G-AlphaQ Signaling

Pathway network for the G-AlphaQ Signaling SuperPath

Sources:

QIAGEN
PubChem

Pathways in the G-AlphaQ Signaling SuperPath

#	Name	Source	Genes
1	G-AlphaQ Signaling	QIAGEN	AKT1 AKT2 AKT3 ARAF ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 BRAF BTK CALM1 CALM2 CALM3 CHUK CSK DIRAS3 ELK1 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GPLD1 GRB2 GRK2 GSK3B GYS1 GYS2 HRAS IKBKB IKBKE IKBKG ITPR1 ITPR2 ITPR3 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MCF2L MRAS NET1 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA NFKBIB NFKBIE NRAS PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PLCG1 PLCG2 PLD1 PLD2 PLD3 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PTK2B RAF1 RGS1 RGS10 RGS11 RGS12 RGS13 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS21 RGS22 RGS3 RGS4 RGS5 RGS6 RGS7 RGS8 RGS9 RHOA RHOB RHOC RHOD RHOG RHOH RND2 RND3 ROCK1 ROCK2 RRAS RRAS2 SOS1 SOS2 (see all 142) (see less)
2	Thrombin Signaling	QIAGEN	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKT1 AKT2 AKT3 ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 CAMK1 CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 DIRAS3 EGF EGFR ELK1 F2 F2R F2RL2 F2RL3 FYN GATA1 GATA2 GATA3 GATA4 GATA5 GATA6 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 HRAS IKBKB ITPR1 ITPR2 ITPR3 KRAS MAP2K1 MAP2K2 MAPK11 MAPK12 MAPK13 MAPK14 MRAS MYL9 MYLK NET1 NFKB1 NRAS PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PPP1R12A PPP1R12B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PTK2 PTK2B RAF1 RHOA RHOB RHOC RHOD RHOG RHOH RND2 RND3 ROCK1 ROCK2 RPS6KB1 RRAS RRAS2 SLC2A4 SRC TBP (see all 143) (see less)
3	G-AlphaI Signaling	QIAGEN	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 BRAF CAV1 DIRAS3 ELK1 GNAI1 GNAI2 GNAI3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 HRAS KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MCF2L MRAS NET1 NRAS PPP1CB PPP1R12A PPP1R12B PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAF1 RAP1A RAP1GAP RGS1 RGS10 RGS11 RGS12 RGS13 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS21 RGS22 RGS3 RGS4 RGS5 RGS6 RGS7 RGS8 RGS9 RHOA RHOB RHOC RHOD RHOG RHOH RND2 RND3 ROCK1 ROCK2 RRAS RRAS2 SOS1 SOS2 SRC STAT3 (see all 107) (see less)
4	PAR4-mediated thrombin signaling events	PubChem	F2 F2RL2 F2RL3 GNA13 GNB1 GNG2 MYL2 PLCB2 RHOA ROCK1 (see all 10) (see less)

