G-protein signaling_Rap1A regulation pathway

No Pathway Network information available for G-protein signaling_Rap1A regulation pathway

Pathways in the G-protein signaling_Rap1A regulation pathway SuperPath

#	Name	Source	Genes
1	G-protein signaling_Rap1A regulation pathway	GeneGo (Thomson Reuters)	ADCY1 BRAF CD247 CD3D CD3E CD3G CRKL FNTA GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ KIFAP3 KRIT1 MAGI1 MRAS NEDD4 PGGT1B PLCD1 PRKACA PRKACB PRKACG RAF1 RALGDS RAP1A RAP1GAP RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RASA1 RASA3 RASGRP2 RASGRP3 SIPA1 TRA TRAC TRAJ18 TRAV24 TRB TRBV11-1 TRBV11-2 TRBV11-3 TRBV17 TSC2 ZAP70 (see all 50) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADCY1	Adenylate Cyclase 1	Protein Coding	1
2	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
3	KRIT1	KRIT1 Ankyrin Repeat Containing	Protein Coding	1
4	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
5	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
6	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
7	CD247	CD247 Molecule	Protein Coding	1
8	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
9	FNTA	Farnesyltransferase, CAAX Box, Subunit Alpha	Protein Coding	1
10	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
11	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
12	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
13	GNAO1	G Protein Subunit Alpha O1	Protein Coding	1
14	GNAS	GNAS Complex Locus	Protein Coding	1
15	GNAZ	G Protein Subunit Alpha Z	Protein Coding	1
16	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	1
17	NEDD4	NEDD4 E3 Ubiquitin Protein Ligase	Protein Coding	1
18	PGGT1B	Protein Geranylgeranyltransferase Type I Subunit Beta	Protein Coding	1
19	PLCD1	Phospholipase C Delta 1	Protein Coding	1
20	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
21	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
22	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
23	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
24	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	1
25	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
26	RAP1GAP	RAP1 GTPase Activating Protein	Protein Coding	1
27	RAP1GDS1	Rap1 GTPase-GDP Dissociation Stimulator 1	Protein Coding	1
28	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
29	SIPA1	Signal-Induced Proliferation-Associated 1	Protein Coding	1
30	TRA	T Cell Receptor Alpha Locus	Protein Coding	1
31	TRB	T Cell Receptor Beta Locus	Protein Coding	1
32	TSC2	TSC Complex Subunit 2	Protein Coding	1
33	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
34	MAGI1	Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 1	Protein Coding	1
35	RAPGEF2	Rap Guanine Nucleotide Exchange Factor 2	Protein Coding	1
36	RAPGEF5	Rap Guanine Nucleotide Exchange Factor 5	Protein Coding	1
37	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	1
38	RAPGEF3	Rap Guanine Nucleotide Exchange Factor 3	Protein Coding	1
39	RAPGEF4	Rap Guanine Nucleotide Exchange Factor 4	Protein Coding	1
40	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
41	RASA3	RAS P21 Protein Activator 3	Protein Coding	1
42	KIFAP3	Kinesin Associated Protein 3	Protein Coding	1
43	RASGRP3	RAS Guanyl Releasing Protein 3	Protein Coding	1
44	TRBV17	T Cell Receptor Beta Variable 17 (Non-Functional)	Protein Coding	1
45	TRBV11-3	T Cell Receptor Beta Variable 11-3	Protein Coding	1
46	TRBV11-2	T Cell Receptor Beta Variable 11-2	Protein Coding	1
47	TRBV11-1	T Cell Receptor Beta Variable 11-1	Protein Coding	1
48	TRAV24	T Cell Receptor Alpha Variable 24	Protein Coding	1
49	TRAJ18	T Cell Receptor Alpha Joining 18	Protein Coding	1
50	TRAC	T Cell Receptor Alpha Constant	Protein Coding	1

