G-protein signaling TC21 regulation pathway

Pathway network for the G-protein signaling TC21 regulation pathway SuperPath

Sources:

GeneGo (Thomson Reuters)
Reactome

Pathways in the G-protein signaling TC21 regulation pathway SuperPath

#	Name	Source	Genes
1	G-protein signaling TC21 regulation pathway	GeneGo (Thomson Reuters)	BCR BRAF DOK1 DOK2 GNA12 GNA13 GRB2 LCK MAP2K1 MAP2K2 MAPK1 MAPK3 NF1 RAF1 RAP1A RAPGEF1 RASA1 RASA2 RASGRF1 RASGRP1 RASGRP2 RASGRP3 RRAS2 SRC (see all 24) (see less)
2	G-protein signaling M-RAS regulation pathway	GeneGo (Thomson Reuters)	ARAF BCR BRAF DOK1 DOK2 GNA12 GNA13 LCK MAP2K1 MAP2K2 MAPK1 MAPK3 MRAS NF1 RAF1 RAP1A RASA1 RASA2 RASGRF1 RASGRP1 RASGRP3 SOS1 SOS2 SRC (see all 24) (see less)
3	Negative feedback regulation of MAPK pathway	Reactome	BRAF MAP2K1 MAP2K2 MAPK1 MAPK3 RAF1 (see all 6) (see less)
4	Signaling by MAP2K mutants	Reactome	MAP2K1 MAP2K2 MAPK1 MAPK3

Gene overlap in member pathways for G-protein signaling TC21 regulation pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	4
2	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	4
3	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	4
4	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	4
5	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	3
6	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	3
7	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	2
8	DOK1	Docking Protein 1	Protein Coding	2
9	GNA12	G Protein Subunit Alpha 12	Protein Coding	2
10	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
11	NF1	Neurofibromin 1	Protein Coding	2
12	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	2
13	RASA1	RAS P21 Protein Activator 1	Protein Coding	2
14	RASA2	RAS P21 Protein Activator 2	Protein Coding	2
15	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	2
16	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
17	DOK2	Docking Protein 2	Protein Coding	2
18	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	2
19	GNA13	G Protein Subunit Alpha 13	Protein Coding	2
20	RASGRP3	RAS Guanyl Releasing Protein 3	Protein Coding	2
21	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
22	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	1
23	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	1
24	RRAS2	RAS Related 2	Protein Coding	1
25	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
26	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
27	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
28	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1

