G-protein signaling RAC1 in cellular process

Pathway network for the G-protein signaling RAC1 in cellular process SuperPath

Sources:

GeneGo (Thomson Reuters)
PubChem

Pathways in the G-protein signaling RAC1 in cellular process SuperPath

#	Name	Source	Genes
1	G-protein signaling RAC1 in cellular process	GeneGo (Thomson Reuters)	ACTB ACTG1 ACTR2 ACTR3 ACTR3B ARFIP2 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 CDC42 CYBA CYBB CYFIP2 DMPK MAP3K11 MCF2L NCF1 NCF2 NCK1 NCKAP1 PAK1 PAK2 PAK3 PARD6A PARD6B PARD6G PIP5K1A PIP5K1B PIP5K1C PLD1 PRKCZ RAC1 RHOA WASF1 WASF2 (see all 40) (see less)
2	CDC42 signaling events	PubChem	ACTR2 ACTR3 APC ARHGDIA ARHGEF6 ARHGEF7 ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ATF2 BAIAP2 BCAR1 CBL CDC42 CDC42BPA CDH1 CFL1 CTNNA1 CTNNB1 DIAPH3 DLG1 ENAH EPS8 EXOC7 F2RL2 GSK3B HES5 HRAS IQGAP1 IQGAP3 JUN LIMK1 LIMK2 MAP2K3 MAP2K4 MAP2K7 MAP3K1 MAP3K11 MAPK14 MAPK3 MAPK8 MAPK9 MTOR MYL2 PAK1 PAK2 PAK4 PARD6A PAX6 PIK3CA PIK3R1 PLD1 PLPP1 PRKCE PRKCZ RAC1 RAF1 RASGRF1 RPS6KB1 SEPTIN2 TIAM1 TNK2 VAV2 WASL (see all 66) (see less)
3	RAC1 signaling pathway	PubChem	ABI1 ABI2 ACTR2 ACTR3 ARHGAP5 ARHGDIA ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ATF2 BAIAP2 BCAR1 BRK1 CDH1 CFL1 CRK CTNNA1 CTNNB1 CYBA CYBB CYFIP2 IQGAP1 IQGAP3 JUN LIMK1 MAP2K3 MAP2K4 MAP2K7 MAP3K1 MAP3K11 MAPK14 MAPK8 MAPK9 NCF1 NCF2 NCKAP1 NOX1 NOXA1 NOXO1 PAK1 PAK2 PIP5K1A PIP5K1B PIP5K1C PLCB2 RAC1 RACGAP1 STAT3 STAT5A WASF1 WASF2 (see all 53) (see less)
4	Cytoskeleton remodeling CDC42 in cellular processes	GeneGo (Thomson Reuters)	ACTB ACTG1 ACTR2 ACTR3 ACTR3B ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDC42BPA CDC42EP2 CDC42EP3 CDC42SE1 CFL1 CFL2 COPG2 DSTN LIMK1 LIMK2 MAP3K11 PAK1 PAK2 PAK3 PAK4 PARD6A PARD6B PARD6G PRKCZ RAF1 WAS WASL (see all 34) (see less)

