G-Beta Gamma Signaling

Pathway network for the G-Beta Gamma Signaling SuperPath

Sources:

QIAGEN

Pathways in the G-Beta Gamma Signaling SuperPath

#	Name	Source	Genes
1	G-Beta Gamma Signaling	QIAGEN	ADCY1 ADCY2 AKT1 AKT2 AKT3 ARAF ARHGEF6 BRAF BTK CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CAV1 CDC42 DNM2 EGFR GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 HBEGF HRAS KCNJ3 KCNJ5 KCNJ6 KCNJ9 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MRAS NRAS PAK1 PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PLCG1 PLCG2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 RAF1 RRAS RRAS2 SOS1 SOS2 SRC (see all 121) (see less)
2	CRHR Pathway	QIAGEN	ADCY1 ADCY2 ADCY3 ATF2 ATF4 BDNF BRAF CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CALM1 CALM2 CALM3 CAMK4 CDKN2A CNR1 CREB1 CREB3 CREB3L4 CRH CRHR1 CRHR2 ELK1 EP300 FASLG FOS GLI1 GLI2 GLI3 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GUCY1A1 GUCY1A2 GUCY1B1 GUCY2D GUCY2EP GUCY2F ITPR1 ITPR2 ITPR3 IVL JUN JUND KRT1 MAP2K1 MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MEF2A MEF2C MEF2D NOS1 NOS2 NOS2P1 NOS2P2 NOS3 NPR1 NPR2 NR4A1 PLCG1 PLCG2 POMC PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PTCH1 PTCH2 PTGS2 RAF1 RAP1A RAP1B SMO UCN UCN3 UTS2 VEGFA VEGFC VEGFD (see all 154) (see less)
3	GHRH Signaling	QIAGEN	ADCY1 ADCY2 ADCY3 ATF4 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CREB1 CREB3 CREB3L4 CREBBP EP300 GH1 GH2 GHRH GHRHR GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 ITPR1 ITPR2 ITPR3 PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B SCN10A SCN11A SCN1A SCN1B SCN2A SCN2B SCN3A SCN3B SCN4A SCN4B SCN5A SCN7A SCN8A SCN9A SCNN1A SCNN1B SCNN1D SCNN1G (see all 109) (see less)