Gene overlap in member pathways for G-AlphaQ Signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RHOA	Ras Homolog Family Member A	Protein Coding	4
2	GNB1	G Protein Subunit Beta 1	Protein Coding	4
3	GNG2	G Protein Subunit Gamma 2	Protein Coding	4
4	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	4
5	RHOB	Ras Homolog Family Member B	Protein Coding	3
6	RHOC	Ras Homolog Family Member C	Protein Coding	3
7	RHOD	Ras Homolog Family Member D	Protein Coding	3
8	RND3	Rho Family GTPase 3	Protein Coding	3
9	RHOG	Ras Homolog Family Member G	Protein Coding	3
10	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	3
11	ARHGEF10	Rho Guanine Nucleotide Exchange Factor 10	Protein Coding	3
12	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	3
13	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	3
14	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	3
15	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	3
16	ARHGEF4	Rho Guanine Nucleotide Exchange Factor 4	Protein Coding	3
17	ARHGEF5	Rho Guanine Nucleotide Exchange Factor 5	Protein Coding	3
18	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	3
19	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	3
20	ARHGEF9	Cdc42 Guanine Nucleotide Exchange Factor 9	Protein Coding	3
21	RHOH	Ras Homolog Family Member H	Protein Coding	3
22	DIRAS3	DIRAS Family GTPase 3	Protein Coding	3
23	RND2	Rho Family GTPase 2	Protein Coding	3
24	ELK1	ETS Transcription Factor ELK1	Protein Coding	3
25	GNB2	G Protein Subunit Beta 2	Protein Coding	3
26	GNB3	G Protein Subunit Beta 3	Protein Coding	3
27	GNB4	G Protein Subunit Beta 4	Protein Coding	3
28	GNB5	G Protein Subunit Beta 5	Protein Coding	3
29	GNG10	G Protein Subunit Gamma 10	Protein Coding	3
30	GNG11	G Protein Subunit Gamma 11	Protein Coding	3
31	GNG12	G Protein Subunit Gamma 12	Protein Coding	3
32	GNG13	G Protein Subunit Gamma 13	Protein Coding	3
33	GNG3	G Protein Subunit Gamma 3	Protein Coding	3
34	GNG4	G Protein Subunit Gamma 4	Protein Coding	3
35	GNG5	G Protein Subunit Gamma 5	Protein Coding	3
36	GNG7	G Protein Subunit Gamma 7	Protein Coding	3
37	GNG8	G Protein Subunit Gamma 8	Protein Coding	3
38	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	3
39	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	3
40	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
41	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
42	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	3
43	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	3
44	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	3
45	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	3
46	NET1	Neuroepithelial Cell Transforming 1	Protein Coding	3
47	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	3
48	PLCB2	Phospholipase C Beta 2	Protein Coding	3
49	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	3
50	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	3
51	RRAS	RAS Related	Protein Coding	3
52	RRAS2	RAS Related 2	Protein Coding	3
53	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
54	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
55	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
56	ARHGEF15	Rho Guanine Nucleotide Exchange Factor 15	Protein Coding	2
57	ARHGEF16	Rho Guanine Nucleotide Exchange Factor 16	Protein Coding	2
58	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
59	RGS22	Regulator Of G Protein Signaling 22	Protein Coding	2
60	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
61	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	2
62	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	2
63	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	2
64	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
65	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
66	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	2
67	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
68	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
69	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
70	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
71	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	2
72	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	2
73	PLCB1	Phospholipase C Beta 1	Protein Coding	2
74	PLCB3	Phospholipase C Beta 3	Protein Coding	2
75	PLCB4	Phospholipase C Beta 4	Protein Coding	2
76	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
77	PLCG2	Phospholipase C Gamma 2	Protein Coding	2
78	PRKCA	Protein Kinase C Alpha	Protein Coding	2
79	PRKCB	Protein Kinase C Beta	Protein Coding	2
80	PRKCD	Protein Kinase C Delta	Protein Coding	2
81	PRKCE	Protein Kinase C Epsilon	Protein Coding	2
82	PRKCG	Protein Kinase C Gamma	Protein Coding	2
83	PRKCH	Protein Kinase C Eta	Protein Coding	2
84	PRKCI	Protein Kinase C Iota	Protein Coding	2
85	PRKD1	Protein Kinase D1	Protein Coding	2
86	PRKD3	Protein Kinase D3	Protein Coding	2
87	PRKCQ	Protein Kinase C Theta	Protein Coding	2
88	PRKCZ	Protein Kinase C Zeta	Protein Coding	2
89	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	2
90	RGS1	Regulator Of G Protein Signaling 1	Protein Coding	2
91	RGS10	Regulator Of G Protein Signaling 10	Protein Coding	2
92	RGS11	Regulator Of G Protein Signaling 11	Protein Coding	2
93	RGS12	Regulator Of G Protein Signaling 12	Protein Coding	2
94	RGS13	Regulator Of G Protein Signaling 13	Protein Coding	2
95	RGS14	Regulator Of G Protein Signaling 14	Protein Coding	2
96	RGS16	Regulator Of G Protein Signaling 16	Protein Coding	2
97	RGS17	Regulator Of G Protein Signaling 17	Protein Coding	2
98	RGS18	Regulator Of G Protein Signaling 18	Protein Coding	2
99	RGS19	Regulator Of G Protein Signaling 19	Protein Coding	2
100	RGS2	Regulator Of G Protein Signaling 2	Protein Coding	2
101	RGS20	Regulator Of G Protein Signaling 20	Protein Coding	2
102	RGS21	Regulator Of G Protein Signaling 21	Protein Coding	2
103	RGS3	Regulator Of G Protein Signaling 3	Protein Coding	2
104	RGS4	Regulator Of G Protein Signaling 4	Protein Coding	2
105	RGS5	Regulator Of G Protein Signaling 5	Protein Coding	2
106	RGS6	Regulator Of G Protein Signaling 6	Protein Coding	2
107	RGS7	Regulator Of G Protein Signaling 7	Protein Coding	2