Gene overlap in member pathways for G-protein signaling RAC1 in cellular process SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	4
2	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	4
3	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	4
4	ARPC5	Actin Related Protein 2/3 Complex Subunit 5	Protein Coding	4
5	ARPC4	Actin Related Protein 2/3 Complex Subunit 4	Protein Coding	4
6	ARPC3	Actin Related Protein 2/3 Complex Subunit 3	Protein Coding	4
7	ARPC1B	Actin Related Protein 2/3 Complex Subunit 1B	Protein Coding	4
8	ACTR3	Actin Related Protein 3	Protein Coding	4
9	ACTR2	Actin Related Protein 2	Protein Coding	4
10	ARPC2	Actin Related Protein 2/3 Complex Subunit 2	Protein Coding	4
11	CDC42	Cell Division Cycle 42	Protein Coding	3
12	PRKCZ	Protein Kinase C Zeta	Protein Coding	3
13	RAC1	Rac Family Small GTPase 1	Protein Coding	3
14	BAIAP2	BAR/IMD Domain Containing Adaptor Protein 2	Protein Coding	3
15	PARD6A	Par-6 Family Cell Polarity Regulator Alpha	Protein Coding	3
16	CFL1	Cofilin 1	Protein Coding	3
17	LIMK1	LIM Domain Kinase 1	Protein Coding	3
18	ACTB	Actin Beta	Protein Coding	2
19	ACTG1	Actin Gamma 1	Protein Coding	2
20	CYBA	Cytochrome B-245 Alpha Chain	Protein Coding	2
21	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	2
22	NCF2	Neutrophil Cytosolic Factor 2	Protein Coding	2
23	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	2
24	PLD1	Phospholipase D1	Protein Coding	2
25	PIP5K1A	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha	Protein Coding	2
26	PIP5K1B	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta	Protein Coding	2
27	WASF1	WASP Family Member 1	Protein Coding	2
28	WASF2	WASP Family Member 2	Protein Coding	2
29	ARPC1A	Actin Related Protein 2/3 Complex Subunit 1A	Protein Coding	2
30	NCKAP1	NCK Associated Protein 1	Protein Coding	2
31	PIP5K1C	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Gamma	Protein Coding	2
32	CYFIP2	Cytoplasmic FMR1 Interacting Protein 2	Protein Coding	2
33	BRK1	BRICK1 Subunit Of SCAR/WAVE Actin Nucleating Complex	Protein Coding	2
34	ACTR3B	Actin Related Protein 3B	Protein Coding	2
35	PARD6G	Par-6 Family Cell Polarity Regulator Gamma	Protein Coding	2
36	PARD6B	Par-6 Family Cell Polarity Regulator Beta	Protein Coding	2
37	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	2
38	LIMK2	LIM Domain Kinase 2	Protein Coding	2
39	CDC42BPA	CDC42 Binding Protein Kinase Alpha	Protein Coding	2
40	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	2
41	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	2
42	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	2
43	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	2
44	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	2
45	IQGAP3	IQ Motif Containing GTPase Activating Protein 3	Protein Coding	2
46	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
47	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	2
48	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
49	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	2
50	CTNNB1	Catenin Beta 1	Protein Coding	2
51	CTNNA1	Catenin Alpha 1	Protein Coding	2
52	CDH1	Cadherin 1	Protein Coding	2
53	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
54	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	2
55	ATF2	Activating Transcription Factor 2	Protein Coding	2
56	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	2
57	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	2
58	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
59	RHOA	Ras Homolog Family Member A	Protein Coding	1
60	DMPK	DM1 Protein Kinase	Protein Coding	1
61	NCK1	NCK Adaptor Protein 1	Protein Coding	1
62	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	1
63	ARFIP2	ARF Interacting Protein 2	Protein Coding	1
64	ENAH	ENAH Actin Regulator	Protein Coding	1
65	EPS8	EGFR Pathway Substrate 8, Signaling Adaptor	Protein Coding	1
66	F2RL2	Coagulation Factor II Thrombin Receptor Like 2	Protein Coding	1
67	MYL2	Myosin Light Chain 2	Protein Coding	1
68	TNK2	Tyrosine Kinase Non Receptor 2	Protein Coding	1
69	PLPP1	Phospholipid Phosphatase 1	Protein Coding	1
70	DLG1	Discs Large MAGUK Scaffold Protein 1	Protein Coding	1
71	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	1
72	DIAPH3	Diaphanous Related Formin 3	Protein Coding	1
73	HES5	Hes Family BHLH Transcription Factor 5	Protein Coding	1
74	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
75	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
76	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	1
77	PAX6	Paired Box 6	Protein Coding	1
78	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
79	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
80	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
81	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
82	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
83	SEPTIN2	Septin 2	Protein Coding	1
84	EXOC7	Exocyst Complex Component 7	Protein Coding	1
85	CBL	Cbl Proto-Oncogene	Protein Coding	1
86	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
87	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
88	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
89	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
90	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
91	ABI2	Abl Interactor 2	Protein Coding	1
92	ABI1	Abl Interactor 1	Protein Coding	1
93	ARHGAP5	Rho GTPase Activating Protein 5	Protein Coding	1
94	NOXA1	NADPH Oxidase Activator 1	Protein Coding	1
95	NOX1	NADPH Oxidase 1	Protein Coding	1
96	NOXO1	NADPH Oxidase Organizer 1	Protein Coding	1
97	RACGAP1	Rac GTPase Activating Protein 1	Protein Coding	1
98	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
99	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
100	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
101	PLCB2	Phospholipase C Beta 2	Protein Coding	1
102	CFL2	Cofilin 2	Protein Coding	1
103	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
104	CDC42EP2	CDC42 Effector Protein 2	Protein Coding	1
105	CDC42EP3	CDC42 Effector Protein 3	Protein Coding	1
106	DSTN	Destrin, Actin Depolymerizing Factor	Protein Coding	1
107	COPG2	Coat Protein Complex I Subunit Gamma 2	Protein Coding	1
108	CDC42SE1	CDC42 Small Effector 1	Protein Coding	1