Disorders associated with G-protein signaling TC21 regulation pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cardiofaciocutaneous syndrome	Direct
2	Rasopathy	Enrichment	BRAF, MAP2K1, MAP2K2, MRAS, NF1, RAF1, SOS1, SOS2	11.04
3	Noonan syndrome 1	Enrichment	BRAF, MAP2K1, MAP2K2, MRAS, RAF1, RASA2, SOS1, SOS2	10.39
4	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, MAP2K1, MAP2K2, RAF1	10.36
5	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, MAP2K1, MAP2K2	9.62
6	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	6.31
7	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	6.01
8	Pulmonic stenosis	Enrichment	BRAF, SOS1	5.52
9	Pilomyxoid astrocytoma	Enrichment	BRAF, RAF1	5.47
10	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, RAF1	5.34
11	Lung non-small cell carcinoma	Enrichment	BRAF, MAP2K1	5.05
12	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2, NF1	4.75
13	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR, MAPK1	4.75
14	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, RASA1	4.20
15	Noonan syndrome 3	Enrichment	RAF1, SOS1	4.20
16	Arteriovenous malformation	Enrichment	MAP2K1, RASA1	3.97
17	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, RASA1	3.87
18	Noonan syndrome 5	Enrichment	RAF1	3.35
19	Melorheostosis, isolated	Enrichment	MAP2K1	3.35
20	Noonan syndrome 7	Enrichment	BRAF	3.35
21	Leopard syndrome 3	Enrichment	BRAF	3.35
22	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	3.35
23	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	3.35
24	Noonan syndrome 13	Enrichment	MAPK1	3.35
25	Lymphangioma	Enrichment	BRAF	3.35
26	Phace association	Enrichment	BRAF	3.35
27	Melorheostosis	Enrichment	MAP2K1	3.35
28	Leopard syndrome 2	Enrichment	RAF1	3.35
29	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	3.35
30	Trigonitis	Enrichment	RAF1	3.35
31	Syringocystadenoma papilliferum	Enrichment	BRAF	3.35
32	Ganglioglioma	Enrichment	BRAF	3.35
33	Nongerminomatous germ cell tumor	Enrichment	BRAF	3.35
34	Phace syndrome	Enrichment	BRAF	3.35
35	Classic hairy cell leukemia	Enrichment	BRAF	3.35
36	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	3.29
37	Tafro syndrome	Enrichment	MAP2K2	3.05
38	Ataxia-telangiectasia	Enrichment	BRAF	2.88
39	Tethered spinal cord syndrome	Enrichment	BRAF	2.88
40	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	2.75
41	Craniopharyngioma	Enrichment	BRAF	2.75
42	Newborn respiratory distress syndrome	Enrichment	BRAF	2.75
43	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.75
44	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	2.75
45	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	2.75
46	Immunodeficiency 22	Enrichment	LCK	2.75
47	Thrombocytopenia 6	Enrichment	SRC	2.75
48	Plexiform neurofibroma	Enrichment	NF1	2.75
49	Neurofibroma	Enrichment	NF1	2.75
50	Neurofibromatosis	Enrichment	NF1	2.75
51	Chromosome 17q11.2 deletion syndrome	Enrichment	NF1	2.75
52	Optic nerve glioma	Enrichment	NF1	2.75
53	Immunodeficiency 64	Enrichment	RASGRP1	2.75
54	Gorham's disease	Enrichment	RASA1	2.75
55	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	2.75
56	Pallister-killian syndrome	Enrichment	ARAF	2.75
57	Noonan syndrome 4	Enrichment	SOS1	2.75
58	Noonan syndrome 9	Enrichment	SOS2	2.75
59	Noonan syndrome 11	Enrichment	MRAS	2.75
60	Wilms tumor 5	Enrichment	BRAF	2.58
61	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	2.51
62	Gallbladder cancer	Enrichment	BRAF	2.51
63	Follicular thyroid carcinoma	Enrichment	BRAF	2.51
64	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	2.45
65	Cafe-au-lait spots, multiple	Enrichment	NF1	2.45
66	Myopia 28, autosomal recessive	Enrichment	DOK1	2.45
67	Noonan syndrome 12	Enrichment	RRAS2	2.45
68	Chromosome 17q11.2 duplication syndrome, 1.4-mb	Enrichment	NF1	2.45
69	Bardet-biedl syndrome 9	Enrichment	NF1	2.45
70	Pleomorphic rhabdomyosarcoma	Enrichment	NF1	2.45
71	Fibromatosis, gingival, 1	Enrichment	SOS1	2.45
72	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	2.40
73	Primary hyperaldosteronism	Enrichment	BRAF	2.40
