FOXO-mediated transcription

Pathway network for the FOXO-mediated transcription SuperPath

Sources:

Reactome

Pathways in the FOXO-mediated transcription SuperPath

#	Name	Source	Genes
1	FOXO-mediated transcription	Reactome	ABCA6 AGRP AKT1 AKT2 AKT3 ATXN3 BBC3 BCL2L11 BCL6 BTG1 CAT CAV1 CCNG2 CDKN1A CDKN1B CITED2 CREBBP DDIT3 EP300 FBXO32 FOXG1 FOXO1 FOXO3 FOXO4 G6PC1 GADD45A GCK HDAC1 HDAC2 IGFBP1 INS KAT2B KLF4 MSTN NFYA NFYB NFYC NPY NR3C1 PCBP4 PCK1 PINK1 PLXNA4 POMC PPARGC1A RBL2 RETN SFN SIN3A SIRT1 SIRT3 SMAD2 SMAD3 SMAD4 SOD2 SREBF1 STK11 TRIM63 TXN TXNIP YWHAB YWHAG YWHAQ YWHAZ (see all 64) (see less)
2	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Reactome	ABCA6 AGRP ATXN3 CAT FBXO32 FOXO1 FOXO3 FOXO4 G6PC1 GCK HDAC1 HDAC2 IGFBP1 INS NPY NR3C1 PCK1 PLXNA4 POMC PPARGC1A RETN SIN3A SIRT3 SMAD2 SMAD3 SMAD4 SOD2 SREBF1 TRIM63 (see all 29) (see less)
3	FOXO-mediated transcription of cell cycle genes	Reactome	BTG1 CAV1 CCNG2 CDKN1A CDKN1B FOXG1 FOXO1 FOXO3 FOXO4 GADD45A KLF4 MSTN PCBP4 RBL2 SMAD2 SMAD3 SMAD4 (see all 17) (see less)
4	FOXO-mediated transcription of cell death genes	Reactome	BBC3 BCL2L11 BCL6 CITED2 CREBBP DDIT3 EP300 FOXO1 FOXO3 FOXO4 NFYA NFYB NFYC PINK1 STK11 (see all 15) (see less)
5	Regulation of localization of FOXO transcription factors	Reactome	AKT1 AKT2 AKT3 FOXO1 FOXO3 FOXO4 SFN YWHAB YWHAG YWHAQ YWHAZ (see all 11) (see less)
6	Regulation of FOXO transcriptional activity by acetylation	Reactome	CREBBP EP300 FOXO1 FOXO3 FOXO4 KAT2B SIRT1 SIRT3 TXN TXNIP (see all 10) (see less)

