G-protein signaling_Regulation of CDC42 activity

No Pathway Network information available for G-protein signaling_Regulation of CDC42 activity

Pathways in the G-protein signaling_Regulation of CDC42 activity SuperPath

#	Name	Source	Genes
1	G-protein signaling_Regulation of CDC42 activity	GeneGo (Thomson Reuters)	ABR ARHGAP1 ARHGAP17 ARHGAP31 ARHGAP32 ARHGAP5 ARHGDIA ARHGDIB ARHGDIG BCR BNIP2 CASP1 CASP3 CDC42 CHN2 DEF6 DLC1 DOCK11 DOCK6 DOCK9 ECT2 EZR FGD1 FGD4 FGFR1 FYN MCF2 MCF2L RALBP1 RASA1 SPATA13 TNK2 (see all 32) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABR	ABR Activator Of RhoGEF And GTPase	Protein Coding	1
2	ARHGAP1	Rho GTPase Activating Protein 1	Protein Coding	1
3	ARHGAP5	Rho GTPase Activating Protein 5	Protein Coding	1
4	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	1
5	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	1
6	ARHGDIG	Rho GDP Dissociation Inhibitor Gamma	Protein Coding	1
7	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	1
8	BNIP2	BCL2 Interacting Protein 2	Protein Coding	1
9	CASP1	Caspase 1	Protein Coding	1
10	CASP3	Caspase 3	Protein Coding	1
11	CDC42	Cell Division Cycle 42	Protein Coding	1
12	CHN2	Chimerin 2	Protein Coding	1
13	ECT2	Epithelial Cell Transforming 2	Protein Coding	1
14	FGD1	FYVE, RhoGEF And PH Domain Containing 1	Protein Coding	1
15	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
16	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
17	MCF2	MCF.2 Cell Line Derived Transforming Sequence	Protein Coding	1
18	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
19	EZR	Ezrin	Protein Coding	1
20	ARHGAP32	Rho GTPase Activating Protein 32	Protein Coding	1
21	TNK2	Tyrosine Kinase Non Receptor 2	Protein Coding	1
22	DLC1	DLC1 Rho GTPase Activating Protein	Protein Coding	1
23	RALBP1	RalA Binding Protein 1	Protein Coding	1
24	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	1
25	DOCK9	Dedicator Of Cytokinesis 9	Protein Coding	1
26	DEF6	DEF6 Guanine Nucleotide Exchange Factor	Protein Coding	1
27	ARHGAP17	Rho GTPase Activating Protein 17	Protein Coding	1
28	ARHGAP31	Rho GTPase Activating Protein 31	Protein Coding	1
29	DOCK6	Dedicator Of Cytokinesis 6	Protein Coding	1
30	FGD4	FYVE, RhoGEF And PH Domain Containing 4	Protein Coding	1
31	DOCK11	Dedicator Of Cytokinesis 11	Protein Coding	1
32	SPATA13	Spermatogenesis Associated 13	Protein Coding	1