74	Ventricular septal defect	Enrichment	BRAF	2.40
75	Myeloma, multiple	Enrichment	BRAF, NF1	2.36
76	Melanoma	Enrichment	BRAF	2.35
77	Specific learning disability	Enrichment	MAPK1	2.31
78	Lip and oral cavity carcinoma	Enrichment	BRAF	2.28
79	Watson syndrome	Enrichment	NF1	2.28
80	Neurofibromatosis, familial spinal	Enrichment	NF1	2.28
81	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR	2.28
82	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	NF1	2.28
83	Wieacker-wolff syndrome	Enrichment	RASA1	2.28
84	Brain cancer	Enrichment	NF1	2.28
85	Nuchal bleb, familial	Enrichment	SOS1	2.28
86	Lung cancer susceptibility 3	Enrichment	BRAF	2.21
87	Wilms tumor 1	Enrichment	BRAF	2.18
88	Embryonal rhabdomyosarcoma	Enrichment	NF1	2.15
89	Pilocytic astrocytoma	Enrichment	NF1	2.15
90	Middle aortic syndrome	Enrichment	NF1	2.15
91	Gingival fibromatosis	Enrichment	SOS1	2.15
92	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	2.15
93	Melanoma, cutaneous malignant 1	Enrichment	BRAF	2.13
94	Dandy-walker syndrome	Enrichment	BRAF	2.13
95	Heart, malformation of	Enrichment	MAPK1	2.10
96	Arteriovenous malformations of the brain	Enrichment	BRAF	2.08
97	Diffuse large b-cell lymphoma	Enrichment	BRAF	2.08
98	Capillary malformations, congenital	Enrichment	RASA1	2.05
99	Rhabdomyosarcoma 2	Enrichment	NF1	2.05
100	Colorectal cancer	Enrichment	BRAF, SRC	1.99
101	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.98
102	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.98
103	Hemangioma, capillary infantile	Enrichment	RASA1	1.98
104	Basal cell carcinoma 1	Enrichment	RASA1	1.98
105	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.98
106	Myelofibrosis	Enrichment	SRC	1.91
107	Leukemia, chronic myeloid	Enrichment	BCR	1.91
108	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.91
109	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	BCR	1.91
110	Differentiated thyroid carcinoma	Enrichment	BRAF	1.89
111	Ewing sarcoma	Enrichment	NF1	1.85
112	Lung cancer	Enrichment	BRAF	1.85
113	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.84
114	Left ventricular noncompaction	Enrichment	RAF1	1.81
115	Autism spectrum disorder	Enrichment	MAP2K1, NF1	1.80
116	Neurofibromatosis, type i	Enrichment	NF1	1.80
117	Leukemia, acute lymphoblastic 3	Enrichment	NF1	1.80
118	Juvenile myelomonocytic leukemia	Enrichment	NF1	1.68
119	Aortic valve disease 1	Enrichment	SOS1	1.64
120	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.63
121	Osteoporosis	Enrichment	SRC	1.61
122	Pheochromocytoma	Enrichment	NF1	1.61
123	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.61
124	Rhabdomyosarcoma	Enrichment	NF1	1.55
125	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	NF1	1.44
126	Skin disease	Enrichment	NF1	1.42
127	Precursor t-cell acute lymphoblastic leukemia	Enrichment	BCR	1.40
128	Bladder cancer	Enrichment	NF1	1.30
129	Microcephaly	Enrichment	MAPK1	1.27
130	Severe combined immunodeficiency	Enrichment	LCK	1.25
131	Gastric cancer	Enrichment	NF1	1.13
132	Thrombocytopenia	Enrichment	SRC	1.09
133	Hereditary breast ovarian cancer syndrome	Enrichment	NF1	1.03
134	Ovarian cancer	Enrichment	RRAS2	0.78
135	Inherited cancer-predisposing syndrome	Enrichment	NF1	0.68

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G-protein signaling TC21 regulation pathway

Pathway Network for G-protein signaling TC21 regulation pathway

Pathway network for the G-protein signaling TC21 regulation pathway SuperPath

Member Pathways for G-protein signaling TC21 regulation pathway

Pathways in the G-protein signaling TC21 regulation pathway SuperPath

Gene overlap in member pathways for G-protein signaling TC21 regulation pathway SuperPath

Associated Genes for G-protein signaling TC21 regulation pathway

Associated Disorders for G-protein signaling TC21 regulation pathway

Disorders associated with G-protein signaling TC21 regulation pathway SuperPath

STRING Interaction Network for G-protein signaling TC21 regulation pathway

Sources for G-protein signaling TC21 regulation pathway