthase 1	Protein Coding	1
19	ACADM	Acyl-CoA Dehydrogenase Medium Chain	Protein Coding	1
20	G6PC1	Glucose-6-Phosphatase Catalytic Subunit 1	Protein Coding	1
21	F2	Coagulation Factor II, Thrombin	Protein Coding	1
22	FOXF1	Forkhead Box F1	Protein Coding	1
23	SP1	Sp1 Transcription Factor	Protein Coding	1
24	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
25	ALAS1	5''-Aminolevulinate Synthase 1	Protein Coding	1
26	ALB	Albumin	Protein Coding	1
27	TFRC	Transferrin Receptor	Protein Coding	1
28	APOA1	Apolipoprotein A1	Protein Coding	1
29	KCNJ11	Potassium Inwardly Rectifying Channel Subfamily J Member 11	Protein Coding	1
30	ALDOB	Aldolase, Fructose-Bisphosphate B	Protein Coding	1
31	LPL	Lipoprotein Lipase	Protein Coding	1
32	PCK1	Phosphoenolpyruvate Carboxykinase 1	Protein Coding	1
33	PKLR	Pyruvate Kinase L/R	Protein Coding	1
34	PDX1	Pancreatic And Duodenal Homeobox 1	Protein Coding	1
35	HNF1A	HNF1 Homeobox A	Protein Coding	1
36	INS	Insulin	Protein Coding	1
37	HNF4A	Hepatocyte Nuclear Factor 4 Alpha	Protein Coding	1
38	GCK	Glucokinase	Protein Coding	1
39	SLC2A2	Solute Carrier Family 2 Member 2	Protein Coding	1
40	ABCC8	ATP Binding Cassette Subfamily C Member 8	Protein Coding	1