Disorders associated with G-protein signaling_Regulation of CDC42 activity SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Adams-oliver syndrome 1	Enrichment	ARHGAP31, DOCK6	4.79
2	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR, FGFR1	4.79
3	Adams-oliver syndrome	Enrichment	ARHGAP31, DOCK6	3.95
4	Osteoglophonic dysplasia	Enrichment	FGFR1	2.63
5	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.63
6	Trigonocephaly 1	Enrichment	FGFR1	2.63
7	Autoinflammatory disease, multisystem, with immune dysregulation, x-linked	Enrichment	DOCK11	2.63
8	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.63
9	Charcot-marie-tooth disease, demyelinating, type 4h	Enrichment	FGD4	2.63
10	Immunodeficiency 87 and autoimmunity	Enrichment	DEF6	2.63
11	Charcot-marie-tooth disease type 4h	Enrichment	FGD4	2.63
12	Hartsfield syndrome	Enrichment	FGFR1	2.63
13	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.63
14	Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression	Enrichment	TNK2	2.63
15	Gorham's disease	Enrichment	RASA1	2.63
16	Nocarh syndrome	Enrichment	CDC42	2.63
17	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.63
18	Pfeiffer syndrome	Enrichment	FGFR1	2.33
19	Jackson-weiss syndrome	Enrichment	FGFR1	2.33
20	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	2.33
21	Adams-oliver syndrome 2	Enrichment	DOCK6	2.33
22	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	2.33
23	Immune system disease	Enrichment	CDC42	2.33
24	Paget's disease of bone	Enrichment	DOCK6	2.33
25	Aarskog syndrome	Enrichment	FGD1	2.33
26	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.33
27	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	2.15
28	Aarskog-scott syndrome	Enrichment	FGD1	2.15
29	Intellectual developmental disorder, x-linked, syndromic, claes-jensen type	Enrichment	FGD1	2.15
30	Hypercholanemia, familial 1	Enrichment	DOCK6	2.15
31	Wieacker-wolff syndrome	Enrichment	RASA1	2.15
32	Syndromic x-linked intellectual disability claes-jensen type	Enrichment	FGD1	2.15
33	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR	2.03
34	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.03
35	Capillary malformations, congenital	Enrichment	RASA1	1.93
36	Martsolf syndrome 1	Enrichment	ARHGAP5	1.93
37	Holoprosencephaly	Enrichment	FGFR1	1.93
38	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.93
39	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.85
40	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.85
41	Holoprosencephaly 1	Enrichment	FGFR1	1.85
42	Hemangioma, capillary infantile	Enrichment	RASA1	1.85
43	Basal cell carcinoma 1	Enrichment	RASA1	1.85
44	Capillary malformation-arteriovenous malformation 1	Enrichment	RASA1	1.79
45	Leukemia, chronic myeloid	Enrichment	BCR	1.79
46	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.79
47	Pilomyxoid astrocytoma	Enrichment	FGFR1	1.79
48	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	BCR	1.79
49	Arteriovenous malformation	Enrichment	RASA1	1.68
50	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.68
51	Myopathy, x-linked, with excessive autophagy	Enrichment	RASA1	1.63
52	Septooptic dysplasia	Enrichment	FGFR1	1.55
53	Hypercholesterolemia, familial, 1	Enrichment	DOCK6	1.52
54	Neural tube defects	Enrichment	DLC1	1.52
55	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.49
56	Familial hypercholesterolemia	Enrichment	DOCK6	1.46
57	Gliosarcoma	Enrichment	FGFR1	1.43
58	Microform holoprosencephaly	Enrichment	FGFR1	1.43
59	Lobar holoprosencephaly	Enrichment	FGFR1	1.43
60	Giant cell glioblastoma	Enrichment	FGFR1	1.40
61	Charcot-marie-tooth disease type 4	Enrichment	FGD4	1.38
62	Semilobar holoprosencephaly	Enrichment	FGFR1	1.38
63	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	1.38
64	Parkinson's disease	Enrichment	TNK2	1.36
65	Tooth agenesis	Enrichment	FGFR1	1.30
66	Kallmann syndrome	Enrichment	FGFR1	1.28
67	Precursor t-cell acute lymphoblastic leukemia	Enrichment	BCR	1.28
68	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGDIA	1.11
69	Cerebral palsy	Enrichment	ARHGAP31	1.05
70	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	0.89
71	Colorectal cancer	Enrichment	DLC1	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G-protein signaling_Regulation of CDC42 activity

Pathway Network for G-protein signaling_Regulation of CDC42 activity

Member Pathways for G-protein signaling_Regulation of CDC42 activity

Pathways in the G-protein signaling_Regulation of CDC42 activity SuperPath

Associated Genes for G-protein signaling_Regulation of CDC42 activity

Associated Disorders for G-protein signaling_Regulation of CDC42 activity

Disorders associated with G-protein signaling_Regulation of CDC42 activity SuperPath

STRING Interaction Network for G-protein signaling_Regulation of CDC42 activity

Sources for G-protein signaling_Regulation of CDC42 activity