Gene overlap in member pathways for G-Beta Gamma Signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADCY1	Adenylate Cyclase 1	Protein Coding	3
2	ADCY2	Adenylate Cyclase 2	Protein Coding	3
3	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	3
4	CACNA1B	Calcium Voltage-Gated Channel Subunit Alpha1 B	Protein Coding	3
5	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	3
6	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	3
7	CACNA1E	Calcium Voltage-Gated Channel Subunit Alpha1 E	Protein Coding	3
8	CACNA1F	Calcium Voltage-Gated Channel Subunit Alpha1 F	Protein Coding	3
9	CACNA1G	Calcium Voltage-Gated Channel Subunit Alpha1 G	Protein Coding	3
10	CACNA1H	Calcium Voltage-Gated Channel Subunit Alpha1 H	Protein Coding	3
11	CACNA1I	Calcium Voltage-Gated Channel Subunit Alpha1 I	Protein Coding	3
12	CACNA1S	Calcium Voltage-Gated Channel Subunit Alpha1 S	Protein Coding	3
13	CACNA2D1	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 1	Protein Coding	3
14	CACNA2D2	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2	Protein Coding	3
15	CACNA2D3	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 3	Protein Coding	3
16	CACNA2D4	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 4	Protein Coding	3
17	CACNB1	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1	Protein Coding	3
18	CACNB2	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2	Protein Coding	3
19	CACNB3	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 3	Protein Coding	3
20	CACNB4	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 4	Protein Coding	3
21	CACNG1	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 1	Protein Coding	3
22	CACNG2	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 2	Protein Coding	3
23	CACNG3	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 3	Protein Coding	3
24	CACNG4	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 4	Protein Coding	3
25	CACNG5	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5	Protein Coding	3
26	CACNG6	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 6	Protein Coding	3
27	CACNG7	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7	Protein Coding	3
28	CACNG8	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8	Protein Coding	3
29	GNA11	G Protein Subunit Alpha 11	Protein Coding	3
30	GNA12	G Protein Subunit Alpha 12	Protein Coding	3
31	GNA13	G Protein Subunit Alpha 13	Protein Coding	3
32	GNA14	G Protein Subunit Alpha 14	Protein Coding	3
33	GNA15	G Protein Subunit Alpha 15	Protein Coding	3
34	GNAI1	G Protein Subunit Alpha I1	Protein Coding	3
35	GNAI2	G Protein Subunit Alpha I2	Protein Coding	3
36	GNAI3	G Protein Subunit Alpha I3	Protein Coding	3
37	GNAL	G Protein Subunit Alpha L	Protein Coding	3
38	GNAO1	G Protein Subunit Alpha O1	Protein Coding	3
39	GNAS	GNAS Complex Locus	Protein Coding	3
40	GNAT1	G Protein Subunit Alpha Transducin 1	Protein Coding	3
41	GNAT2	G Protein Subunit Alpha Transducin 2	Protein Coding	3
42	GNAZ	G Protein Subunit Alpha Z	Protein Coding	3
43	GNB1	G Protein Subunit Beta 1	Protein Coding	3
44	GNB2	G Protein Subunit Beta 2	Protein Coding	3
45	GNB3	G Protein Subunit Beta 3	Protein Coding	3
46	GNB4	G Protein Subunit Beta 4	Protein Coding	3
47	GNB5	G Protein Subunit Beta 5	Protein Coding	3
48	GNG10	G Protein Subunit Gamma 10	Protein Coding	3
49	GNG11	G Protein Subunit Gamma 11	Protein Coding	3
50	GNG12	G Protein Subunit Gamma 12	Protein Coding	3
51	GNG13	G Protein Subunit Gamma 13	Protein Coding	3
52	GNG2	G Protein Subunit Gamma 2	Protein Coding	3
53	GNG3	G Protein Subunit Gamma 3	Protein Coding	3
54	GNG4	G Protein Subunit Gamma 4	Protein Coding	3
55	GNG5	G Protein Subunit Gamma 5	Protein Coding	3
56	GNG7	G Protein Subunit Gamma 7	Protein Coding	3
57	GNG8	G Protein Subunit Gamma 8	Protein Coding	3
58	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	3
59	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	3
60	PLCG1	Phospholipase C Gamma 1	Protein Coding	3
61	PLCG2	Phospholipase C Gamma 2	Protein Coding	3
62	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	3
63	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	3
64	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	3
65	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	3
66	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	3
67	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	3
68	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	3
69	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
70	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
71	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
72	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
73	PLCB1	Phospholipase C Beta 1	Protein Coding	2
74	PLCB2	Phospholipase C Beta 2	Protein Coding	2
75	PLCB3	Phospholipase C Beta 3	Protein Coding	2
76	PLCB4	Phospholipase C Beta 4	Protein Coding	2
77	PRKCA	Protein Kinase C Alpha	Protein Coding	2
78	PRKCB	Protein Kinase C Beta	Protein Coding	2
79	PRKCD	Protein Kinase C Delta	Protein Coding	2
80	PRKCE	Protein Kinase C Epsilon	Protein Coding	2
81	PRKCG	Protein Kinase C Gamma	Protein Coding	2
82	PRKCH	Protein Kinase C Eta	Protein Coding	2
83	PRKCI	Protein Kinase C Iota	Protein Coding	2
84	PRKD1	Protein Kinase D1	Protein Coding	2
85	PRKD3	Protein Kinase D3	Protein Coding	2
86	PRKCQ	Protein Kinase C Theta	Protein Coding	2
87	PRKCZ	Protein Kinase C Zeta	Protein Coding	2
88	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
89	ADCY3	Adenylate Cyclase 3	Protein Coding	2
90	ATF4	Activating Transcription Factor 4	Protein Coding	2
91	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
92	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	2
93	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	2
94	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
95	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	2
96	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	2
97	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	2
98	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
99	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
100	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
101	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
102	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	1
103	BTK	Bruton Tyrosine Kinase	Protein Coding	1
104	CAV1	Caveolin 1	Protein Coding	1
105	CDC42	Cell Division Cycle 42	Protein Coding	1
106	DNM2	Dynamin 2	Protein Coding	1
107	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	1
108	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
109	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
110	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
111	KCNJ3	Potassium Inwardly Rectifying Channel Subfamily J Member 3	Protein Coding	1
112	KCNJ5	Potassium Inwardly Rectifying Channel Subfamily J Member 5	Protein Coding	1
113	KCNJ6	Potassium Inwardly Rectifying Channel Subfamily J Member 6	Protein Coding	1
114	KCNJ9	Potassium Inwardly Rectifying Channel Subfamily J Member 9	Protein Coding	1
115	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
116	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
117	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
118	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
119	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
120	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
121	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
122	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
123	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
124	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
125	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
126	RRAS	RAS Related	Protein Coding	1
127	RRAS2	RAS Related 2	Protein Coding	1
128	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
129	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
130	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
131	ATF2	Activating Transcription Factor 2	Protein Coding	1
132	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	1
133	CALM1	Calmodulin 1	Protein Coding	1
134	CALM2	Calmodulin 2	Protein Coding	1
135	CALM3	Calmodulin 3	Protein Coding	1
136	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	1
137	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
138	CNR1	Cannabinoid Receptor 1	Protein Coding	1
139	CRH	Corticotropin Releasing Hormone	Protein Coding	1
140	CRHR1	Corticotropin Releasing Hormone Receptor 1	Protein Coding	1
141	CRHR2	Corticotropin Releasing Hormone Receptor 2	Protein Coding	1
142	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
143	VEGFD	Vascular Endothelial Growth Factor D	Protein Coding	1
144	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
145	GLI1	GLI Family Zinc Finger 1	Protein Coding	1
146	GLI2	GLI Family Zinc Finger 2	Protein Coding	1
147	GLI3	GLI Family Zinc Finger 3	Protein Coding	1
148	GUCY1A2	Guanylate Cyclase 1 Soluble Subunit Alpha 2	Protein Coding	1
149	GUCY1A1	Guanylate Cyclase 1 Soluble Subunit Alpha 1	Protein Coding	1
150	GUCY1B1	Guanylate Cyclase 1 Soluble Subunit Beta 1	Protein Coding	1
151	GUCY2D	Guanylate Cyclase 2D, Retinal	Protein Coding	1
152	GUCY2EP	Guanylate Cyclase 2E, Pseudogene	Pseudogene	1
153	GUCY2F	Guanylate Cyclase 2F, Retinal	Protein Coding	1
154	IVL	Involucrin	Protein Coding	1
155	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
156	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
157	KRT1	Keratin 1	Protein Coding	1
158	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
159	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
160	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
161	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
162	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
163	MAP3K6	Mitogen-Activated Protein Kinase Kinase Kinase 6	Protein Coding	1
164	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
165	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
166	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
167	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
168	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	1
169	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
170	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	1
171	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
172	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
173	NOS2P1	Nitric Oxide Synthase 2 Pseudogene 1	Pseudogene	1
174	NOS2P2	Nitric Oxide Synthase 2 Pseudogene 2	Pseudogene	1
175	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
176	NPR1	Natriuretic Peptide Receptor 1	Protein Coding	1
177	NPR2	Natriuretic Peptide Receptor 2	Protein Coding	1
178	NR4A1	Nuclear Receptor Subfamily 4 Group A Member 1	Protein Coding	1
179	POMC	Proopiomelanocortin	Protein Coding	1
180	PTCH1	Patched 1	Protein Coding	1
181	PTCH2	Patched 2	Protein Coding	1
182	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
183	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
184	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
185	SMO	Smoothened, Frizzled Class Receptor	Protein Coding	1
186	FASLG	Fas Ligand	Protein Coding	1
187	UCN	Urocortin	Protein Coding	1
188	UCN3	Urocortin 3	Protein Coding	1
189	UTS2	Urotensin 2	Protein Coding	1
190	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
191	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	1
192	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
193	GH1	Growth Hormone 1	Protein Coding	1
194	GH2	Growth Hormone 2	Protein Coding	1
195	GHRH	Growth Hormone Releasing Hormone	Protein Coding	1
196	GHRHR	Growth Hormone Releasing Hormone Receptor	Protein Coding	1
197	PLCD1	Phospholipase C Delta 1	Protein Coding	1
198	PLCD3	Phospholipase C Delta 3	Protein Coding	1
199	PLCD4	Phospholipase C Delta 4	Protein Coding	1
200	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1
201	PLCZ1	Phospholipase C Zeta 1	Protein Coding	1
202	SCN10A	Sodium Voltage-Gated Channel Alpha Subunit 10	Protein Coding	1
203	SCN11A	Sodium Voltage-Gated Channel Alpha Subunit 11	Protein Coding	1
204	SCN1A	Sodium Voltage-Gated Channel Alpha Subunit 1	Protein Coding	1
205	SCN1B	Sodium Voltage-Gated Channel Beta Subunit 1	Protein Coding	1
206	SCN2A	Sodium Voltage-Gated Channel Alpha Subunit 2	Protein Coding	1
207	SCN2B	Sodium Voltage-Gated Channel Beta Subunit 2	Protein Coding	1
208	SCN3A	Sodium Voltage-Gated Channel Alpha Subunit 3	Protein Coding	1
209	SCN3B	Sodium Voltage-Gated Channel Beta Subunit 3	Protein Coding	1
210	SCN4A	Sodium Voltage-Gated Channel Alpha Subunit 4	Protein Coding	1
211	SCN4B	Sodium Voltage-Gated Channel Beta Subunit 4	Protein Coding	1
212	SCN5A	Sodium Voltage-Gated Channel Alpha Subunit 5	Protein Coding	1
213	SCN7A	Sodium Voltage-Gated Channel Alpha Subunit 7	Protein Coding	1
214	SCN8A	Sodium Voltage-Gated Channel Alpha Subunit 8	Protein Coding	1
215	SCN9A	Sodium Voltage-Gated Channel Alpha Subunit 9	Protein Coding	1
216	SCNN1A	Sodium Channel Epithelial 1 Subunit Alpha	Protein Coding	1
217	SCNN1B	Sodium Channel Epithelial 1 Subunit Beta	Protein Coding	1
218	SCNN1D	Sodium Channel Epithelial 1 Subunit Delta	Protein Coding	1
219	SCNN1G	Sodium Channel Epithelial 1 Subunit Gamma	Protein Coding	1

