G0 and Early G1

Pathway network for the G0 and Early G1 SuperPath

Sources:

Reactome

Pathways in the G0 and Early G1 SuperPath

#	Name	Source	Genes
1	G0 and Early G1	Reactome	CCNA1 CCNA2 CCNE1 CCNE2 CDC25A CDC6 CDK1 CDK2 DYRK1A E2F1 E2F4 E2F5 HDAC1 LIN37 LIN52 LIN54 LIN9 MAX MYBL2 MYC PCNA RBBP4 RBL1 RBL2 TFDP1 TFDP2 TOP2A (see all 27) (see less)
2	G1/S-Specific Transcription	Reactome	CCNA1 CCNE1 CDC45 CDC6 CDK1 CDT1 DHFR E2F1 E2F4 E2F5 E2F6 FBXO5 HDAC1 LIN37 LIN52 LIN54 LIN9 ORC1 PCNA POLA1 RBBP4 RBL1 RBL2 RRM2 TFDP1 TFDP2 TK1 TYMS (see all 28) (see less)
3	Transcription of E2F targets under negative control by DREAM complex	Reactome	CDC25A CDC6 E2F1 E2F4 E2F5 HDAC1 LIN37 LIN52 LIN54 LIN9 MAX MYC PCNA RBBP4 RBL1 RBL2 TFDP1 TFDP2 TOP2A (see all 19) (see less)
4	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	Reactome	CCNA2 CDK1 E2F1 E2F4 E2F5 HDAC1 LIN37 LIN52 LIN54 LIN9 MYBL2 RBBP4 RBL1 RBL2 TFDP1 TFDP2 (see all 16) (see less)

Gene overlap in member pathways for G0 and Early G1 SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LIN54	Lin-54 DREAM MuvB Core Complex Component	Protein Coding	4
2	E2F1	E2F Transcription Factor 1	Protein Coding	4
3	E2F4	E2F Transcription Factor 4	Protein Coding	4
4	E2F5	E2F Transcription Factor 5	Protein Coding	4
5	LIN9	Lin-9 DREAM MuvB Core Complex Component	Protein Coding	4
6	HDAC1	Histone Deacetylase 1	Protein Coding	4
7	LIN37	Lin-37 DREAM MuvB Core Complex Component	Protein Coding	4
8	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	4
9	RBL1	RB Transcriptional Corepressor Like 1	Protein Coding	4
10	RBL2	RB Transcriptional Corepressor Like 2	Protein Coding	4
11	TFDP1	Transcription Factor Dp-1	Protein Coding	4
12	TFDP2	Transcription Factor Dp-2	Protein Coding	4
13	LIN52	Lin-52 DREAM MuvB Core Complex Component	Protein Coding	4
14	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	3
15	CDK1	Cyclin Dependent Kinase 1	Protein Coding	3
16	CDC6	Cell Division Cycle 6	Protein Coding	3
17	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	2
18	MYBL2	MYB Proto-Oncogene Like 2	Protein Coding	2
19	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	2
20	TOP2A	DNA Topoisomerase II Alpha	Protein Coding	2
21	CCNA2	Cyclin A2	Protein Coding	2
22	CCNA1	Cyclin A1	Protein Coding	2
23	CCNE1	Cyclin E1	Protein Coding	2
24	CDC25A	Cell Division Cycle 25A	Protein Coding	2
25	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
26	DYRK1A	Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A	Protein Coding	1
27	CCNE2	Cyclin E2	Protein Coding	1
28	DHFR	Dihydrofolate Reductase	Protein Coding	1
29	E2F6	E2F Transcription Factor 6	Protein Coding	1
30	FBXO5	F-Box Protein 5	Protein Coding	1
31	ORC1	Origin Recognition Complex Subunit 1	Protein Coding	1
32	POLA1	DNA Polymerase Alpha 1, Catalytic Subunit	Protein Coding	1
33	RRM2	Ribonucleotide Reductase Regulatory Subunit M2	Protein Coding	1
34	TK1	Thymidine Kinase 1	Protein Coding	1
35	TYMS	Thymidylate Synthetase	Protein Coding	1
36	CDT1	Chromatin Licensing And DNA Replication Factor 1	Protein Coding	1
37	CDC45	Cell Division Cycle 45	Protein Coding	1

Disorders associated with G0 and Early G1 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Meier-gorlin syndrome 1	Enrichment	CDC45, CDC6, CDT1, ORC1	8.52
2	Brunet-wagner neurodevelopmental syndrome	Enrichment	RBL2	2.93
3	Polydactyly-macrocephaly syndrome	Enrichment	MAX	2.85
4	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.85
5	Meier-gorlin syndrome 5	Enrichment	CDC6	2.85
6	Intellectual developmental disorder, autosomal dominant 7	Enrichment	DYRK1A	2.70
7	Van esch-o'driscoll syndrome	Enrichment	POLA1	2.69
8	Pigmentary disorder, reticulate, with systemic manifestations, x-linked	Enrichment	POLA1	2.69
9	Meier-gorlin syndrome 4	Enrichment	CDT1	2.69
10	Megaloblastic anemia due to dihydrofolate reductase deficiency	Enrichment	DHFR	2.69
11	Meier-gorlin syndrome 7	Enrichment	CDC45	2.69
12	Burkitt lymphoma	Enrichment	MYC	2.55
13	Dyskeratosis congenita, digenic	Enrichment	TYMS	2.38
14	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.38
15	Partington syndrome	Enrichment	POLA1	2.21
16	Familial adenomatous polyposis 4	Enrichment	DHFR	2.21
17	Enophthalmos	Enrichment	DYRK1A	2.10
18	Ciliary dyskinesia, primary, 40	Enrichment	E2F6	1.99
19	Pheochromocytoma	Enrichment	MAX	1.71
20	Polycystic liver disease	Enrichment	CDC25A	1.63
21	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	1.63
22	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	1.54
23	Male infertility with spermatogenesis disorder	Enrichment	DYRK1A	1.53
24	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.50
25	Dyskeratosis congenita	Enrichment	TYMS	1.41
26	Endometrial cancer	Enrichment	DHFR	1.37
27	Microphthalmia	Enrichment	DYRK1A	1.37
28	Inherited cancer-predisposing syndrome	Enrichment	MAX	0.77
29	Autism spectrum disorder	Enrichment	DYRK1A	0.71
30	Microcephaly	Enrichment	DYRK1A	0.66
31	Complex neurodevelopmental disorder	Enrichment	DYRK1A	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for G0 and Early G1

Pathway network for the G0 and Early G1 SuperPath

Member Pathways for G0 and Early G1

Pathways in the G0 and Early G1 SuperPath

Gene overlap in member pathways for G0 and Early G1 SuperPath

Associated Genes for G0 and Early G1

Associated Disorders for G0 and Early G1

Disorders associated with G0 and Early G1 SuperPath

STRING Interaction Network for G0 and Early G1

Sources for G0 and Early G1