G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

No Pathway Network information available for G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

Pathways in the G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins SuperPath

#	Name	Source	Genes
1	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins	GeneGo (Thomson Reuters)	ARHGEF1 ARHGEF12 ATF2 BLNK BTK CDC42 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 JUN MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K20 MAP3K4 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MEF2C PAK1 PIK3CG PIK3R5 PKN1 PLCB1 PLCB2 PLCB3 PLCB4 PRKCE PTK2B RAC1 RHOA ROCK1 SRC VAV1 VAV2 (see all 64) (see less)
2	G-protein signaling G-Protein alpha-12 signaling pathway	GeneGo (Thomson Reuters)	AKAP13 ARHGEF1 ARHGEF11 ARHGEF12 BTK CDC42 GNA12 GNA13 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 LIMK1 MAP2K1 MAP2K2 MAP2K4 MAP3K1 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MRAS PAK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PLCE1 PLCG1 PLCG2 PRKACA PRKACB PRKACG RAC1 RAF1 RAP1A RAPGEF5 RASA2 RHOA ROCK1 ROCK2 RRAS RRAS2 YWHAB (see all 63) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RHOA	Ras Homolog Family Member A	Protein Coding	2
2	BTK	Bruton Tyrosine Kinase	Protein Coding	2
3	CDC42	Cell Division Cycle 42	Protein Coding	2
4	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
5	GNA12	G Protein Subunit Alpha 12	Protein Coding	2
6	GNB1	G Protein Subunit Beta 1	Protein Coding	2
7	GNB2	G Protein Subunit Beta 2	Protein Coding	2
8	GNB3	G Protein Subunit Beta 3	Protein Coding	2
9	GNG3	G Protein Subunit Gamma 3	Protein Coding	2
10	GNG4	G Protein Subunit Gamma 4	Protein Coding	2
11	GNG5	G Protein Subunit Gamma 5	Protein Coding	2
12	GNG7	G Protein Subunit Gamma 7	Protein Coding	2
13	GNG10	G Protein Subunit Gamma 10	Protein Coding	2
14	GNG11	G Protein Subunit Gamma 11	Protein Coding	2
15	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	2
16	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	2
17	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	2
18	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
19	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
20	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
21	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	2
22	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	2
23	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	2
24	RAC1	Rac Family Small GTPase 1	Protein Coding	2
25	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	2
26	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
27	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	2
28	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	2
29	GNA13	G Protein Subunit Alpha 13	Protein Coding	2
30	GNB5	G Protein Subunit Beta 5	Protein Coding	2
31	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	2
32	GNG13	G Protein Subunit Gamma 13	Protein Coding	2
33	GNG2	G Protein Subunit Gamma 2	Protein Coding	2
34	GNG12	G Protein Subunit Gamma 12	Protein Coding	2
35	GNB4	G Protein Subunit Beta 4	Protein Coding	2
36	GNG8	G Protein Subunit Gamma 8	Protein Coding	2
37	ATF2	Activating Transcription Factor 2	Protein Coding	1
38	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
39	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
40	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
41	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
42	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
43	GNAO1	G Protein Subunit Alpha O1	Protein Coding	1
44	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
45	GNAZ	G Protein Subunit Alpha Z	Protein Coding	1
46	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
47	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
48	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
49	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
50	PLCB2	Phospholipase C Beta 2	Protein Coding	1
51	PLCB3	Phospholipase C Beta 3	Protein Coding	1
52	PLCB4	Phospholipase C Beta 4	Protein Coding	1
53	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
54	PKN1	Protein Kinase N1	Protein Coding	1
55	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
56	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
57	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
58	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
59	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
60	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
61	PLCB1	Phospholipase C Beta 1	Protein Coding	1
62	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
63	BLNK	B Cell Linker	Protein Coding	1
64	MAP3K20	Mitogen-Activated Protein Kinase Kinase Kinase 20	Protein Coding	1
65	LIMK1	LIM Domain Kinase 1	Protein Coding	1
66	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
67	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
68	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
69	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
70	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
71	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
72	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
73	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
74	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
75	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
76	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
77	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
78	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
79	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
80	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
81	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
82	RASA2	RAS P21 Protein Activator 2	Protein Coding	1
83	RRAS	RAS Related	Protein Coding	1
84	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
85	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
86	RAPGEF5	Rap Guanine Nucleotide Exchange Factor 5	Protein Coding	1
87	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	1
88	AKAP13	A-Kinase Anchoring Protein 13	Protein Coding	1
89	RRAS2	RAS Related 2	Protein Coding	1
90	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
91	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1