Disorders associated with G-protein signaling RAC1 in cellular process SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chronic granulomatous disease	Enrichment	CYBA, CYBB, NCF1, NCF2	8.09
2	Colorectal cancer	Enrichment	APC, CDH1, CTNNA1, CTNNB1, PIK3CA, PIK3R1	5.41
3	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.21
4	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1, NCF2	4.60
5	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, HRAS, RAF1	4.32
6	Granulomatous disease, chronic, x-linked	Enrichment	CYBB, NCF1	4.30
7	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	4.16
8	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.16
9	Desmoid tumor	Enrichment	APC, CTNNB1	4.16
10	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, CTNNA1	4.05
11	Ovarian cancer	Enrichment	APC, CDH1, CTNNB1, MAP3K1, PIK3CA	3.89
12	Craniopharyngioma	Enrichment	APC, CTNNB1	3.86
13	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, CDC42	3.86
14	Hepatocellular carcinoma	Enrichment	APC, CTNNB1, PIK3CA	3.80
15	Noonan syndrome 1	Enrichment	CBL, HRAS, RAF1	3.74
16	Hemimegalencephaly	Enrichment	MTOR, PIK3CA	3.64
17	Rasopathy	Enrichment	CBL, HRAS, RAF1	3.58
18	Bladder cancer	Enrichment	CTNNB1, HRAS, PIK3CA	3.44
19	Breast cancer	Enrichment	APC, CDH1, JUN, PIK3CA	3.32
20	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.32
21	Noonan syndrome 3	Enrichment	HRAS, RAF1	3.32
22	Gallbladder cancer	Enrichment	CTNNB1, PIK3CA	3.32
23	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.32
24	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.19
25	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.09
26	Adult hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	3.09
27	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	2.99
28	Gastric cancer	Enrichment	APC, CDH1, PIK3CA	2.93
29	Lung non-small cell carcinoma	Enrichment	HRAS, PIK3CA	2.90
30	Hereditary breast carcinoma	Enrichment	APC, CDH1, PIK3CA	2.90
31	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	2.83
32	Medulloblastoma	Enrichment	APC, CTNNB1	2.69
33	Cleft lip/palate	Enrichment	CDH1, DLG1	2.69
34	Baraitser-winter syndrome 1	Enrichment	ACTB	2.60
35	Thrombocytopenia 1	Enrichment	WAS	2.60
36	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.60
37	Noonan syndrome 5	Enrichment	RAF1	2.60
38	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.60
39	Knobloch syndrome 2	Enrichment	PAK2	2.60
40	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.60
41	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.60
42	Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia	Enrichment	ARPC1B	2.60
43	Nemaline myopathy 7	Enrichment	CFL2	2.60
44	Becker nevus syndrome	Enrichment	ACTB	2.60
45	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.60
46	Leopard syndrome 2	Enrichment	RAF1	2.60
47	Was-related disorders	Enrichment	WAS	2.60
48	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.60
49	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.60
50	Trigonitis	Enrichment	RAF1	2.60
51	Baraitser-winter syndrome	Enrichment	ACTB	2.60
52	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.60
53	Nocarh syndrome	Enrichment	CDC42	2.60
54	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.60
55	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.57
56	Williams-beuren syndrome	Enrichment	LIMK1, NCF1	2.57
57	Granulomatous disease, chronic, autosomal recessive, 4	Enrichment	CYBA	2.53
58	Immunodeficiency 34	Enrichment	CYBB	2.53
59	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.53
60	Neurodevelopmental disorder with absent language and variable seizures	Enrichment	WASF1	2.53
61	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.53
62	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.53
63	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.53
64	Microcephaly	Enrichment	ACTB, ACTG1, PAK3	2.45
65	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.41
66	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.41
67	46,xy sex reversal 6	Enrichment	MAP3K1	2.41
68	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.41
69	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.41
70	Adenoid ameloblastoma	Enrichment	CTNNB1	2.41