Disorders associated with G-Beta Gamma Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Brugada syndrome	Enrichment	CACNA1C, CACNA2D1, CACNB2, SCN10A, SCN1B, SCN2B, SCN3B, SCN5A, SCNN1A	11.72
2	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS2, SOS1, SOS2	11.07
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	10.73
4	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2, SOS1, SOS2	10.70
5	Lung non-small cell carcinoma	Enrichment	BRAF, EGFR, HRAS, KRAS, MAP2K1, NRAS	9.69
6	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.22
7	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.22
8	Developmental and epileptic encephalopathy	Enrichment	CACNA1E, CACNA2D2, GNAO1, SCN1A, SCN2A, SCN3A, SCN8A	7.91
9	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	6.69
10	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA1A, CACNA1B, CACNA2D1, SCN1A, SCN1B, SCN3A, SCN8A	6.52
11	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	6.39
12	Liddle syndrome 1	Enrichment	SCNN1A, SCNN1B, SCNN1G	6.30
13	Pseudohypoaldosteronism, type ib1, autosomal recessive	Enrichment	SCNN1A, SCNN1B, SCNN1G	6.30
14	Hereditary sodium channelopathy-related small fibers neuropathy	Enrichment	SCN10A, SCN11A, SCN9A	6.30
15	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	6.16
16	Dravet syndrome	Enrichment	SCN1A, SCN1B, SCN2A, SCN9A	6.10
17	Familial atrial fibrillation	Enrichment	SCN1B, SCN2B, SCN3B, SCN4B, SCN5A	5.94
18	Erythermalgia, primary	Enrichment	SCN10A, SCN11A, SCN9A	5.70
19	Idiopathic bronchiectasis	Enrichment	SCNN1A, SCNN1B, SCNN1G	5.70
20	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.56
21	Long qt syndrome 1	Enrichment	CACNA1C, ITPR3, SCN10A, SCN4B, SCN5A	5.43
22	Generalized epilepsy with febrile seizures plus	Enrichment	SCN1A, SCN1B, SCN2A, SCN9A	5.43
23	Paroxysmal extreme pain disorder	Enrichment	SCN10A, SCN11A, SCN9A	5.30
24	Cone-rod dystrophy 6	Enrichment	CACNA1F, CACNA2D4, GNAT2, GUCY2D	4.83
25	Brugada syndrome 1	Enrichment	CACNA2D1, SCN10A, SCN5A	4.76
26	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	SCN10A, SCN11A, SCN9A	4.76
27	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1, SCN1A, SCN1B, SCN2A, SCN9A	4.74
28	Polydactyly, postaxial, type a1	Enrichment	EP300, GLI1, GLI3, PTCH1	4.70
29	Centralopathic epilepsy	Enrichment	PLCB1, SCN1A, SCN1B, SCN2A, SCN9A	4.64
30	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	4.63
31	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	4.63
32	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	4.63
33	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	4.63
34	West syndrome	Enrichment	GNAO1, PLCB1, SCN1A, SCN2A, SCN8A	4.59
35	Congenital stationary night blindness	Enrichment	CACNA1F, CACNA2D4, GNAT1, GNB3	4.51
36	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1, SCN1A, SCN2A	4.39
37	Primary hyperaldosteronism	Enrichment	BRAF, CACNA1H, GNAS	4.25
38	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	4.19
39	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	4.11
40	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.10
41	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.10
42	Cardiac conduction defect	Enrichment	CACNA1C, SCN1B, SCN5A	3.98
43	Ellis-van creveld syndrome	Enrichment	GLI1, PRKACA, PRKACB	3.94
44	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS	3.92
45	Postaxial polydactyly type b	Enrichment	GLI1, GLI3	3.89
46	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	3.84
47	Lip and oral cavity carcinoma	Enrichment	BRAF, EGFR, HRAS	3.84
48	Generalized epilepsy with febrile seizures plus, type 1	Enrichment	SCN1A, SCN1B	3.72
49	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1A, CACNA1C	3.72
50	Isolated growth hormone deficiency, type ib	Enrichment	GH1, GHRHR	3.72
51	Anastomosing haemangioma	Enrichment	GNA11, GNA14	3.72
52	Hereditary episodic ataxia	Enrichment	CACNA1A, SCN2A	3.72
53	Rare genetic intellectual disability	Enrichment	CREBBP, EP300, GNAO1	3.67
54	Lung cancer susceptibility 3	Enrichment	BRAF, EGFR, KRAS	3.63
55	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11, PIK3R1	3.63
56	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.63
57	Epilepsy	Enrichment	SCN1A, SCN2A, SCN3A, SCN8A	3.54
58	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1, SCN1B, SCN2A	3.42
59	Auriculocondylar syndrome 1	Enrichment	GNAI3, PLCB4	3.42
60	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C, SCN5A	3.42
61	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1, SCN2A	3.42
62	Achromatopsia 4	Enrichment	GNAI3, GNAT2	3.42
63	Developmental and epileptic encephalopathy 52	Enrichment	CACNA1A, SCN1B	3.42
64	Episodic ataxia	Enrichment	CACNA1A, SCN2A	3.42
65	Hereditary progressive cardiac conduction defect	Enrichment	SCN1B, SCN5A	3.42
66	Familial or sporadic hemiplegic migraine	Enrichment	CACNA1A, SCN1A	3.42
67	Familial sick sinus syndrome	Enrichment	GNB2, SCN5A	3.42
68	Long qt syndrome	Enrichment	CACNA1C, CACNA1S, CALM1, CALM2	3.40
69	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3R2	3.33
70	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.33
71	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.33
72	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.33
73	Arteriovenous malformations of the brain	Enrichment	BRAF, EGFR, KRAS	3.22
74	Heart conduction disease	Enrichment	CACNA1C, SCN5A	3.20
75	Cardiac arrest	Enrichment	CACNA2D1, SCN5A	3.20
76	Self-limited infantile epilepsy	Enrichment	SCN2A, SCN8A	3.20
77	Autosomal dominant non-syndromic intellectual disability	Enrichment	CACNA1I, CACNG2, GNB1, SCN8A	3.17
78	Spastic ataxia	Enrichment	CACNA1G, CACNB4, ITPR1, SCN2A	3.07
79	Melanoma, uveal	Enrichment	GNA11, PLCB4	3.03
80	Hypokalemic periodic paralysis, type 1	Enrichment	CACNA1S, SCN4A	3.03
81	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.03
82	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.03
83	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1, SCN1A, SCN8A	2.99
84	Colorectal cancer	Enrichment	AKT1, BRAF, NRAS, PIK3R1, SRC	2.97
85	Breast adenocarcinoma	Enrichment	AKT1, KRAS	2.94
86	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS	2.94
87	Focal epilepsy	Enrichment	SCN2A, SCN8A	2.88
88	Craniosynostosis	Enrichment	GLI2, GLI3, NPR2	2.85
89	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	2.79
90	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.79
91	Gallbladder cancer	Enrichment	BRAF, KRAS	2.79
92	Lennox-gastaut syndrome	Enrichment	CACNA1A, SCN1A	2.76