Disorders associated with G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2, MRAS, RAF1, RASA2, RRAS, RRAS2	10.57
2	Rasopathy	Enrichment	MAP2K1, MAP2K2, MRAS, RAF1, RRAS2	6.95
3	Melanoma, uveal	Enrichment	GNA11, GNAQ, PLCB4	5.70
4	Immune system disease	Enrichment	CDC42, PIK3CD	4.67
5	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	4.66
6	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2, RAF1	4.38
7	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.20
8	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.20
9	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.20
10	Anastomosing haemangioma	Enrichment	GNA11, GNAQ	4.18
11	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	3.90
12	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	3.90
13	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	3.90
14	Auriculocondylar syndrome 1	Enrichment	GNAI3, PLCB4	3.88
15	Capillary malformations, congenital	Enrichment	GNA11, GNAQ	3.66
16	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.50
17	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.36
18	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.13
19	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA	3.13
20	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA	3.03
21	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.03
22	Lung non-small cell carcinoma	Enrichment	MAP2K1, PIK3CA	2.94
23	Macrodactyly	Enrichment	PIK3CA	2.33
24	Noonan syndrome 5	Enrichment	RAF1	2.33
25	Melorheostosis, isolated	Enrichment	MAP2K1	2.33
26	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.33
27	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.33
28	Cowden syndrome 5	Enrichment	PIK3CA	2.33
29	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.33
30	46,xy sex reversal 6	Enrichment	MAP3K1	2.33
31	Immunodeficiency 62	Enrichment	ARHGEF1	2.33
32	Noonan syndrome 11	Enrichment	MRAS	2.33
33	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.33
34	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.33
35	Noonan syndrome 13	Enrichment	MAPK1	2.33
36	Short syndrome	Enrichment	PIK3R1	2.33
37	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.33
38	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.33
39	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.33
40	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.33
41	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.33
42	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.33
43	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.33
44	Melorheostosis	Enrichment	MAP2K1	2.33
45	Leopard syndrome 2	Enrichment	RAF1	2.33
46	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.33
47	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.33
48	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.33
49	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.33
50	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.33
51	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.33
52	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.33
53	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.33
54	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.33
55	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.33
56	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.33
57	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.33
58	Sick sinus syndrome 4	Enrichment	GNB2	2.33
59	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.33
60	Trigonitis	Enrichment	RAF1	2.33
61	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.33
62	Hypospadias	Enrichment	PIK3CA	2.33
63	Rare venous malformation	Enrichment	PIK3CA	2.33
64	Diaphragmatic eventration	Enrichment	PIK3CA	2.33
65	Nocarh syndrome	Enrichment	CDC42	2.33
66	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.33
67	Rare combined vascular malformation	Enrichment	PIK3CA	2.33
68	Cavernous lymphangioma	Enrichment	PIK3CA	2.33
69	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.33
70	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.33
71	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.33
72	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.33
73	Macrodactyly of toe	Enrichment	PIK3CA	2.33
74	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.33
75	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	2.33
76	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.33
77	Sturge-weber syndrome	Enrichment	GNAQ	2.33
78	Ventricular tachycardia, familial	Enrichment	GNAI2	2.33
79	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.33
80	Myopathy, centronuclear, 6, with fiber-type disproportion	Enrichment	MAP3K20	2.33
81	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.33
82	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.33
83	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.33
84	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	2.33
85	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.33
86	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.33
87	Thrombocytopenia 6	Enrichment	SRC	2.33
88	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.33
89	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.33
90	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.33
91	Gnao1-related disorder	Enrichment	GNAO1	2.33
92	Mef2c-related disorder	Enrichment	MEF2C	2.33
93	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.33
94	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	2.03
95	Keratosis, seborrheic	Enrichment	PIK3CA	2.03
96	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.03
97	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.03
98	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.03
99	Noonan syndrome 8	Enrichment	PIK3CA	2.03
100	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.03
101	Agammaglobulinemia, x-linked	Enrichment	BTK	2.03
102	Noonan syndrome 12	Enrichment	RRAS2	2.03
103	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.03
104	Fibrolamellar carcinoma	Enrichment	PRKACA	2.03
105	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.03
106	Tafro syndrome	Enrichment	MAP2K2	2.03
107	Cerebral visual impairment	Enrichment	GNB1	2.03
108	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.03
109	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	2.03
110	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.03
111	Agammaglobulinemia 4, autosomal recessive	Enrichment	BLNK	2.03
