FTO obesity variant mechanism

No Pathway Network information available for FTO obesity variant mechanism

#	Name	Source	Genes
1	FTO obesity variant mechanism	WikiPathways	ARID5B FTO IRX3 IRX5 PPARGC1A PRDM16 TBX1 UCP1 (see all 8) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ARID5B	AT-Rich Interaction Domain 5B	Protein Coding	1
2	IRX3	Iroquois Homeobox 3	Protein Coding	1
3	FTO	FTO Alpha-Ketoglutarate Dependent Dioxygenase	Protein Coding	1
4	UCP1	Uncoupling Protein 1	Protein Coding	1
5	TBX1	T-Box Transcription Factor 1	Protein Coding	1
6	PRDM16	PR/SET Domain 16	Protein Coding	1
7	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
8	IRX5	Iroquois Homeobox 5	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Velocardiofacial syndrome	Enrichment	TBX1	3.23
2	Left ventricular noncompaction 8	Enrichment	PRDM16	3.23
3	Growth retardation, developmental delay, and facial dysmorphism	Enrichment	FTO	3.23
4	Body mass index quantitative trait locus 14	Enrichment	FTO	3.23
5	Chromosome 22q11.2 duplication syndrome	Enrichment	TBX1	2.93
6	Hamamy syndrome	Enrichment	IRX5	2.93
7	Craniofacial dysplasia - osteopenia syndrome	Enrichment	IRX5	2.93
8	Kbg syndrome	Enrichment	TBX1	2.53
9	Persistent truncus arteriosus	Enrichment	TBX1	2.53
10	Conotruncal heart malformations	Enrichment	TBX1	2.45
11	Digeorge syndrome	Enrichment	TBX1	2.15
12	Chromosome 1p36 deletion syndrome	Enrichment	PRDM16	2.12
13	Tetralogy of fallot	Enrichment	TBX1	1.82
14	Left ventricular noncompaction	Enrichment	PRDM16	1.69
15	Body mass index quantitative trait locus 11	Enrichment	FTO	1.54
16	Familial isolated dilated cardiomyopathy	Enrichment	PRDM16	1.51
17	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	1.47

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for FTO obesity variant mechanism