Disorders associated with FOXA2 and FOXA3 transcription factor networks SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Maturity-onset diabetes of the young	Enrichment	ABCC8, GCK, HNF1A, HNF4A, INS, KCNJ11, PDX1	16.00
2	Type 2 diabetes mellitus	Enrichment	ABCC8, GCK, HNF1A, HNF4A, KCNJ11, PDX1, SLC2A2	10.87
3	Permanent neonatal diabetes mellitus	Enrichment	ABCC8, GCK, INS, KCNJ11, PDX1	10.47
4	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	ABCC8, GCK, HADH, KCNJ11	9.01
5	Nonsyndromic genetic hyperinsulinism	Enrichment	ABCC8, GCK, HADH, KCNJ11	9.01
6	Diabetes mellitus	Enrichment	GCK, HNF1A, INS, KCNJ11	7.68
7	Maturity-onset diabetes of the young, type 3	Enrichment	GCK, HNF1A, HNF4A	7.02
8	Neonatal diabetes mellitus	Enrichment	ABCC8, INS, KCNJ11	7.02
9	Hypoglycemia	Enrichment	ABCC8, G6PC1, KCNJ11	6.63
10	Maturity-onset diabetes of the young, type 1	Enrichment	GCK, HNF4A	5.07
11	Diabetes mellitus, permanent neonatal, 1	Enrichment	GCK, KCNJ11	5.07
12	Hyperinsulinism	Enrichment	HNF4A, KCNJ11	5.07
13	Hyperinsulinism due to hnf1a deficiency	Enrichment	HNF1A, HNF4A	5.07
14	Hyperinsulinemic hypoglycemia	Enrichment	ABCC8, HADH	4.60
15	Dend syndrome	Enrichment	ABCC8, KCNJ11	4.60
16	Transient neonatal diabetes mellitus	Enrichment	ABCC8, KCNJ11	4.07
17	Type 1 diabetes mellitus	Enrichment	HNF1A, INS	3.90
18	Non-acquired combined pituitary hormone deficiency	Enrichment	FOXA2	3.66
19	Combined pituitary hormone deficiency	Enrichment	FOXA2	2.75
20	Carpal tunnel syndrome 1	Enrichment	TTR	2.53
21	Adenosine triphosphate, elevated, of erythrocytes	Enrichment	PKLR	2.53
22	Proteus syndrome	Enrichment	AKT1	2.53
23	Hyperthyroxinemia, dystransthyretinemic	Enrichment	TTR	2.53
24	Hepatic adenomas, familial	Enrichment	HNF1A	2.53
25	Pancreatic agenesis 1	Enrichment	PDX1	2.53
26	3-hydroxyacyl-coa dehydrogenase deficiency	Enrichment	HADH	2.53
27	Anemia, congenital, nonspherocytic hemolytic, 2	Enrichment	PKLR	2.53
28	Phosphoenolpyruvate carboxykinase deficiency, cytosolic	Enrichment	PCK1	2.53
29	Hyperinsulinemic hypoglycemia, familial, 2	Enrichment	KCNJ11	2.53
30	Maturity-onset diabetes of the young, type 4	Enrichment	PDX1	2.53
31	Prothrombin deficiency, congenital	Enrichment	F2	2.53
32	Maturity-onset diabetes of the young, type 2	Enrichment	GCK	2.53
33	Amyloidosis, hereditary systemic 1	Enrichment	TTR	2.53
34	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.53
35	Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young	Enrichment	HNF4A	2.53
36	Hyperthyroxinemia, familial dysalbuminemic	Enrichment	ALB	2.53
37	Acyl-coa dehydrogenase, medium-chain, deficiency of	Enrichment	ACADM	2.53
38	Alpha-fetoprotein, hereditary persistence of	Enrichment	AFP	2.53
39	Maturity-onset diabetes of the young, type 12	Enrichment	ABCC8	2.53
40	Body mass index quantitative trait locus 4	Enrichment	UCP2	2.53
41	Diabetes mellitus, transient neonatal, 3	Enrichment	KCNJ11	2.53
42	Hyperinsulinemic hypoglycemia, familial, 3	Enrichment	GCK	2.53
43	Cowden syndrome 6	Enrichment	AKT1	2.53
44	Immunodeficiency 46	Enrichment	TFRC	2.53
45	Diabetes mellitus, permanent neonatal, 2	Enrichment	KCNJ11	2.53
46	Alpha-fetoprotein deficiency	Enrichment	AFP	2.53
47	Maturity-onset diabetes of the young, type 13	Enrichment	KCNJ11	2.53
48	Type 1 diabetes mellitus 20	Enrichment	HNF1A	2.53
49	Pregnancy loss, recurrent 2	Enrichment	F2	2.53
50	Autosomal dominant hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.53
51	Congenital analbuminemia	Enrichment	ALB	2.53
52	Plexiform neurofibroma	Enrichment	NF1	2.53
53	Analbuminemia	Enrichment	ALB	2.53
54	Neurofibroma	Enrichment	NF1	2.53
55	Amyloidosis	Enrichment	TTR	2.53
56	Neurofibromatosis	Enrichment	NF1	2.53
57	Diazoxide-resistant focal hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.53
58	Gestational diabetes	Enrichment	GCK	2.53
59	Prothrombin deficiency	Enrichment	F2	2.53
60	Hyperinsulinism due to hnf4a deficiency	Enrichment	HNF4A	2.53
61	Chromosome 17q11.2 deletion syndrome	Enrichment	NF1	2.53
62	Optic nerve glioma	Enrichment	NF1	2.53
63	Congestive heart failure	Enrichment	ABCC8	2.53
64	Medium-chain acyl-coenzyme a dehydrogenase deficiency	Enrichment	ACADM	2.53