108	RGS8	Regulator Of G Protein Signaling 8	Protein Coding	2
109	RGS9	Regulator Of G Protein Signaling 9	Protein Coding	2
110	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
111	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	2
112	ADCY1	Adenylate Cyclase 1	Protein Coding	2
113	ADCY2	Adenylate Cyclase 2	Protein Coding	2
114	ADCY3	Adenylate Cyclase 3	Protein Coding	2
115	ADCY4	Adenylate Cyclase 4	Protein Coding	2
116	ADCY5	Adenylate Cyclase 5	Protein Coding	2
117	ADCY6	Adenylate Cyclase 6	Protein Coding	2
118	ADCY7	Adenylate Cyclase 7	Protein Coding	2
119	ADCY8	Adenylate Cyclase 8	Protein Coding	2
120	ADCY9	Adenylate Cyclase 9	Protein Coding	2
121	F2	Coagulation Factor II, Thrombin	Protein Coding	2
122	F2RL2	Coagulation Factor II Thrombin Receptor Like 2	Protein Coding	2
123	F2RL3	F2R Like Thrombin Or Trypsin Receptor 3	Protein Coding	2
124	GNA13	G Protein Subunit Alpha 13	Protein Coding	2
125	GNAI1	G Protein Subunit Alpha I1	Protein Coding	2
126	GNAI2	G Protein Subunit Alpha I2	Protein Coding	2
127	GNAI3	G Protein Subunit Alpha I3	Protein Coding	2
128	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	2
129	PPP1R12B	Protein Phosphatase 1 Regulatory Subunit 12B	Protein Coding	2
130	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
131	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	1
132	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
133	BTK	Bruton Tyrosine Kinase	Protein Coding	1
134	CALM1	Calmodulin 1	Protein Coding	1
135	CALM2	Calmodulin 2	Protein Coding	1
136	CALM3	Calmodulin 3	Protein Coding	1
137	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
138	CSK	C-Terminal Src Kinase	Protein Coding	1
139	GPLD1	Glycosylphosphatidylinositol Specific Phospholipase D1	Protein Coding	1
140	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
141	GYS1	Glycogen Synthase 1	Protein Coding	1
142	GYS2	Glycogen Synthase 2	Protein Coding	1
143	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
144	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
145	NFAT5	Nuclear Factor Of Activated T Cells 5	Protein Coding	1
146	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
147	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
148	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	1
149	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	1
150	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
151	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
152	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
153	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
154	PLD1	Phospholipase D1	Protein Coding	1
155	PLD2	Phospholipase D2	Protein Coding	1
156	PLD3	Phospholipase D Family Member 3	Protein Coding	1
157	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
158	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
159	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	1
160	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	1
161	PPP3R2	Protein Phosphatase 3 Regulatory Subunit B, Beta	Protein Coding	1
162	CAMK1	Calcium/Calmodulin Dependent Protein Kinase I	Protein Coding	1
163	CAMK1G	Calcium/Calmodulin Dependent Protein Kinase IG	Protein Coding	1
164	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
165	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
166	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	1
167	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
168	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	1
169	EGF	Epidermal Growth Factor	Protein Coding	1
170	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
171	F2R	Coagulation Factor II Thrombin Receptor	Protein Coding	1
172	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
173	GATA1	GATA Binding Protein 1	Protein Coding	1
174	GATA2	GATA Binding Protein 2~Name Same As:- HGNC:18350	Protein Coding	1
175	GATA3	GATA Binding Protein 3	Protein Coding	1
176	GATA4	GATA Binding Protein 4	Protein Coding	1
177	GATA5	GATA Binding Protein 5	Protein Coding	1
178	GATA6	GATA Binding Protein 6	Protein Coding	1
179	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
180	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
181	GNA14	G Protein Subunit Alpha 14	Protein Coding	1
182	GNA15	G Protein Subunit Alpha 15	Protein Coding	1
183	GNAL	G Protein Subunit Alpha L	Protein Coding	1
184	GNAO1	G Protein Subunit Alpha O1	Protein Coding	1
185	GNAS	GNAS Complex Locus	Protein Coding	1
186	GNAT1	G Protein Subunit Alpha Transducin 1	Protein Coding	1
187	GNAT2	G Protein Subunit Alpha Transducin 2	Protein Coding	1
188	GNAZ	G Protein Subunit Alpha Z	Protein Coding	1
189	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
190	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
191	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
192	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
193	MYL9	Myosin Light Chain 9	Protein Coding	1
194	MYLK	Myosin Light Chain Kinase	Protein Coding	1
195	PLCD1	Phospholipase C Delta 1	Protein Coding	1
196	PLCD3	Phospholipase C Delta 3	Protein Coding	1
197	PLCD4	Phospholipase C Delta 4	Protein Coding	1
198	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1
199	PLCZ1	Phospholipase C Zeta 1	Protein Coding	1
200	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
201	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
202	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	1
203	TBP	TATA-Box Binding Protein	Protein Coding	1
204	CAV1	Caveolin 1	Protein Coding	1
205	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	1
206	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
207	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
208	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
209	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
210	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
211	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	1
212	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	1
213	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
214	RAP1GAP	RAP1 GTPase Activating Protein	Protein Coding	1
215	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
216	MYL2	Myosin Light Chain 2	Protein Coding	1