93	Alternating hemiplegia of childhood	Enrichment	CACNA1A, SCN2A	2.76
94	Basal cell nevus syndrome 1	Enrichment	PTCH1, PTCH2	2.73
95	Basal cell carcinoma 1	Enrichment	PTCH1, PTCH2	2.73
96	Adrenocortical carcinoma	Enrichment	CDKN2A, PRKAR1A	2.73
97	Bladder cancer	Enrichment	EGFR, HRAS, KRAS	2.67
98	Cone dystrophy	Enrichment	CACNA2D4, GNAT2, GUCY2D	2.61
99	Body mass index quantitative trait locus 11	Enrichment	ADCY3, BDNF, GNAS, POMC	2.61
100	Autism	Enrichment	CREBBP, SCN1A, SCN2A, SCN8A	2.57
101	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	2.56
102	Eye disease	Enrichment	CACNA1F, CACNA2D4, GNAT2	2.56
103	Lung cancer	Enrichment	BRAF, EGFR, KRAS	2.55
104	Fetal akinesia deformation sequence 1	Enrichment	SCN4A, SCN5A, SCN8A	2.49
105	Movement disease	Enrichment	GNAO1, SCN2A	2.47
106	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	2.47
107	Cerebral palsy	Enrichment	CACNA1A, CACNA1C, GNB1	2.43
108	Congenital long qt syndrome	Enrichment	ITPR3, SCN5A	2.40
109	Breast cancer	Enrichment	AKT1, CACNA2D1, GNG3, KRAS	2.35
110	Distal arthrogryposis	Enrichment	SCN4A, SCN5A, SCN8A	2.34
111	Stroke, ischemic	Enrichment	NOS3, PRKCH	2.27
112	Melanoma	Enrichment	BRAF, CDKN2A	2.27
113	Leukemia, acute lymphoblastic	Enrichment	CDKN2A, GNB1	2.18
114	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.09
115	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.09
116	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.09
117	Thyrotoxic periodic paralysis 1	Enrichment	CACNA1S	2.09
118	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.09
119	Epilepsy, idiopathic generalized 9	Enrichment	CACNB4	2.09
120	Carney complex, type 1	Enrichment	PRKAR1A	2.09
121	Brugada syndrome 4	Enrichment	CACNB2	2.09
122	Brugada syndrome 5	Enrichment	SCN1B	2.09
123	Osseous heteroplasia, progressive	Enrichment	GNAS	2.09
124	Bronchiectasis with or without elevated sweat chloride 2	Enrichment	SCNN1A	2.09
125	Bronchiectasis with or without elevated sweat chloride 3	Enrichment	SCNN1G	2.09
126	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	2.09
127	Long qt syndrome 10	Enrichment	SCN4B	2.09
128	Episodic pain syndrome, familial, 3	Enrichment	SCN11A	2.09
129	Developmental and epileptic encephalopathy 11	Enrichment	SCN2A	2.09
130	Neuropathy, hereditary sensory and autonomic, type vii	Enrichment	SCN11A	2.09
131	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	2.09
132	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.09
133	Episodic ataxia, type 5	Enrichment	CACNB4	2.09
134	Ventricular tachycardia, familial	Enrichment	GNAI2	2.09
135	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.09
136	Atrial fibrillation, familial, 14	Enrichment	SCN2B	2.09
137	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.09
138	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.09
139	Pseudohypoaldosteronism, type ib2, autosomal recessive	Enrichment	SCNN1B	2.09
140	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.09
141	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.09
142	Neurodevelopmental disorder with speech impairment and with or without seizures	Enrichment	CACNA1I	2.09
143	Liddle syndrome 2	Enrichment	SCNN1G	2.09
144	Congenital myopathy 18	Enrichment	CACNA1S	2.09
145	Myoclonus, familial, 2	Enrichment	SCN8A	2.09
146	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.09
147	Developmental and epileptic encephalopathy 62	Enrichment	SCN3A	2.09
148	Liddle syndrome 3	Enrichment	SCNN1A	2.09
149	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.09
150	Cone-rod dystrophy, x-linked, 3	Enrichment	CACNA1F	2.09
151	Retinal cone dystrophy 4	Enrichment	CACNA2D4	2.09
152	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.09
153	Atrial fibrillation, familial, 13	Enrichment	SCN1B	2.09
154	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.09
155	Myxoma, intracardiac	Enrichment	PRKAR1A	2.09
156	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	2.09
157	Primary aldosteronism, seizures, and neurologic abnormalities	Enrichment	CACNA1D	2.09
158	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.09
159	Brugada syndrome 3	Enrichment	CACNA1C	2.09
160	Epilepsy, childhood absence 6	Enrichment	CACNA1H	2.09
161	Malignant hyperthermia 5	Enrichment	CACNA1S	2.09
162	Night blindness, congenital stationary, autosomal dominant 3	Enrichment	GNAT1	2.09
163	Episodic ataxia, type 9	Enrichment	SCN2A	2.09
164	Intellectual developmental disorder, autosomal dominant 10	Enrichment	CACNG2	2.09
165	Sinoatrial node dysfunction and deafness	Enrichment	CACNA1D	2.09
166	Episodic pain syndrome, familial, 2	Enrichment	SCN10A	2.09
167	Dystonia 25	Enrichment	GNAL	2.09
168	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.09
169	Night blindness, congenital stationary, type 1g	Enrichment	GNAT1	2.09
170	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.09
171	Benign familial infantile epilepsy	Enrichment	SCN2A	2.09
172	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.09
173	Brugada syndrome 7	Enrichment	SCN3B	2.09
174	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.09
175	Spinocerebellar ataxia 42	Enrichment	CACNA1G	2.09
176	Developmental and epileptic encephalopathy 110	Enrichment	CACNA2D1	2.09
177	Disorders of gnas inactivation	Enrichment	GNAS	2.09
178	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.09
179	Epilepsy, familial focal, with variable foci 4	Enrichment	SCN3A	2.09
180	Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits	Enrichment	CACNA1G	2.09
181	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.09
182	Developmental and epileptic encephalopathy 69	Enrichment	CACNA1E	2.09
183	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.09
184	Hyperaldosteronism, familial, type iv	Enrichment	CACNA1H	2.09
185	Isolated growth hormone deficiency, type iv	Enrichment	GHRHR	2.09
186	Sick sinus syndrome 4	Enrichment	GNB2	2.09
187	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.09
188	Muscular channelopathy	Enrichment	SCN4A	2.09
189	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.09
190	Pseudohypoaldosteronism, type ib3, autosomal recessive	Enrichment	SCNN1G	2.09
191	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.09
192	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.09
193	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.09
194	Conn's syndrome	Enrichment	CACNA1H	2.09
195	Sporadic hemiplegic migraine	Enrichment	CACNA1A	2.09
196	Atypical timothy syndrome	Enrichment	CACNA1C	2.09
197	Aldosterone-producing adenoma with seizures and neurological abnormalities	Enrichment	CACNA1D	2.09
198	Menke-hennekam syndrome	Enrichment	CREBBP	2.09
199	Monostotic fibrous dysplasia	Enrichment	GNAS	2.09
200	Timothy syndrome type 2	Enrichment	CACNA1C	2.09
201	Gnao1-related disorder	Enrichment	GNAO1	2.09
202	Periodic paralysis with transient compartment-like syndrome	Enrichment	CACNA1S	2.09
203	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.09
204	Kaposiform hemangioendothelioma	Enrichment	GNA14	2.09
205	Mazabraud syndrome	Enrichment	GNAS	2.09
206	Timothy syndrome type 1	Enrichment	CACNA1C	2.09
207	Cacna1c-related disorders	Enrichment	CACNA1C	2.09
208	Benign paroxysmal torticollis of infancy	Enrichment	CACNA1A	2.09
209	Sudden infant death syndrome	Enrichment	SCN1A, SCN5A	2.09
210	Proteus syndrome	Enrichment	AKT1	2.05
211	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.05
212	Oculoectodermal syndrome	Enrichment	KRAS	2.05
213	Pallister-killian syndrome	Enrichment	ARAF	2.05
214	Noonan syndrome 5	Enrichment	RAF1	2.05
215	Noonan syndrome 4	Enrichment	SOS1	2.05
216	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.05
217	Long qt syndrome 13	Enrichment	KCNJ5	2.05
218	Melorheostosis, isolated	Enrichment	MAP2K1	2.05
219	Noonan syndrome 7	Enrichment	BRAF	2.05
220	Leopard syndrome 3	Enrichment	BRAF	2.05
221	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.05
222	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.05
223	Melanosis, neurocutaneous	Enrichment	NRAS	2.05
224	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	2.05
225	Noonan syndrome 9	Enrichment	SOS2	2.05
226	Noonan syndrome 6	Enrichment	NRAS	2.05
227	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.05
228	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.05
229	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.05
230	Noonan syndrome 11	Enrichment	MRAS	2.05
231	Noonan syndrome 13	Enrichment	MAPK1	2.05
232	Short syndrome	Enrichment	PIK3R1	2.05
233	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.05
234	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.05
235	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	2.05
236	Hyperaldosteronism, familial, type iii	Enrichment	KCNJ5	2.05
237	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.05
238	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.05
239	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.05
240	Lymphangioma	Enrichment	BRAF	2.05
241	Phace association	Enrichment	BRAF	2.05
242	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.05
243	Melorheostosis	Enrichment	MAP2K1	2.05
244	Leopard syndrome 2	Enrichment	RAF1	2.05
245	Lethal congenital contracture syndrome 5	Enrichment	DNM2	2.05
246	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.05
247	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.05
248	Cowden syndrome 6	Enrichment	AKT1	2.05
249	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.05
250	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.05
251	Thrombocytopenia 6	Enrichment	SRC	2.05
252	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.05
253	Trigonitis	Enrichment	RAF1	2.05
254	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	2.05
255	Capillary hemangioma	Enrichment	AKT3	2.05
256	Congenital pulmonary airway malformation	Enrichment	KRAS	2.05
257	Nocarh syndrome	Enrichment	CDC42	2.05
258	Syringocystadenoma papilliferum	Enrichment	BRAF	2.05
259	Ganglioglioma	Enrichment	BRAF	2.05
260	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.05
261	Phace syndrome	Enrichment	BRAF	2.05
262	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.05
263	Classic hairy cell leukemia	Enrichment	BRAF	2.05
264	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.05
265	Neurocutaneous melanocytosis	Enrichment	NRAS	2.05
266	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.05
267	Congenital myopathy	Enrichment	CACNA1S, SCN4A	2.00
268	Congenital nervous system abnormality	Enrichment	CACNA1A, CREBBP, GNAO1, GNB5	1.98
269	Nervous system disease	Enrichment	CACNA1A, CREBBP, GNAO1, GNB5	1.98
270	Medulloblastoma	Enrichment	PTCH1, PTCH2	1.97
271	Ichthyosis hystrix, curth-macklin type	Enrichment	KRT1	1.94
272	Pallister-hall syndrome	Enrichment	GLI3	1.94
273	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	1.94
274	Greig cephalopolysyndactyly syndrome	Enrichment	GLI3	1.94
275	Palmoplantar keratoderma, nonepidermolytic	Enrichment	KRT1	1.94
276	Curry-jones syndrome	Enrichment	SMO	1.94
277	Schilbach-rott syndrome	Enrichment	PTCH1	1.94
278	Polydactyly, preaxial iv	Enrichment	GLI3	1.94
279	Polydactyly, preaxial i	Enrichment	GLI1	1.94
280	46,xy sex reversal 6	Enrichment	MAP3K1	1.94
281	Culler-jones syndrome	Enrichment	GLI2	1.94
282	Ichthyosis, annular epidermolytic, 2	Enrichment	KRT1	1.94
283	Polydactyly, postaxial, type a8	Enrichment	GLI1	1.94
284	Hereditary lymphedema id	Enrichment	VEGFC	1.94
285	Night blindness, congenital stationary, type1i	Enrichment	GUCY2D	1.94
286	Lymphatic malformation 4	Enrichment	VEGFC	1.94
287	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	1.94
288	Keratosis palmoplantaris striata iii	Enrichment	KRT1	1.94
289	Microvascular complications of diabetes 1	Enrichment	VEGFA	1.94
290	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	1.94
291	Holoprosencephaly 9	Enrichment	GLI2	1.94
292	Moyamoya disease 6 with or without achalasia	Enrichment	GUCY1A1	1.94
293	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	1.94
294	Long qt syndrome 16	Enrichment	CALM3	1.94
295	Moyamoya disease with early-onset achalasia	Enrichment	GUCY1A1	1.94
296	Long qt syndrome 15	Enrichment	CALM2	1.94
297	Cdkn2a cancer predisposition	Enrichment	CDKN2A	1.94
298	Palmoplantar keratoderma, epidermolytic, 2	Enrichment	KRT1	1.94
299	5q14.3 microdeletion syndrome	Enrichment	MEF2C	1.94
300	Cerebral cavernous malformations 5	Enrichment	MAP3K3	1.94
301	Turner syndrome	Enrichment	PTCH1	1.94
302	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	1.94
303	Congenital primary lymphedema of gordon	Enrichment	VEGFC	1.94
304	Monosomy 9q22.3	Enrichment	PTCH1	1.94
305	Mef2c-related disorder	Enrichment	MEF2C	1.94
306	Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome	Enrichment	GLI2	1.94
307	Verrucous hemangioma	Enrichment	MAP3K3	1.94
308	Septopreoptic holoprosencephaly	Enrichment	GLI2, PTCH1	1.91
309	Midline interhemispheric variant of holoprosencephaly	Enrichment	GLI2, PTCH1	1.91
310	Diffuse large b-cell lymphoma	Enrichment	BRAF, BTK	1.91
