G-protein signaling_H-RAS regulation pathway

No Pathway Network information available for G-protein signaling_H-RAS regulation pathway

Pathways in the G-protein signaling_H-RAS regulation pathway SuperPath

#	Name	Source	Genes
1	G-protein signaling_H-RAS regulation pathway	GeneGo (Thomson Reuters)	ADRB1 ANGPT1 BCR DOK1 DOK2 FNTA FNTB GDNF GFRA1 GIPC1 GRB2 HRAS ICMT LCK MAGI1 PDGFB PDGFRB PIK3CA PIK3CB PIK3CD RAF1 RALGDS RAPGEF2 RASA1 RASA3 RASGRF1 RASGRF2 RASGRP1 RASGRP3 RASGRP4 RET SHC1 SOS1 SOS2 SRC TEK TIAM1 (see all 37) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADRB1	Adrenoceptor Beta 1	Protein Coding	1
2	ANGPT1	Angiopoietin 1	Protein Coding	1
3	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	1
4	DOK1	Docking Protein 1	Protein Coding	1
5	FNTA	Farnesyltransferase, CAAX Box, Subunit Alpha	Protein Coding	1
6	FNTB	Farnesyltransferase, CAAX Box, Subunit Beta	Protein Coding	1
7	GDNF	Glial Cell Derived Neurotrophic Factor	Protein Coding	1
8	GFRA1	GDNF Family Receptor Alpha 1	Protein Coding	1
9	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
10	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
11	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
12	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
13	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
14	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
15	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
16	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
17	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
18	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	1
19	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
20	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	1
21	RASGRF2	Ras Protein Specific Guanine Nucleotide Releasing Factor 2	Protein Coding	1
22	RET	Ret Proto-Oncogene	Protein Coding	1
23	SHC1	SHC Adaptor Protein 1	Protein Coding	1
24	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
25	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
26	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
27	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	1
28	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
29	DOK2	Docking Protein 2	Protein Coding	1
30	MAGI1	Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 1	Protein Coding	1
31	RAPGEF2	Rap Guanine Nucleotide Exchange Factor 2	Protein Coding	1
32	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	1
33	GIPC1	GIPC PDZ Domain Containing Family Member 1	Protein Coding	1
34	RASA3	RAS P21 Protein Activator 3	Protein Coding	1
35	ICMT	Isoprenylcysteine Carboxyl Methyltransferase	Protein Coding	1
36	RASGRP3	RAS Guanyl Releasing Protein 3	Protein Coding	1
37	RASGRP4	RAS Guanyl Releasing Protein 4	Protein Coding	1