112	Agammaglobulinemia 4	Enrichment	BLNK	2.03
113	Autosomal dominant hypocalcemia	Enrichment	GNA11	2.03
114	Split-foot malformation with mesoaxial polydactyly	Enrichment	MAP3K20	2.03
115	Ocular melanoma	Enrichment	PLCB4	2.03
116	Hypopituitarism	Enrichment	GNAI2	2.03
117	Ovarian cancer	Enrichment	MAP3K1, PIK3CA, RRAS2	1.94
118	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.86
119	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.86
120	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.86
121	Nephrotic syndrome, type 3	Enrichment	PLCE1	1.86
122	Agammaglobulinemia 1	Enrichment	BTK	1.86
123	Keratoacanthoma	Enrichment	PIK3CA	1.86
124	West syndrome	Enrichment	GNAO1, PLCB1	1.74
125	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.73
126	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.73
127	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.73
128	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.73
129	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.73
130	Cerebrovascular disease	Enrichment	PIK3CA	1.73
131	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.73
132	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.73
133	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.73
134	Familial sick sinus syndrome	Enrichment	GNB2	1.73
135	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.73
136	Achromatopsia 4	Enrichment	GNAI3	1.73
137	Hemimegalencephaly	Enrichment	PIK3CA	1.64
138	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.56
139	Cowden syndrome 1	Enrichment	PIK3CA	1.56
140	Breast adenocarcinoma	Enrichment	PIK3CA	1.56
141	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.56
142	Split-hand/foot malformation 1	Enrichment	MAP3K20	1.55
143	Nevus, epidermal	Enrichment	PIK3CA	1.49
144	Noonan syndrome 3	Enrichment	RAF1	1.49
145	Gallbladder cancer	Enrichment	PIK3CA	1.49
146	Pilomyxoid astrocytoma	Enrichment	RAF1	1.49
147	Overgrowth syndrome	Enrichment	PIK3R1	1.49
148	Myelofibrosis	Enrichment	SRC	1.49
149	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.44
150	Lennox-gastaut syndrome	Enrichment	MAPK10	1.44
151	Hypothyroidism	Enrichment	GNB1	1.44
152	Choreatic disease	Enrichment	GNAO1	1.43
153	Nephrotic syndrome, type 1	Enrichment	PLCE1	1.39
154	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.39
155	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.39
156	Cowden syndrome	Enrichment	PIK3CA	1.39
157	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.38
158	Breast cancer	Enrichment	GNG3, PIK3CA	1.32
159	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.30
160	Myelodysplastic syndrome	Enrichment	GNB1	1.30
161	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.30
162	Specific learning disability	Enrichment	MAPK1	1.30
163	Movement disease	Enrichment	GNAO1	1.29
164	Juvenile myelomonocytic leukemia	Enrichment	RRAS	1.26
165	Meningioma	Enrichment	PIK3CA	1.26
166	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.26
167	Nk-cell enteropathy	Enrichment	PIK3CB	1.23
168	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	1.21
169	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.20
170	Osteoporosis	Enrichment	SRC	1.19
171	Lynch syndrome	Enrichment	PIK3CA	1.17
172	Congenital myopathy 4a, autosomal dominant	Enrichment	MAP3K20	1.16
173	Rare genetic intellectual disability	Enrichment	GNAO1	1.16
174	Hypertension, essential	Enrichment	GNB3	1.12
175	Cleft palate, isolated	Enrichment	GNB1	1.12
176	Heart, malformation of	Enrichment	MAPK1	1.09
177	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	1.09
178	Diffuse large b-cell lymphoma	Enrichment	BTK	1.07
179	Williams-beuren syndrome	Enrichment	LIMK1	1.05
180	Focal segmental glomerulosclerosis	Enrichment	PLCE1	1.05
181	Congenital nervous system abnormality	Enrichment	GNAO1, GNB5	1.05
182	Nervous system disease	Enrichment	GNAO1, GNB5	1.05
183	Autism spectrum disorder	Enrichment	GNB1, MAP2K1	1.04
184	Cardiomyopathy, dilated, 1a	Enrichment	RAPGEF5	1.03
185	Endometrial cancer	Enrichment	PIK3CA	1.03
186	Centronuclear myopathy	Enrichment	MAP3K20	1.02
187	Hepatocellular carcinoma	Enrichment	PIK3CA	1.01
188	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.01
189	Congenital stationary night blindness	Enrichment	GNB3	0.99
190	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.98
191	Microcephaly	Enrichment	GNB1, MAPK1	0.95
192	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1	0.95
193	Strabismus	Enrichment	GNB1	0.93
194	Bladder cancer	Enrichment	PIK3CA	0.90
195	Prostate cancer	Enrichment	PIK3CA	0.90
196	Lung cancer	Enrichment	PIK3CA	0.86
197	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.85
198	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	0.83
199	Left ventricular noncompaction	Enrichment	RAF1	0.82
200	Dystonia	Enrichment	GNB1	0.82
201	Developmental and epileptic encephalopathy	Enrichment	GNAO1	0.80
202	Cerebral palsy	Enrichment	GNB1	0.78
203	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.75
204	Gastric cancer	Enrichment	PIK3CA	0.74
205	Nephrotic syndrome	Enrichment	PLCE1	0.74
206	Centralopathic epilepsy	Enrichment	PLCB1	0.73
207	Hereditary breast carcinoma	Enrichment	PIK3CA	0.73
208	Thrombocytopenia	Enrichment	SRC	0.69
209	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	0.68
210	Hypertelorism	Enrichment	PIK3CA	0.67
211	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.66
212	Myeloma, multiple	Enrichment	PIK3R2	0.64
213	Undetermined early-onset epileptic encephalopathy	Enrichment	LIMK1	0.64
214	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.62
215	Dilated cardiomyopathy	Enrichment	RAF1	0.51
216	Complex neurodevelopmental disorder	Enrichment	GNB2	0.36

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

Pathway Network for G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

Member Pathways for G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

Pathways in the G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins SuperPath

Associated Genes for G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

Associated Disorders for G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

Disorders associated with G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins SuperPath

STRING Interaction Network for G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

Sources for G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins