G-protein beta:gamma signalling

Pathway network for the G-protein beta:gamma signalling SuperPath

Sources:

Reactome

Pathways in the G-protein beta:gamma signalling SuperPath

#	Name	Source	Genes
1	G-protein beta:gamma signalling	Reactome	AKT1 AKT2 AKT3 ARHGEF6 BTK CDC42 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PAK1 PDPK1 PIK3CG PIK3R5 PIK3R6 PLCB1 PLCB2 PLCB3 RHOA (see all 32) (see less)
2	G beta:gamma signalling through PI3Kgamma	Reactome	AKT1 AKT2 AKT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PDPK1 PIK3CG PIK3R5 PIK3R6 RHOA (see all 25) (see less)
3	G beta:gamma signalling through CDC42	Reactome	ARHGEF6 CDC42 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PAK1 (see all 20) (see less)
4	G beta:gamma signalling through BTK	Reactome	BTK GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 (see all 18) (see less)

Gene overlap in member pathways for G-protein beta:gamma signalling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GNB5	G Protein Subunit Beta 5	Protein Coding	4
2	GNB1	G Protein Subunit Beta 1	Protein Coding	4
3	GNB2	G Protein Subunit Beta 2	Protein Coding	4
4	GNB3	G Protein Subunit Beta 3	Protein Coding	4
5	GNG3	G Protein Subunit Gamma 3	Protein Coding	4
6	GNG4	G Protein Subunit Gamma 4	Protein Coding	4
7	GNG5	G Protein Subunit Gamma 5	Protein Coding	4
8	GNG7	G Protein Subunit Gamma 7	Protein Coding	4
9	GNG10	G Protein Subunit Gamma 10	Protein Coding	4
10	GNG11	G Protein Subunit Gamma 11	Protein Coding	4
11	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	4
12	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	4
13	GNG13	G Protein Subunit Gamma 13	Protein Coding	4
14	GNG2	G Protein Subunit Gamma 2	Protein Coding	4
15	GNG12	G Protein Subunit Gamma 12	Protein Coding	4
16	GNB4	G Protein Subunit Beta 4	Protein Coding	4
17	GNG8	G Protein Subunit Gamma 8	Protein Coding	4
18	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
19	PIK3R6	Phosphoinositide-3-Kinase Regulatory Subunit 6	Protein Coding	2
20	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
21	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
22	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
23	RHOA	Ras Homolog Family Member A	Protein Coding	2
24	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
25	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
26	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	2
27	BTK	Bruton Tyrosine Kinase	Protein Coding	2
28	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	2
29	CDC42	Cell Division Cycle 42	Protein Coding	2
30	PLCB1	Phospholipase C Beta 1	Protein Coding	1
31	PLCB2	Phospholipase C Beta 2	Protein Coding	1
32	PLCB3	Phospholipase C Beta 3	Protein Coding	1

Disorders associated with G-protein beta:gamma signalling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.88
2	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.88
3	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.88
4	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.88
5	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.88
6	Sick sinus syndrome 4	Enrichment	GNB2	2.88
7	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.83
8	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	2.83
9	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.83
10	Nocarh syndrome	Enrichment	CDC42	2.83
11	Proteus syndrome	Enrichment	AKT1	2.73
12	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.73
13	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.73
14	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.73
15	Cowden syndrome 6	Enrichment	AKT1	2.73
16	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.73
17	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.73
18	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.73
19	Capillary hemangioma	Enrichment	AKT3	2.73
20	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.73
21	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.63
22	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	2.58
23	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.58
24	Agammaglobulinemia, x-linked	Enrichment	BTK	2.58
25	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.58
26	Cerebral visual impairment	Enrichment	GNB1	2.58
27	Immune system disease	Enrichment	CDC42	2.53
28	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.43
29	Senior-loken syndrome 7	Enrichment	AKT3	2.43
30	Bardet-biedl syndrome 16	Enrichment	AKT3	2.43
31	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	2.40
32	Agammaglobulinemia 1	Enrichment	BTK	2.40
33	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	2.28
34	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	2.28
35	Familial sick sinus syndrome	Enrichment	GNB2	2.28
36	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.23
37	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.13
38	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.13
39	Breast cancer	Enrichment	AKT1, GNG3	2.08
40	Hemimegalencephaly	Enrichment	AKT3	2.04
41	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	2.03
42	Hypothyroidism	Enrichment	GNB1	1.98
43	Hemihyperplasia, isolated	Enrichment	RHOA	1.96
44	Breast adenocarcinoma	Enrichment	AKT1	1.96
45	Megacolon	Enrichment	AKT3	1.89
46	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.84
47	Myelodysplastic syndrome	Enrichment	GNB1	1.84
48	Cowden syndrome	Enrichment	AKT1	1.78
49	Polymicrogyria	Enrichment	AKT3	1.74
50	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.68
51	Meningioma	Enrichment	AKT1	1.66
52	Hypertension, essential	Enrichment	GNB3	1.65
53	Cleft palate, isolated	Enrichment	GNB1	1.65
54	Diffuse large b-cell lymphoma	Enrichment	BTK	1.60
55	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.54
56	Congenital stationary night blindness	Enrichment	GNB3	1.52
57	Strabismus	Enrichment	GNB1	1.45
58	Dystonia	Enrichment	GNB1	1.34
59	Cerebral palsy	Enrichment	GNB1	1.30
60	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	1.29
61	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	1.19
62	Type 2 diabetes mellitus	Enrichment	AKT2	1.13
63	Hereditary breast carcinoma	Enrichment	AKT1	1.11
64	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	1.03
65	Centralopathic epilepsy	Enrichment	PLCB1	1.01
66	West syndrome	Enrichment	PLCB1	1.01
67	Congenital nervous system abnormality	Enrichment	GNB5	0.88
68	Nervous system disease	Enrichment	GNB5	0.88
69	Autism spectrum disorder	Enrichment	GNB1	0.87
70	Colorectal cancer	Enrichment	AKT1	0.83
71	Microcephaly	Enrichment	GNB1	0.82
72	Complex neurodevelopmental disorder	Enrichment	GNB2	0.82
73	Ovarian cancer	Enrichment	AKT1	0.77

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G-protein beta:gamma signalling

Pathway Network for G-protein beta:gamma signalling

Pathway network for the G-protein beta:gamma signalling SuperPath

Member Pathways for G-protein beta:gamma signalling

Pathways in the G-protein beta:gamma signalling SuperPath

Gene overlap in member pathways for G-protein beta:gamma signalling SuperPath

Associated Genes for G-protein beta:gamma signalling

Associated Disorders for G-protein beta:gamma signalling

Disorders associated with G-protein beta:gamma signalling SuperPath

STRING Interaction Network for G-protein beta:gamma signalling

Sources for G-protein beta:gamma signalling