71	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.41
72	Breast lobular carcinoma	Enrichment	CDH1	2.41
73	Congenital dyserythropoietic anemia type iiib	Enrichment	RACGAP1	2.41
74	Anemia, congenital dyserythropoietic, type iiib, autosomal recessive	Enrichment	RACGAP1	2.41
75	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.41
76	Microcystic stromal tumor	Enrichment	CTNNB1	2.41
77	Endometrial cancer	Enrichment	CDH1, PIK3CA	2.34
78	Hepatoblastoma	Enrichment	APC, CTNNB1	2.34
79	Macrodactyly	Enrichment	PIK3CA	2.31
80	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.31
81	Cowden syndrome 5	Enrichment	PIK3CA	2.31
82	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.31
83	Short syndrome	Enrichment	PIK3R1	2.31
84	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	2.31
85	Auditory neuropathy, autosomal dominant 1	Enrichment	DIAPH3	2.31
86	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.31
87	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.31
88	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.31
89	Deafness, autosomal recessive 102	Enrichment	EPS8	2.31
90	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.31
91	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.31
92	Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression	Enrichment	TNK2	2.31
93	Neurodevelopmental disorder with seizures and brain atrophy	Enrichment	EXOC7	2.31
94	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.31
95	Hypospadias	Enrichment	PIK3CA	2.31
96	Rare venous malformation	Enrichment	PIK3CA	2.31
97	Familial adenomatous polyposis	Enrichment	APC	2.31
98	Diaphragmatic eventration	Enrichment	PIK3CA	2.31
99	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.31
100	Rare combined vascular malformation	Enrichment	PIK3CA	2.31
101	Cavernous lymphangioma	Enrichment	PIK3CA	2.31
102	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.31
103	Gardner syndrome	Enrichment	APC	2.31
104	5q22 microdeletion syndrome	Enrichment	APC	2.31
105	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.31
106	Attenuated familial adenomatous polyposis	Enrichment	APC	2.31
107	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.31
108	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.31
109	Macrodactyly of toe	Enrichment	PIK3CA	2.31
110	Neutropenia, severe congenital, x-linked	Enrichment	WAS	2.30
111	Wiskott-aldrich syndrome	Enrichment	WAS	2.30
112	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.30
113	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.30
114	Developmental delay, language impairment, and ocular abnormalities	Enrichment	ARPC4	2.30
115	Immunodeficiency 113 with autoimmunity and autoinflammation	Enrichment	ARPC5	2.30
116	Immune system disease	Enrichment	CDC42	2.30
117	Immunodeficiency 133	Enrichment	ARPC5	2.30
118	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	2.23
119	Lethal congenital contracture syndrome 3	Enrichment	PIP5K1C	2.23
120	Immunodeficiency 72 with autoinflammation and lymphoproliferation	Enrichment	NCKAP1	2.23
121	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.23
122	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	PIP5K1A	2.23
123	Immunodeficiency 72	Enrichment	NCKAP1	2.23
124	Blepharocheilodontic syndrome 1	Enrichment	CDH1	2.11
125	Anemia, congenital dyserythropoietic, type iiia	Enrichment	RACGAP1	2.11
126	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.11
127	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.11
128	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.11
129	Teratoma	Enrichment	CTNNB1	2.11
130	Prostate cancer	Enrichment	CDH1, PIK3CA	2.06
131	Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	Enrichment	CYBA	2.05
132	Developmental and epileptic encephalopathy 65	Enrichment	CYFIP2	2.05
133	Autoimmune polyendocrine syndrome type 1	Enrichment	CYBA	2.05
134	Keratitis, hereditary	Enrichment	PAX6	2.01
135	Foveal hypoplasia 1	Enrichment	PAX6	2.01
136	Costello syndrome	Enrichment	HRAS	2.01
137	Ovarian germ cell cancer	Enrichment	CBL	2.01
138	Keratosis, seborrheic	Enrichment	PIK3CA	2.01
139	Optic nerve hypoplasia, bilateral	Enrichment	PAX6	2.01
140	Noonan syndrome 8	Enrichment	PIK3CA	2.01
141	Cebalid syndrome	Enrichment	MTOR	2.01