65	Intermediate dend syndrome	Enrichment	KCNJ11	2.53
66	Hereditary amyloidosis	Enrichment	TTR	2.53
67	Attrv30m amyloidosis	Enrichment	TTR	2.53
68	Diazoxide-resistant focal hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.53
69	Hyperinsulinism due to ucp2 deficiency	Enrichment	UCP2	2.53
70	Autosomal recessive hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.53
71	Atresia of urethra	Enrichment	FOXF1	2.53
72	Attrv122i amyloidosis	Enrichment	TTR	2.53
73	Autosomal dominant hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.53
74	Autosomal recessive hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.53
75	Cafe-au-lait spots, multiple	Enrichment	NF1	2.23
76	Pancreas, dorsal, agenesis of	Enrichment	PDX1	2.23
77	Fanconi-bickel syndrome	Enrichment	SLC2A2	2.23
78	Hyperlipoproteinemia, type i	Enrichment	LPL	2.23
79	Galactosemia ii	Enrichment	NR3C1	2.23
80	Fructose intolerance, hereditary	Enrichment	ALDOB	2.23
81	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.23
82	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	HADH	2.23
83	Bone marrow failure syndrome 2	Enrichment	GCK	2.23
84	Mononeuropathy of the median nerve, mild	Enrichment	TTR	2.23
85	Hypoglycemia, leucine-induced	Enrichment	ABCC8	2.23
86	Lipase deficiency, combined	Enrichment	LPL	2.23
87	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.23
88	Diabetes mellitus, transient neonatal, 2	Enrichment	ABCC8	2.23
89	Hyperproinsulinemia	Enrichment	INS	2.23
90	Chromosome 17q11.2 duplication syndrome, 1.4-mb	Enrichment	NF1	2.23
91	Pyloric stenosis, infantile hypertrophic, 5	Enrichment	FOXF1	2.23
92	Central precocious puberty	Enrichment	DLK1	2.23
93	Diabetes mellitus, permanent neonatal, 3	Enrichment	ABCC8	2.23
94	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.23
95	Choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction	Enrichment	NKX2-1	2.23
96	Bardet-biedl syndrome 9	Enrichment	NF1	2.23
97	Familial lipoprotein lipase deficiency	Enrichment	LPL	2.23
98	Hypoalphalipoproteinemia, primary, 2, intermediate	Enrichment	APOA1	2.23
99	Amyloidosis, hereditary systemic 3	Enrichment	APOA1	2.23
100	Pleomorphic rhabdomyosarcoma	Enrichment	NF1	2.23
101	Idiopathic/heritable pulmonary arterial hypertension	Enrichment	FOXF1	2.23
102	Nkx2-1-related disorders	Enrichment	NKX2-1	2.23
103	Type 1 diabetes mellitus 2	Enrichment	INS	2.05
104	Nijmegen breakage syndrome	Enrichment	GCK	2.05
105	Watson syndrome	Enrichment	NF1	2.05
106	Heart defects, congenital, and other congenital anomalies	Enrichment	ACADVL	2.05
107	Alveolar capillary dysplasia with misalignment of pulmonary veins	Enrichment	FOXF1	2.05
108	Neurofibromatosis, familial spinal	Enrichment	NF1	2.05
109	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	NF1	2.05
110	Keratoderma-ichthyosis-deafness syndrome, autosomal recessive	Enrichment	HNF1A	2.05
111	Hypoalphalipoproteinemia, primary, 2	Enrichment	APOA1	2.05
112	Intellectual developmental disorder, autosomal dominant 62	Enrichment	ACADVL	2.05
113	Precocious puberty, central, 2	Enrichment	DLK1	2.05
114	Chromophobe renal cell carcinoma	Enrichment	HNF1A	2.05
115	Brain cancer	Enrichment	NF1	2.05
116	Spastic paraplegia 50, autosomal recessive	Enrichment	APOA1	2.05
117	Dlg4-related synaptopathy	Enrichment	ACADVL	2.05
118	Phosphoenolpyruvate carboxykinase deficiency	Enrichment	PCK1	2.05
119	Melanoma of soft tissue	Enrichment	CREB1	2.05
120	Cerebral sinovenous thrombosis	Enrichment	F2	2.05
121	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	ALB	1.93
122	Chorea, benign hereditary	Enrichment	NKX2-1	1.93
123	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	ACADVL	1.93
124	Glycogen storage disease ia	Enrichment	G6PC1	1.93
125	Thyroid cancer, nonmedullary, 1	Enrichment	NKX2-1	1.93
126	Tyrosinemia, type ii	Enrichment	TAT	1.93
127	Dermatitis, atopic	Enrichment	KCNJ11	1.93
128	Neurofibromatosis-noonan syndrome	Enrichment	NF1	1.93
129	Hypoalphalipoproteinemia, primary, 1	Enrichment	APOA1	1.93
130	Kagami-ogata syndrome	Enrichment	DLK1	1.93
131	Temple syndrome	Enrichment	DLK1	1.93
132	Hereditary ataxia	Enrichment	NKX2-1	1.93
