G-protein signaling_Rac2 regulation pathway

No Pathway Network information available for G-protein signaling_Rac2 regulation pathway

Pathways in the G-protein signaling_Rac2 regulation pathway SuperPath

#	Name	Source	Genes
1	G-protein signaling_Rac2 regulation pathway	GeneGo (Thomson Reuters)	ABR ARHGDIA BCR CYBA CYBB EZR FNTA NCF1 NCF2 NOS2 NOXA1 PAK1 PGGT1B PIK3R1 PIK3R2 PLCB2 PREX1 RAC2 RACGAP1 RDX SP1 SP3 TIAM1 VAV1 (see all 24) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABR	ABR Activator Of RhoGEF And GTPase	Protein Coding	1
2	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	1
3	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	1
4	CYBA	Cytochrome B-245 Alpha Chain	Protein Coding	1
5	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	1
6	FNTA	Farnesyltransferase, CAAX Box, Subunit Alpha	Protein Coding	1
7	NCF2	Neutrophil Cytosolic Factor 2	Protein Coding	1
8	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
9	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
10	PGGT1B	Protein Geranylgeranyltransferase Type I Subunit Beta	Protein Coding	1
11	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
12	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
13	PLCB2	Phospholipase C Beta 2	Protein Coding	1
14	RAC2	Rac Family Small GTPase 2	Protein Coding	1
15	RDX	Radixin	Protein Coding	1
16	SP1	Sp1 Transcription Factor	Protein Coding	1
17	SP3	Sp3 Transcription Factor	Protein Coding	1
18	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
19	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
20	EZR	Ezrin	Protein Coding	1
21	NOXA1	NADPH Oxidase Activator 1	Protein Coding	1
22	RACGAP1	Rac GTPase Activating Protein 1	Protein Coding	1
23	PREX1	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1	Protein Coding	1
24	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	1

Disorders associated with G-protein signaling_Rac2 regulation pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chronic granulomatous disease	Enrichment	CYBA, CYBB, NCF1, NCF2	9.01
2	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1, NCF2	5.05
3	Granulomatous disease, chronic, x-linked	Enrichment	CYBB, NCF1	4.75
4	Granulomatous disease, chronic, autosomal recessive, 4	Enrichment	CYBA	2.75
5	Immunodeficiency 34	Enrichment	CYBB	2.75
6	Deafness, autosomal recessive 24	Enrichment	RDX	2.75
7	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.75
8	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.75
9	Short syndrome	Enrichment	PIK3R1	2.75
10	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.75
11	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.75
12	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.75
13	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.75
14	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.75
15	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.75
16	Congenital dyserythropoietic anemia type iiib	Enrichment	RACGAP1	2.75
17	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.75
18	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.75
19	Anemia, congenital dyserythropoietic, type iiib, autosomal recessive	Enrichment	RACGAP1	2.75
20	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.75
21	Anemia, congenital dyserythropoietic, type iiia	Enrichment	RACGAP1	2.45
22	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	2.45
23	Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	Enrichment	CYBA	2.28
24	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	2.28
25	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR	2.28
26	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.28
27	Immunodeficiency 14	Enrichment	PIK3R1	2.28
28	Autoimmune polyendocrine syndrome type 1	Enrichment	CYBA	2.28
29	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	2.15
30	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR	2.15
31	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.15
32	Leukemia, chronic myeloid	Enrichment	BCR	1.91
33	Overgrowth syndrome	Enrichment	PIK3R1	1.91
34	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	BCR	1.91
35	Cardiomyopathy, familial hypertrophic, 4	Enrichment	NCF1	1.80
36	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.76
37	Williams-beuren syndrome	Enrichment	NCF1	1.46
38	Malaria	Enrichment	NOS2	1.40
39	Precursor t-cell acute lymphoblastic leukemia	Enrichment	BCR	1.40
40	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGDIA	1.23
41	Non-syndromic genetic deafness	Enrichment	RDX	1.21
42	Nonsyndromic hearing loss	Enrichment	RDX	1.14
43	Myeloma, multiple	Enrichment	PIK3R2	1.02
44	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	1.01
45	Rare genetic deafness	Enrichment	RDX	0.88
46	Colorectal cancer	Enrichment	PIK3R1	0.84
47	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	RDX	0.83
48	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.70

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G-protein signaling_Rac2 regulation pathway

Pathway Network for G-protein signaling_Rac2 regulation pathway

Member Pathways for G-protein signaling_Rac2 regulation pathway

Pathways in the G-protein signaling_Rac2 regulation pathway SuperPath

Associated Genes for G-protein signaling_Rac2 regulation pathway

Associated Disorders for G-protein signaling_Rac2 regulation pathway

Disorders associated with G-protein signaling_Rac2 regulation pathway SuperPath

STRING Interaction Network for G-protein signaling_Rac2 regulation pathway

Sources for G-protein signaling_Rac2 regulation pathway