G-protein signaling_Regulation of RAC1 activity

No Pathway Network information available for G-protein signaling_Regulation of RAC1 activity

Pathways in the G-protein signaling_Regulation of RAC1 activity SuperPath

#	Name	Source	Genes
1	G-protein signaling_Regulation of RAC1 activity	GeneGo (Thomson Reuters)	ABR ARHGAP1 ARHGAP12 ARHGAP22 ARHGAP24 ARHGAP32 ARHGAP9 ARHGDIA ARHGDIB ARHGEF2 ARHGEF4 BCR CASP1 CASP3 CD19 CD247 CD3D CD3E CD3G CHN2 DEF6 ECT2 EZR FNTA HRAS KIFAP3 LCP2 MCF2 PGGT1B RAC1 RACGAP1 RALBP1 RAP1GDS1 SRGAP3 TIAM1 TNK2 TRA TRAC TRAJ18 TRAV24 TRB TRBV11-1 TRBV11-2 TRBV11-3 TRBV17 VAV1 VAV2 ZAP70 (see all 48) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABR	ABR Activator Of RhoGEF And GTPase	Protein Coding	1
2	ARHGAP1	Rho GTPase Activating Protein 1	Protein Coding	1
3	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	1
4	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	1
5	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	1
6	CASP1	Caspase 1	Protein Coding	1
7	CASP3	Caspase 3	Protein Coding	1
8	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
9	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
10	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
11	CD247	CD247 Molecule	Protein Coding	1
12	CD19	CD19 Molecule	Protein Coding	1
13	CHN2	Chimerin 2	Protein Coding	1
14	ECT2	Epithelial Cell Transforming 2	Protein Coding	1
15	FNTA	Farnesyltransferase, CAAX Box, Subunit Alpha	Protein Coding	1
16	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
17	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	1
18	MCF2	MCF.2 Cell Line Derived Transforming Sequence	Protein Coding	1
19	PGGT1B	Protein Geranylgeranyltransferase Type I Subunit Beta	Protein Coding	1
20	RAC1	Rac Family Small GTPase 1	Protein Coding	1
21	RAP1GDS1	Rap1 GTPase-GDP Dissociation Stimulator 1	Protein Coding	1
22	TRA	T Cell Receptor Alpha Locus	Protein Coding	1
23	TRB	T Cell Receptor Beta Locus	Protein Coding	1
24	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
25	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
26	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
27	EZR	Ezrin	Protein Coding	1
28	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
29	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	1
30	ARHGAP32	Rho GTPase Activating Protein 32	Protein Coding	1
31	SRGAP3	SLIT-ROBO Rho GTPase Activating Protein 3	Protein Coding	1
32	TNK2	Tyrosine Kinase Non Receptor 2	Protein Coding	1
33	RALBP1	RalA Binding Protein 1	Protein Coding	1
34	KIFAP3	Kinesin Associated Protein 3	Protein Coding	1
35	TRBV17	T Cell Receptor Beta Variable 17 (Non-Functional)	Protein Coding	1
36	TRBV11-3	T Cell Receptor Beta Variable 11-3	Protein Coding	1
37	TRBV11-2	T Cell Receptor Beta Variable 11-2	Protein Coding	1
38	TRBV11-1	T Cell Receptor Beta Variable 11-1	Protein Coding	1
39	TRAV24	T Cell Receptor Alpha Variable 24	Protein Coding	1
40	TRAJ18	T Cell Receptor Alpha Joining 18	Protein Coding	1
41	TRAC	T Cell Receptor Alpha Constant	Protein Coding	1
42	RACGAP1	Rac GTPase Activating Protein 1	Protein Coding	1
43	DEF6	DEF6 Guanine Nucleotide Exchange Factor	Protein Coding	1
44	ARHGEF4	Rho Guanine Nucleotide Exchange Factor 4	Protein Coding	1
45	ARHGAP22	Rho GTPase Activating Protein 22	Protein Coding	1
46	ARHGAP9	Rho GTPase Activating Protein 9	Protein Coding	1
47	ARHGAP24	Rho GTPase Activating Protein 24	Protein Coding	1
48	ARHGAP12	Rho GTPase Activating Protein 12	Protein Coding	1

