G-protein signaling_K-RAS regulation pathway

No Pathway Network information available for G-protein signaling_K-RAS regulation pathway

Pathways in the G-protein signaling_K-RAS regulation pathway SuperPath

#	Name	Source	Genes
1	G-protein signaling_K-RAS regulation pathway	GeneGo (Thomson Reuters)	ARAF BRAF EGF EGFR EPO EPOR FNTA FNTB GRB2 ICMT KIFAP3 KRAS LCK PIK3CA PRKCQ RAF1 RALGDS RAP1GDS1 RASGRF1 RASGRP1 RASGRP2 RASSF1 RGL1 RGL2 SHC1 SOS1 SOS2 (see all 27) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
2	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
3	EGF	Epidermal Growth Factor	Protein Coding	1
4	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
5	EPO	Erythropoietin	Protein Coding	1
6	EPOR	Erythropoietin Receptor	Protein Coding	1
7	FNTA	Farnesyltransferase, CAAX Box, Subunit Alpha	Protein Coding	1
8	FNTB	Farnesyltransferase, CAAX Box, Subunit Beta	Protein Coding	1
9	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
10	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
11	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
12	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
13	PRKCQ	Protein Kinase C Theta	Protein Coding	1
14	RGL2	Ral Guanine Nucleotide Dissociation Stimulator Like 2	Protein Coding	1
15	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
16	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	1
17	RAP1GDS1	Rap1 GTPase-GDP Dissociation Stimulator 1	Protein Coding	1
18	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	1
19	SHC1	SHC Adaptor Protein 1	Protein Coding	1
20	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
21	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
22	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	1
23	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	1
24	RASSF1	Ras Association Domain Family Member 1	Protein Coding	1
25	KIFAP3	Kinesin Associated Protein 3	Protein Coding	1
26	RGL1	Ral Guanine Nucleotide Dissociation Stimulator Like 1	Protein Coding	1
27	ICMT	Isoprenylcysteine Carboxyl Methyltransferase	Protein Coding	1

Disorders associated with G-protein signaling_K-RAS regulation pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	BRAF, KRAS, RAF1, SOS1, SOS2	9.15
2	Rasopathy	Enrichment	BRAF, KRAS, RAF1, SOS1, SOS2	8.87
3	Lung non-small cell carcinoma	Enrichment	BRAF, EGFR, KRAS, PIK3CA	8.39
4	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, KRAS, RAF1, SOS1	7.78
5	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS, PIK3CA	6.85
6	Noonan syndrome 3	Enrichment	KRAS, RAF1, SOS1	6.61
7	Gallbladder cancer	Enrichment	BRAF, KRAS, PIK3CA	6.61
8	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	6.61
9	Lung cancer	Enrichment	BRAF, EGFR, KRAS, PIK3CA	6.37
10	Lip and oral cavity carcinoma	Enrichment	BRAF, EGFR, PIK3CA	5.82
11	Lung cancer susceptibility 3	Enrichment	BRAF, EGFR, KRAS	5.60
12	Pulmonic stenosis	Enrichment	BRAF, SOS1	5.42
13	Arteriovenous malformations of the brain	Enrichment	BRAF, EGFR, KRAS	5.18
14	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS	4.64
15	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS	4.64
16	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	4.64
17	Bladder cancer	Enrichment	EGFR, KRAS, PIK3CA	4.61
18	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	4.24
19	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	4.24
20	Nevus, epidermal	Enrichment	KRAS, PIK3CA	4.10
21	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	4.10
22	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, RAF1	3.97
23	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	3.87
24	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.40
25	Breast cancer	Enrichment	KRAS, PIK3CA, SHC1	3.36
26	Ovarian cancer	Enrichment	EGFR, KRAS, PIK3CA	2.99
27	Differentiated thyroid carcinoma	Enrichment	BRAF, KRAS	2.82
28	Macrodactyly	Enrichment	PIK3CA	2.70
29	Oculoectodermal syndrome	Enrichment	KRAS	2.70
30	Pallister-killian syndrome	Enrichment	ARAF	2.70
31	Noonan syndrome 5	Enrichment	RAF1	2.70
32	Hypomagnesemia 4, renal	Enrichment	EGF	2.70
33	Noonan syndrome 4	Enrichment	SOS1	2.70
34	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.70
35	Noonan syndrome 7	Enrichment	BRAF	2.70
36	Leopard syndrome 3	Enrichment	BRAF	2.70
37	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.70
38	Cowden syndrome 5	Enrichment	PIK3CA	2.70
39	Noonan syndrome 9	Enrichment	SOS2	2.70
40	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	2.70
41	Microvascular complications of diabetes 2	Enrichment	EPO	2.70
42	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	2.70
43	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.70
44	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.70
45	Lymphangioma	Enrichment	BRAF	2.70
46	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.70
47	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.70
48	Phace association	Enrichment	BRAF	2.70
49	Leopard syndrome 2	Enrichment	RAF1	2.70
50	Erythrocytosis, familial, 5	Enrichment	EPO	2.70
51	Immunodeficiency 22	Enrichment	LCK	2.70
52	Alfadhel syndrome	Enrichment	RAP1GDS1	2.70
53	Trigonitis	Enrichment	RAF1	2.70
54	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.70
55	Hypospadias	Enrichment	PIK3CA	2.70
56	Congenital pulmonary airway malformation	Enrichment	KRAS	2.70
57	Rare venous malformation	Enrichment	PIK3CA	2.70
58	Immunodeficiency 64	Enrichment	RASGRP1	2.70
59	Diaphragmatic eventration	Enrichment	PIK3CA	2.70
60	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	2.70
61	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.70
62	Syringocystadenoma papilliferum	Enrichment	BRAF	2.70
63	Rare combined vascular malformation	Enrichment	PIK3CA	2.70
64	Ganglioglioma	Enrichment	BRAF	2.70
65	Cavernous lymphangioma	Enrichment	PIK3CA	2.70
66	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.70
67	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.70
68	Phace syndrome	Enrichment	BRAF	2.70
69	Classic hairy cell leukemia	Enrichment	BRAF	2.70
70	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.70
71	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.70
72	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.70
73	Macrodactyly of toe	Enrichment	PIK3CA	2.70
74	Gastric cancer	Enrichment	KRAS, PIK3CA	2.48
75	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	2.46
76	Fibromatosis, gingival, 1	Enrichment	SOS1	2.40
77	Keratosis, seborrheic	Enrichment	PIK3CA	2.40
78	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.40
79	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS	2.40
80	Noonan syndrome 8	Enrichment	PIK3CA	2.40
81	Diamond-blackfan anemia-like	Enrichment	EPO	2.40
82	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.40
83	Myeloma, multiple	Enrichment	BRAF, KRAS	2.26
84	Ataxia-telangiectasia	Enrichment	BRAF	2.22
85	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.22
86	Nuchal bleb, familial	Enrichment	SOS1	2.22
87	Langerhans cell histiocytosis	Enrichment	BRAF	2.22
88	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.22
89	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.22
90	Primary polycythemia	Enrichment	EPOR	2.22
91	Tethered spinal cord syndrome	Enrichment	BRAF	2.22
92	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.22
93	Keratoacanthoma	Enrichment	PIK3CA	2.22
94	Erythrocytosis, familial, 1	Enrichment	EPOR	2.10
95	Schimmelpenning-feuerstein-mims syndrome	Enrichment	KRAS	2.10
96	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.10
97	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	2.10
98	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.10
99	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.10
100	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS	2.10
101	Ciliary dyskinesia, primary, 22	Enrichment	RASSF1	2.10
102	Cerebrovascular disease	Enrichment	PIK3CA	2.10
103	Craniopharyngioma	Enrichment	BRAF	2.10
104	Pilocytic astrocytoma	Enrichment	KRAS	2.10
105	Newborn respiratory distress syndrome	Enrichment	BRAF	2.10
106	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.10
107	Gingival fibromatosis	Enrichment	SOS1	2.10
108	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	2.10
109	Capillary malformations, congenital	Enrichment	PIK3CA	2.00
110	Hemimegalencephaly	Enrichment	PIK3CA	2.00
111	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	1.96
112	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.92
113	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.92
114	Wilms tumor 5	Enrichment	BRAF	1.92
115	Autosomal dominant secondary polycythemia	Enrichment	EPO	1.92
116	Colorectal cancer	Enrichment	BRAF, PIK3CA	1.89
117	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	1.86
118	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.86
119	Leukemia, chronic myeloid	Enrichment	KRAS	1.86
120	Follicular thyroid carcinoma	Enrichment	BRAF	1.86
121	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.80
122	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.75
123	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.75
124	Arteriovenous malformation	Enrichment	PIK3CA	1.75
125	Primary hyperaldosteronism	Enrichment	BRAF	1.75
126	Ventricular septal defect	Enrichment	BRAF	1.75
127	Cowden syndrome	Enrichment	PIK3CA	1.75
128	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.70
129	Melanoma	Enrichment	BRAF	1.70
130	Juvenile myelomonocytic leukemia	Enrichment	KRAS	1.63
131	Meningioma	Enrichment	PIK3CA	1.63
132	Aortic valve disease 1	Enrichment	SOS1	1.59
133	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.56
134	Wilms tumor 1	Enrichment	BRAF	1.53
135	Gliosarcoma	Enrichment	EGFR	1.50
136	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.48
137	Dandy-walker syndrome	Enrichment	BRAF	1.48
138	Giant cell glioblastoma	Enrichment	EGFR	1.48
139	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.43
140	Endometrial cancer	Enrichment	PIK3CA	1.39
141	Hepatocellular carcinoma	Enrichment	PIK3CA	1.37
142	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.33
143	Pancreatic cancer	Enrichment	KRAS	1.31
144	Prostate cancer	Enrichment	PIK3CA	1.25
145	Non-immune hydrops fetalis	Enrichment	KRAS	1.22
146	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.20
147	Severe combined immunodeficiency	Enrichment	LCK	1.20
148	Left ventricular noncompaction	Enrichment	RAF1	1.17
149	Leukemia, acute myeloid	Enrichment	KRAS	1.12
150	Hypertelorism	Enrichment	PIK3CA	1.01
151	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.00
152	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.98
153	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.63

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G-protein signaling_K-RAS regulation pathway

Pathway Network for G-protein signaling_K-RAS regulation pathway

Member Pathways for G-protein signaling_K-RAS regulation pathway

Pathways in the G-protein signaling_K-RAS regulation pathway SuperPath

Associated Genes for G-protein signaling_K-RAS regulation pathway

Associated Disorders for G-protein signaling_K-RAS regulation pathway

Disorders associated with G-protein signaling_K-RAS regulation pathway SuperPath

STRING Interaction Network for G-protein signaling_K-RAS regulation pathway

Sources for G-protein signaling_K-RAS regulation pathway