142	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.01
143	Cardiomyopathy, familial hypertrophic, 10	Enrichment	MYL2	2.01
144	Periampullary adenoma	Enrichment	APC	2.01
145	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	2.01
146	Myopathy, myofibrillar, 12, infantile-onset, with cardiomyopathy	Enrichment	MYL2	2.01
147	Smith-kingsmore syndrome	Enrichment	MTOR	2.01
148	Malignant germ cell tumor of ovary	Enrichment	CBL	2.01
149	Wooly hair nevus	Enrichment	HRAS	2.01
150	Aminoacylase 1 deficiency	Enrichment	ACTB	2.00
151	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.00
152	Knobloch syndrome	Enrichment	PAK2	2.00
153	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	2.00
154	Familial hypertrophic cardiomyopathy	Enrichment	MYL2, RAF1	1.95
155	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.93
156	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.93
157	Anus, imperforate	Enrichment	CTNNB1	1.93
158	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.93
159	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.93
160	Hyper ige syndrome	Enrichment	STAT3	1.93
161	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	1.93
162	Myotonic dystrophy 1	Enrichment	DMPK	1.93
163	Knobloch syndrome 1	Enrichment	PAK2	1.90
164	Coloboma of choroid and retina	Enrichment	ACTG1	1.90
165	Gillespie syndrome	Enrichment	PAX6	1.84
166	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.84
167	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.84
168	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.84
169	Large congenital melanocytic nevus	Enrichment	HRAS	1.84
170	Immunodeficiency 14	Enrichment	PIK3R1	1.84
171	Spermatocytoma	Enrichment	HRAS	1.84
172	Colon adenocarcinoma	Enrichment	APC	1.84
173	Keratoacanthoma	Enrichment	PIK3CA	1.84
174	Apc-associated polyposis conditions	Enrichment	APC	1.84
175	Typical nemaline myopathy	Enrichment	CFL2	1.83
176	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	1.81
177	Pilomatrixoma	Enrichment	CTNNB1	1.81
178	Alazami syndrome	Enrichment	CTNNB1	1.81
179	Pilomyxoid astrocytoma	Enrichment	RAF1	1.76
180	Hemihyperplasia, isolated	Enrichment	RHOA	1.76
181	Aniridia 1	Enrichment	PAX6	1.71
182	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.71
183	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.71
184	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.71
185	Cerebrovascular disease	Enrichment	PIK3CA	1.71
186	Epidermolytic nevus	Enrichment	HRAS	1.71
187	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.71
188	Eyelid coloboma	Enrichment	PAX6	1.71
189	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.71
190	Lens coloboma	Enrichment	PAX6	1.71
191	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.71
192	Martsolf syndrome 1	Enrichment	ARHGAP5	1.71
193	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1, CTNNA1	1.71
194	Undetermined early-onset epileptic encephalopathy	Enrichment	CYFIP2, LIMK1	1.70
195	Bethlem myopathy 1a	Enrichment	DMPK	1.69
196	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.63
197	Adrenocortical carcinoma	Enrichment	CTNNB1	1.63
198	Cleft lip with or without cleft palate	Enrichment	CDH1	1.63
199	Capillary malformations, congenital	Enrichment	PIK3CA	1.62
200	Familial adenomatous polyposis 1	Enrichment	APC	1.62
201	Myeloproliferative neoplasm	Enrichment	CBL	1.62
202	Aniridia	Enrichment	PAX6	1.62
203	Aggressive systemic mastocytosis	Enrichment	CBL	1.62
204	Cat eye syndrome	Enrichment	ACTG1	1.61
205	Cardiomyopathy, familial hypertrophic, 4	Enrichment	NCF1	1.58
206	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.58
207	Inherited cancer-predisposing syndrome	Enrichment	APC, CDH1, CTNNA1	1.58
208	Hypertelorism	Enrichment	PAX6, PIK3CA	1.58
209	Combined immunodeficiency	Enrichment	ARPC1B	1.56
210	Combined t cell and b cell immunodeficiency	Enrichment	ARPC1B	1.56
211	Combined t and b cell immunodeficiency	Enrichment	ARPC1B	1.56
212	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.54
213	Coloboma of optic nerve	Enrichment	PAX6	1.54
214	Cowden syndrome 1	Enrichment	PIK3CA	1.54
215	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	PAX6	1.54
216	Anterior segment dysgenesis 5	Enrichment	PAX6	1.54
