G-protein signaling_Cross-talk between Ras-family GTPases

No Pathway Network information available for G-protein signaling_Cross-talk between Ras-family GTPases

Pathways in the G-protein signaling_Cross-talk between Ras-family GTPases SuperPath

#	Name	Source	Genes
1	G-protein signaling_Cross-talk between Ras-family GTPases	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 ARHGAP5 BRAF CDC42 HRAS MCF2L MRAS PDPK1 PIK3CA PIK3CB PIK3CD PLD1 RAC1 RAF1 RALA RALBP1 RALGDS RAP1A RAPGEF5 RASA1 RHOA TIAM1 (see all 24) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
2	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
3	RHOA	Ras Homolog Family Member A	Protein Coding	1
4	ARHGAP5	Rho GTPase Activating Protein 5	Protein Coding	1
5	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
6	CDC42	Cell Division Cycle 42	Protein Coding	1
7	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
8	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
9	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
10	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
11	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
12	PLD1	Phospholipase D1	Protein Coding	1
13	RAC1	Rac Family Small GTPase 1	Protein Coding	1
14	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
15	RALA	RAS Like Proto-Oncogene A	Protein Coding	1
16	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	1
17	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
18	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
19	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
20	RAPGEF5	Rap Guanine Nucleotide Exchange Factor 5	Protein Coding	1
21	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
22	RALBP1	RalA Binding Protein 1	Protein Coding	1
23	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
24	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	1