Disorders associated with G-protein signaling_H-RAS regulation pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Arteriovenous malformation	Enrichment	HRAS, PIK3CA, RASA1, TEK	8.23
2	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA, RASA1, TEK	8.01
3	Noonan syndrome 1	Enrichment	HRAS, RAF1, SOS1, SOS2	6.40
4	Noonan syndrome 3	Enrichment	HRAS, RAF1, SOS1	6.19
5	Rasopathy	Enrichment	HRAS, RAF1, SOS1, SOS2	6.17
6	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, RAF1, SOS1	5.08
7	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	4.14
8	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	3.97
9	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.82
10	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA, RASA1	3.82
11	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.70
12	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	3.70
13	Congenital central hypoventilation syndrome	Enrichment	GDNF, RET	3.59
14	Renal agenesis, bilateral	Enrichment	GFRA1, RET	3.59
15	Lung non-small cell carcinoma	Enrichment	HRAS, PIK3CA	3.41
16	Meningioma	Enrichment	PDGFB, PIK3CA	3.33
17	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.33
18	Breast cancer	Enrichment	PIK3CA, RET, SHC1	2.96
19	Hepatocellular carcinoma	Enrichment	PIK3CA, RET	2.79
20	Colorectal cancer	Enrichment	PIK3CA, RET, SRC	2.77
21	Multiple endocrine neoplasia, type iib	Enrichment	RET	2.56
22	Macrodactyly	Enrichment	PIK3CA	2.56
23	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.56
24	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.56
25	Noonan syndrome 5	Enrichment	RAF1	2.56
26	Noonan syndrome 4	Enrichment	SOS1	2.56
27	Resting heart rate, variation in	Enrichment	ADRB1	2.56
28	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.56
29	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.56
30	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.56
31	Cowden syndrome 5	Enrichment	PIK3CA	2.56
32	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.56
33	Noonan syndrome 9	Enrichment	SOS2	2.56
34	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	2.56
35	Angioedema, hereditary, 5	Enrichment	ANGPT1	2.56
36	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.56
37	Venous malformations, multiple cutaneous and mucosal	Enrichment	TEK	2.56
38	Renal hypodysplasia/aplasia 4	Enrichment	GFRA1	2.56
39	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.56
40	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.56
41	Oculopharyngodistal myopathy 2	Enrichment	GIPC1	2.56
42	Leopard syndrome 2	Enrichment	RAF1	2.56
43	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.56
44	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.56
45	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.56
46	Hirschsprung disease 3	Enrichment	GDNF	2.56
47	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.56
48	Immunodeficiency 22	Enrichment	LCK	2.56
49	Thrombocytopenia 6	Enrichment	SRC	2.56
50	Glaucoma 3, primary congenital, e	Enrichment	TEK	2.56
51	Epilepsy, familial adult myoclonic, 7	Enrichment	RAPGEF2	2.56
52	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.56
53	Short sleep, familial natural, 2	Enrichment	ADRB1	2.56
54	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.56
55	Trigonitis	Enrichment	RAF1	2.56
56	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.56
57	Hypospadias	Enrichment	PIK3CA	2.56
58	Bockenheimer syndrome	Enrichment	TEK	2.56
59	Thyroid cancer	Enrichment	RET	2.56
60	Rare venous malformation	Enrichment	PIK3CA	2.56
61	Immunodeficiency 64	Enrichment	RASGRP1	2.56
62	Gorham's disease	Enrichment	RASA1	2.56
63	Diaphragmatic eventration	Enrichment	PIK3CA	2.56
64	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	2.56
65	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.56
66	Rare combined vascular malformation	Enrichment	PIK3CA	2.56
67	Cavernous lymphangioma	Enrichment	PIK3CA	2.56
68	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.56
69	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.56
70	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.56
71	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.56
72	Macrodactyly of toe	Enrichment	PIK3CA	2.56
73	Gastrointestinal system disease	Enrichment	RET	2.56
74	Multiple endocrine neoplasia	Enrichment	RET	2.56
75	Bladder cancer	Enrichment	HRAS, PIK3CA	2.55
76	Hirschsprung disease 1	Enrichment	GDNF, RET	2.55
77	Differentiated thyroid carcinoma	Enrichment	HRAS, RET	2.55
78	Blue rubber bleb nevus	Enrichment	TEK	2.26
79	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.26
80	Fibromatosis, gingival, 1	Enrichment	SOS1	2.26
81	Costello syndrome	Enrichment	HRAS	2.26
82	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.26
83	Pulmonic stenosis	Enrichment	SOS1	2.26
84	Keratosis, seborrheic	Enrichment	PIK3CA	2.26
85	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.26
86	Noonan syndrome 8	Enrichment	PIK3CA	2.26
87	Myopia 28, autosomal recessive	Enrichment	DOK1	2.26
88	Infantile myofibromatosis	Enrichment	PDGFRB	2.26
89	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.26
90	Medullary thyroid carcinoma	Enrichment	RET	2.26
91	Immune system disease	Enrichment	PIK3CD	2.26
92	Wooly hair nevus	Enrichment	HRAS	2.26
93	Hereditary breast carcinoma	Enrichment	PIK3CA, RET	2.20