Disorders associated with G-protein signaling_Regulation of RAC1 activity SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	7.38
2	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, ZAP70	7.01
3	Immunodeficiency 7	Enrichment	TRA, TRAC	4.44
4	Precursor t-cell acute lymphoblastic leukemia	Enrichment	BCR, TRA, TRB	4.15
5	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.45
6	Immunodeficiency 87 and autoimmunity	Enrichment	DEF6	2.45
7	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.45
8	Immunodeficiency 81	Enrichment	LCP2	2.45
9	Immunodeficiency 48	Enrichment	ZAP70	2.45
10	Immunodeficiency 18	Enrichment	CD3E	2.45
11	Immunodeficiency 25	Enrichment	CD247	2.45
12	Immunodeficiency, common variable, 3	Enrichment	CD19	2.45
13	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.45
14	Alfadhel syndrome	Enrichment	RAP1GDS1	2.45
15	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.45
16	Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression	Enrichment	TNK2	2.45
17	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.45
18	Congenital dyserythropoietic anemia type iiib	Enrichment	RACGAP1	2.45
19	Immunodeficiency 19	Enrichment	CD3D	2.45
20	Anemia, congenital dyserythropoietic, type iiib, autosomal recessive	Enrichment	RACGAP1	2.45
21	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.45
22	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.45
23	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.45
24	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGAP24, ARHGDIA	2.19
25	Anemia, congenital dyserythropoietic, type iiia	Enrichment	RACGAP1	2.15
26	Costello syndrome	Enrichment	HRAS	2.15
27	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.15
28	Spastic paraplegia 70, autosomal recessive	Enrichment	ARHGAP9	2.15
29	Trypsinogen deficiency	Enrichment	TRB	2.15
30	Immunodeficiency 17	Enrichment	CD3G	2.15
31	Common variable immunodeficiency phenotype due to cd19/cd81 deficiency	Enrichment	CD19	2.15
32	Wooly hair nevus	Enrichment	HRAS	2.15
33	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR	1.98
34	Large congenital melanocytic nevus	Enrichment	HRAS	1.98
35	Spermatocytoma	Enrichment	HRAS	1.98
36	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.85
37	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR	1.85
38	Epidermolytic nevus	Enrichment	HRAS	1.85
39	Vitamin d-dependent rickets, type 2a	Enrichment	TRB	1.76
40	Nevus, epidermal	Enrichment	HRAS	1.61
41	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.61
42	Leukemia, chronic myeloid	Enrichment	BCR	1.61
43	Noonan syndrome 3	Enrichment	HRAS	1.61
44	Pilomyxoid astrocytoma	Enrichment	SRGAP3	1.61
45	Follicular thyroid carcinoma	Enrichment	HRAS	1.61
46	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.61
47	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.61
48	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	BCR	1.61
49	Melanocytic nevus syndrome, congenital	Enrichment	HRAS	1.55
50	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.50
51	Arteriovenous malformation	Enrichment	HRAS	1.50
52	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.46
53	Combined immunodeficiency	Enrichment	ZAP70	1.42
54	Lung non-small cell carcinoma	Enrichment	HRAS	1.42
55	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	1.42
56	Combined t and b cell immunodeficiency	Enrichment	ZAP70	1.42
57	Lip and oral cavity carcinoma	Enrichment	HRAS	1.38
58	Hereditary chronic pancreatitis	Enrichment	TRB	1.31
59	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS	1.29
60	Rhabdomyosarcoma	Enrichment	HRAS	1.26
61	Pancreatitis, hereditary	Enrichment	TRB	1.23
62	Parkinson's disease	Enrichment	TNK2	1.19
63	Noonan syndrome 1	Enrichment	HRAS	1.11
64	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.05
65	Rasopathy	Enrichment	HRAS	1.05
66	Bladder cancer	Enrichment	HRAS	1.01
67	Differentiated thyroid carcinoma	Enrichment	HRAS	1.01
68	Non-immune hydrops fetalis	Enrichment	HRAS	0.98
69	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	0.73
70	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.45

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G-protein signaling_Regulation of RAC1 activity

Pathway Network for G-protein signaling_Regulation of RAC1 activity

Member Pathways for G-protein signaling_Regulation of RAC1 activity

Pathways in the G-protein signaling_Regulation of RAC1 activity SuperPath

Associated Genes for G-protein signaling_Regulation of RAC1 activity

Associated Disorders for G-protein signaling_Regulation of RAC1 activity

Disorders associated with G-protein signaling_Regulation of RAC1 activity SuperPath

STRING Interaction Network for G-protein signaling_Regulation of RAC1 activity

Sources for G-protein signaling_Regulation of RAC1 activity