Gene overlap in member pathways for FOXO-mediated transcription SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FOXO1	Forkhead Box O1	Protein Coding	6
2	FOXO3	Forkhead Box O3	Protein Coding	6
3	FOXO4	Forkhead Box O4	Protein Coding	6
4	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	3
5	EP300	EP300 Lysine Acetyltransferase	Protein Coding	3
6	SIRT3	Sirtuin 3	Protein Coding	3
7	SMAD2	SMAD Family Member 2	Protein Coding	3
8	SMAD3	SMAD Family Member 3	Protein Coding	3
9	SMAD4	SMAD Family Member 4	Protein Coding	3
10	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
11	BCL2L11	BCL2 Like 11	Protein Coding	2
12	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	2
13	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	2
14	CITED2	Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 2	Protein Coding	2
15	TXNIP	Thioredoxin Interacting Protein	Protein Coding	2
16	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	2
17	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	2
18	FBXO32	F-Box Protein 32	Protein Coding	2
19	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	2
20	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	2
21	AGRP	Agouti Related Neuropeptide	Protein Coding	2
22	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
23	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
24	FOXG1	Forkhead Box G1	Protein Coding	2
25	SIRT1	Sirtuin 1	Protein Coding	2
26	ABCA6	ATP Binding Cassette Subfamily A Member 6	Protein Coding	2
27	G6PC1	Glucose-6-Phosphatase Catalytic Subunit 1	Protein Coding	2
28	SIN3A	SIN3 Transcription Regulator Family Member A	Protein Coding	2
29	GCK	Glucokinase	Protein Coding	2
30	MSTN	Myostatin	Protein Coding	2
31	BBC3	BCL2 Binding Component 3	Protein Coding	2
32	SFN	Stratifin	Protein Coding	2
33	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	2
34	HDAC1	Histone Deacetylase 1	Protein Coding	2
35	HDAC2	Histone Deacetylase 2	Protein Coding	2
36	IGFBP1	Insulin Like Growth Factor Binding Protein 1	Protein Coding	2
37	INS	Insulin	Protein Coding	2
38	ATXN3	Ataxin 3	Protein Coding	2
39	NFYA	Nuclear Transcription Factor Y Subunit Alpha	Protein Coding	2
40	NFYB	Nuclear Transcription Factor Y Subunit Beta	Protein Coding	2
41	NFYC	Nuclear Transcription Factor Y Subunit Gamma	Protein Coding	2
42	NPY	Neuropeptide Y	Protein Coding	2
43	PCK1	Phosphoenolpyruvate Carboxykinase 1	Protein Coding	2
44	POMC	Proopiomelanocortin	Protein Coding	2
45	RETN	Resistin	Protein Coding	2
46	PCBP4	Poly(RC) Binding Protein 4	Protein Coding	2
47	RBL2	RB Transcriptional Corepressor Like 2	Protein Coding	2
48	BCL6	BCL6 Transcription Repressor	Protein Coding	2
49	PINK1	PTEN Induced Kinase 1	Protein Coding	2
50	SOD2	Superoxide Dismutase 2	Protein Coding	2
51	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	2
52	STK11	Serine/Threonine Kinase 11	Protein Coding	2
53	BTG1	BTG Anti-Proliferation Factor 1	Protein Coding	2
54	TXN	Thioredoxin	Protein Coding	2
55	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	2
56	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	2
57	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	2
58	TRIM63	Tripartite Motif Containing 63	Protein Coding	2
59	CAT	Catalase	Protein Coding	2
60	CAV1	Caveolin 1	Protein Coding	2
61	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	2
62	CCNG2	Cyclin G2	Protein Coding	2
63	PLXNA4	Plexin A4	Protein Coding	2
64	KLF4	KLF Transcription Factor 4	Protein Coding	2