Disorders associated with G-AlphaQ Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS2, SOS1, SOS2	16.00
2	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	10.79
3	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2, SOS1, SOS2	10.61
4	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.43
5	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.43
6	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS	7.91
7	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	6.90
8	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	6.60
9	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	6.32
10	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.72
11	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	4.79
12	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	4.79
13	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	4.79
14	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	4.79
15	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	4.22
16	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.21
17	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.21
18	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS	4.13
19	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	4.00
20	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	3.96
21	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.74
22	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	3.59
23	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11, PIK3R1	3.48
24	Anastomosing haemangioma	Enrichment	GNA11, GNA14	3.48
25	Cerebral palsy	Enrichment	F2, GNB1	3.45
26	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.44
27	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.44
28	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3R2	3.19
29	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.19
30	Auriculocondylar syndrome 1	Enrichment	GNAI3, PLCB4	3.19
31	Achromatopsia 4	Enrichment	GNAI3, GNAT2	3.19
32	Prothrombin deficiency, congenital	Enrichment	F2	3.13
33	Pregnancy loss, recurrent 2	Enrichment	F2	3.13
34	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	3.13
35	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	3.13
36	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	3.13
37	Prothrombin deficiency	Enrichment	F2	3.13
38	Congenital heart defects, multiple types, 4	Enrichment	GATA4, GATA6	2.97
39	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	2.90
40	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.90
41	Gallbladder cancer	Enrichment	BRAF, KRAS	2.90
42	Cardiomyopathy, familial hypertrophic, 10	Enrichment	MYL2	2.83
43	Myopathy, myofibrillar, 12, infantile-onset, with cardiomyopathy	Enrichment	MYL2	2.83
44	Cerebral visual impairment	Enrichment	GNB1	2.83
45	Breast adenocarcinoma	Enrichment	AKT1, KRAS	2.80
46	Melanoma, uveal	Enrichment	GNA11, PLCB4	2.79
47	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS	2.79
48	Familial atrial fibrillation	Enrichment	GATA4, GATA5, GATA6	2.70
49	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.67
50	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	2.67
51	Cerebral sinovenous thrombosis	Enrichment	F2	2.66
52	Tetralogy of fallot	Enrichment	GATA4, GATA5, GATA6	2.60
53	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	2.57
54	Bladder cancer	Enrichment	EGFR, HRAS, KRAS	2.46
55	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS	2.41
56	Hemihyperplasia, isolated	Enrichment	RHOA	2.35
57	Acute promyelocytic leukemia	Enrichment	PRKAR1A, STAT3	2.34
58	Stroke, ischemic	Enrichment	F2, PRKCH	2.33
59	Thrombophilia due to thrombin defect	Enrichment	F2	2.29
60	Familial isolated restrictive cardiomyopathy	Enrichment	MYL2	2.29
61	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	2.28
62	Glycogen storage disease	Enrichment	GYS1, GYS2	2.25
63	Myelodysplastic syndrome	Enrichment	GATA2, GNB1	2.24
64	Dystonia	Enrichment	CAMK2B, GNAL, GNB1	2.23
65	Hypothyroidism	Enrichment	GNB1	2.23
66	Hypertension, essential	Enrichment	GNB3, RGS5	2.11
67	Dandy-walker syndrome	Enrichment	BRAF, PPP1CB	2.11
68	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.10
69	Oculoectodermal syndrome	Enrichment	KRAS	2.10
70	Developmental and epileptic encephalopathy 8	Enrichment	ARHGEF9	2.10
71	Noonan syndrome 5	Enrichment	RAF1	2.10
72	Noonan syndrome 4	Enrichment	SOS1	2.10
73	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.10
74	Carney complex, type 1	Enrichment	PRKAR1A	2.10
75	Melorheostosis, isolated	Enrichment	MAP2K1	2.10
76	Noonan syndrome 7	Enrichment	BRAF	2.10
77	Leopard syndrome 3	Enrichment	BRAF	2.10
78	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.10
79	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.10
80	Melanosis, neurocutaneous	Enrichment	NRAS	2.10
81	Noonan syndrome 9	Enrichment	SOS2	2.10
82	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	2.10
83	Noonan syndrome 6	Enrichment	NRAS	2.10
84	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.10
85	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.10
86	Ventricular tachycardia, familial	Enrichment	GNAI2	2.10
87	Immunodeficiency 62	Enrichment	ARHGEF1	2.10
88	Noonan syndrome 11	Enrichment	MRAS	2.10
89	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.10
90	Noonan syndrome 13	Enrichment	MAPK1	2.10
91	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.10
92	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	2.10
93	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	2.10
94	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.10