311	Ovarian cancer	Enrichment	AKT1, EGFR, KRAS, RRAS2	1.90
312	Myeloma, multiple	Enrichment	BRAF, KRAS, PIK3R2	1.87
313	Microform holoprosencephaly	Enrichment	GLI2, PTCH1	1.86
314	Lobar holoprosencephaly	Enrichment	GLI2, PTCH1	1.86
315	Centronuclear myopathy	Enrichment	CACNA1S, DNM2	1.83
316	Hypertension, essential	Enrichment	GNB3, NOS3	1.81
317	Melanoma, cutaneous malignant 1	Enrichment	BRAF, CDKN2A	1.81
318	Alobar holoprosencephaly	Enrichment	GLI2, PTCH1	1.81
319	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.80
320	Atrial standstill 1	Enrichment	SCN5A	1.80
321	Progressive familial heart block, type ia	Enrichment	SCN5A	1.80
322	Paramyotonia congenita	Enrichment	SCN4A	1.80
323	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	1.80
324	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.80
325	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.80
326	Batten-turner congenital myopathy	Enrichment	SCN4A	1.80
327	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.80
328	Thumb deformity	Enrichment	CREBBP	1.80
329	Indifference to pain, congenital, autosomal recessive	Enrichment	SCN9A	1.80
330	Polymyoclonus, infantile	Enrichment	SCNN1B	1.80
331	Timothy syndrome	Enrichment	CACNA1C	1.80
332	Night blindness, congenital stationary, type 2a	Enrichment	CACNA1F	1.80
333	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.80
334	Alternating hemiplegia of childhood 1	Enrichment	CACNA1A	1.80
335	Pseudopseudohypoparathyroidism	Enrichment	GNAS	1.80
336	Seizures, benign familial infantile, 3	Enrichment	SCN2A	1.80
337	Sick sinus syndrome 1	Enrichment	SCN5A	1.80
338	Myotonia, potassium-aggravated	Enrichment	SCN4A	1.80
339	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.80
340	Angioma, tufted	Enrichment	GNA14	1.80
341	Atrial fibrillation, familial, 10	Enrichment	SCN5A	1.80
342	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.80
343	Spermatogenic failure 17	Enrichment	PLCZ1	1.80
344	Migraine, familial hemiplegic, 3	Enrichment	SCN1A	1.80
345	Cognitive impairment with or without cerebellar ataxia	Enrichment	SCN8A	1.80
346	Long qt syndrome 3	Enrichment	SCN5A	1.80
347	Long qt syndrome 8	Enrichment	CACNA1C	1.80
348	Developmental and epileptic encephalopathy 6b	Enrichment	SCN1A	1.80
349	Sinoatrial node disease	Enrichment	SCN5A	1.80
350	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	1.80
351	Congenital myopathy 22a, classic	Enrichment	SCN4A	1.80
352	Congenital myopathy 22b, severe fetal	Enrichment	SCN4A	1.80
353	Menke-hennekam syndrome 2	Enrichment	EP300	1.80
354	Usher syndrome, type iv	Enrichment	PRKAR1A	1.80
355	Kowarski syndrome	Enrichment	GH1	1.80
356	Myasthenic syndrome, congenital, 16	Enrichment	SCN4A	1.80
357	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.80
358	Autosomal dominant hypocalcemia	Enrichment	GNA11	1.80
359	Acrodysostosis	Enrichment	PRKAR1A	1.80
360	Benign familial neonatal epilepsy	Enrichment	SCN2A	1.80
361	Pseudohypoparathyroidism	Enrichment	GNAS	1.80
362	Developmental and epileptic encephalopathy 30	Enrichment	SCN2A	1.80
363	Body mass index quantitative trait locus 19	Enrichment	ADCY3	1.80
364	Fibrolamellar carcinoma	Enrichment	PRKACA	1.80
365	Ocular melanoma	Enrichment	PLCB4	1.80
366	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	1.80
367	Hypopituitarism	Enrichment	GNAI2	1.80
368	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	CACNA1D	1.80
369	Hypokalemic periodic paralysis, type 2	Enrichment	SCN4A	1.80
370	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.80
371	Scn1a seizure disorders	Enrichment	SCN1A	1.80
372	Seizures, benign familial infantile, 5	Enrichment	SCN8A	1.80
373	Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements	Enrichment	CACNA1B	1.80
374	Malignant migrating partial seizures of infancy	Enrichment	SCN2A	1.80
375	Developmental and epileptic encephalopathy 76	Enrichment	SCN1A	1.80
376	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	1.80
377	Short stature due to growth hormone qualitative anomaly	Enrichment	GH1	1.80
378	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	1.80
379	Small fiber neuropathy	Enrichment	SCN9A	1.80
380	Benign neonatal seizures	Enrichment	SCN2A	1.80
381	Isolated atrial standstill	Enrichment	SCN5A	1.80
382	Pseudohypoaldosteronism	Enrichment	SCNN1A	1.80
383	Progressive bulbar palsy	Enrichment	CACNA1A	1.80
384	Cerebral visual impairment	Enrichment	GNB1	1.80
385	Phakomatosis cesioflammea	Enrichment	GNA11	1.80
386	Microcephaly	Enrichment	EP300, GNAO1, GNB1, SCN1A	1.76
387	Semilobar holoprosencephaly	Enrichment	GLI2, PTCH1	1.76
388	Complex neurodevelopmental disorder	Enrichment	CACNA1C, GNB2, SCN2A, SCN8A	1.75
389	Andersen cardiodysrhythmic periodic paralysis	Enrichment	KCNJ5	1.75
390	Fibromatosis, gingival, 1	Enrichment	SOS1	1.75
391	Costello syndrome	Enrichment	HRAS	1.75
392	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.75
393	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.75
394	Keppen-lubinsky syndrome	Enrichment	KCNJ6	1.75
395	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.75
396	Agammaglobulinemia, x-linked	Enrichment	BTK	1.75
397	Noonan syndrome 12	Enrichment	RRAS2	1.75
398	Senior-loken syndrome 7	Enrichment	AKT3	1.75
399	Immune system disease	Enrichment	CDC42	1.75
400	Bardet-biedl syndrome 16	Enrichment	AKT3	1.75
401	Tafro syndrome	Enrichment	MAP2K2	1.75
402	Wooly hair nevus	Enrichment	HRAS	1.75
403	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C, RAF1	1.72
404	Strabismus	Enrichment	CACNA1A, GNB1	1.71
405	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.65
406	Pallister-hall-like syndrome	Enrichment	SMO	1.65
407	Keratoderma, palmoplantar, with nail dystrophy and hereditary motor-sensory neuropathy	Enrichment	KRT1	1.65
408	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.65
409	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.65
410	White-sutton syndrome	Enrichment	GLI2	1.65
411	Epiphyseal chondrodysplasia, miura type	Enrichment	NPR2	1.65
412	Long qt syndrome 14	Enrichment	CALM1	1.65
413	Tibial hemimelia	Enrichment	GLI3	1.65
414	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.65
415	Synpolydactyly	Enrichment	GLI3	1.65
416	Acromesomelic dysplasia 1	Enrichment	NPR2	1.65
417	Commissural facial cleft	Enrichment	PTCH2	1.65
418	Mccune-albright syndrome	Enrichment	GNAS	1.62
419	Dystonia 12	Enrichment	SCN2A	1.62
420	Van der woude syndrome 1	Enrichment	CACNA1E	1.62
421	Gillespie syndrome	Enrichment	ITPR1	1.62