Disorders associated with FOXO-mediated transcription SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	5.14
2	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	5.14
3	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4	4.68
4	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	4.51
5	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	4.29
6	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3	4.28
7	Diffuse large b-cell lymphoma	Enrichment	CREBBP, FOXO1	4.08
8	Permanent neonatal diabetes mellitus	Enrichment	GCK, INS	3.91
9	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4, STK11	3.66
10	Diabetes mellitus	Enrichment	GCK, INS	3.62
11	Menke-hennekam syndrome 1	Enrichment	CREBBP	3.13
12	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	3.13
13	Menke-hennekam syndrome	Enrichment	CREBBP	3.13
14	Proteus syndrome	Enrichment	AKT1	3.09
15	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	3.09
16	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	3.09
17	Cowden syndrome 6	Enrichment	AKT1	3.09
18	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	3.09
19	Capillary hemangioma	Enrichment	AKT3	3.09
20	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	3.09
21	Maturity-onset diabetes of the young	Enrichment	GCK, INS	3.09
22	Type 2 diabetes mellitus	Enrichment	AKT2, GCK, RETN	3.00
23	Atrial septal defect 8	Enrichment	CITED2	2.96
24	Sinus venosus atrial septal defect	Enrichment	CITED2	2.96
25	Intestinal polyposis syndrome	Enrichment	STK11	2.96
26	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.90
27	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.90
28	Brunet-wagner neurodevelopmental syndrome	Enrichment	RBL2	2.90
29	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.90
30	Neuroendocrine tumor	Enrichment	CDKN1B	2.90
31	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.90
32	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.90
33	Heritable thoracic aortic disease	Enrichment	SMAD4	2.90
34	Foxg1 syndrome due to intragenic alteration	Enrichment	FOXG1	2.90
35	Foxg1 syndrome due to 14q12 microdeletion	Enrichment	FOXG1	2.90
36	Thumb deformity	Enrichment	CREBBP	2.83
37	Menke-hennekam syndrome 2	Enrichment	EP300	2.83
38	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.83
39	Senior-loken syndrome 7	Enrichment	AKT3	2.79
40	Bardet-biedl syndrome 16	Enrichment	AKT3	2.79
41	Phosphoenolpyruvate carboxykinase deficiency, cytosolic	Enrichment	PCK1	2.67
42	Microvascular complications of diabetes 6	Enrichment	SOD2	2.67
43	Maturity-onset diabetes of the young, type 2	Enrichment	GCK	2.67
44	Mucoepithelial dysplasia, hereditary	Enrichment	SREBF1	2.67
45	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.67
46	Cardiomyopathy, familial hypertrophic, 31	Enrichment	TRIM63	2.67
47	Ifap syndrome 2	Enrichment	SREBF1	2.67
48	Hyperinsulinemic hypoglycemia, familial, 3	Enrichment	GCK	2.67
49	Acatalasemia	Enrichment	CAT	2.67
50	Gestational diabetes	Enrichment	GCK	2.67
51	Chromosome 15q24 deletion syndrome	Enrichment	SIN3A	2.67
52	Tethered spinal cord syndrome	Enrichment	CREBBP	2.66
53	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.66
54	Peutz-jeghers syndrome	Enrichment	STK11	2.66
55	Intravascular large b-cell lymphoma	Enrichment	BCL6	2.66
56	Ventricular septal defect 2	Enrichment	CITED2	2.66
57	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6	2.66
58	Myhre syndrome	Enrichment	SMAD4	2.60
59	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.60
60	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.60
61	Muscle hypertrophy	Enrichment	MSTN	2.60
62	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.60
63	Myostatin-related muscle hypertrophy	Enrichment	MSTN	2.60
64	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.49
65	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.49
66	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	2.49
67	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL6	2.48
68	Testicular germ cell cancer	Enrichment	STK11	2.48
69	Myxoid liposarcoma	Enrichment	DDIT3	2.48
70	Testicular cancer	Enrichment	STK11	2.48
71	Apc-associated polyposis conditions	Enrichment	STK11	2.48
72	Rhabdomyosarcoma 2	Enrichment	FOXO1	2.43
73	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.43
74	Juvenile polyposis syndrome	Enrichment	SMAD4	2.43
75	Loeys-dietz syndrome 1	Enrichment	SMAD2	2.43
76	Hemimegalencephaly	Enrichment	AKT3	2.39
77	Maturity-onset diabetes of the young, type 1	Enrichment	GCK	2.37
78	Galactosemia ii	Enrichment	NR3C1	2.37
79	Diabetes mellitus, permanent neonatal, 1	Enrichment	GCK	2.37
80	Bone marrow failure syndrome 2	Enrichment	GCK	2.37
81	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.37
82	Hyperproinsulinemia	Enrichment	INS	2.37
83	Witteveen-kolk syndrome	Enrichment	SIN3A	2.37
84	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.37
85	Hypertrichosis	Enrichment	CREBBP	2.35