217	Breast adenocarcinoma	Enrichment	PIK3CA	1.54
218	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.54
219	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.51
220	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.51
221	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.49
222	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.47
223	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.47
224	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.47
225	Follicular thyroid carcinoma	Enrichment	HRAS	1.47
226	Familial isolated restrictive cardiomyopathy	Enrichment	MYL2	1.47
227	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.38
228	Colonic benign neoplasm	Enrichment	APC	1.37
229	Cowden syndrome	Enrichment	PIK3CA	1.37
230	Peters-plus syndrome	Enrichment	PAX6	1.32
231	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.32
232	Acute promyelocytic leukemia	Enrichment	STAT3	1.30
233	Lissencephaly	Enrichment	ACTG1	1.29
234	Centronuclear myopathy	Enrichment	CFL2	1.29
235	Complex neurodevelopmental disorder	Enrichment	PAK3, WASF1	1.29
236	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.27
237	Juvenile myelomonocytic leukemia	Enrichment	CBL	1.25
238	Meningioma	Enrichment	PIK3CA	1.25
239	Dilated cardiomyopathy	Enrichment	MYL2, RAF1	1.24
240	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.23
241	Microphthalmia/coloboma 12	Enrichment	PAX6	1.21
242	Polycystic liver disease	Enrichment	CTNNB1	1.19
243	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.19
244	Heart disease	Enrichment	MYL2	1.18
245	Coloboma of macula	Enrichment	PAX6	1.15
246	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.15
247	Congenital myopathy 4a, autosomal dominant	Enrichment	MYL2	1.15
248	Anterior segment dysgenesis	Enrichment	PAX6	1.15
249	Lynch syndrome	Enrichment	PIK3CA	1.15
250	Rare genetic intellectual disability	Enrichment	MTOR	1.15
251	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.14
252	Craniosynostosis	Enrichment	CTNNA1	1.12
253	Cardiomyopathy, dilated, 1e	Enrichment	MYL2	1.10
254	Cakut	Enrichment	ACTG1	1.09
255	Left ventricular noncompaction	Enrichment	RAF1	1.07
256	Non-syndromic genetic deafness	Enrichment	ACTG1	1.06
257	Parkinson's disease	Enrichment	TNK2	1.05
258	Macs syndrome	Enrichment	PAX6	1.03
259	Nonsyndromic hearing loss	Enrichment	ACTG1	1.00
260	Microphthalmia	Enrichment	PAX6	0.99
261	Thrombocytopenia	Enrichment	WAS	0.94
262	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.92
263	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.91
264	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGDIA	0.90
265	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.90
266	Differentiated thyroid carcinoma	Enrichment	HRAS	0.88
267	Non-immune hydrops fetalis	Enrichment	HRAS	0.85
268	Lung cancer	Enrichment	PIK3CA	0.84
269	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	0.79
270	Rare genetic deafness	Enrichment	ACTG1	0.74
271	Hypertrophic cardiomyopathy	Enrichment	MYL2	0.72
272	Deafness, autosomal recessive	Enrichment	EPS8	0.58
273	Autosomal recessive nonsyndromic deafness	Enrichment	EPS8	0.57
274	Congenital nervous system abnormality	Enrichment	CTNNB1	0.47
275	Nervous system disease	Enrichment	CTNNB1	0.47
276	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	EPS8	0.45
277	Hereditary retinal dystrophy	Enrichment	CTNNA1	0.17
278	Fundus dystrophy	Enrichment	CTNNA1	0.17

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G-protein signaling RAC1 in cellular process

Pathway Network for G-protein signaling RAC1 in cellular process

Pathway network for the G-protein signaling RAC1 in cellular process SuperPath

Member Pathways for G-protein signaling RAC1 in cellular process

Pathways in the G-protein signaling RAC1 in cellular process SuperPath

Gene overlap in member pathways for G-protein signaling RAC1 in cellular process SuperPath

Associated Genes for G-protein signaling RAC1 in cellular process

Associated Disorders for G-protein signaling RAC1 in cellular process

Disorders associated with G-protein signaling RAC1 in cellular process SuperPath

STRING Interaction Network for G-protein signaling RAC1 in cellular process

Sources for G-protein signaling RAC1 in cellular process