422	Nephrotic syndrome, type 3	Enrichment	PLCE1	1.62
423	Generalized epilepsy with febrile seizures plus, type 2	Enrichment	SCN1A	1.62
424	Developmental and epileptic encephalopathy 13	Enrichment	SCN8A	1.62
425	Generalized epilepsy with febrile seizures plus, type 7	Enrichment	SCN9A	1.62
426	Tremor, hereditary essential, 6	Enrichment	SCN4A	1.62
427	Tethered spinal cord syndrome	Enrichment	CREBBP	1.62
428	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.62
429	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.62
430	Melanoma of soft tissue	Enrichment	CREB1	1.62
431	Thyrotoxic periodic paralysis	Enrichment	CACNA1S	1.62
432	Ataxia-telangiectasia	Enrichment	BRAF	1.58
433	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.58
434	Nuchal bleb, familial	Enrichment	SOS1	1.58
435	Myopathy, centronuclear, x-linked	Enrichment	DNM2	1.58
436	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.58
437	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.58
438	Agammaglobulinemia 1	Enrichment	BTK	1.58
439	Immunodeficiency 14	Enrichment	PIK3R1	1.58
440	Spermatocytoma	Enrichment	HRAS	1.58
441	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.58
442	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.51
443	Migraine, familial hemiplegic, 1	Enrichment	CACNA1A	1.50
444	Isolated growth hormone deficiency, type ii	Enrichment	GH1	1.50
445	Spinocerebellar ataxia 6	Enrichment	CACNA1A	1.50
446	Neuropathy, hereditary sensory and autonomic, type iia	Enrichment	SCN9A	1.50
447	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.50
448	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.50
449	Aland island eye disease	Enrichment	CACNA1F	1.50
450	Developmental and epileptic encephalopathy 2	Enrichment	CACNA1A	1.50
451	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.50
452	Carney complex variant	Enrichment	PRKAR1A	1.50
453	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.50
454	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.50
455	Long qt syndrome 2	Enrichment	SCN5A	1.50
456	Hyperkalemic periodic paralysis	Enrichment	SCN4A	1.50
457	Developmental and epileptic encephalopathy 42	Enrichment	CACNA1A	1.50
458	Cerebellar atrophy with seizures and variable developmental delay	Enrichment	CACNA2D2	1.50
459	Hereditary sensory and autonomic neuropathy type 2	Enrichment	SCN9A	1.50
460	Atrial fibrillation	Enrichment	SCN5A	1.50
461	Sotos syndrome 1	Enrichment	SCN4A	1.50
462	Malignant hyperthermia	Enrichment	CACNA1S	1.50
463	Sick sinus syndrome	Enrichment	SCN5A	1.50
464	Paroxysmal familial ventricular fibrillation	Enrichment	SCN5A	1.50
465	Dystonia	Enrichment	GNAL, GNB1	1.49
466	Palmoplantar keratoderma, epidermolytic, 1	Enrichment	KRT1	1.47
467	Acrocallosal syndrome	Enrichment	GLI3	1.47
468	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.47
469	Aarskog-scott syndrome	Enrichment	GLI3	1.47
470	Obesity, early-onset, with adrenal insufficiency and red hair	Enrichment	POMC	1.47
471	Ichthyosis with confetti	Enrichment	KRT1	1.47
472	Holoprosencephaly 7	Enrichment	PTCH1	1.47
473	Ichthyosis, annular epidermolytic, 1	Enrichment	KRT1	1.47
474	Epilepsy, familial focal, with variable foci 2	Enrichment	NPR2	1.47
475	Umbilical hernia	Enrichment	GLI3	1.47
476	Keratosis palmoplantaris striata	Enrichment	KRT1	1.47
477	Polr3-related leukodystrophy	Enrichment	GUCY2D	1.47
478	Annular epidermolytic ichthyosis	Enrichment	KRT1	1.47
479	Mpv17-related mitochondrial dna maintenance defect	Enrichment	UCN	1.47
480	Autosomal dominant epidermolytic ichthyosis	Enrichment	KRT1	1.47
481	Obesity due to pro-opiomelanocortin deficiency	Enrichment	POMC	1.47
482	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.45
483	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.45
484	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.45
485	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.45
486	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.45
487	Hereditary ataxia	Enrichment	PRKCG	1.45
488	Craniopharyngioma	Enrichment	BRAF	1.45
489	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.45
490	Pilocytic astrocytoma	Enrichment	KRAS	1.45
491	Newborn respiratory distress syndrome	Enrichment	BRAF	1.45
492	Epidermolytic nevus	Enrichment	HRAS	1.45
493	Gingival fibromatosis	Enrichment	SOS1	1.45
494	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.45
495	Capillary malformations, congenital	Enrichment	GNA11	1.40
496	Sotos syndrome	Enrichment	SCN4A	1.40
497	Episodic ataxia, type 2	Enrichment	CACNA1A	1.40
498	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	SCN8A	1.40
499	Night blindness, congenital stationary, type 1c	Enrichment	GNAT1	1.40
500	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.40
501	Amblyopia	Enrichment	CACNA1F	1.40
502	Congenital short qt syndrome	Enrichment	CACNA2D1	1.40
503	Sensory peripheral neuropathy	Enrichment	SCN11A	1.40
504	Cone-rod dystrophy 2	Enrichment	CACNA1F, CACNA2D4, GUCY2D	1.38
505	Hirschsprung disease 1	Enrichment	GLI3, SMO	1.37
506	Hemimegalencephaly	Enrichment	AKT3	1.36
507	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.36
508	Polydactyly, preaxial ii	Enrichment	PTCH1	1.35
509	Mitochondrial dna depletion syndrome 6	Enrichment	UCN	1.35
510	Autoimmune lymphoproliferative syndrome	Enrichment	FASLG	1.35
511	Short stature with nonspecific skeletal abnormalities 1	Enrichment	NPR2	1.35
512	Congenital generalized lipodystrophy	Enrichment	FOS	1.35
513	Charcot-marie-tooth disease, axonal, type 2ee	Enrichment	UCN	1.35
514	Idiopathic achalasia	Enrichment	NOS1	1.35
515	Epidermolytic hyperkeratosis	Enrichment	KRT1	1.35
516	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.33
517	Pain disorder	Enrichment	SCN4A	1.33
518	Hypertrichosis	Enrichment	CREBBP	1.33
519	Childhood absence epilepsy	Enrichment	CACNA1H	1.33
520	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.31
521	Myopathy, centronuclear, 1	Enrichment	DNM2	1.28
522	Cowden syndrome 1	Enrichment	EGFR	1.28
523	Wilms tumor 5	Enrichment	BRAF	1.28
524	Limited scleroderma	Enrichment	CAV1	1.28
525	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	SCN3A	1.26
526	Brachydactyly	Enrichment	GNAS	1.26
527	Alzheimer disease 2	Enrichment	NOS3	1.26
528	Epidermolytic hyperkeratosis 1	Enrichment	KRT1	1.26
529	Choroidal dystrophy, central areolar, 1	Enrichment	GUCY2D	1.26
530	3-methylglutaconic aciduria, type iii	Enrichment	GUCY2D	1.26
531	Pre-eclampsia	Enrichment	NOS3	1.26
532	Histiocytoid hemangioma	Enrichment	FOS	1.26
533	Hereditary breast carcinoma	Enrichment	AKT1, KRAS	1.23