95	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.10
96	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.10
97	Myxoma, intracardiac	Enrichment	PRKAR1A	2.10
98	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.10
99	Slowed nerve conduction velocity, autosomal dominant	Enrichment	ARHGEF10	2.10
100	Prolonged electroretinal response suppression 1	Enrichment	RGS9	2.10
101	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.10
102	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	2.10
103	Lymphangioma	Enrichment	BRAF	2.10
104	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.10
105	Phace association	Enrichment	BRAF	2.10
106	Melorheostosis	Enrichment	MAP2K1	2.10
107	Leopard syndrome 2	Enrichment	RAF1	2.10
108	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.10
109	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.10
110	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.10
111	Brain small vessel disease 5 with osteoporosis	Enrichment	ARHGEF15	2.10
112	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.10
113	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.10
114	Thrombocytopenia 6	Enrichment	SRC	2.10
115	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.10
116	Sick sinus syndrome 4	Enrichment	GNB2	2.10
117	Trigonitis	Enrichment	RAF1	2.10
118	Immunodeficiency 129	Enrichment	RHOH	2.10
119	T-cell immunodeficiency with epidermodysplasia verruciformis	Enrichment	RHOH	2.10
120	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.10
121	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.10
122	Congenital pulmonary airway malformation	Enrichment	KRAS	2.10
123	Syringocystadenoma papilliferum	Enrichment	BRAF	2.10
124	Ganglioglioma	Enrichment	BRAF	2.10
125	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.10
126	Phace syndrome	Enrichment	BRAF	2.10
127	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.10
128	Classic hairy cell leukemia	Enrichment	BRAF	2.10
129	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.10
130	Neurocutaneous melanocytosis	Enrichment	NRAS	2.10
131	Protein-deficiency anemia	Enrichment	GATA1, NRAS	2.10
132	Leukemia, acute lymphoblastic	Enrichment	GNB1	2.09
133	Leukemia, acute myeloid	Enrichment	GATA2, KRAS, NRAS	2.07
134	Aortic aneurysm, familial thoracic 1	Enrichment	GATA4, MYLK	2.03
135	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS	2.02
136	Diffuse large b-cell lymphoma	Enrichment	BRAF, STAT3	2.02
137	Heart disease	Enrichment	MYL2	1.99
138	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	1.98
139	Proteus syndrome	Enrichment	AKT1	1.98
140	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	1.98
141	Pallister-killian syndrome	Enrichment	ARAF	1.98
142	Incontinentia pigmenti	Enrichment	IKBKG	1.98
143	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	1.98
144	Cardiac valvular dysplasia 1	Enrichment	PLD1	1.98
145	Fetal encasement syndrome	Enrichment	CHUK	1.98
146	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	1.98
147	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	1.98
148	Immunodeficiency 15b	Enrichment	IKBKB	1.98
149	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	1.98
150	Immunodeficiency 15a	Enrichment	IKBKB	1.98
151	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	1.98
152	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	1.98
153	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	1.98
154	Short syndrome	Enrichment	PIK3R1	1.98
155	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	1.98
156	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	1.98
157	Auriculocondylar syndrome 2a	Enrichment	PLCB4	1.98
158	Isolated growth hormone deficiency type iii	Enrichment	BTK	1.98
159	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	1.98
160	Spinocerebellar ataxia 14	Enrichment	PRKCG	1.98
161	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	1.98
162	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	1.98
163	Long qt syndrome 16	Enrichment	CALM3	1.98
164	Cowden syndrome 6	Enrichment	AKT1	1.98
165	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	1.98
166	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	1.98
167	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	1.98
168	Bartsocas-papas syndrome 2	Enrichment	CHUK	1.98
169	Auriculocondylar syndrome 2b	Enrichment	PLCB4	1.98
170	Long qt syndrome 15	Enrichment	CALM2	1.98
171	Capillary hemangioma	Enrichment	AKT3	1.98
172	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	1.98
173	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	1.98
174	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	1.98
175	Inflammatory bowel disease-recurrent sinopulmonary infections syndrome	Enrichment	NFAT5	1.98
176	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	1.98
177	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	1.98
178	Anemia, congenital, nonspherocytic hemolytic, 9	Enrichment	GATA1	1.98
179	Thrombocytopenia, x-linked, with or without dyserythropoietic anemia	Enrichment	GATA1	1.98
180	Thrombocytopenia with beta-thalassemia, x-linked	Enrichment	GATA1	1.98
181	Hypomagnesemia 4, renal	Enrichment	EGF	1.98
182	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	1.98
183	Osseous heteroplasia, progressive	Enrichment	GNAS	1.98
184	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	1.98
185	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	1.98
186	Atrioventricular septal defect 4	Enrichment	GATA4	1.98
187	Atrioventricular septal defect 5	Enrichment	GATA6	1.98