Disorders associated with G-protein signaling_Cross-talk between Ras-family GTPases SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	BRAF, HRAS, MRAS, RAF1	7.19
2	Rasopathy	Enrichment	BRAF, HRAS, MRAS, RAF1	6.96
3	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, RAF1	6.57
4	Arteriovenous malformation	Enrichment	HRAS, PIK3CA, RASA1	6.39
5	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA, RASA1	6.24
6	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, PIK3CA	6.10
7	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS, PIK3CA	5.97
8	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, RAF1	5.66
9	Immune system disease	Enrichment	CDC42, PIK3CD	5.52
10	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA	4.75
11	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	4.75
12	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	4.52
13	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	4.52
14	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	4.35
15	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	4.35
16	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.35
17	Nevus, epidermal	Enrichment	HRAS, PIK3CA	4.20
18	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS	4.20
19	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA, RASA1	4.20
20	Noonan syndrome 3	Enrichment	HRAS, RAF1	4.20
21	Gallbladder cancer	Enrichment	BRAF, PIK3CA	4.20
22	Pilomyxoid astrocytoma	Enrichment	BRAF, RAF1	4.20
23	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS	4.20
24	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.97
25	Meningioma	Enrichment	AKT1, PIK3CA	3.71
26	Colorectal cancer	Enrichment	AKT1, BRAF, PIK3CA	3.33
27	Bladder cancer	Enrichment	HRAS, PIK3CA	2.93
28	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS	2.93
29	Lung cancer	Enrichment	BRAF, PIK3CA	2.84
30	Macrodactyly	Enrichment	PIK3CA	2.75
31	Proteus syndrome	Enrichment	AKT1	2.75
32	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.75
33	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.75
34	Noonan syndrome 5	Enrichment	RAF1	2.75
35	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.75
36	Noonan syndrome 7	Enrichment	BRAF	2.75
37	Leopard syndrome 3	Enrichment	BRAF	2.75
38	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.75
39	Cowden syndrome 5	Enrichment	PIK3CA	2.75
40	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.75
41	Hiatt-neu-cooper neurodevelopmental syndrome	Enrichment	RALA	2.75
42	Noonan syndrome 11	Enrichment	MRAS	2.75
43	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.75
44	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.75
45	Lymphangioma	Enrichment	BRAF	2.75
46	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.75
47	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.75
48	Phace association	Enrichment	BRAF	2.75
49	Leopard syndrome 2	Enrichment	RAF1	2.75
50	Cowden syndrome 6	Enrichment	AKT1	2.75
51	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.75
52	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.75
53	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.75
54	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.75
55	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.75
56	Trigonitis	Enrichment	RAF1	2.75
57	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.75
58	Hypospadias	Enrichment	PIK3CA	2.75
59	Capillary hemangioma	Enrichment	AKT3	2.75
60	Rare venous malformation	Enrichment	PIK3CA	2.75
61	Gorham's disease	Enrichment	RASA1	2.75
62	Diaphragmatic eventration	Enrichment	PIK3CA	2.75
63	Nocarh syndrome	Enrichment	CDC42	2.75
64	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.75
65	Syringocystadenoma papilliferum	Enrichment	BRAF	2.75
66	Rare combined vascular malformation	Enrichment	PIK3CA	2.75
67	Ganglioglioma	Enrichment	BRAF	2.75
68	Cavernous lymphangioma	Enrichment	PIK3CA	2.75
69	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.75
70	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.75
71	Phace syndrome	Enrichment	BRAF	2.75
72	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.75
73	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.75
74	Classic hairy cell leukemia	Enrichment	BRAF	2.75
75	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.75
76	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.75
77	Macrodactyly of toe	Enrichment	PIK3CA	2.75
78	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.75
79	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.57
80	Costello syndrome	Enrichment	HRAS	2.45
81	Pulmonic stenosis	Enrichment	BRAF	2.45
82	Keratosis, seborrheic	Enrichment	PIK3CA	2.45
83	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.45
84	Noonan syndrome 8	Enrichment	PIK3CA	2.45
85	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.45
86	Senior-loken syndrome 7	Enrichment	AKT3	2.45
87	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.45
88	Bardet-biedl syndrome 16	Enrichment	AKT3	2.45
89	Wooly hair nevus	Enrichment	HRAS	2.45
90	Ataxia-telangiectasia	Enrichment	BRAF	2.28
91	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.28
92	Langerhans cell histiocytosis	Enrichment	BRAF	2.28
93	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.28
94	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD	2.28
95	Tethered spinal cord syndrome	Enrichment	BRAF	2.28
96	Large congenital melanocytic nevus	Enrichment	HRAS	2.28
97	Wieacker-wolff syndrome	Enrichment	RASA1	2.28
98	Immunodeficiency 14	Enrichment	PIK3CD	2.28
99	Spermatocytoma	Enrichment	HRAS	2.28
100	Keratoacanthoma	Enrichment	PIK3CA	2.28
101	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.15
102	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF	2.15
103	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	2.15
104	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.15
105	Cardiofaciocutaneous syndrome	Enrichment	BRAF	2.15
106	Cerebrovascular disease	Enrichment	PIK3CA	2.15
107	Craniopharyngioma	Enrichment	BRAF	2.15
108	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.15
109	Newborn respiratory distress syndrome	Enrichment	BRAF	2.15
110	Epidermolytic nevus	Enrichment	HRAS	2.15
111	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.15
112	Breast cancer	Enrichment	AKT1, PIK3CA	2.11
113	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	2.06
114	Martsolf syndrome 1	Enrichment	ARHGAP5	2.05
115	Cowden syndrome 1	Enrichment	PIK3CA	1.98
116	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.98
117	Wilms tumor 5	Enrichment	BRAF	1.98
118	Hemangioma, capillary infantile	Enrichment	RASA1	1.98
119	Basal cell carcinoma 1	Enrichment	RASA1	1.98
120	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.98
121	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.91
122	Megacolon	Enrichment	AKT3	1.91
123	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.87
124	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.85
125	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.80
126	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.80
127	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.80
128	Primary hyperaldosteronism	Enrichment	BRAF	1.80
129	Ventricular septal defect	Enrichment	BRAF	1.80
130	Polymicrogyria	Enrichment	AKT3	1.76
131	Melanoma	Enrichment	BRAF	1.76
132	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD	1.76
133	Complex neurodevelopmental disorder	Enrichment	RALA, TIAM1	1.70
134	Nk-cell enteropathy	Enrichment	PIK3CB	1.64
135	Lung cancer susceptibility 3	Enrichment	BRAF	1.61
136	Wilms tumor 1	Enrichment	BRAF	1.58
137	Lynch syndrome	Enrichment	PIK3CA	1.58
138	Rhabdomyosarcoma	Enrichment	HRAS	1.55
139	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.53
140	Dandy-walker syndrome	Enrichment	BRAF	1.53
141	Arteriovenous malformations of the brain	Enrichment	BRAF	1.48
142	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.48
143	Cardiomyopathy, dilated, 1a	Enrichment	RAPGEF5	1.44
144	Endometrial cancer	Enrichment	PIK3CA	1.44
145	Hepatocellular carcinoma	Enrichment	PIK3CA	1.42
146	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.38
147	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.35
148	Prostate cancer	Enrichment	PIK3CA	1.30
149	Non-immune hydrops fetalis	Enrichment	HRAS	1.27
150	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.25
151	Left ventricular noncompaction	Enrichment	RAF1	1.22
152	Type 2 diabetes mellitus	Enrichment	AKT2	1.14
153	Gastric cancer	Enrichment	PIK3CA	1.13
154	Hypertelorism	Enrichment	PIK3CA	1.05
155	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.05
156	Myeloma, multiple	Enrichment	BRAF	1.02

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G-protein signaling_Cross-talk between Ras-family GTPases

Pathway Network for G-protein signaling_Cross-talk between Ras-family GTPases

Member Pathways for G-protein signaling_Cross-talk between Ras-family GTPases

Pathways in the G-protein signaling_Cross-talk between Ras-family GTPases SuperPath

Associated Genes for G-protein signaling_Cross-talk between Ras-family GTPases

Associated Disorders for G-protein signaling_Cross-talk between Ras-family GTPases

Disorders associated with G-protein signaling_Cross-talk between Ras-family GTPases SuperPath

STRING Interaction Network for G-protein signaling_Cross-talk between Ras-family GTPases

Sources for G-protein signaling_Cross-talk between Ras-family GTPases