G-protein signaling_Rap2B regulation pathway
Pathways in the G-protein signaling_Rap2B regulation pathway SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | G-protein signaling_Rap2B regulation pathway | GeneGo (Thomson Reuters) |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | ADRB1 | Adrenoceptor Beta 1 | Protein Coding | 1 |
| 2 | FNTA | Farnesyltransferase, CAAX Box, Subunit Alpha | Protein Coding | 1 |
| 3 | PGGT1B | Protein Geranylgeranyltransferase Type I Subunit Beta | Protein Coding | 1 |
| 4 | RAP2B | RAP2B, Member Of RAS Oncogene Family | Protein Coding | 1 |
| 5 | RAPGEF2 | Rap Guanine Nucleotide Exchange Factor 2 | Protein Coding | 1 |
| 6 | RAPGEF5 | Rap Guanine Nucleotide Exchange Factor 5 | Protein Coding | 1 |
| 7 | MRAS | Muscle RAS Oncogene Homolog | Protein Coding | 1 |
| 8 | PLCE1 | Phospholipase C Epsilon 1 | Protein Coding | 1 |
Disorders associated with G-protein signaling_Rap2B regulation pathway SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Resting heart rate, variation in | Enrichment | ADRB1 | 3.23 |
| 2 | Noonan syndrome 11 | Enrichment | MRAS | 3.23 |
| 3 | Epilepsy, familial adult myoclonic, 7 | Enrichment | RAPGEF2 | 3.23 |
| 4 | Short sleep, familial natural, 2 | Enrichment | ADRB1 | 3.23 |
| 5 | Nephrotic syndrome, type 3 | Enrichment | PLCE1 | 2.75 |
| 6 | Nephrotic syndrome, type 1 | Enrichment | PLCE1 | 2.28 |
| 7 | Focal segmental glomerulosclerosis | Enrichment | PLCE1 | 1.93 |
| 8 | Cardiomyopathy, dilated, 1a | Enrichment | RAPGEF5 | 1.91 |
| 9 | Noonan syndrome 1 | Enrichment | MRAS | 1.87 |
| 10 | Rasopathy | Enrichment | MRAS | 1.82 |
| 11 | Genetic steroid-resistant nephrotic syndrome | Enrichment | PLCE1 | 1.70 |
| 12 | Nephrotic syndrome | Enrichment | PLCE1 | 1.60 |