188	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	1.98
189	Pituitary adenoma 3, multiple types	Enrichment	GNAS	1.98
190	Congenital heart defects, multiple types, 5	Enrichment	GATA5	1.98
191	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	1.98
192	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	1.98
193	Anemia, x-linked, with or without neutropenia and/or platelet abnormalities	Enrichment	GATA1	1.98
194	Lymphedema, primary, with myelodysplasia	Enrichment	GATA2	1.98
195	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	1.98
196	Atrial septal defect 2	Enrichment	GATA4	1.98
197	Night blindness, congenital stationary, autosomal dominant 3	Enrichment	GNAT1	1.98
198	Immunodeficiency 21	Enrichment	GATA2	1.98
199	Dystonia 25	Enrichment	GNAL	1.98
200	Night blindness, congenital stationary, type 1g	Enrichment	GNAT1	1.98
201	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	1.98
202	Testicular anomalies with or without congenital heart disease	Enrichment	GATA4	1.98
203	Disorders of gnas inactivation	Enrichment	GNAS	1.98
204	Atrial septal defect 9	Enrichment	GATA6	1.98
205	8p23.1 microdeletion syndrome	Enrichment	GATA4	1.98
206	Deafness-lymphedema-leukemia syndrome	Enrichment	GATA2	1.98
207	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	1.98
208	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	1.98
209	Acute megakaryoblastic leukemia in children with down syndrome	Enrichment	GATA1	1.98
210	Thrombocytopenia with congenital dyserythropoietic anemia	Enrichment	GATA1	1.98
211	Partial atrioventricular septal defect with ventricular hypoplasia	Enrichment	GATA4	1.98
212	Monostotic fibrous dysplasia	Enrichment	GNAS	1.98
213	Gnao1-related disorder	Enrichment	GNAO1	1.98
214	Phakomatosis cesiomarmorata	Enrichment	GNA11	1.98
215	Kaposiform hemangioendothelioma	Enrichment	GNA14	1.98
216	Mazabraud syndrome	Enrichment	GNAS	1.98
217	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	1.98
218	Congenital myopathy 4a, autosomal dominant	Enrichment	MYL2	1.96
219	Cleft palate, isolated	Enrichment	GNB1	1.90
220	Cardiomyopathy, dilated, 1e	Enrichment	MYL2	1.90
221	Colorectal cancer	Enrichment	AKT1, BRAF, NRAS, PIK3R1	1.88
222	Patent foramen ovale	Enrichment	GATA4, GATA6	1.82
223	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, GNB1	1.80
224	Fibromatosis, gingival, 1	Enrichment	SOS1	1.80
225	Costello syndrome	Enrichment	HRAS	1.80
226	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.80
227	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.80
228	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	1.80
229	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.80
230	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	1.80
231	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.80
232	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.80
233	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	1.80
234	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	1.80
235	Noonan syndrome 12	Enrichment	RRAS2	1.80
236	Usher syndrome, type iv	Enrichment	PRKAR1A	1.80
237	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	1.80
238	Acrodysostosis	Enrichment	PRKAR1A	1.80
239	Body mass index quantitative trait locus 19	Enrichment	ADCY3	1.80
240	Fibrolamellar carcinoma	Enrichment	PRKACA	1.80
241	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	1.80
242	Hypopituitarism	Enrichment	GNAI2	1.80
243	Bradyopsia	Enrichment	RGS9	1.80
244	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.80
245	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	1.80
246	Tafro syndrome	Enrichment	MAP2K2	1.80
247	Wooly hair nevus	Enrichment	HRAS	1.80
248	Strabismus	Enrichment	GNB1	1.70
249	Myeloma, multiple	Enrichment	BRAF, KRAS, PIK3R2	1.68
250	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.68
251	Glycogen storage disease 0, liver	Enrichment	GYS2	1.68
252	Immunodeficiency 33	Enrichment	IKBKG	1.68
253	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.68
254	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.68
255	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.68
256	Charcot-marie-tooth disease, demyelinating, type 4f	Enrichment	PLD3	1.68
257	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.68
258	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.68
259	Long qt syndrome 14	Enrichment	CALM1	1.68
260	Agammaglobulinemia, x-linked	Enrichment	BTK	1.68
261	Spinocerebellar ataxia 46	Enrichment	PLD3	1.68
262	Glycogen storage disease 0, muscle	Enrichment	GYS1	1.68
263	Senior-loken syndrome 7	Enrichment	AKT3	1.68
264	Ocular melanoma	Enrichment	PLCB4	1.68
265	Bardet-biedl syndrome 16	Enrichment	AKT3	1.68
266	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.68
267	Glycogen storage disorder due to hepatic glycogen synthase deficiency	Enrichment	GYS2	1.68
268	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	1.68
269	Charcot-marie-tooth disease type 4f	Enrichment	PLD3	1.68
270	Glycogen storage disease due to muscle and heart glycogen synthase deficiency	Enrichment	GYS1	1.68
271	Common variable immunodeficiency 12	Enrichment	NFKB1	1.68
272	Myeloproliferative syndrome, transient	Enrichment	GATA1	1.68
273	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	1.68
274	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	1.68
275	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.68
276	Porphyria, congenital erythropoietic	Enrichment	GATA1	1.68
277	Spinocerebellar ataxia 17	Enrichment	TBP	1.68
