FoxO family signaling

No Pathway Network information available for FoxO family signaling

Pathways in the FoxO family signaling SuperPath

#	Name	Source	Genes
1	FoxO family signaling	PubChem	AKT1 BCL2L11 BCL6 CAT CCNB1 CDK2 CDKN1B CHUK CTNNB1 FASLG FBXO32 FOXO1 FOXO3 FOXO4 G6PC1 GADD45A IKBKB KAT2B MAPK8 MST1 PLK1 RAN RBL2 SFN SGK1 SIRT1 SKP2 SOD2 USP7 XPO1 ZFAND5 (see all 31) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ZFAND5	Zinc Finger AN1-Type Containing 5	Protein Coding	1
2	FBXO32	F-Box Protein 32	Protein Coding	1
3	BCL6	BCL6 Transcription Repressor	Protein Coding	1
4	FOXO4	Forkhead Box O4	Protein Coding	1
5	RBL2	RB Transcriptional Corepressor Like 2	Protein Coding	1
6	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
7	SOD2	Superoxide Dismutase 2	Protein Coding	1
8	BCL2L11	BCL2 Like 11	Protein Coding	1
9	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
10	FASLG	Fas Ligand	Protein Coding	1
11	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
12	SGK1	Serum/Glucocorticoid Regulated Kinase 1	Protein Coding	1
13	XPO1	Exportin 1	Protein Coding	1
14	MST1	Macrophage Stimulating 1	Protein Coding	1
15	USP7	Ubiquitin Specific Peptidase 7	Protein Coding	1
16	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
17	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
18	RAN	RAN, Member RAS Oncogene Family	Protein Coding	1
19	G6PC1	Glucose-6-Phosphatase Catalytic Subunit 1	Protein Coding	1
20	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
21	CTNNB1	Catenin Beta 1	Protein Coding	1
22	SIRT1	Sirtuin 1	Protein Coding	1
23	FOXO3	Forkhead Box O3	Protein Coding	1
24	FOXO1	Forkhead Box O1	Protein Coding	1
25	PLK1	Polo Like Kinase 1	Protein Coding	1
26	SFN	Stratifin	Protein Coding	1
27	SKP2	S-Phase Kinase Associated Protein 2	Protein Coding	1
28	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
29	CCNB1	Cyclin B1	Protein Coding	1
30	CAT	Catalase	Protein Coding	1
31	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1

Disorders associated with FoxO family signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6, XPO1	5.30
2	Ovarian cancer	Enrichment	AKT1, CDKN1B, CTNNB1	2.81
3	Proteus syndrome	Enrichment	AKT1	2.64
4	Microvascular complications of diabetes 6	Enrichment	SOD2	2.64
5	Fetal encasement syndrome	Enrichment	CHUK	2.64
6	Immunodeficiency 15b	Enrichment	IKBKB	2.64
7	Brunet-wagner neurodevelopmental syndrome	Enrichment	RBL2	2.64
8	Immunodeficiency 15a	Enrichment	IKBKB	2.64
9	Neuroendocrine tumor	Enrichment	CDKN1B	2.64
10	Acatalasemia	Enrichment	CAT	2.64
11	Cowden syndrome 6	Enrichment	AKT1	2.64
12	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.64
13	Adenoid ameloblastoma	Enrichment	CTNNB1	2.64
14	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.64
15	Microcystic stromal tumor	Enrichment	CTNNB1	2.64
16	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.34
17	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.34
18	Intravascular large b-cell lymphoma	Enrichment	BCL6	2.34
19	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.34
20	Hao-fountain syndrome	Enrichment	USP7	2.34
21	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.34
22	Teratoma	Enrichment	CTNNB1	2.34
23	Desmoid disease, hereditary	Enrichment	CTNNB1	2.16
24	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	2.16
25	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.16
26	Anus, imperforate	Enrichment	CTNNB1	2.16
27	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.16
28	Desmoid tumor	Enrichment	CTNNB1	2.16
29	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL6	2.16
30	Glycogen storage disease ia	Enrichment	G6PC1	2.04
31	Autoimmune lymphoproliferative syndrome	Enrichment	FASLG	2.04
32	Pilomatrixoma	Enrichment	CTNNB1	2.04
33	Alazami syndrome	Enrichment	CTNNB1	2.04
34	Craniopharyngioma	Enrichment	CTNNB1	2.04
35	Primary hyperparathyroidism	Enrichment	CDKN1B	2.04
36	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.94
37	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.94
38	Cholangitis, primary sclerosing	Enrichment	MST1	1.94
39	Follicular lymphoma	Enrichment	BCL6	1.94
40	Hypoglycemia	Enrichment	G6PC1	1.94
41	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.87
42	Adrenocortical carcinoma	Enrichment	CTNNB1	1.87
43	Breast adenocarcinoma	Enrichment	AKT1	1.87
44	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.80
45	Gallbladder cancer	Enrichment	CTNNB1	1.80
46	Colorectal cancer	Enrichment	AKT1, CTNNB1	1.78
47	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.74
48	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.69
49	Cowden syndrome	Enrichment	AKT1	1.69
50	Glycogen storage disease	Enrichment	G6PC1	1.60
51	Meningioma	Enrichment	AKT1	1.57
52	Medulloblastoma	Enrichment	CTNNB1	1.50
53	Polycystic liver disease	Enrichment	CTNNB1	1.42
54	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.42
55	Diffuse large b-cell lymphoma	Enrichment	FOXO1	1.37
56	Hepatoblastoma	Enrichment	CTNNB1	1.33
57	Hepatocellular carcinoma	Enrichment	CTNNB1	1.31
58	Bladder cancer	Enrichment	CTNNB1	1.19
59	Lung cancer	Enrichment	FASLG	1.15
60	Severe combined immunodeficiency	Enrichment	IKBKB	1.14
61	Hereditary breast carcinoma	Enrichment	AKT1	1.02
62	Myeloma, multiple	Enrichment	SGK1	0.92
63	Breast cancer	Enrichment	AKT1	0.80
64	Congenital nervous system abnormality	Enrichment	CTNNB1	0.67
65	Nervous system disease	Enrichment	CTNNB1	0.67
66	Microcephaly	Enrichment	CTNNB1	0.61
67	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B	0.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

FoxO family signaling

Pathway Network for FoxO family signaling

Member Pathways for FoxO family signaling

Pathways in the FoxO family signaling SuperPath

Associated Genes for FoxO family signaling

Associated Disorders for FoxO family signaling

Disorders associated with FoxO family signaling SuperPath

STRING Interaction Network for FoxO family signaling

Sources for FoxO family signaling