94	Thyroid carcinoma, familial medullary	Enrichment	RET	2.09
95	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.09
96	Nuchal bleb, familial	Enrichment	SOS1	2.09
97	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.09
98	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR	2.09
99	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD	2.09
100	Large congenital melanocytic nevus	Enrichment	HRAS	2.09
101	Wieacker-wolff syndrome	Enrichment	RASA1	2.09
102	Gingival overgrowth	Enrichment	RET	2.09
103	Immunodeficiency 14	Enrichment	PIK3CD	2.09
104	Spermatocytoma	Enrichment	HRAS	2.09
105	Keratoacanthoma	Enrichment	PIK3CA	2.09
106	Hypertelorism	Enrichment	PIK3CA, RET	2.06
107	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.96
108	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.96
109	Glaucoma 3, primary infantile, b	Enrichment	TEK	1.96
110	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR	1.96
111	Central hypoventilation syndrome, congenital, 1	Enrichment	RET	1.96
112	Cerebrovascular disease	Enrichment	PIK3CA	1.96
113	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.96
114	Epidermolytic nevus	Enrichment	HRAS	1.96
115	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.96
116	Haddad syndrome	Enrichment	RET	1.96
117	Gingival fibromatosis	Enrichment	SOS1	1.96
118	Hereditary angioedema with normal c1inh not related to f12 or plg variant	Enrichment	ANGPT1	1.96
119	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.96
120	Multiple endocrine neoplasia, type iia	Enrichment	RET	1.87
121	Hemimegalencephaly	Enrichment	PIK3CA	1.87
122	Primary hypereosinophilic syndrome	Enrichment	PDGFRB	1.87
123	Cowden syndrome 1	Enrichment	PIK3CA	1.79
124	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.79
125	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.79
126	Hemangioma, capillary infantile	Enrichment	RASA1	1.79
127	Basal cell carcinoma 1	Enrichment	RASA1	1.79
128	Breast adenocarcinoma	Enrichment	PIK3CA	1.79
129	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.79
130	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	RET	1.79
131	Oculopharyngodistal myopathy 1	Enrichment	GIPC1	1.72
132	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.72
133	Glaucoma 3, primary congenital, a	Enrichment	TEK	1.72
134	Myelofibrosis	Enrichment	SRC	1.72
135	Leukemia, chronic myeloid	Enrichment	BCR	1.72
136	Gallbladder cancer	Enrichment	PIK3CA	1.72
137	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.72
138	Pilomyxoid astrocytoma	Enrichment	RAF1	1.72
139	Follicular thyroid carcinoma	Enrichment	HRAS	1.72
140	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	BCR	1.72
141	Renal hypodysplasia/aplasia 1	Enrichment	RET	1.67
142	Hypothyroidism	Enrichment	RET	1.67
143	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.61
144	Ventricular septal defect	Enrichment	TEK	1.61
145	Cowden syndrome	Enrichment	PIK3CA	1.61
146	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD	1.57
147	Meningioma, familial	Enrichment	PDGFB	1.53
148	Ovarian cancer	Enrichment	PIK3CA, RET	1.51
149	Renal hypodysplasia/aplasia 3	Enrichment	RET	1.49
150	Aortic valve disease 1	Enrichment	SOS1	1.46
151	Nk-cell enteropathy	Enrichment	PIK3CB	1.46
152	Osteoporosis	Enrichment	SRC	1.43
153	Pheochromocytoma	Enrichment	RET	1.43
154	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.43
155	Hydrocephalus	Enrichment	PDGFRB	1.40
156	Lynch syndrome	Enrichment	PIK3CA	1.40
157	Rhabdomyosarcoma	Enrichment	HRAS	1.37
158	Dandy-walker syndrome	Enrichment	PDGFRB	1.34
159	Endometrial cancer	Enrichment	PIK3CA	1.25
160	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	RET	1.25
161	Precursor t-cell acute lymphoblastic leukemia	Enrichment	BCR	1.22
162	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.20
163	Tetralogy of fallot	Enrichment	RET	1.16
164	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.16
165	Prostate cancer	Enrichment	PIK3CA	1.12
166	Non-immune hydrops fetalis	Enrichment	HRAS	1.09
167	Lung cancer	Enrichment	PIK3CA	1.08
168	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.06
169	Severe combined immunodeficiency	Enrichment	LCK	1.06
170	Left ventricular noncompaction	Enrichment	RAF1	1.04
171	Cerebral palsy	Enrichment	PDGFRB	0.99
172	Gastric cancer	Enrichment	PIK3CA	0.95
173	Sensorineural hearing loss	Enrichment	RET	0.91
174	Thrombocytopenia	Enrichment	SRC	0.91
175	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.87
176	Dilated cardiomyopathy	Enrichment	RAF1	0.71
177	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.54
178	Inherited cancer-predisposing syndrome	Enrichment	RET	0.52

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G-protein signaling_H-RAS regulation pathway

Pathway Network for G-protein signaling_H-RAS regulation pathway

Member Pathways for G-protein signaling_H-RAS regulation pathway

Pathways in the G-protein signaling_H-RAS regulation pathway SuperPath

Associated Genes for G-protein signaling_H-RAS regulation pathway

Associated Disorders for G-protein signaling_H-RAS regulation pathway

Disorders associated with G-protein signaling_H-RAS regulation pathway SuperPath

STRING Interaction Network for G-protein signaling_H-RAS regulation pathway

Sources for G-protein signaling_H-RAS regulation pathway