Fructose metabolism

Pathway network for the Fructose metabolism SuperPath

Sources:

Reactome
WikiPathways
PubChem

Pathways in the Fructose metabolism SuperPath

#	Name	Source	Genes
1	Fructose metabolism	Reactome	AKR1B1 ALDH1A1 ALDOB GLYCTK KHK SORD TKFC (see all 7) (see less)
2	Disorders of fructose metabolism	WikiPathways	ALDH1A1 ALDOB FBP1 G6PC1 GLYCTK GPI HK1 KHK PFKL PGM1 SLC2A2 SLC5A1 SORD TPI1 (see all 14) (see less)
3	Fructose catabolism	Reactome	ALDH1A1 ALDOB GLYCTK KHK TKFC
4	Polyol pathway	WikiPathways	AKR1B1 ALDOB KHK SORD
5	Fructose biosynthesis	Reactome	AKR1B1 SORD
6	methylglyoxal degradation III	PubChem	AKR1B1
7	Glycogen storage disease type Ia (G6PC)	Reactome	G6PC1
8	sorbitol degradation I	PubChem	SORD
9	Hereditary fructose intolerance	Reactome	ALDOB

Gene overlap in member pathways for Fructose metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ALDOB	Aldolase, Fructose-Bisphosphate B	Protein Coding	5
2	SORD	Sorbitol Dehydrogenase	Protein Coding	5
3	AKR1B1	Aldo-Keto Reductase Family 1 Member B	Protein Coding	4
4	KHK	Ketohexokinase	Protein Coding	4
5	GLYCTK	Glycerate Kinase	Protein Coding	3
6	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	3
7	TKFC	Triokinase And FMN Cyclase	Protein Coding	2
8	G6PC1	Glucose-6-Phosphatase Catalytic Subunit 1	Protein Coding	2
9	PFKL	Phosphofructokinase, Liver Type	Protein Coding	1
10	TPI1	Triosephosphate Isomerase 1	Protein Coding	1
11	SLC5A1	Solute Carrier Family 5 Member 1	Protein Coding	1
12	SLC2A2	Solute Carrier Family 2 Member 2	Protein Coding	1
13	PGM1	Phosphoglucomutase 1	Protein Coding	1
14	HK1	Hexokinase 1	Protein Coding	1
15	GPI	Glucose-6-Phosphate Isomerase	Protein Coding	1
16	FBP1	Fructose-Bisphosphatase 1	Protein Coding	1

Disorders associated with Fructose metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Glycogen storage disease ia	Direct
2	Fructose intolerance, hereditary	Direct
3	Neuronopathy, distal hereditary motor, autosomal recessive 8	Enrichment	SORD	4.13
4	Fructosuria, essential	Enrichment	KHK	3.53
5	D-glyceric aciduria	Enrichment	GLYCTK	3.43
6	Triokinase and fmn cyclase deficiency syndrome	Enrichment	TKFC	3.43
7	Inherited metabolic disorder	Enrichment	TKFC	3.43
8	Anemia, congenital, nonspherocytic hemolytic, 5	Enrichment	HK1	2.99
9	Fructose-1,6-bisphosphatase deficiency	Enrichment	FBP1	2.99
10	Triosephosphate isomerase deficiency	Enrichment	TPI1	2.99
11	Retinitis pigmentosa 79	Enrichment	HK1	2.99
12	Glucose/galactose malabsorption	Enrichment	SLC5A1	2.99
13	Neuropathy, hereditary motor and sensory, russe type	Enrichment	HK1	2.99
14	Neurodevelopmental disorder with visual defects and brain anomalies	Enrichment	HK1	2.99
15	Anemia, congenital, nonspherocytic hemolytic, 4	Enrichment	GPI	2.99
16	Sengers syndrome	Enrichment	TKFC	2.96
17	Neuromuscular disease	Enrichment	SORD	2.88
18	Fanconi-bickel syndrome	Enrichment	SLC2A2	2.69
19	Congenital disorder of glycosylation, type it	Enrichment	PGM1	2.69
20	Renal glucosuria	Enrichment	SLC5A1	2.38
21	Hypoglycemia	Enrichment	G6PC1	2.29
22	Hereditary spherocytosis	Enrichment	GPI	2.21
23	Hemolytic anemia	Enrichment	GPI	2.14
24	Glycogen storage disease	Enrichment	G6PC1	1.95
25	Congenital long qt syndrome	Enrichment	SLC2A2	1.91
26	Congenital disorder of glycosylation, type in	Enrichment	PGM1	1.76
27	Long qt syndrome 1	Enrichment	SLC2A2	1.52
28	Type 2 diabetes mellitus	Enrichment	SLC2A2	1.37
29	Autism spectrum disorder	Enrichment	HK1	0.97
30	Retinitis pigmentosa	Enrichment	HK1	0.70
31	Hereditary retinal dystrophy	Enrichment	HK1	0.58
32	Fundus dystrophy	Enrichment	HK1	0.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Fructose metabolism

Pathway Network for Fructose metabolism

Pathway network for the Fructose metabolism SuperPath

Member Pathways for Fructose metabolism

Pathways in the Fructose metabolism SuperPath

Gene overlap in member pathways for Fructose metabolism SuperPath

Associated Genes for Fructose metabolism

Associated Disorders for Fructose metabolism

Disorders associated with Fructose metabolism SuperPath

STRING Interaction Network for Fructose metabolism

Sources for Fructose metabolism