133	Embryonal rhabdomyosarcoma	Enrichment	NF1	1.93
134	Pilocytic astrocytoma	Enrichment	NF1	1.93
135	Newborn respiratory distress syndrome	Enrichment	ABCC8	1.93
136	Hydrocephalus, congenital, 2, with or without brain or eye anomalies	Enrichment	ACADM	1.93
137	Coronary artery anomaly	Enrichment	LPL	1.93
138	Vacterl association	Enrichment	FOXF1	1.93
139	Genetic central precocious puberty in male	Enrichment	DLK1	1.93
140	Middle aortic syndrome	Enrichment	NF1	1.93
141	Clear cell papillary renal cell carcinoma	Enrichment	HNF1A	1.93
142	Myeloma, multiple	Enrichment	NF1, NKX2-1	1.93
143	Hyperlipidemia, familial combined, 3	Enrichment	LPL	1.83
144	Amyloidosis, hereditary systemic 2	Enrichment	APOA1	1.83
145	Vater/vacterl association	Enrichment	FOXF1	1.83
146	Congenital myopathy 3 with rigid spine	Enrichment	HMGCS1	1.83
147	Rhabdomyosarcoma 2	Enrichment	NF1	1.83
148	Polyhydramnios	Enrichment	ABCC8	1.83
149	Clear cell renal cell carcinoma	Enrichment	HNF1A	1.76
150	Breast adenocarcinoma	Enrichment	AKT1	1.76
151	Hypertrichosis	Enrichment	KCNJ11	1.76
152	Hypothyroidism, congenital, nongoitrous, 2	Enrichment	NKX2-1	1.69
153	Thrombophilia due to thrombin defect	Enrichment	F2	1.69
154	Hemolytic anemia	Enrichment	PKLR	1.69
155	Breast cancer	Enrichment	AKT1, HNF1A	1.69
156	Gastroesophageal reflux	Enrichment	ABCC8	1.63
157	Ewing sarcoma	Enrichment	NF1	1.63
158	Choreatic disease	Enrichment	NKX2-1	1.63
159	Neurofibromatosis, type i	Enrichment	NF1	1.58
160	Leukemia, acute lymphoblastic 3	Enrichment	NF1	1.58
161	Primary hyperaldosteronism	Enrichment	NR3C1	1.58
162	Ventricular septal defect	Enrichment	FOXF1	1.58
163	Cowden syndrome	Enrichment	AKT1	1.58
164	Stroke, ischemic	Enrichment	F2	1.54
165	Combined immunodeficiency	Enrichment	TFRC	1.50
166	Atrial heart septal defect	Enrichment	ABCC8	1.50
167	Glycogen storage disease	Enrichment	G6PC1	1.50
168	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	1.50
169	Interatrial communication	Enrichment	ABCC8	1.50
170	Combined t and b cell immunodeficiency	Enrichment	TFRC	1.50
171	Digeorge syndrome	Enrichment	HNF1A	1.46
172	Juvenile myelomonocytic leukemia	Enrichment	NF1	1.46
173	Meningioma	Enrichment	AKT1	1.46
174	Congenital long qt syndrome	Enrichment	SLC2A2	1.46
175	Ovarian cancer	Enrichment	AKT1, HNF1A	1.45
176	Pheochromocytoma	Enrichment	NF1	1.39
177	Renal cell carcinoma, nonpapillary	Enrichment	HNF1A	1.36
178	Rhabdomyosarcoma	Enrichment	NF1	1.34
179	Polycystic liver disease	Enrichment	HNF4A	1.31
180	Autosomal dominant polycystic liver disease	Enrichment	HNF4A	1.31
181	Cardiomyopathy, dilated, 1a	Enrichment	LPL	1.22
182	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	NF1	1.22
183	Skin disease	Enrichment	NF1	1.20
184	Rasopathy	Enrichment	NF1	1.13
185	Bladder cancer	Enrichment	NF1	1.09
186	Differentiated thyroid carcinoma	Enrichment	NKX2-1	1.09
187	Long qt syndrome 1	Enrichment	SLC2A2	1.07
188	Cerebral palsy	Enrichment	F2	0.96
189	Myopathy	Enrichment	ACADVL	0.95
190	Charcot-marie-tooth disease	Enrichment	TTR	0.94
191	Gastric cancer	Enrichment	NF1	0.92
192	Hereditary breast carcinoma	Enrichment	AKT1	0.91
193	Body mass index quantitative trait locus 11	Enrichment	UCP2	0.86
194	Hereditary breast ovarian cancer syndrome	Enrichment	NF1	0.82
195	Primary ovarian insufficiency	Enrichment	AFP	0.80
196	Colorectal cancer	Enrichment	AKT1	0.64
197	Autism spectrum disorder	Enrichment	NF1	0.56
198	Inherited cancer-predisposing syndrome	Enrichment	NF1	0.49

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

FOXA2 and FOXA3 transcription factor networks

Pathway Network for FOXA2 and FOXA3 transcription factor networks

Member Pathways for FOXA2 and FOXA3 transcription factor networks

Pathways in the FOXA2 and FOXA3 transcription factor networks SuperPath

Associated Genes for FOXA2 and FOXA3 transcription factor networks

Associated Disorders for FOXA2 and FOXA3 transcription factor networks

Disorders associated with FOXA2 and FOXA3 transcription factor networks SuperPath

STRING Interaction Network for FOXA2 and FOXA3 transcription factor networks

Sources for FOXA2 and FOXA3 transcription factor networks