534	Myelofibrosis	Enrichment	SRC	1.22
535	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.22
536	Megacolon	Enrichment	AKT3	1.22
537	Overgrowth syndrome	Enrichment	PIK3R1	1.22
538	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.20
539	Isolated growth hormone deficiency, type ia	Enrichment	GH1	1.20
540	Hypothyroidism	Enrichment	GNB1	1.20
541	Choreatic disease	Enrichment	GNAO1	1.20
542	Difference of sex development	Enrichment	CACNA1A	1.20
543	Li-fraumeni syndrome	Enrichment	CDKN2A	1.18
544	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	1.18
545	Moyamoya disease 1	Enrichment	GUCY1A1	1.18
546	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.18
547	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.16
548	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	SCNN1B	1.15
549	Nephrotic syndrome, type 1	Enrichment	PLCE1	1.15
550	Charge syndrome	Enrichment	EP300	1.15
551	Myoclonic-atonic epilepsy	Enrichment	SCN1A	1.15
552	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C	1.15
553	Bilateral perisylvian polymicrogyria	Enrichment	SCN3A	1.15
554	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	SCN5A	1.15
555	Autosomal dominant sleep-related hypermotor epilepsy	Enrichment	CRH	1.11
556	Congenital hydrocephalus	Enrichment	PTCH1	1.11
557	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A	1.11
558	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.11
559	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.11
560	Ventricular septal defect	Enrichment	BRAF	1.11
561	Cowden syndrome	Enrichment	AKT1	1.11
562	Polymicrogyria	Enrichment	SCN3A	1.11
563	Achromatopsia	Enrichment	GNAT2	1.11
564	Migraine with or without aura 1	Enrichment	CACNA1A	1.07
565	Epilepsy, myoclonic juvenile	Enrichment	CACNB4	1.07
566	Epilepsy, idiopathic generalized	Enrichment	CACNA1H	1.07
567	Myelodysplastic syndrome	Enrichment	GNB1	1.07
568	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.07
569	Leber congenital amaurosis 1	Enrichment	GUCY2D	1.06
570	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.06
571	Combined pituitary hormone deficiency	Enrichment	GLI2	1.06
572	Optic atrophy plus syndrome	Enrichment	CACNA1F, GUCY2D	1.05
573	Postsynaptic congenital myasthenic syndromes	Enrichment	SCN4A	1.03
574	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.03
575	Specific learning disability	Enrichment	MAPK1	1.03
576	Congenital central hypoventilation syndrome	Enrichment	BDNF	1.01
577	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.00
578	Meningioma	Enrichment	AKT1	0.99
579	Multiple sclerosis	Enrichment	ITPR1	0.97
580	Heart disease	Enrichment	CREBBP	0.97
581	Aortic valve disease 1	Enrichment	SOS1	0.96
582	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	0.96
583	Protein-deficiency anemia	Enrichment	NRAS	0.96
584	Corpus callosum, agenesis of	Enrichment	CREBBP	0.94
585	Myopia	Enrichment	CACNA1F	0.94
586	Anterior segment dysgenesis	Enrichment	ITPR1	0.94
587	Isolated corpus callosum agenesis	Enrichment	CREBBP	0.94
588	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	0.94
589	Osteoporosis	Enrichment	SRC	0.93
590	46,xy partial gonadal dysgenesis	Enrichment	SOS1	0.93
591	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	0.93
592	Wolff-parkinson-white syndrome	Enrichment	SCN5A	0.92
593	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	SCN5A	0.92
594	Wilms tumor 1	Enrichment	BRAF	0.90
595	Lynch syndrome	Enrichment	KRAS	0.90
596	Autism spectrum disorder	Enrichment	GNB1, MAP2K1, MEF2C	0.90
597	Cleft palate, isolated	Enrichment	GNB1	0.89
598	Cardiomyopathy, dilated, 1e	Enrichment	SCN5A	0.89
599	Rhabdomyosarcoma	Enrichment	HRAS	0.87
600	Gliosarcoma	Enrichment	EGFR	0.87
601	Diaphragmatic hernia, congenital	Enrichment	GLI3	0.86
602	Dandy-walker syndrome	Enrichment	BRAF	0.85
603	Giant cell glioblastoma	Enrichment	EGFR	0.85
604	Heart, malformation of	Enrichment	MAPK1	0.83
605	Focal segmental glomerulosclerosis	Enrichment	PLCE1	0.83
606	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	0.80
607	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.79
608	Malaria	Enrichment	SCN8A	0.77
609	Scoliosis	Enrichment	CREBBP	0.75
610	Alzheimer disease, familial, 1	Enrichment	NOS3	0.75
611	Auditory neuropathy	Enrichment	CACNA1A	0.72
612	Inherited cancer-predisposing syndrome	Enrichment	CDKN2A, PRKAR1A, PTCH1	0.72
613	Pancreatic cancer	Enrichment	KRAS	0.70
614	Macs syndrome	Enrichment	PTCH1	0.69
615	Hereditary retinal dystrophy	Enrichment	CACNA1F, CACNA2D4, GNAT1, GNAT2	0.69
616	Fundus dystrophy	Enrichment	CACNA1F, CACNA2D4, GNAT1, GNAT2	0.69
617	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.68
618	Retinitis pigmentosa	Enrichment	CACNA1F, CACNA2D4, GNAT1, GUCY2D	0.66
619	Myocardial infarction	Enrichment	GUCY1A1	0.65
620	Microphthalmia	Enrichment	PTCH1	0.65
621	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A	0.64
622	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	0.62
623	Left ventricular noncompaction	Enrichment	SCN5A	0.61
624	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.59
625	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	0.56
626	Myopathy	Enrichment	SCN4A	0.56
627	Nephrotic syndrome	Enrichment	PLCE1	0.53
628	Charcot-marie-tooth disease	Enrichment	DNM2	0.51
629	Type 2 diabetes mellitus	Enrichment	AKT2	0.50
630	Gastric cancer	Enrichment	KRAS	0.49
631	Familial isolated dilated cardiomyopathy	Enrichment	SCN5A	0.46
632	Thrombocytopenia	Enrichment	SRC	0.46
633	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.41
634	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.34
635	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GLI2	0.33
636	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.31
637	Primary ovarian insufficiency	Enrichment	NOS3	0.31
638	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.29
639	Leber plus disease	Enrichment	GUCY2D	0.18

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G-Beta Gamma Signaling

Pathway Network for G-Beta Gamma Signaling

Pathway network for the G-Beta Gamma Signaling SuperPath

Member Pathways for G-Beta Gamma Signaling

Pathways in the G-Beta Gamma Signaling SuperPath

Gene overlap in member pathways for G-Beta Gamma Signaling SuperPath

Associated Genes for G-Beta Gamma Signaling

Associated Disorders for G-Beta Gamma Signaling

Disorders associated with G-Beta Gamma Signaling SuperPath

STRING Interaction Network for G-Beta Gamma Signaling

Sources for G-Beta Gamma Signaling