278	Pseudopseudohypoparathyroidism	Enrichment	GNAS	1.68
279	Angioma, tufted	Enrichment	GNA14	1.68
280	Spermatogenic failure 17	Enrichment	PLCZ1	1.68
281	Neutropenia, severe congenital, 8, autosomal dominant	Enrichment	GATA6	1.68
282	Acute basophilic leukemia	Enrichment	GATA1	1.68
283	Autosomal dominant hypocalcemia	Enrichment	GNA11	1.68
284	Pseudohypoparathyroidism	Enrichment	GNAS	1.68
285	46,xy sex reversal 3	Enrichment	GATA4	1.68
286	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	1.68
287	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	1.68
288	Megacystis-microcolon-intestinal hypoperistalsis syndrome 4	Enrichment	MYL9	1.68
289	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	1.68
290	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	1.68
291	Phakomatosis cesioflammea	Enrichment	GNA11	1.68
292	Ovarian cancer	Enrichment	AKT1, EGFR, KRAS, RRAS2	1.66
293	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.63
294	Ataxia-telangiectasia	Enrichment	BRAF	1.63
295	Nuchal bleb, familial	Enrichment	SOS1	1.63
296	Tethered spinal cord syndrome	Enrichment	BRAF	1.63
297	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.63
298	Hyper ige syndrome	Enrichment	STAT3	1.63
299	Spermatocytoma	Enrichment	HRAS	1.63
300	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	1.63
301	Familial hypertrophic cardiomyopathy	Enrichment	MYL2	1.62
302	Congenital stationary night blindness	Enrichment	GNAT1, GNB3	1.62
303	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.61
304	Lung cancer	Enrichment	BRAF, KRAS	1.58
305	Gillespie syndrome	Enrichment	ITPR1	1.51
306	Succinic semialdehyde dehydrogenase deficiency	Enrichment	GPLD1	1.51
307	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.51
308	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.51
309	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.51
310	Agammaglobulinemia 1	Enrichment	BTK	1.51
311	Immunodeficiency 14	Enrichment	PIK3R1	1.51
312	Chorea, benign hereditary	Enrichment	ADCY5	1.51
313	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.51
314	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.51
315	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.51
316	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.51
317	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.51
318	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.51
319	Carney complex variant	Enrichment	PRKAR1A	1.51
320	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.51
321	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.51
322	Craniopharyngioma	Enrichment	BRAF	1.51
323	Pilocytic astrocytoma	Enrichment	KRAS	1.51
324	Newborn respiratory distress syndrome	Enrichment	BRAF	1.51
325	Epidermolytic nevus	Enrichment	HRAS	1.51
326	Gingival fibromatosis	Enrichment	SOS1	1.51
327	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.51
328	Familial sick sinus syndrome	Enrichment	GNB2	1.51
329	Hypertrophic cardiomyopathy	Enrichment	MYL2	1.50
330	Mccune-albright syndrome	Enrichment	GNAS	1.50
331	Heart defects, congenital, and other congenital anomalies	Enrichment	GATA6	1.50
332	Nephrotic syndrome, type 3	Enrichment	PLCE1	1.50
333	Aortic aneurysm, familial thoracic 7	Enrichment	MYLK	1.50
334	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.50
335	End stage renal disease	Enrichment	GATA3	1.50
336	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.50
337	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.50
338	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.41
339	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.38
340	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.38
341	Hereditary ataxia	Enrichment	PRKCG	1.38
342	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYLK	1.38
343	Down syndrome	Enrichment	GATA1	1.38
344	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.38
345	Transposition of the great arteries	Enrichment	GATA4	1.38
346	Middle aortic syndrome	Enrichment	GATA6	1.38
347	Long qt syndrome	Enrichment	CALM1, CALM2	1.38
348	Breast cancer	Enrichment	AKT1, GNG3, KRAS	1.36
349	Wilms tumor 5	Enrichment	BRAF	1.33
350	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.33
351	Limited scleroderma	Enrichment	CAV1	1.33
352	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.29
353	Hemimegalencephaly	Enrichment	AKT3	1.29
354	Capillary malformations, congenital	Enrichment	GNA11	1.29
355	Visceral myopathy 1	Enrichment	MYLK	1.29
356	Night blindness, congenital stationary, type 1c	Enrichment	GNAT1	1.29
357	Ventricular septal defect 1	Enrichment	GATA4	1.29
358	Acute megakaryocytic leukemia	Enrichment	GATA1	1.29
359	Persistent truncus arteriosus	Enrichment	GATA6	1.29
360	Myelofibrosis	Enrichment	SRC	1.27
361	Dilated cardiomyopathy	Enrichment	MYL2	1.24
362	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.21
363	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.21
364	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.21
365	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.21
366	Cowden syndrome 1	Enrichment	EGFR	1.21
367	Conotruncal heart malformations	Enrichment	GATA6	1.21
368	Charcot-marie-tooth disease	Enrichment	ARHGEF10, PLD3	1.16
369	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.16
370	Primary hyperaldosteronism	Enrichment	BRAF	1.16
371	Ventricular septal defect	Enrichment	BRAF	1.16
372	Megacolon	Enrichment	AKT3	1.15
373	Common variable immunodeficiency	Enrichment	NFKB1	1.15
374	Overgrowth syndrome	Enrichment	PIK3R1	1.15