Disorders associated with G-protein signaling_Rap1A regulation pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	7.33
2	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, ZAP70	6.91
3	Immunodeficiency 7	Enrichment	TRA, TRAC	4.40
4	Noonan syndrome 1	Enrichment	BRAF, MRAS, RAF1	4.10
5	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	4.10
6	Rasopathy	Enrichment	BRAF, MRAS, RAF1	3.94
7	Pilomyxoid astrocytoma	Enrichment	BRAF, RAF1	3.56
8	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, RAF1	3.43
9	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.33
10	Primary hyperaldosteronism	Enrichment	BRAF, GNAS	3.33
11	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, RAF1	2.87
12	Precursor t-cell acute lymphoblastic leukemia	Enrichment	TRA, TRB	2.49
13	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.43
14	Noonan syndrome 5	Enrichment	RAF1	2.43
15	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.43
16	Osseous heteroplasia, progressive	Enrichment	GNAS	2.43
17	Noonan syndrome 7	Enrichment	BRAF	2.43
18	Leopard syndrome 3	Enrichment	BRAF	2.43
19	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	2.43
20	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.43
21	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	2.43
22	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	2.43
23	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.43
24	Ventricular tachycardia, familial	Enrichment	GNAI2	2.43
25	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.43
26	Noonan syndrome 11	Enrichment	MRAS	2.43
27	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.43
28	Immunodeficiency 48	Enrichment	ZAP70	2.43
29	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.43
30	Immunodeficiency 18	Enrichment	CD3E	2.43
31	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.43
32	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	2.43
33	Immunodeficiency 25	Enrichment	CD247	2.43
34	Lymphangioma	Enrichment	BRAF	2.43
35	Phace association	Enrichment	BRAF	2.43
36	Leopard syndrome 2	Enrichment	RAF1	2.43
37	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.43
38	Disorders of gnas inactivation	Enrichment	GNAS	2.43
39	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.43
40	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.43
41	Epilepsy, familial adult myoclonic, 7	Enrichment	RAPGEF2	2.43
42	Alfadhel syndrome	Enrichment	RAP1GDS1	2.43
43	Trigonitis	Enrichment	RAF1	2.43
44	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.43
45	Gorham's disease	Enrichment	RASA1	2.43
46	Syringocystadenoma papilliferum	Enrichment	BRAF	2.43
47	Immunodeficiency 19	Enrichment	CD3D	2.43
48	Ganglioglioma	Enrichment	BRAF	2.43
49	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.43
50	Monostotic fibrous dysplasia	Enrichment	GNAS	2.43
51	Phace syndrome	Enrichment	BRAF	2.43
52	Gnao1-related disorder	Enrichment	GNAO1	2.43
53	Classic hairy cell leukemia	Enrichment	BRAF	2.43
54	Mazabraud syndrome	Enrichment	GNAS	2.43
55	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.43
56	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.13
57	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.13
58	Pulmonic stenosis	Enrichment	BRAF	2.13
59	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.13
60	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.13
61	Lymphangioleiomyomatosis	Enrichment	TSC2	2.13
62	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.13
63	Autoinflammatory disease, familial, behcet-like 3	Enrichment	SIPA1	2.13
64	Cerebral cavernous malformation 1	Enrichment	KRIT1	2.13
65	Pseudohypoparathyroidism	Enrichment	GNAS	2.13
66	Fibrolamellar carcinoma	Enrichment	PRKACA	2.13
67	Trypsinogen deficiency	Enrichment	TRB	2.13
68	Immunodeficiency 17	Enrichment	CD3G	2.13
69	Hypopituitarism	Enrichment	GNAI2	2.13
70	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.13
71	Mccune-albright syndrome	Enrichment	GNAS	1.96
72	Cerebral cavernous malformations	Enrichment	KRIT1	1.96
73	Ataxia-telangiectasia	Enrichment	BRAF	1.96
74	Tuberous sclerosis 1	Enrichment	TSC2	1.96
75	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.96
76	Langerhans cell histiocytosis	Enrichment	BRAF	1.96
77	Tuberous sclerosis 2	Enrichment	TSC2	1.96
78	Tethered spinal cord syndrome	Enrichment	BRAF	1.96
79	Wieacker-wolff syndrome	Enrichment	RASA1	1.96
80	Hamartoma	Enrichment	TSC2	1.96
81	Xanthinuria, type ii	Enrichment	TSC2	1.96
82	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.96
83	Cavernous hemangioma	Enrichment	KRIT1	1.96
84	West syndrome	Enrichment	GNAO1, TSC2	1.94
85	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF	1.83
86	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.83
87	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.83
88	Auriculocondylar syndrome 1	Enrichment	GNAI3	1.83
