G-protein signaling_RhoB regulation pathway

No Pathway Network information available for G-protein signaling_RhoB regulation pathway

#	Name	Source	Genes
1	G-protein signaling_RhoB regulation pathway	GeneGo (Thomson Reuters)	ARHGDIA ARHGDIG ARHGEF10L ARHGEF2 ARHGEF3 DIAPH1 DIAPH3 EZR FNTA FNTB PGGT1B PKN1 PLCE1 RHOB RHPN2 RTKN VAV2 (see all 17) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RHOB	Ras Homolog Family Member B	Protein Coding	1
2	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	1
3	ARHGDIG	Rho GDP Dissociation Inhibitor Gamma	Protein Coding	1
4	DIAPH1	Diaphanous Related Formin 1	Protein Coding	1
5	FNTA	Farnesyltransferase, CAAX Box, Subunit Alpha	Protein Coding	1
6	FNTB	Farnesyltransferase, CAAX Box, Subunit Beta	Protein Coding	1
7	PGGT1B	Protein Geranylgeranyltransferase Type I Subunit Beta	Protein Coding	1
8	PKN1	Protein Kinase N1	Protein Coding	1
9	RTKN	Rhotekin	Protein Coding	1
10	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
11	EZR	Ezrin	Protein Coding	1
12	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	1
13	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	1
14	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1
15	ARHGEF10L	Rho Guanine Nucleotide Exchange Factor 10 Like	Protein Coding	1
16	DIAPH3	Diaphanous Related Formin 3	Protein Coding	1
17	RHPN2	Rhophilin Rho GTPase Binding Protein 2	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGDIA, PLCE1	3.09
2	Deafness, autosomal dominant 1, with or without thrombocytopenia	Enrichment	DIAPH1	2.90
3	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.90
4	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.90
5	Auditory neuropathy, autosomal dominant 1	Enrichment	DIAPH3	2.90
6	Seizures, cortical blindness, and microcephaly syndrome	Enrichment	DIAPH1	2.90
7	Diaph1-related sensorineural hearing loss-thrombocytopenia syndrome	Enrichment	DIAPH1	2.90
8	Nephrotic syndrome, type 3	Enrichment	PLCE1	2.43
9	Moyamoya disease 1	Enrichment	DIAPH1	2.13
10	Pendred syndrome	Enrichment	DIAPH1	2.13
11	Nephrotic syndrome, type 1	Enrichment	PLCE1	1.95
12	Focal segmental glomerulosclerosis	Enrichment	PLCE1	1.61
13	Auditory neuropathy	Enrichment	DIAPH1	1.49
14	Epilepsy	Enrichment	DIAPH1	1.31
15	Nephrotic syndrome	Enrichment	PLCE1	1.28
16	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	DIAPH3	1.20
17	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	1.15
18	Rare genetic deafness	Enrichment	DIAPH1	1.02
19	Microcephaly	Enrichment	DIAPH1	0.84

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for G-protein signaling_RhoB regulation pathway