375	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.15
376	Brachydactyly	Enrichment	GNAS	1.15
377	Type 2 diabetes mellitus	Enrichment	AKT2, SLC2A4	1.14
378	Melanoma	Enrichment	BRAF	1.12
379	Hereditary breast carcinoma	Enrichment	AKT1, KRAS	1.11
380	Autism spectrum disorder	Enrichment	GNB1	1.11
381	West syndrome	Enrichment	GNAO1, PLCB1	1.11
382	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.09
383	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.09
384	Choreatic disease	Enrichment	GNAO1	1.09
385	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.08
386	Specific learning disability	Enrichment	MAPK1	1.08
387	Microcephaly	Enrichment	GNB1	1.06
388	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.04
389	Coronary heart disease 5	Enrichment	IKBKG	1.04
390	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.04
391	Cowden syndrome	Enrichment	AKT1	1.04
392	Thrombocytopenia	Enrichment	GATA1, SRC	1.04
393	Nephrotic syndrome, type 1	Enrichment	PLCE1	1.04
394	Adult hepatocellular carcinoma	Enrichment	EGF	1.04
395	Familial thoracic aortic aneurysm and dissection	Enrichment	MYLK	1.04
396	Body mass index quantitative trait locus 11	Enrichment	ADCY3, GNAS	1.01
397	Aortic valve disease 1	Enrichment	SOS1	1.01
398	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.00
399	Polymicrogyria	Enrichment	AKT3	1.00
400	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.00
401	Achromatopsia	Enrichment	GNAT2	1.00
402	Congenital nervous system abnormality	Enrichment	CAMK2B, GNAO1, GNB5	0.99
403	Nervous system disease	Enrichment	CAMK2B, GNAO1, GNB5	0.99
404	Osteoporosis	Enrichment	SRC	0.98
405	46,xy partial gonadal dysgenesis	Enrichment	SOS1	0.98
406	Movement disease	Enrichment	GNAO1	0.96
407	Wilms tumor 1	Enrichment	BRAF	0.95
408	Lynch syndrome	Enrichment	KRAS	0.95
409	Meningioma	Enrichment	AKT1	0.93
410	Congenital long qt syndrome	Enrichment	ITPR3	0.93
411	Rhabdomyosarcoma	Enrichment	HRAS	0.92
412	Melanoma, cutaneous malignant 1	Enrichment	BRAF	0.90
413	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	0.89
414	Diaphragmatic hernia, congenital	Enrichment	GATA6	0.89
415	Heart, malformation of	Enrichment	MAPK1	0.88
416	Multiple sclerosis	Enrichment	ITPR1	0.86
417	Cone-rod dystrophy 6	Enrichment	GNAT2	0.86
418	Anterior segment dysgenesis	Enrichment	ITPR1	0.84
419	Rare genetic intellectual disability	Enrichment	GNAO1	0.83
420	Gliosarcoma	Enrichment	NFKBIA	0.81
421	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.80
422	Sudden infant death syndrome	Enrichment	CALM2	0.79
423	Giant cell glioblastoma	Enrichment	NFKBIA	0.79
424	Charcot-marie-tooth disease type 4	Enrichment	PLD3	0.76
425	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.76
426	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	0.76
427	Pancreatic cancer	Enrichment	KRAS	0.75
428	Parkinson's disease	Enrichment	TBP	0.74
429	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.73
430	Focal segmental glomerulosclerosis	Enrichment	PLCE1	0.72
431	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	0.70
432	Malaria	Enrichment	IKBKG	0.67
433	Diamond-blackfan anemia 1	Enrichment	GATA1	0.66
434	Parkinson disease, late-onset	Enrichment	TBP	0.65
435	Cone dystrophy	Enrichment	GNAT2	0.65
436	Jeune thoracic dystrophy	Enrichment	GRK2	0.64
437	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1	0.63
438	Left ventricular noncompaction	Enrichment	RAF1	0.62
439	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	0.60
440	Developmental and epileptic encephalopathy	Enrichment	ARHGEF15	0.60
441	Asphyxiating thoracic dystrophy	Enrichment	GRK2	0.59
442	Gastric cancer	Enrichment	KRAS	0.54
443	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	0.53
444	Severe combined immunodeficiency	Enrichment	IKBKB	0.53
445	Cakut	Enrichment	GATA3	0.52
446	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	0.52
447	Eye disease	Enrichment	GNAT2	0.51
448	Diamond-blackfan anemia	Enrichment	GATA1	0.50
449	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.46
450	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.45
451	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.45
452	Centralopathic epilepsy	Enrichment	PLCB1	0.44
453	Nephrotic syndrome	Enrichment	PLCE1	0.44
454	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MYLK	0.43
455	Spastic ataxia	Enrichment	ITPR1	0.37
456	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.35
457	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GATA4	0.35
458	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.34
459	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.30
460	Leber plus disease	Enrichment	RGS9	0.28
461	Autism	Enrichment	CAMK2G	0.27
462	Complex neurodevelopmental disorder	Enrichment	GNB2	0.20
463	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.19
464	Hereditary retinal dystrophy	Enrichment	GNAT1, GNAT2	0.09
465	Fundus dystrophy	Enrichment	GNAT1, GNAT2	0.09
466	Retinitis pigmentosa	Enrichment	GNAT1	0.05

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G-AlphaQ Signaling

Pathway Network for G-AlphaQ Signaling

Pathway network for the G-AlphaQ Signaling SuperPath

Member Pathways for G-AlphaQ Signaling

Pathways in the G-AlphaQ Signaling SuperPath

Gene overlap in member pathways for G-AlphaQ Signaling SuperPath

Associated Genes for G-AlphaQ Signaling

Associated Disorders for G-AlphaQ Signaling

Disorders associated with G-AlphaQ Signaling SuperPath

STRING Interaction Network for G-AlphaQ Signaling

Sources for G-AlphaQ Signaling