89	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL	1.83
90	Focal cortical dysplasia, type ii	Enrichment	TSC2	1.83
91	Achromatopsia 4	Enrichment	GNAI3	1.83
92	Cardiofaciocutaneous syndrome	Enrichment	BRAF	1.83
93	Tuberous sclerosis	Enrichment	TSC2	1.83
94	Craniopharyngioma	Enrichment	BRAF	1.83
95	Newborn respiratory distress syndrome	Enrichment	BRAF	1.83
96	Familial cerebral cavernous malformations	Enrichment	KRIT1	1.83
97	Isolated focal cortical dysplasia type ii	Enrichment	TSC2	1.83
98	Capillary malformations, congenital	Enrichment	RASA1	1.74
99	Vitamin d-dependent rickets, type 2a	Enrichment	TRB	1.74
100	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.66
101	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.66
102	Wilms tumor 5	Enrichment	BRAF	1.66
103	Hemangioma, capillary infantile	Enrichment	RASA1	1.66
104	Basal cell carcinoma 1	Enrichment	RASA1	1.66
105	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.59
106	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	1.59
107	Capillary malformation-arteriovenous malformation 1	Enrichment	RASA1	1.59
108	Noonan syndrome 3	Enrichment	RAF1	1.59
109	Brachydactyly	Enrichment	GNAS	1.59
110	Polycystic kidney disease 1	Enrichment	TSC2	1.59
111	Gallbladder cancer	Enrichment	BRAF	1.59
112	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.59
113	Follicular thyroid carcinoma	Enrichment	BRAF	1.59
114	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.59
115	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.59
116	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.54
117	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.54
118	Choreatic disease	Enrichment	GNAO1	1.54
119	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.49
120	Arteriovenous malformation	Enrichment	RASA1	1.49
121	Adult hepatocellular carcinoma	Enrichment	TSC2	1.49
122	Ventricular septal defect	Enrichment	BRAF	1.49
123	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	1.46
124	Myopathy, x-linked, with excessive autophagy	Enrichment	RASA1	1.44
125	Melanoma	Enrichment	BRAF	1.44
126	Combined immunodeficiency	Enrichment	ZAP70	1.40
127	Lung non-small cell carcinoma	Enrichment	BRAF	1.40
128	Movement disease	Enrichment	GNAO1	1.40
129	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	1.40
130	Combined t and b cell immunodeficiency	Enrichment	ZAP70	1.40
131	Lip and oral cavity carcinoma	Enrichment	BRAF	1.36
132	Lung cancer susceptibility 3	Enrichment	BRAF	1.30
133	Hereditary chronic pancreatitis	Enrichment	TRB	1.30
134	Wilms tumor 1	Enrichment	BRAF	1.27
135	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.27
136	Rare genetic intellectual disability	Enrichment	GNAO1	1.27
137	Congenital nervous system abnormality	Enrichment	GNAO1, TSC2	1.24
138	Nervous system disease	Enrichment	GNAO1, TSC2	1.24
139	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.22
140	Pancreatitis, hereditary	Enrichment	TRB	1.22
141	Dandy-walker syndrome	Enrichment	BRAF	1.22
142	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	1.19
143	Arteriovenous malformations of the brain	Enrichment	BRAF	1.17
144	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.17
145	Cardiomyopathy, dilated, 1a	Enrichment	RAPGEF5	1.13
146	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.07
147	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1	1.05
148	Differentiated thyroid carcinoma	Enrichment	BRAF	0.99
149	Lung cancer	Enrichment	BRAF	0.95
150	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.94
151	Left ventricular noncompaction	Enrichment	RAF1	0.92
152	Developmental and epileptic encephalopathy	Enrichment	GNAO1	0.90
153	Body mass index quantitative trait locus 11	Enrichment	GNAS	0.77
154	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.75
155	Myeloma, multiple	Enrichment	BRAF	0.73
156	Colorectal cancer	Enrichment	BRAF	0.56
157	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.55
158	Ovarian cancer	Enrichment	TSC2	0.51
159	Autism spectrum disorder	Enrichment	TSC2	0.48
160	Microcephaly	Enrichment	GNAO1	0.44
161	Inherited cancer-predisposing syndrome	Enrichment	TSC2	0.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G-protein signaling_Rap1A regulation pathway

Pathway Network for G-protein signaling_Rap1A regulation pathway

Member Pathways for G-protein signaling_Rap1A regulation pathway

Pathways in the G-protein signaling_Rap1A regulation pathway SuperPath

Associated Genes for G-protein signaling_Rap1A regulation pathway

Associated Disorders for G-protein signaling_Rap1A regulation pathway

Disorders associated with G-protein signaling_Rap1A regulation pathway SuperPath

STRING Interaction Network for G-protein signaling_Rap1A regulation pathway

Sources for G-protein signaling_Rap1A regulation pathway