86	Breast adenocarcinoma	Enrichment	AKT1	2.31
87	Aortic aneurysm	Enrichment	SMAD3	2.30
88	Primary hyperparathyroidism	Enrichment	CDKN1B	2.30
89	Body mass index quantitative trait locus 11	Enrichment	AGRP, POMC	2.29
90	Familial adenomatous polyposis 1	Enrichment	STK11	2.26
91	Follicular lymphoma	Enrichment	BCL6	2.26
92	Megacolon	Enrichment	AKT3	2.25
93	Pancreatic cancer	Enrichment	SMAD4, STK11	2.21
94	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	2.20
95	Type 1 diabetes mellitus 2	Enrichment	INS	2.19
96	Nijmegen breakage syndrome	Enrichment	GCK	2.19
97	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	SREBF1	2.19
98	Obesity, early-onset, with adrenal insufficiency and red hair	Enrichment	POMC	2.19
99	Phosphoenolpyruvate carboxykinase deficiency	Enrichment	PCK1	2.19
100	Obesity due to pro-opiomelanocortin deficiency	Enrichment	POMC	2.19
101	Charge syndrome	Enrichment	EP300	2.18
102	Testicular germ cell tumor	Enrichment	STK11	2.18
103	Parkinson disease 6, autosomal recessive early-onset	Enrichment	PINK1	2.18
104	Cowden syndrome	Enrichment	AKT1	2.14
105	Limited scleroderma	Enrichment	CAV1	2.13
106	Colorectal cancer	Enrichment	AKT1, EP300, SMAD4	2.10
107	Polymicrogyria	Enrichment	AKT3	2.09
108	Glycogen storage disease ia	Enrichment	G6PC1	2.07
109	Maturity-onset diabetes of the young, type 3	Enrichment	GCK	2.07
110	Neonatal diabetes mellitus	Enrichment	INS	2.07
111	Rett syndrome	Enrichment	FOXG1	2.06
112	Gallbladder cancer	Enrichment	SMAD4	2.06
113	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	2.06
114	Specific learning disability	Enrichment	YWHAG	2.05
115	Meningioma	Enrichment	AKT1	2.01
116	Rett syndrome, congenital variant	Enrichment	FOXG1	2.00
117	Heart disease	Enrichment	CREBBP	1.99
118	Hypoglycemia	Enrichment	G6PC1	1.97
119	Melanoma	Enrichment	STK11	1.96
120	Polydactyly, postaxial, type a1	Enrichment	EP300	1.96
121	Corpus callosum, agenesis of	Enrichment	CREBBP	1.96
122	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.96
123	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.96
124	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.95
125	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, SMAD4	1.93
126	Optic nerve disease	Enrichment	FOXG1	1.90
127	Machado-joseph disease	Enrichment	ATXN3	1.89
128	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	GCK	1.89
129	Type 1 diabetes mellitus	Enrichment	INS	1.89
130	Nonsyndromic genetic hyperinsulinism	Enrichment	GCK	1.89
131	Early-onset parkinson's disease	Enrichment	PINK1	1.88
132	Lip and oral cavity carcinoma	Enrichment	STK11	1.88
133	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.86
134	Stereotypic movement disorder	Enrichment	FOXG1	1.79
135	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.76
136	Gastric cancer	Enrichment	SMAD4, STK11	1.76
137	Scoliosis	Enrichment	CREBBP	1.76
138	Melanoma, cutaneous malignant 1	Enrichment	STK11	1.73
139	Primary hyperaldosteronism	Enrichment	NR3C1	1.72
140	Patent foramen ovale	Enrichment	CITED2	1.70
141	Isolated congenital microcephaly	Enrichment	FOXG1	1.70
142	Glycogen storage disease	Enrichment	G6PC1	1.63
143	Ehlers-danlos syndrome	Enrichment	SMAD3	1.63
144	Lissencephaly	Enrichment	FOXG1	1.58
145	Tetralogy of fallot	Enrichment	CITED2	1.55
146	Undetermined early-onset epileptic encephalopathy	Enrichment	FOXG1, YWHAG	1.54
147	Strabismus	Enrichment	FOXG1	1.48
148	Visceral heterotaxy 5	Enrichment	CITED2	1.47
149	Hereditary breast carcinoma	Enrichment	AKT1	1.45
150	Bladder cancer	Enrichment	CDKN1A	1.45
151	Connective tissue disease	Enrichment	SMAD3	1.40
152	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	1.40
153	Parkinson's disease	Enrichment	ATXN3	1.40
154	Myeloma, multiple	Enrichment	CREBBP	1.39
155	Parkinson disease, late-onset	Enrichment	ATXN3	1.30
156	Autism	Enrichment	CREBBP	1.29
157	Thrombocytopenia	Enrichment	SMAD4	1.23
158	Breast cancer	Enrichment	AKT1	1.23
159	Hirschsprung disease 1	Enrichment	SREBF1	1.22
160	Congenital nervous system abnormality	Enrichment	CREBBP	1.12
161	Nervous system disease	Enrichment	CREBBP	1.12
162	Ovarian cancer	Enrichment	AKT1	1.10
163	Microcephaly	Enrichment	EP300	1.06
164	Hypertrophic cardiomyopathy	Enrichment	TRIM63	1.06
165	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	0.93

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

FOXO-mediated transcription

Pathway Network for FOXO-mediated transcription

Pathway network for the FOXO-mediated transcription SuperPath

Member Pathways for FOXO-mediated transcription

Pathways in the FOXO-mediated transcription SuperPath

Gene overlap in member pathways for FOXO-mediated transcription SuperPath

Associated Genes for FOXO-mediated transcription

Associated Disorders for FOXO-mediated transcription

Disorders associated with FOXO-mediated transcription SuperPath

STRING Interaction Network for FOXO-mediated transcription

Sources for FOXO-mediated transcription